PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 11,833,539 $66.7M 1.22% 0 13F-HR Timeline Group Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 7,911,669 $44.6M 3.42% 0 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 7,690,405 $43.4M 1.29% +274,500 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 5,815,000 $32.8M 1.2% +2,840,000 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 5,811,423 $32.8M 0.34% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 4,869,682 $27.5M <0.01% +144,564 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 3,454,959 $19.5M <0.01% +371,109 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 2,663,863 $15M 0.01% +71,166 13F-HR Timeline Group ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 2,612,000 $14.7M 0.36% +1,676,000 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 2,416,108 $13.6M 0.02% +1,083,103 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 2,029,898 $11.4M <0.01% -884,229 13F-HR Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 1,860,542 $10.5M 0.77% -38,800 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 1,682,805 $9.49M 0.03% 0 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,603,336 $9.04M 0.54% -95,922 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 1,599,233 $9.02M <0.01% +1 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 1,400,000 $7.9M 0.01% -2,600,000 13F-HR Timeline Group Monashee Investment Management LLC More: the full row for Monashee Investment Management LLC 1,349,771 $7.61M 4.29% new 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,267,392 $7.15M <0.01% -19,851 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,087,413 $6.13M <0.01% -5,886 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,006,306 $5.68M <0.01% +329,679 13F-HR/A Timeline Group Finepoint Capital LP More: the full row for Finepoint Capital LP 961,251 $5.42M 1.02% 0 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 911,908 $5.14M +187,763 Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 3 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 815,254 $4.6M -4,373 Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 705,955 $3.98M 2.33% +409,000 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 679,084 $3.83M <0.01% +235,543 13F-HR Timeline Group Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 418,371 $2.36M 0.22% +21,975 13F-HR Timeline Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 413,625 $2.33M 3.7% -135,557 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 412,777 $2.33M <0.01% -33,739 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 394,976 $2.23M <0.01% 0 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 394,266 $2.22M <0.01% +136,420 13F-HR/A Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 360,937 $2.04M <0.01% -371,671 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 344,294 $1.94M <0.01% -445,702 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 316,823 $1.79M 0.01% -315,000 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 300,000 $1.69M 0.37% -300,000 13F-HR Timeline Group PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 226,755 $1.28M <0.01% -170,433 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 213,409 $1.2M <0.01% +121,822 13F-HR Timeline Group Apis Capital Advisors, LLC More: the full row for Apis Capital Advisors, LLC 196,000 $1.11M 0.19% 0 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 185,682 $1.05M <0.01% -40,715 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 182,869 $1.03M 0.01% +114,867 13F-HR Timeline Knott David M Jr More: the full row for Knott David M Jr 162,440 $916K 0.42% 0 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 161,537 $911K <0.01% -522 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 160,409 $905K 0.12% -16,281 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 153,407 $865K <0.01% -2,443 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 152,126 $858K <0.01% +34,758 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 144,699 $816K <0.01% -3,961 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 138,136 $779K <0.01% -20,966 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 131,957 $744K <0.01% +900 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 128,260 $723K <0.01% new 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 116,632 $658K <0.01% -793,069 13F-HR Timeline Group Fisher Asset Management, LLC More: the full row for Fisher Asset Management, LLC 103,481 $584K <0.01% new 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 97,322 $549K <0.01% +26,271 13F-HR Timeline Group Quantum Private Wealth, LLC More: the full row for Quantum Private Wealth, LLC 94,231 $531K 0.16% 0 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 82,572 $466K <0.01% -11,709 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 81,830 $462K <0.01% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 76,107 $429K <0.01% +30,900 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 74,630 $421K <0.01% +1,600 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 60,534 $341K 0.01% -23,467 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 52,800 $298K <0.01% -410,900 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 52,799 $298K 0.01% -16,281 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 50,054 $282K <0.01% new 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 39,962 $225K <0.01% -12,198 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 36,147 $204K <0.01% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 35,633 $201K 0.01% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 35,087 $198K <0.01% 0 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 34,485 $194K <0.01% +4,539 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 31,757 $179K <0.01% -3,946 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 31,130 $176K +728 Timeline CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 30,600 $173K <0.01% 0 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 30,007 $169K <0.01% -16,991 13F-HR Timeline FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 25,005 $141K 0.02% +6,491 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 24,889 $140K <0.01% +8,574 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 23,460 $132K <0.01% -15,000 13F-HR Timeline HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 22,151 $127K <0.01% -1,441 13F-HR/A Timeline Group Lido Advisors, LLC in group Lido Advisors, LLC More: the full row for Lido Advisors, LLC 20,175 $124K <0.01% 0 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 20,876 $118K <0.01% new 13F-HR Timeline AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 20,647 $116K 0.03% -3,388 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 20,270 $114K <0.01% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 18,253 $103K <0.01% -4,236 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 17,389 $98.1K <0.01% 0 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 14,919 $84K <0.01% -141,903 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 14,218 $80.2K <0.01% +1,362 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 13,078 $73.8K <0.01% 0 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 12,695 $71.6K 0.01% -954 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 11,160 $62.9K <0.01% 0 13F-HR Timeline Group COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 10,852 $61.2K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 10,671 $60.2K <0.01% +3,669 13F-HR Timeline Group MARTINGALE ASSET MANAGEMENT L P More: the full row for MARTINGALE ASSET MANAGEMENT L P 10,574 $59.6K <0.01% +346 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 7,204 $40.6K <0.01% -3,007 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 7,100 $40K <0.01% 0 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 6,553 $37K <0.01% +1,803 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 5,270 $29.7K <0.01% 0 13F-HR Timeline Group Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 4,955 $27.9K <0.01% 0 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 4,926 $27.8K <0.01% 0 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 4,836 $27.3K <0.01% -55,700 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 4,952 $27K <0.01% new 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 4,494 $25K <0.01% +15 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 4,296 $24K <0.01% -373,944 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 3,710 $20.9K <0.01% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 3,631 $20.5K <0.01% -491 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 3,507 $19.8K <0.01% -2,685 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 3,398 $19.2K <0.01% -670 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 2,017 $11.4K <0.01% +1,987 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,852 $10K <0.01% +1,073 13F-HR Timeline QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 1,605 $9.05K <0.01% +1,174 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,530 $8.63K <0.01% -145 13F-HR Timeline HANTZ FINANCIAL SERVICES, INC. More: the full row for HANTZ FINANCIAL SERVICES, INC. 1,000 $6K <0.01% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 756 $4.26K <0.01% -8 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 656 $3.7K <0.01% -128 13F-HR Timeline Group True Wealth Design, LLC More: the full row for True Wealth Design, LLC 582 $3.28K <0.01% +18 13F-HR Timeline Osbon Capital Management LLC More: the full row for Osbon Capital Management LLC 501 $2.83K <0.01% 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 344 $1.94K <0.01% +244 13F-HR/A Timeline Group Physician Wealth Advisors, Inc. More: the full row for Physician Wealth Advisors, Inc. 312 $1.76K <0.01% 0 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 304 $1.72K <0.01% -108 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 300 $1.69K <0.01% 0 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 298 $1.68K <0.01% 0 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 242 $1.36K <0.01% +146 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 222 $1.25K <0.01% new 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 231 $1K <0.01% -169 13F-HR Timeline Group Basecamp Wealth Advisors LLC More: the full row for Basecamp Wealth Advisors LLC 137 $773 <0.01% 13F-HR Timeline Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 135 $762 <0.01% 0 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 123 $694 <0.01% 0 13F-HR Timeline