TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 16,811,963 $58.8M 2.27% +3,315,755 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 15,219,994 $53.3M 1.28% 0 13F-HR Timeline Group MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 14,101,159 $49.4M 1.5% +6,951,666 13F-HR Timeline Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 9,840,108 $34.4M 0.15% -185,043 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Vivo Capital, LLC More: the full row for Vivo Capital, LLC 9,545,466 $33.4M 2.69% +3,502,000 13F-HR Timeline ENAVATE SCIENCES GP, LLC More: the full row for ENAVATE SCIENCES GP, LLC 7,788,150 $27.3M 8.32% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 7,370,747 $25.8M <0.01% +957,614 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 7,062,799 $24.7M <0.01% +2,212,794 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 5,186,500 $18.2M 0.03% +761,632 13F-HR Timeline Group MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 5,075,970 $17.8M 2.91% -546,535 13F-HR Timeline BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 4,750,000 $16.6M 0.67% new 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 4,474,702 $15.7M 0.92% -488,253 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 4,137,562 $14.5M <0.01% +2,907 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 3,237,572 $11.3M 0.01% +2,386,367 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 3,106,513 $10.9M <0.01% +1,135,145 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 2,944,469 $10.3M <0.01% +625,337 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 2,833,988 $9.92M 1.44% +1,584,207 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 2,826,362 $9.89M 0.02% new 13F-HR Timeline Group Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 2,591,525 $9.07M 2.82% 0 13F-HR Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 2,500,000 $8.75M 0.11% new 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 2,050,000 $7.17M 0.71% new 13F-HR Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 2,028,886 $7.1M 0.44% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,999,278 $7M <0.01% -126,439 13F-HR/A Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,700,927 $5.95M <0.01% +1,549,785 13F-HR Timeline Group Monashee Investment Management LLC More: the full row for Monashee Investment Management LLC 1,250,000 $4.38M 2.18% +1,085,000 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,039,671 $3.64M <0.01% +923,323 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 946,661 $3.31M 0.82% +420,001 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 872,938 $3.06M 2.31% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 861,935 $3.02M <0.01% +127,241 13F-HR Timeline Group ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 840,090 $2.94M 3.04% new 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 700,000 $2.45M 0.14% new 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 476,291 $1.67M 0.01% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 335,250 $1.17M <0.01% +61,778 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 318,124 $1.11M <0.01% -29,916 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 259,211 $907K <0.01% 0 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 233,271 $816K <0.01% new 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 223,176 $781K <0.01% +11,993 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 222,418 $778K <0.01% -19,303 13F-HR/A Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 198,271 $694K <0.01% -65,255 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 186,952 $654K <0.01% -61,797 13F-HR/A Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 175,556 $619K <0.01% +3,329 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 154,170 $540K 0.03% -571,340 13F-HR Timeline CM Management, LLC More: the full row for CM Management, LLC 150,000 $525K 0.44% new 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 149,313 $523K <0.01% -223,368 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 139,313 $488K <0.01% +25,826 13F-HR Timeline Atom Investors LP More: the full row for Atom Investors LP 106,674 $373K 0.03% new 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 104,160 $365K <0.01% -12,510 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 95,785 $335K <0.01% +11,888 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 87,853 $307K <0.01% +67,080 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 83,007 $291K <0.01% +8,410 13F-HR Timeline Group CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 80,000 $280K 0.01% -20,000 13F-HR/A Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 79,000 $276K <0.01% -145,600 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 73,801 $258K <0.01% +41,252 13F-HR/A Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 70,959 $248K <0.01% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 68,173 $239K <0.01% +15,449 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 60,927 $213K <0.01% +49,443 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 60,656 $212K <0.01% +1,921 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 59,148 $207K <0.01% +10,697 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 58,347 $204K <0.01% -599 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 56,588 $199K <0.01% +9,646 13F-HR Timeline CAXTON CORP More: the full row for CAXTON CORP 53,503 $187K 0.82% +10,038 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 49,850 $176K <0.01% -314 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 50,000 $175K 0.02% +25,000 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 47,427 $166K <0.01% new 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 45,877 $161K <0.01% new 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 42,470 $149K <0.01% 0 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 41,400 $145K <0.01% new 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 38,936 $136K <0.01% -5,287 13F-HR Timeline Simplicity Wealth,LLC More: the full row for Simplicity Wealth,LLC 37,034 $130K 0.01% -47,602 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 33,161 $116K <0.01% -2,392 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 31,679 $111K <0.01% -43,853 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 30,407 $106K <0.01% 0 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 28,331 $99.2K <0.01% +5,398 13F-HR Timeline SIG BROKERAGE, LP More: the full row for SIG BROKERAGE, LP 26,365 $92.3K 0.02% -10,028 13F-HR Timeline Walleye Trading LLC in group Walleye Capital LLC More: the full row for Walleye Trading LLC 25,000 $87.5K <0.01% 0 13F-HR Timeline Group CAPTRUST FINANCIAL ADVISORS More: the full row for CAPTRUST FINANCIAL ADVISORS 20,524 $71.8K <0.01% +199 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 19,960 $69.9K <0.01% -107,312 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 19,523 $68.3K <0.01% +10,038 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 17,900 $62.6K <0.01% 0 13F-HR Timeline Independent Advisor Alliance More: the full row for Independent Advisor Alliance 17,894 $62.6K <0.01% -526 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 17,214 $60.2K <0.01% -9,945 13F-HR Timeline Group ProShare Advisors LLC More: the full row for ProShare Advisors LLC 17,004 $59.5K <0.01% -1,791 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 16,950 $59.3K <0.01% -15,465 13F-HR Timeline Group PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 16,468 $57.6K <0.01% new 13F-HR Timeline Focus Partners Wealth in group Focus Partners Wealth More: the full row for Focus Partners Wealth 15,805 $56K <0.01% +2,206 13F-HR Timeline Group Sequoia Financial Advisors, LLC More: the full row for Sequoia Financial Advisors, LLC 15,753 $55.1K <0.01% -732 13F-HR Timeline Welch & Forbes LLC More: the full row for Welch & Forbes LLC 15,000 $52.5K <0.01% new 13F-HR Timeline ROVIN CAPITAL /UT/ /ADV More: the full row for ROVIN CAPITAL /UT/ /ADV 13,495 $47K 0.01% 0 13F-HR/A Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 12,652 $44.3K <0.01% +2,164 13F-HR Timeline Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 12,681 $44K <0.01% new 13F-HR Timeline Group North Star Investment Management Corp. More: the full row for North Star Investment Management Corp. 12,500 $43.8K <0.01% 0 13F-HR Timeline Strategic Wealth Partners, Ltd. More: the full row for Strategic Wealth Partners, Ltd. 12,100 $42.4K <0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 10,651 $37.3K <0.01% -21,059 13F-HR Timeline Group CIBC Bancorp USA Inc. in group CIBC Bancorp USA Inc. More: the full row for CIBC Bancorp USA Inc. 10,600 $37.1K <0.01% 13F-HR/A Timeline Group ACT Advisors, LLC. More: the full row for ACT Advisors, LLC. 10,376 $36.3K 0.01% 0 13F-HR Timeline Stonebrook Private Inc. More: the full row for Stonebrook Private Inc. 10,230 $35.8K 0.01% -366 13F-HR Timeline Apollon Wealth Management, LLC in group Apollon Wealth Management, LLC More: the full row for Apollon Wealth Management, LLC 10,015 $35.1K <0.01% new 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 9,643 $33.7K <0.01% 0 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 7,785 $27.2K <0.01% +7,592 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 7,536 $26.4K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 7,394 $25.9K <0.01% +4 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 6,229 $21.8K <0.01% 0 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 6,039 $21.1K <0.01% -8,539 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 5,822 $20.4K <0.01% +485 13F-HR Timeline Group MCF Advisors LLC More: the full row for MCF Advisors LLC 5,540 $19.4K <0.01% +2,770 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 5,248 $18.4K <0.01% 0 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 4,978 $17.4K <0.01% -5 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 4,093 $14K <0.01% +3,139 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 3,335 $11.7K <0.01% +2,060 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 3,077 $11K <0.01% 0 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 1,891 $7K <0.01% +645 13F-HR Timeline Group Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 1,642 $5.75K <0.01% new 13F-HR Timeline Group Cape Investment Advisory, Inc. More: the full row for Cape Investment Advisory, Inc. 1,317 $4.61K <0.01% new 13F-HR Timeline BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 526 $2K <0.01% new 13F-HR Timeline Group QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 405 $1.42K <0.01% new 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 388 $1.36K <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 330 $1.16K <0.01% -24 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 225 $787 <0.01% new 13F-HR Timeline Marshall & Sterling Wealth Advisors Inc. More: the full row for Marshall & Sterling Wealth Advisors Inc. 200 $700 <0.01% 0 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 120 $420 <0.01% 0 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 19 $67 <0.01% new 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 8 $28 <0.01% new 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 6 $21 <0.01% new 13F-HR/A Timeline Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 4 $14 <0.01% new 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 4 $14 <0.01% new 13F-HR Timeline