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Disclosery

SPRB SPRUCE BIOSCIENCES INC

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COM NEW (common), issuer CIK 1683553

32 managers (32 13F filers) reported a position in SPRB shares at 2025-12-31, 753,855 shares in all. 24 filers opened a position and 2 filers sold out during the quarter.

Managers
32
13F filers
32
New
24
Added
4
Reduced
1
Sold out
2
Shares held by filers
753,855

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
Ikarian Capital, LLCin group Ikarian Capital, LLC121,356$10.6M1.37%+108,02413F-HRTimelineGroup
Squadron Capital Management LLC70,000$6.1M2.72%13F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC69,999$6.1M<0.01%new13F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…58,949$5.14M<0.01%new13F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC58,000$5.05M0.38%new13F-HR/ATimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.51,671$4.5M0.01%new13F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC47,933$4.18M0.11%new13F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management40,000$3.48M0.01%new13F-HRTimelineGroup
Carlyle Group Inc.in group Carlyle Group Inc.38,620$3.3M0.02%-2,857,89813F-HRTimelineGroup
ExodusPoint Capital Management, LP25,271$2.2M0.02%new13F-HRTimeline
Schonfeld Strategic Advisors LLC24,767$2.16M0.01%new13F-HRTimeline
Quinn Opportunity Partners LLC22,810$1.99M0.09%new13F-HRTimeline
Caligan Partners LP20,514$1.79M0.16%new13F-HRTimeline
Stonepine Capital Management, LLC19,742$1.72M1.36%new13F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC17,873$1.56M<0.01%new13F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.16,938$1.48M<0.01%new13F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC12,732$1.11M<0.01%new13F-HRTimelineGroup
SUPERSTRING CAPITAL MANAGEMENT LP12,137$1.06M0.57%new13F-HRTimeline
STATE STREET CORPin group STATE STREET CORP6,400$558K<0.01%new13F-HRTimelineGroup
UBS Group AGin group UBS Group AG4,902$427K<0.01%+4,77013F-HRTimelineGroup
Resolute Capital Asset Partners LLC4,000$348K0.17%new13F-HRTimeline
SkyView Investment Advisors, LLC3,000$261K0.03%new13F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP2,422$211K<0.01%new13F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS2,000$174K<0.01%new13F-HRTimelineGroup
Lion Point Capital, LP1,000$87.1K0.45%013F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY388$33.8K<0.01%+29013F-HR/ATimelineGroup
Sound Income Strategies, LLC200$14.7K<0.01%new13F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/93$8.1K<0.01%+9013F-HRTimelineGroup
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP84$7.32K<0.01%new13F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA40$3K<0.01%new13F-HRTimelineGroup
CALDWELL SUTTER CAPITAL, INC.13$1.13K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1$87<0.01%new13F-HRTimelineGroup