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Disclosery

SPRO SPERO THERAPEUTICS INC

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COM (common), issuer CIK 1701108

55 managers (56 13F filers) reported a position in SPRO shares at 2025-12-31, 21,119,399 shares in all. 15 filers opened a position and 6 filers sold out during the quarter.

Managers
55
13F filers
56
New
15
Added
14
Reduced
12
Sold out
6
Shares held by filers
21,119,399

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
GSK plc9,190,606$21.4M2.68%13F-HRTimeline
Pfizer Inc2,362,348$5.5M2.33%013F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC2,083,462$4.85M<0.01%+93,60713F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC1,279,522$2.98M<0.01%-173,24313F-HRTimeline
Alphabet Inc.in group Alphabet Inc.889,979$2.07M0.08%013F-HRTimelineGroup
Anson Funds Management LPin group Anson Funds Management LP625,062$1.46M0.19%-978,50713F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding589,170$1.37M+539,771Timeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC529,195$1.23M<0.01%+1,71813F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.433,616$1.01M<0.01%-1,15213F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC397,864$927K<0.01%new13F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…293,700$684K<0.01%new13F-HRTimelineGroup
Informed Momentum Co LLC218,084$508K0.06%-64,36113F-HRTimeline
STATE STREET CORPin group STATE STREET CORP210,151$490K<0.01%+19,20013F-HRTimelineGroup
Ionic Capital Management LLC195,939$457K0.45%-12,78613F-HRTimeline
GSA CAPITAL PARTNERS LLP178,930$417K0.04%+72,03613F-HRTimeline
INTREPID FAMILY OFFICE LLC165,000$384K0.37%+55,00013F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC158,344$369K<0.01%+115,35613F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO132,010$308K<0.01%new13F-HRTimelineGroup
OMERS ADMINISTRATION Corp131,127$306K<0.01%new13F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP120,984$282K<0.01%-8,65913F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC119,434$278K<0.01%new13F-HRTimelineGroup
UBS Group AGin group UBS Group AG116,447$271K<0.01%+89,34613F-HRTimelineGroup
BRIDGEWAY CAPITAL MANAGEMENT, LLC114,800$267K0.01%013F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC113,839$265K0.02%-1,70013F-HR/ATimelineGroup
Shay Capital LLC60,289$140K0.02%-3,37813F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.43,579$102K<0.01%new13F-HRTimelineGroup
Quadrature Capital Ltdin group Quadrature Capital Ltd37,799$88.1K<0.01%new13F-HRTimelineGroup
SIMPLEX TRADING, LLC35,686$83.1K<0.01%+28,06813F-HRTimeline
Capital Asset Advisory Services LLC32,548$81.7K<0.01%013F-HRTimeline
AXXCESS WEALTH MANAGEMENT, LLC32,548$75.8K<0.01%013F-HR/ATimeline
Three Seasons Wealth, LLC30,000$69.9K0.01%013F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP29,768$69K<0.01%+77413F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co28,565$66.6K<0.01%013F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.24,705$57.6K<0.01%+2,60513F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC24,107$56.2K<0.01%new13F-HRTimelineGroup
Assenagon Asset Management S.A.18,636$43.4K<0.01%-18,35713F-HRTimeline
Torrey Growth & Income Advisors17,025$39.7K0.01%+1,25013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd15,175$35.4K<0.01%-18,62613F-HRTimelineGroup
Texas Yale Capital Corp.10,000$23.3K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…7,215$16.8K<0.01%new13F-HRTimelineGroup
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP6,477$15.1K<0.01%new13F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO5,373$12.5K<0.01%+5,13713F-HRTimelineGroup
FNY Investment Advisers, LLC5,300$12K<0.01%013F-HRTimeline
Cullen/Frost Bankers, Inc.in group Cullen/Frost Bankers, Inc.3,000$6.99K<0.01%new13F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/744$1.73K<0.01%+1113F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY313$729<0.01%-43,06513F-HR/ATimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.290$675<0.01%013F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN200$466<0.01%013F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…200$466<0.01%013F-HR/ATimelineGroup
US BANCORP \DE\in group US BANCORP \DE\151$352<0.01%013F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS40$93<0.01%013F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC17$40<0.01%new13F-HRTimelineGroup
SageView Advisory Group, LLC17$40<0.01%new13F-HRTimeline
Farther Finance Advisors, LLC10$23<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.9$21<0.01%-113F-HRTimeline