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Disclosery

SPRO SPERO THERAPEUTICS INC

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COM (common), issuer CIK 1701108

47 managers (47 13F filers) reported a position in SPRO shares at 2025-09-30, 11,311,502 shares in all. 13 filers opened a position and 11 filers sold out during the quarter.

Managers
47
13F filers
47
New
13
Added
12
Reduced
6
Sold out
11
Shares held by filers
11,311,502

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
Pfizer Inc2,362,348$4.44M1.02%013F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC1,989,855$3.74M<0.01%+39,47413F-HRTimelineGroup
Anson Funds Management LPin group Anson Funds Management LP1,603,569$3.01M0.33%-11,90013F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC1,452,765$2.73M<0.01%+620,60013F-HRTimeline
Alphabet Inc.in group Alphabet Inc.889,979$1.67M0.07%013F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC527,477$992K<0.01%+16,77813F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.434,768$817K<0.01%013F-HRTimelineGroup
Informed Momentum Co LLC282,445$531K0.06%+43,30513F-HRTimeline
Ionic Capital Management LLC208,725$392K0.44%+58,72513F-HRTimeline
STATE STREET CORPin group STATE STREET CORP190,951$359K<0.01%+37,50013F-HRTimelineGroup
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPin group ARROWSTREET CAPITAL, LIMITED …150,516$283K<0.01%new13F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP129,643$244K<0.01%+28,81213F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC115,539$217K0.02%-28,37813F-HRTimelineGroup
BRIDGEWAY CAPITAL MANAGEMENT, LLC114,800$216K<0.01%013F-HRTimeline
INTREPID FAMILY OFFICE LLC110,000$207K0.19%new13F-HRTimeline
GSA CAPITAL PARTNERS LLP106,894$201K0.02%new13F-HRTimeline
Shay Capital LLC63,667$120K0.02%new13F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP49,399$92.9K<0.01%new13F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY43,378$81.5K<0.01%+34,15713F-HR/ATimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC42,988$80.8K<0.01%new13F-HRTimelineGroup
Cubist Systematic Strategies, LLC40,845$76.8K<0.01%+13,70513F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC40,219$75.6K<0.01%new13F-HRTimelineGroup
Assenagon Asset Management S.A.36,993$69.5K<0.01%new13F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd33,801$63.5K<0.01%-75013F-HRTimelineGroup
Capital Asset Advisory Services LLC32,548$61.2K<0.01%013F-HRTimeline
AXXCESS WEALTH MANAGEMENT, LLC32,548$61.2K<0.01%013F-HRTimeline
Rangeley Capital, LLC30,000$56.4K0.05%new13F-HRTimeline
Three Seasons Wealth, LLC30,000$56.4K0.01%013F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP28,994$54.9K<0.01%new13F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co28,565$53.7K<0.01%013F-HRTimelineGroup
UBS Group AGin group UBS Group AG27,101$51K<0.01%+18,90713F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.22,100$41.5K<0.01%+7,13213F-HRTimelineGroup
GROUP ONE TRADING LLC16,879$31.7K<0.01%+8,64013F-HRTimeline
Torrey Growth & Income Advisors15,775$29.7K0.01%13F-HRTimeline
Texas Yale Capital Corp.10,000$18.8K<0.01%013F-HRTimeline
SIMPLEX TRADING, LLC7,618$14K<0.01%-22,70413F-HRTimeline
FNY Investment Advisers, LLC5,300$9K<0.01%new13F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/733$1.38K<0.01%-4,90013F-HR/ATimelineGroup
FMR LLCin group FMR LLC550$1.03K<0.01%new13F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.290$545<0.01%013F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO236$444<0.01%013F-HR/ATimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN200$376<0.01%013F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…200$376<0.01%new13F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\151$284<0.01%013F-HRTimelineGroup
NewEdge Advisors, LLC100$188<0.01%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS40$75<0.01%013F-HRTimelineGroup
SBI Securities Co., Ltd.10$19<0.01%-5213F-HRTimeline