BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 6,293,282 $21.3M 0.87% 0 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 3,566,338 $12.1M 0.2% 0 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,953,127 $10M <0.01% +58,488 13F-HR Timeline Group First Light Asset Management, LLC More: the full row for First Light Asset Management, LLC 2,328,768 $7.89M 0.9% 0 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 2,307,119 $7.82M 1.93% -244,500 13F-HR Timeline Group Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 1,819,912 $6.17M 1.99% -140,000 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 1,671,822 $5.67M 0.04% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 1,585,648 $5.38M 0.01% +1,316,623 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 1,318,842 $4.47M 0.03% -196,908 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 1,264,919 $4.29M 0.01% 0 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,141,237 $3.87M 0.32% -6,709 13F-HR Timeline Group AWM Investment Company, Inc. More: the full row for AWM Investment Company, Inc. 1,100,473 $3.73M 0.51% 0 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 1,025,221 $3.48M 1.13% -101,416 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 933,475 $3.16M 0.01% 0 13F-HR Timeline Group Sanofi More: the full row for Sanofi 814,980 $2.76M 1.66% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 810,876 $2.75M <0.01% +692,015 13F-HR Timeline Group Zimmer Partners, LP More: the full row for Zimmer Partners, LP 754,970 $2.56M 0.05% +4,970 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 690,170 $2.34M 0.13% new 13F-HR/A Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 666,717 $2.26M <0.01% +3,616 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 652,621 $2.21M <0.01% +34,997 13F-HR Timeline Group 22NW, LP More: the full row for 22NW, LP 636,364 $2.16M 1.45% new 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 323,973 $1.1M 1.13% 0 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 312,158 $1.06M 0.04% -29,765 13F-HR Timeline CM Management, LLC More: the full row for CM Management, LLC 275,000 $932K 0.94% 0 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 258,106 $875K <0.01% +113,261 13F-HR/A Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 224,600 $761K <0.01% +102,325 13F-HR/A Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 221,957 $752K <0.01% +47,451 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 213,101 $722K <0.01% +26,100 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 188,485 $639K <0.01% new 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 175,891 $596K <0.01% +53,750 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 130,673 $443K <0.01% +3,788 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 122,773 $416K <0.01% -24,400 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 116,175 $394K <0.01% +93,142 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 114,145 $387K 0.35% -142,228 13F-HR/A Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 113,275 $384K <0.01% new 13F-HR Timeline Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 109,555 $371K 0.06% 0 13F-HR Timeline Allostery Investments LP More: the full row for Allostery Investments LP 100,000 $339K 0.49% 0 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 93,997 $319K <0.01% -95,873 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 70,000 $237K <0.01% 0 13F-HR/A Timeline Group Jain Global LLC More: the full row for Jain Global LLC 67,212 $228K <0.01% new 13F-HR Timeline DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 64,613 $219K 0.18% -11,181 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 61,520 $209K <0.01% +28,897 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 56,500 $192K <0.01% -6,300 13F-HR Timeline INGALLS & SNYDER LLC More: the full row for INGALLS & SNYDER LLC 51,849 $176K 0.01% 0 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 44,436 $151K <0.01% -3,874 13F-HR Timeline Group Pathstone Holdings, LLC in group Pathstone Holdings, LLC More: the full row for Pathstone Holdings, LLC 39,814 $135K <0.01% 0 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 39,371 $133K 0.01% -35,205 13F-HR Timeline LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 37,783 $128K <0.01% new 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 33,400 $113K <0.01% 0 13F-HR Timeline MARCO INVESTMENT MANAGEMENT LLC More: the full row for MARCO INVESTMENT MANAGEMENT LLC 30,344 $103K 0.01% 0 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 29,987 $102K <0.01% 0 13F-HR/A Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 28,713 $97.3K <0.01% new 13F-HR/A Timeline Group Kera Capital Partners, Inc. More: the full row for Kera Capital Partners, Inc. 25,770 $87.4K 0.03% 0 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 23,225 $78.7K <0.01% -295,356 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 22,000 $74.6K <0.01% 0 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 21,733 $74K <0.01% new 13F-HR Timeline WOLVERINE TRADING, LLC More: the full row for WOLVERINE TRADING, LLC 21,342 $71.5K <0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 21,011 $71.2K <0.01% -45,889 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 19,200 $65.1K <0.01% -61,231 13F-HR Timeline Group MERCER GLOBAL ADVISORS INC /ADV More: the full row for MERCER GLOBAL ADVISORS INC /ADV 16,726 $56.7K <0.01% 0 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 16,600 $56.3K 0.01% +600 13F-HR Timeline Group Quantessence Capital LLC More: the full row for Quantessence Capital LLC 16,523 $56K 0.01% new 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 15,089 $51K <0.01% new 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 14,855 $50.4K 0.04% 0 13F-HR Timeline Catalyst Funds Management Pty Ltd More: the full row for Catalyst Funds Management Pty Ltd 13,620 $46.2K 0.01% new 13F-HR Timeline CAPSTONE INVESTMENT ADVISORS, LLC in group CAPSTONE INVESTMENT ADVISORS,… More: the full row for CAPSTONE INVESTMENT ADVISORS, LLC 13,613 $46.1K <0.01% new 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 12,478 $42.3K <0.01% +4,534 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 12,080 $41K <0.01% new 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 12,065 $40.9K <0.01% new 13F-HR Timeline Clarity Capital Partners LLC More: the full row for Clarity Capital Partners LLC 11,500 $39K 0.02% 0 13F-HR Timeline Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 10,866 $36.8K 0.01% -7,513 13F-HR Timeline Capula Management Ltd in group Capula Management Ltd More: the full row for Capula Management Ltd 10,170 $34.5K <0.01% new 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. CW Advisors, LLC More: the full row for CW Advisors, LLC 10,000 $33.9K <0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 9,991 $33K <0.01% -446 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 7,012 $23.8K <0.01% -88,130 13F-HR Timeline Group Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 1,782 $6.04K <0.01% -2,680 13F-HR Timeline Addison Advisors LLC More: the full row for Addison Advisors LLC 1,300 $4.41K <0.01% 0 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 725 $2.43K <0.01% +100 13F-HR/A Timeline Group N.E.W. Advisory Services LLC More: the full row for N.E.W. Advisory Services LLC 626 $2.12K <0.01% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 591 $2K <0.01% 0 13F-HR Timeline IFS Advisors, LLC More: the full row for IFS Advisors, LLC 100 $339 <0.01% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 17 $58 <0.01% 0 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 4 $14 <0.01% -39 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.