Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 2,749,808 $14.2M 1.56% 0 13F-HR Timeline Group Artal Group S.A. in group Artal Group S.A. More: the full row for Artal Group S.A. 2,505,013 $12.9M 0.33% 0 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 2,071,914 $10.7M 0.02% 0 13F-HR Timeline Group SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 1,786,427 $9.22M 1.93% 0 13F-HR Timeline Avidity Partners Management LP More: the full row for Avidity Partners Management LP 1,673,538 $8.64M 0.37% 0 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,471,771 $7.59M 0.02% 0 13F-HR/A Timeline Group Flagship Pioneering, LLC in group Flagship Pioneering, LLC More: the full row for Flagship Pioneering, LLC 1,293,849 $6.68M 0.79% 0 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 968,217 $5M <0.01% +40,171 13F-HR Timeline Group Opaleye Management Inc. More: the full row for Opaleye Management Inc. 865,443 $4.47M 1.02% +77,898 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 828,485 $4.27M 0.13% 0 13F-HR Timeline KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 427,536 $2.21M 0.05% +22,622 13F-HR Timeline Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 340,855 $1.76M 0.49% 0 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 285,803 $1.47M 0.02% +867 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 278,103 $1.44M 0.04% +103,103 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 263,691 $1.36M 0.01% +108,702 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 262,373 $1.35M <0.01% -184,218 13F-HR Timeline Group BlackRock Inc. More: the full row for BlackRock Inc. 259,189 $1.34M <0.01% +2,148 13F-HR Timeline Omega Fund Management, LLC More: the full row for Omega Fund Management, LLC 251,270 $1.3M 0.96% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 226,110 $1.17M <0.01% +5,865 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 160,390 $828K <0.01% +806 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 159,175 $821K 0.73% new 13F-HR/A Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 135,850 $701K 0.17% 0 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 117,435 $606K <0.01% -2,400 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 116,754 $602K 0.01% 0 13F-HR/A Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 76,625 $395K <0.01% +500 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 69,430 $358K <0.01% +11,000 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 63,014 $325K <0.01% -198,069 13F-HR Timeline Group LGT CAPITAL PARTNERS LTD. in group LGT CAPITAL PARTNERS LTD. More: the full row for LGT CAPITAL PARTNERS LTD. 55,000 $284K 0.01% 0 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 51,500 $266K 0.01% 0 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 40,812 $211K <0.01% +3,915 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 40,297 $208K 0.02% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 40,266 $208K -39,567 Timeline 1492 Capital Management LLC More: the full row for 1492 Capital Management LLC 39,244 $202K 0.11% +17,500 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 39,181 $202K <0.01% -133,336 13F-HR Timeline Group SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 37,789 $195K 0.25% new 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 34,578 $178K <0.01% +17,416 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 30,005 $155K <0.01% new 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 28,159 $145K <0.01% -109,722 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 26,622 $137K <0.01% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 22,550 $117K <0.01% 0 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 21,553 $111K <0.01% +21,532 13F-HR Timeline Group CERTUITY, LLC More: the full row for CERTUITY, LLC 21,202 $109K 0.01% new 13F-HR Timeline Clarius Group, LLC More: the full row for Clarius Group, LLC 18,620 $96.1K 0.01% 0 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 18,124 $93.5K <0.01% -15,618 13F-HR Timeline Group Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 15,873 $81.9K <0.01% -154,126 13F-HR Timeline HighTower Advisors, LLC More: the full row for HighTower Advisors, LLC 15,348 $79K <0.01% +431 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 14,091 $72K <0.01% +13,859 13F-HR Timeline Corient Private Wealth LP in group Corient Private Wealth LP More: the full row for Corient Private Wealth LP 12,000 $61.9K <0.01% 0 13F-HR Timeline Group Integrated Wealth Concepts LLC More: the full row for Integrated Wealth Concepts LLC 10,000 $51.6K <0.01% 0 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 9,699 $50K <0.01% -7,762 13F-HR/A Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 6,400 $33K <0.01% new 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 4,500 $23.2K <0.01% 0 13F-HR Timeline EDMOND DE ROTHSCHILD HOLDING S.A. in group EDMOND DE ROTHSCHILD HOLDING … More: the full row for EDMOND DE ROTHSCHILD HOLDING S.A. 4,382 $22.6K <0.01% 0 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 3,880 $20K <0.01% new 13F-HR/A Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 3,421 $18K <0.01% +2,103 13F-HR/A Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,852 $14.7K <0.01% +2,757 13F-HR Timeline Group Redwood Wealth Management Group, LLC More: the full row for Redwood Wealth Management Group, LLC 1,157 $5.97K <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 1,095 $5.65K <0.01% 0 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 1,032 $5.32K <0.01% -53 13F-HR Timeline Group NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 859 $4.23K <0.01% new 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 750 $3.87K <0.01% 0 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 659 $3.4K <0.01% 0 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 549 $2.83K <0.01% 0 13F-HR/A Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 454 $2.34K <0.01% -163 13F-HR Timeline Group FIFTH THIRD BANCORP in group FIFTH THIRD BANK, NATIONAL AS… More: the full row for FIFTH THIRD BANCORP 129 $666 <0.01% 0 13F-HR Timeline Group Activest Wealth Management More: the full row for Activest Wealth Management 87 $449 <0.01% new 13F-HR Timeline Sound Income Strategies, LLC More: the full row for Sound Income Strategies, LLC 76 $392 <0.01% 0 13F-HR Timeline Aviso Financial Inc. More: the full row for Aviso Financial Inc. 21 $108 <0.01% 13F-HR Timeline PSI Advisors, LLC More: the full row for PSI Advisors, LLC 13 $67 <0.01% 0 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 8 $41 <0.01% 0 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.