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Disclosery

LXRX LEXICON PHARMACEUTICALS INC

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COMMON STOCK (common), issuer CIK 1062822

123 managers (124 13F filers) reported a position in LXRX shares at 2025-09-30, 255,140,102 shares in all. 18 filers opened a position and 17 filers sold out during the quarter.

Managers
123
13F filers
124
New
18
Added
26
Reduced
42
Sold out
17
Shares held by filers
255,140,102

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
Artal Group S.A.in group Artal Group S.A.136,180,481$184M24.25%013F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.38,918,903$52.5M2.06%013F-HRTimelineGroup
FMR LLCin group FMR LLC38,679,748$52.2M<0.01%+542,21313F-HRTimelineGroup
VANGUARD GROUP INCgroup of 2 filers holding9,588,441$12.9M+672,075Timeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC3,830,660$5.17M<0.01%+2,187,39613F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.3,394,972$4.58M<0.01%+40,30313F-HRTimelineGroup
Sessa Capital IM, L.P.3,000,000$4.05M0.1%013F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC2,634,027$3.56M<0.01%new13F-HRTimelineGroup
CIBC Private Wealth Group LLCin group CIBC Bancorp USA Inc.2,400,257$3.24M0.01%-50,14313F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC2,397,923$3.24M<0.01%+20,22913F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP1,202,906$1.62M0.14%-1,627,75313F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co1,144,632$1.55M<0.01%+261,40513F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…962,060$1.3M<0.01%+206,40813F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP880,121$1.19M<0.01%+61,50013F-HRTimelineGroup
Schonfeld Strategic Advisors LLC825,633$1.11M0.01%-3,750,51913F-HRTimeline
Hennion & Walsh Asset Management, Inc.779,212$1.05M0.04%-14,18813F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA722,435$975K<0.01%-52,03913F-HRTimelineGroup
JACOBS LEVY EQUITY MANAGEMENT, INC692,727$935K<0.01%new13F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP559,008$755K<0.01%+155,08613F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.521,403$704K<0.01%+100,70313F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC456,530$616K<0.01%-348,13713F-HRTimelineGroup
Compagnie Lombard Odier SCmA410,000$554K0.01%+80,00013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP369,794$499K<0.01%-46,57813F-HRTimelineGroup
UBS Group AGin group UBS Group AG352,922$476K<0.01%-47,81013F-HRTimelineGroup
Monaco Asset Management SAM350,000$472K0.18%-181,60013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd329,536$445K0.02%+263,26013F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC302,931$409K<0.01%-1,099,27913F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC292,400$395K<0.01%new13F-HRTimeline
Quadrature Capital Ltdin group Quadrature Capital Ltd228,209$309K<0.01%new13F-HRTimelineGroup
GROUP ONE TRADING LLC216,244$292K0.01%-130,50813F-HRTimeline
Ikarian Capital, LLCin group Ikarian Capital, LLC176,479$238K0.05%013F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY169,018$228K<0.01%+37,62513F-HR/ATimelineGroup
Cerity Partners LLCin group Cerity Partners LLC158,040$213K<0.01%-48,23913F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.97,400$131K<0.01%new13F-HRTimelineGroup
LPL Financial LLC91,258$123K<0.01%-13,17513F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.75,893$102K<0.01%+72,85813F-HRTimelineGroup
SIMPLEX TRADING, LLC73,287$98K<0.01%+20,60713F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/70,000$94.5K<0.01%-30,00013F-HRTimelineGroup
China Universal Asset Management Co., L…63,698$86K0.01%-9,24513F-HRTimeline
Cubist Systematic Strategies, LLC63,484$85.7K<0.01%-94,72013F-HRTimeline
Straight Path Wealth Management62,666$84.6K0.02%013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC59,347$80.1K<0.01%-266,39913F-HRTimelineGroup
Fortis Group Advisors, LLC57,800$79.8K0.01%013F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC58,676$79.2K<0.01%-36,94113F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/57,804$78K<0.01%+25,70713F-HR/ATimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC56,120$75.8K<0.01%013F-HRTimeline
PINNACLE ASSOCIATES LTD50,815$68.6K<0.01%013F-HRTimeline
Headlands Technologies LLC49,647$67K0.01%new13F-HRTimeline
HRT FINANCIAL LP46,447$62K<0.01%-442,02113F-HRTimeline
WEDBUSH SECURITIES INC40,850$55K<0.01%013F-HRTimeline
Catalyst Funds Management Pty Ltd40,300$54.4K0.01%-13,40013F-HRTimeline
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC36,905$49K<0.01%new13F-HRTimelineGroup
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT…35,714$48.2K0.01%013F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC35,738$48K<0.01%-55,12613F-HRTimeline
Point72 Asia (Singapore) Pte. Ltd.35,024$47.3K0.01%-35,02113F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC35,000$47.2K<0.01%new13F-HRTimelineGroup
Vermillion & White Wealth Management Gr…32,500$43.9K0.02%+26,00013F-HRTimeline
R Squared Ltd32,049$43.3K0.02%+2,49013F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC31,862$43K<0.01%-40813F-HR/ATimelineGroup
Pathstone Holdings, LLCin group Pathstone Holdings, LLC30,208$40.8K<0.01%+16713F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO30,037$40.5K<0.01%+5,35313F-HR/ATimelineGroup
KWB Wealth40,640$38.4K<0.01%013F-HRTimeline
CWM, LLCin group CWM, LLC26,744$36K<0.01%-82,58613F-HRTimelineGroup
Scientech Research LLC24,884$33.6K0.01%-32,97813F-HRTimeline
Cambridge Investment Research Advisors,…23,400$32K<0.01%+1,90013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…23,679$32K<0.01%+10,98913F-HRTimelineGroup
OPPENHEIMER & CO INCin group OPPENHEIMER ASSET MANAGEMENT …23,500$31.7K<0.01%013F-HRTimelineGroup
WOLVERINE TRADING, LLC21,191$29.5K<0.01%new13F-HRTimeline
WEALTH ENHANCEMENT ADVISORY SERVICES, L…18,877$28.7K<0.01%-55,57713F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC21,023$28.4K<0.01%-9213F-HRTimeline
Invera Wealth Advisors, LLC20,000$27K0.02%013F-HRTimeline
TIAA TRUST, NATIONAL ASSOCIATIONin group TIAA20,000$27K<0.01%013F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp19,124$25.8K<0.01%013F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC18,119$24.5K<0.01%-30,42513F-HRTimelineGroup
Cetera Investment Advisers17,524$23.7K<0.01%new13F-HRTimeline
IEQ CAPITAL, LLC16,266$22K<0.01%-175,83513F-HRTimeline
TWO SIGMA SECURITIES, LLC15,881$21.4K<0.01%-26,52413F-HRTimeline
SBI Securities Co., Ltd.15,047$20.3K<0.01%-4,19013F-HRTimeline
CAPTRUST FINANCIAL ADVISORS14,069$19K<0.01%-21,51313F-HRTimeline
Mirae Asset Global Investments Co., Ltd.in group Mirae Asset Global Investment…14,049$19K<0.01%+2013F-HRTimelineGroup
TRUIST FINANCIAL CORPin group TRUIST FINANCIAL CORP14,000$18.9K<0.01%013F-HRTimelineGroup
HBK Sorce Advisory LLC11,786$18K<0.01%013F-HR/ATimeline
ProShare Advisors LLC12,946$17.5K<0.01%-61513F-HRTimeline
Chemistry Wealth Management LLC12,000$16.2K<0.01%013F-HRTimeline
NORTH STAR ASSET MANAGEMENT INC11,500$15.5K<0.01%013F-HRTimeline
SG Americas Securities, LLC10,830$15K<0.01%-2,98413F-HRTimeline
Perennial Investment Advisors, LLC10,990$14.8K<0.01%013F-HRTimeline
Berger Financial Group, Inc10,929$14.8K<0.01%013F-HRTimeline
Steward Partners Investment Advisory, L…10,785$14.6K<0.01%-10,63813F-HRTimeline
NBT BANK, N.A.in group NBT BANK, N.A.10,000$13.5K<0.01%013F-HRTimelineGroup
State of Wyoming8,526$11.5K<0.01%new13F-HRTimeline
GF FUND MANAGEMENT CO. LTD.7,818$10.6K<0.01%new13F-HRTimeline
Arax Advisory Partners5,097$6.88K<0.01%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS4,988$6.73K<0.01%-3,71513F-HRTimelineGroup
Golden State Wealth Management, LLC3,700$5K<0.01%013F-HRTimeline
Advisory Services Network, LLC3,242$4.38K<0.01%new13F-HRTimeline
NISA INVESTMENT ADVISORS, LLC2,592$3.5K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.1,369$2K<0.01%013F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,461$1.97K<0.01%013F-HRTimelineGroup
Physician Wealth Advisors, Inc.1,412$1.91K<0.01%013F-HRTimeline
Rialto Wealth Management, LLC1,313$1.77K<0.01%013F-HRTimeline
Farther Finance Advisors, LLC1,255$1.69K<0.01%+25313F-HRTimeline
Global Retirement Partners, LLC1,000$1.35K<0.01%013F-HRTimeline
Caitong International Asset Management …959$1.29K<0.01%new13F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP892$1.25K<0.01%-1,15013F-HRTimelineGroup
Avion Wealth1,333$1K<0.01%013F-HRTimeline
Fortitude Family Office, LLC706$953<0.01%013F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.742$816<0.01%013F-HRTimelineGroup
Federation des caisses Desjardins du Qu…571$771<0.01%new13F-HRTimeline
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COin group NORTHWESTERN MUTUAL INVESTMEN…514$694<0.01%+1413F-HRTimelineGroup
Essential Partners LLC511$690<0.01%-1,62313F-HRTimeline
TFC Financial Management, Inc.500$675<0.01%new13F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…455$615<0.01%-70813F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…335$452<0.01%new13F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN301$406<0.01%-26,12213F-HRTimelineGroup
SYNTAX RESEARCH, INC.142$192<0.01%013F-HRTimeline
COMERICA BANK122$165<0.01%013F-HRTimeline
Larson Financial Group LLC100$135<0.01%013F-HRTimeline
True Wealth Design, LLC85$115<0.01%-65813F-HRTimeline
Point72 (DIFC) Ltd15$20<0.01%-6,96713F-HRTimeline
RHUMBLINE ADVISERS0$2<0.01%013F-HRTimelineAmount filed as zero, left out of ratios.
IFP Advisors, Inc1$1<0.01%013F-HR/ATimeline
Covestor Ltd81$00%013F-HRTimelineValue filed as zero, left out of ratios.