DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 21,231,974 $61.4M 1.11% 0 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 6,045,351 $17.5M 0.29% 0 13F-HR Timeline Group Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 4,928,040 $14.2M 4.6% +150,000 13F-HR Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 4,110,000 $11.9M 2.4% +2,195,923 13F-HR/A Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 3,655,189 $10.6M 0.01% +2,982,177 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,039,980 $8.79M <0.01% -84,008 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,142,031 $6.19M <0.01% -75,777 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 2,075,882 $6M 0.02% +633,409 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 2,050,535 $5.93M +1,261,766 Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,336,255 $3.86M <0.01% +901,969 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 904,425 $2.61M <0.01% -3,536 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 858,968 $2.48M <0.01% +26,427 13F-HR Timeline Group MANGROVE PARTNERS IM, LLC More: the full row for MANGROVE PARTNERS IM, LLC 770,233 $2.23M 0.24% 0 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 689,290 $1.99M 0.18% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 622,682 $1.8M 0.01% 0 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 567,683 $1.64M 0.01% 0 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 561,742 $1.62M <0.01% -413,229 13F-HR Timeline Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 535,464 $1.55M 0.01% +179,469 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 428,488 $1.24M <0.01% +316,262 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 371,434 $1.07M 0.3% 0 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 343,981 $994K <0.01% -21,687 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 307,198 $888K 0.02% +127,171 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 256,861 $742K <0.01% +38,427 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 250,295 $723K <0.01% +88,393 13F-HR Timeline Group HAP Trading, LLC More: the full row for HAP Trading, LLC 237,776 $687K 0.3% new 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 237,605 $687K 0.11% new 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 228,761 $661K <0.01% new 13F-HR/A Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 227,002 $656K <0.01% +52,214 13F-HR Timeline Group Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 220,201 $636K <0.01% new 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 196,635 $568K 0.15% -169,669 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 169,038 $489K <0.01% -242,342 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 167,404 $484K 0.02% new 13F-HR Timeline Group MONIMUS CAPITAL MANAGEMENT, LP More: the full row for MONIMUS CAPITAL MANAGEMENT, LP 146,284 $423K 0.34% 0 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 140,424 $405K 0.01% +140,160 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 131,622 $380K <0.01% -2,539,649 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 111,400 $322K <0.01% +10,943 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 108,337 $313K <0.01% +63,427 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 103,216 $298K 0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 100,897 $292K <0.01% +100,843 13F-HR/A Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 99,922 $289K 0.02% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 99,889 $289K <0.01% -564 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 84,860 $245K <0.01% +30,601 13F-HR/A Timeline Group WEXFORD CAPITAL LP More: the full row for WEXFORD CAPITAL LP 69,799 $202K 0.06% new 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 69,285 $200K <0.01% +5,001 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 67,358 $195K <0.01% +2,340 13F-HR Timeline Ethic Inc. More: the full row for Ethic Inc. 61,723 $187K <0.01% new 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 62,380 $180K <0.01% +29,320 13F-HR Timeline IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 57,261 $165K <0.01% +40,801 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 55,648 $161K <0.01% -8,969 13F-HR Timeline Group Massar Capital Management, LP More: the full row for Massar Capital Management, LP 51,556 $149K 0.11% new 13F-HR/A Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 48,577 $140K <0.01% -1,799 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 48,225 $139K <0.01% +47,100 13F-HR Timeline Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 46,760 $135K 0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 41,900 $121K <0.01% +7,986 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 39,031 $113K <0.01% -1,006 13F-HR Timeline Group Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 37,518 $108K 0.01% 0 13F-HR Timeline Group JOURNEY STRATEGIC WEALTH LLC More: the full row for JOURNEY STRATEGIC WEALTH LLC 35,695 $103K <0.01% +379 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 33,000 $95.4K 0.1% +5,000 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 32,652 $94K <0.01% +21,948 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 31,515 $91.1K <0.01% -56,012 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 31,354 $90.6K <0.01% -41,295 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 29,559 $85.4K <0.01% +7,065 13F-HR Timeline Group ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 29,030 $83.9K <0.01% +5,750 13F-HR/A Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 26,590 $76.8K -704 Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 26,359 $76.2K <0.01% new 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 25,963 $75K <0.01% -7,959 13F-HR Timeline Walleye Capital LLC group of 2 filers holding More: the full row for Walleye Capital LLC 25,000 $72.2K -17,166 Timeline Fi3 FINANCIAL ADVISORS, LLC More: the full row for Fi3 FINANCIAL ADVISORS, LLC 24,172 $69.9K 0.03% +202 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 21,301 $62K <0.01% +4,991 13F-HR Timeline Next Level Private LLC More: the full row for Next Level Private LLC 20,000 $57.8K 0.02% new 13F-HR Timeline AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 19,853 $57.4K 0.02% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 16,165 $46.7K <0.01% -51 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 15,204 $43.9K <0.01% -908 13F-HR Timeline Group WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 13,629 $43.6K <0.01% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 13,830 $40K <0.01% +12,518 13F-HR Timeline Group Keystone Financial Group More: the full row for Keystone Financial Group 13,000 $37.6K <0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 12,860 $37.2K <0.01% +61 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 12,092 $34.9K <0.01% 0 13F-HR Timeline Group ProShare Advisors LLC More: the full row for ProShare Advisors LLC 11,070 $32K <0.01% -915 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 10,867 $31.4K <0.01% new 13F-HR Timeline Cherry Tree Wealth Management, LLC More: the full row for Cherry Tree Wealth Management, LLC 10,618 $30.7K 0.01% new 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 10,573 $30.6K <0.01% 0 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 10,533 $30.4K <0.01% new 13F-HR Timeline Group OPPENHEIMER & CO INC in group OPPENHEIMER ASSET MANAGEMENT … More: the full row for OPPENHEIMER & CO INC 10,000 $28.9K <0.01% new 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 9,082 $26.2K <0.01% 0 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 8,000 $23.1K <0.01% new 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 7,900 $22.8K <0.01% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 6,619 $19.1K <0.01% 0 13F-HR/A Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 5,911 $17.1K <0.01% -1,000 13F-HR/A Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 5,839 $16.9K <0.01% +1,038 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 5,770 $16.7K <0.01% +1,852 13F-HR Timeline Group Solstein Capital, LLC More: the full row for Solstein Capital, LLC 4,477 $12.9K 0.01% 0 13F-HR Timeline NewEdge Advisors, LLC More: the full row for NewEdge Advisors, LLC 4,121 $11.9K <0.01% new 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 4,121 $11.9K <0.01% 0 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 3,631 $10.5K <0.01% -6,087 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 3,000 $8.67K <0.01% new 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 2,655 $7.67K <0.01% new 13F-HR Timeline Group Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 2,654 $7.67K <0.01% +1,154 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,638 $4.73K <0.01% -2,118 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,583 $4.58K <0.01% 0 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 1,480 $4.28K <0.01% 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,452 $4K <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,175 $3.4K <0.01% 0 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 1,143 $3.3K <0.01% +1,100 13F-HR/A Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 734 $2.12K <0.01% +536 13F-HR Timeline Group True Wealth Design, LLC More: the full row for True Wealth Design, LLC 536 $1.55K <0.01% +226 13F-HR Timeline Rialto Wealth Management, LLC More: the full row for Rialto Wealth Management, LLC 260 $752 <0.01% new 13F-HR Timeline Physician Wealth Advisors, Inc. More: the full row for Physician Wealth Advisors, Inc. 233 $674 <0.01% new 13F-HR Timeline Rise Advisors, LLC More: the full row for Rise Advisors, LLC 233 $673 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 194 $561 <0.01% +3 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 114 $329 <0.01% -79 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 110 $318 <0.01% +75 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 85 $246 <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 17 $49 <0.01% new 13F-HR Timeline Group CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.