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Disclosery

LXRX LEXICON PHARMACEUTICALS INC

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COMMON STOCK (common), issuer CIK 1062822

124 managers (126 13F filers) reported a position in LXRX shares at 2025-12-31, 260,427,476 shares in all. 21 filers opened a position and 17 filers sold out during the quarter.

Managers
124
13F filers
126
New
21
Added
28
Reduced
41
Sold out
17
Shares held by filers
260,427,476

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
Artal Group S.A.in group Artal Group S.A.136,180,481$157M21.91%013F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.38,918,903$44.8M1.34%013F-HRTimelineGroup
FMR LLCin group FMR LLC37,834,207$43.5M<0.01%-845,54113F-HRTimelineGroup
VANGUARD GROUP INCgroup of 2 filers holding9,673,116$11.1M+84,675Timeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC4,821,733$5.54M<0.01%+991,07313F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.3,192,448$3.67M<0.01%-202,52413F-HRTimelineGroup
UBS Group AGin group UBS Group AG3,007,237$3.46M<0.01%+2,654,31513F-HRTimelineGroup
Sessa Capital IM, L.P.3,000,000$3.45M0.07%013F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC2,500,022$2.88M<0.01%+102,09913F-HRTimelineGroup
CIBC Private Wealth Group LLCin group CIBC Bancorp USA Inc.1,950,000$2.24M<0.01%-450,25713F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC1,724,304$1.98M<0.01%+1,267,77413F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC1,710,975$1.97M<0.01%-923,05213F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP1,262,367$1.45M<0.01%new13F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…1,207,242$1.39M<0.01%+245,18213F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co1,055,123$1.21M<0.01%-89,50913F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP996,235$1.15M0.1%-206,67113F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC921,204$1.06M<0.01%+861,85713F-HR/ATimelineGroup
Hennion & Walsh Asset Management, Inc.901,222$1.04M0.04%+122,01013F-HRTimeline
STATE STREET CORPin group STATE STREET CORP884,738$1.02M<0.01%+4,61713F-HRTimelineGroup
Ishara Investments LP880,000$1.01M1.18%13F-HRTimeline
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding818,285$941K+259,277Timeline
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC640,130$732K<0.01%+603,22513F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.594,883$684K<0.01%+73,48013F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP412,164$474K<0.01%+42,37013F-HRTimelineGroup
Compagnie Lombard Odier SCmA410,000$472K0.01%013F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.284,025$327K<0.01%new13F-HRTimelineGroup
OMERS ADMINISTRATION Corp273,800$315K<0.01%new13F-HRTimeline
ExodusPoint Capital Management, LP268,433$309K<0.01%new13F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC263,254$303K<0.01%-29,14613F-HRTimeline
GROUP ONE TRADING LLC224,308$258K0.01%+8,06413F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC194,743$224K<0.01%+162,88113F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY193,035$222K<0.01%+24,01713F-HR/ATimelineGroup
Ikarian Capital, LLCin group Ikarian Capital, LLC164,674$189K0.02%-11,80513F-HRTimelineGroup
Cerity Partners LLCin group Cerity Partners LLC144,944$167K<0.01%-13,09613F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC144,800$167K<0.01%-158,13113F-HRTimelineGroup
Headlands Technologies LLC136,113$157K0.01%+86,46613F-HRTimeline
Lighthouse Investment Partners, LLCin group Lighthouse Investment Partner…126,600$146K<0.01%new13F-HRTimelineGroup
HRT FINANCIAL LP117,549$135K<0.01%+71,10213F-HRTimeline
Monaco Asset Management SAM117,188$135K0.04%-232,81213F-HRTimeline
TWO SIGMA SECURITIES, LLC114,632$132K0.02%+98,75113F-HRTimeline
Graham Capital Management, L.P.109,900$126K<0.01%new13F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/102,097$117K<0.01%+44,29313F-HRTimelineGroup
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…100,532$116K<0.01%new13F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd96,090$111K<0.01%-233,44613F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.92,530$106K<0.01%-4,87013F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC91,670$105K<0.01%+73,55113F-HRTimelineGroup
Quarry LP88,000$101K0.02%new13F-HRTimeline
LPL Financial LLC87,057$100K<0.01%-4,20113F-HRTimeline
CAXTON ASSOCIATES LLP71,027$81.7K<0.01%new13F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/70,000$80.5K<0.01%013F-HRTimelineGroup
Straight Path Wealth Management62,666$72.1K0.02%013F-HRTimeline
State of Wyoming60,571$69.7K0.01%+52,04513F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC60,472$69.5K<0.01%+1,79613F-HRTimelineGroup
Optiver Holding B.V.in group Optiver Holding B.V.52,595$60.5K<0.01%-23,29813F-HRTimelineGroup
Fortis Group Advisors, LLC50,000$58K0.01%-7,80013F-HRTimeline
R Squared Ltd46,579$53.6K0.03%+14,53013F-HRTimeline
BOOTHBAY FUND MANAGEMENT, LLC44,315$51K<0.01%-11,80513F-HRTimeline
WEDBUSH SECURITIES INC40,850$47K<0.01%013F-HRTimeline
KWB Wealth40,640$46.7K<0.01%013F-HRTimeline
Catalyst Funds Management Pty Ltd40,300$46.3K0.01%013F-HRTimeline
CIBC Asset Management Inc39,520$45.4K<0.01%new13F-HRTimeline
Virtu Financial LLCin group Virtu Financial LLC36,468$42K<0.01%new13F-HRTimelineGroup
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT…35,714$41.1K0.01%013F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC33,800$38.9K<0.01%-1,20013F-HRTimelineGroup
EntryPoint Capital, LLC33,618$38.7K0.02%new13F-HRTimeline
Vermillion & White Wealth Management Gr…32,000$36.8K0.02%-50013F-HRTimeline
Leonteq Securities AG30,000$34.5K<0.01%new13F-HRTimeline
Pathstone Holdings, LLCin group Pathstone Holdings, LLC29,969$34.5K<0.01%-23913F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…29,093$33.5K<0.01%+5,41413F-HRTimelineGroup
PINNACLE ASSOCIATES LTD29,015$33.4K<0.01%-21,80013F-HRTimeline
SECURITY NATIONAL BANK OF SIOUX CITY IO…26,650$30.6K0.02%new13F-HRTimeline
OPPENHEIMER & CO INCin group OPPENHEIMER ASSET MANAGEMENT …23,500$27K<0.01%013F-HRTimelineGroup
Cambridge Investment Research Advisors,…21,505$25K<0.01%-1,89513F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC21,191$24.4K<0.01%+16813F-HRTimeline
Invera Wealth Advisors, LLC20,000$23K0.01%013F-HRTimeline
TIAA TRUST, NATIONAL ASSOCIATIONin group TIAA20,000$23K<0.01%013F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp19,124$22K<0.01%013F-HRTimelineGroup
CREDIT AGRICOLE S Ain group CREDIT AGRICOLE S A18,975$21.8K<0.01%new13F-HRTimelineGroup
Quadrature Capital Ltdin group Quadrature Capital Ltd18,414$21.2K<0.01%-209,79513F-HRTimelineGroup
StoneX Group Inc.in group StoneX Group Inc.16,234$18.7K<0.01%new13F-HRTimelineGroup
SIMPLEX TRADING, LLC14,758$17K<0.01%-58,52913F-HRTimeline
Cetera Investment Advisers14,188$16.3K<0.01%-3,33613F-HRTimeline
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC14,090$16.2K<0.01%new13F-HRTimelineGroup
Callan Family Office, LLCin group Callan Family Office, LLC14,090$16.2K<0.01%new13F-HRTimelineGroup
TRUIST FINANCIAL CORPin group TRUIST FINANCIAL CORP14,000$16.1K<0.01%013F-HRTimelineGroup
WEALTH ENHANCEMENT ADVISORY SERVICES, L…13,520$15.4K<0.01%-5,35713F-HRTimeline
Schonfeld Strategic Advisors LLC13,108$15.1K<0.01%-812,52513F-HRTimeline
CWM, LLCin group CWM, LLC13,179$15K<0.01%-13,56513F-HRTimelineGroup
HBK Sorce Advisory LLC11,786$14.5K<0.01%013F-HRTimeline
Chemistry Wealth Management LLC12,000$13.8K<0.01%013F-HRTimeline
CAPTRUST FINANCIAL ADVISORS11,735$13.5K<0.01%-2,33413F-HRTimeline
FWG Holdings, LLC11,350$13.2K<0.01%new13F-HR/ATimeline
Perennial Investment Advisors, LLC10,990$12.6K<0.01%013F-HRTimeline
NBT BANK, N.A.in group NBT BANK, N.A.10,000$11.5K<0.01%013F-HRTimelineGroup
Berger Financial Group, Inc10,000$11.5K<0.01%-92913F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA6,768$7K<0.01%-715,66713F-HRTimelineGroup
Golden State Wealth Management, LLC3,700$4.25K<0.01%013F-HRTimeline
SBI Securities Co., Ltd.3,018$3.47K<0.01%-12,02913F-HRTimeline
Farther Finance Advisors, LLC2,755$3.17K<0.01%+1,50013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC2,592$2.98K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,461$1.68K<0.01%013F-HRTimelineGroup
Physician Wealth Advisors, Inc.1,412$1.62K<0.01%013F-HRTimeline
Rialto Wealth Management, LLC1,313$1.51K<0.01%013F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP1,106$1.27K<0.01%+21413F-HRTimelineGroup
Global Retirement Partners, LLC1,000$1.15K<0.01%013F-HRTimeline
Avion Wealth1,333$1K<0.01%013F-HRTimeline
Fortitude Family Office, LLC706$812<0.01%013F-HRTimeline
Basecamp Wealth Advisors LLC691$795<0.01%13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.642$738<0.01%-10013F-HRTimelineGroup
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COin group NORTHWESTERN MUTUAL INVESTMEN…500$575<0.01%-1413F-HR/ATimelineGroup
Steward Partners Investment Advisory, L…500$575<0.01%-10,28513F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…335$385<0.01%013F-HR/ATimelineGroup
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…158$182<0.01%-29713F-HRTimelineGroup
Caitong International Asset Management …147$169<0.01%-81213F-HR/ATimeline
SYNTAX RESEARCH, INC.142$164<0.01%013F-HRTimeline
COMERICA BANK122$140<0.01%013F-HRTimeline
Larson Financial Group LLC100$115<0.01%013F-HRTimeline
True Wealth Design, LLC49$57<0.01%-3613F-HRTimeline
Arax Advisory Partners41$47<0.01%-5,05613F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS11$13<0.01%-4,97713F-HRTimelineGroup
RHUMBLINE ADVISERS0$2<0.01%013F-HRTimelineAmount filed as zero, left out of ratios.
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN1$1<0.01%-30013F-HRTimelineGroup
Motiv8 Investments LLC200$00%new13F-HRTimelineValue filed as zero, left out of ratios.
Covestor Ltd81$00%013F-HRTimelineValue filed as zero, left out of ratios.