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ORACLE INVESTMENT MANAGEMENT INC

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13F filer, CIK 1012622, GREENWICH, CT

ORACLE INVESTMENT MANAGEMENT INC reported $167,936,629 across 22 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-18. Its ten largest share positions make up 98.01% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001012622-26-000001

Period
2025-12-31
Reported value
$168M
Holdings
22
Top 10 weight
98.01%
New
8
Sold out
6

Largest buys vs the previous quarter

SecurityShares changeApprox. value
ARDXadded+368,798$2.15M
TSHAnew+265,000$1.46M
EWTXnew+38,343$951K
DAWNnew+100,000$932K
PSNLadded+109,908$875K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
PLTRexited-29,500-$5.38M
CNCexited-110,300-$3.94M
TDOCreduced-351,078-$2.46M
NVAXexited-243,000-$2.11M
KOIDexited-22,400-$719K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001012622-26-000001, largest first. % of portfolio is the value over $152,604,688, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
WGSGENEDX HOLDINGS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 1,126,607 shares; 2024Q2: 1,105,768 shares; 2024Q3: 1,045,768 shares; 2024Q4: 1,023,468 shares; 2025Q1: 969,954 shares; 2025Q2: 922,454 shares; 2025Q3: 889,954 shares; 2025Q4: 884,654 shares 884,654$115M75.4%-5,300Timeline
ARDXARDELYX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 2,039,700 shares; 2024Q2: 1,488,131 shares; 2024Q3: 1,369,200 shares; 2024Q4: 2,089,431 shares; 2025Q1: 2,404,438 shares; 2025Q2: 1,430,728 shares; 2025Q3: 1,503,826 shares; 2025Q4: 1,872,624 shares 1,872,624$10.9M7.15%+368,798Timeline
BHVNBIOHAVEN LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 804,850 shares; 2024Q2: 700,450 shares; 2024Q3: 705,250 shares; 2024Q4: 851,770 shares; 2025Q1: 665,945 shares; 2025Q2: 673,166 shares; 2025Q3: 739,986 shares; 2025Q4: 772,181 shares 772,181$8.72M5.71%+32,195Timeline
QDELQUIDELORTHO CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 157,201 shares; 2024Q2: 118,291 shares; 2024Q3: 118,291 shares; 2024Q4: 118,291 shares; 2025Q1: 118,291 shares; 2025Q2: 118,291 shares; 2025Q3: 118,291 shares; 2025Q4: 118,291 shares 118,291$3.38M2.21%0Timeline
FORAFORIAN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 1,355,807 shares; 2024Q2: 1,356,107 shares; 2024Q3: 1,356,107 shares; 2024Q4: 1,366,107 shares; 2025Q1: 1,366,107 shares; 2025Q2: 1,366,107 shares; 2025Q3: 1,366,107 shares; 2025Q4: 1,366,107 shares 1,366,107$2.9M1.9%0Timeline
PSNLPERSONALIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 229,435 shares; 2025Q4: 339,343 shares 339,343$2.7M1.77%+109,908Timeline
TDOCTELADOC HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 565,900 shares; 2025Q2: 381,000 shares; 2025Q3: 705,416 shares; 2025Q4: 354,338 shares 354,338$2.48M1.63%-351,078Timeline
TSHATAYSHA GENE THERAPIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 265,000 shares 265,000$1.46M0.96%newTimeline
CAVACAVA GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 17,600 shares; 2024Q2: 18,600 shares; 2024Q3: 18,600 shares; 2024Q4: 18,600 shares; 2025Q1: 18,600 shares; 2025Q2: 18,600 shares; 2025Q3: 17,100 shares; 2025Q4: 17,100 shares 17,100$1M0.66%0Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 38,343 shares 38,343$951K0.62%newTimeline
DAWNDAY ONE BIOPHARMACEUTICALS IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 100,000 shares 100,000$932K0.61%newTimeline
ARKGARK ETF TRQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 19,500 shares 19,500$565K0.37%newTimeline
SGMOQSANGAMO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,004,724 shares; 2025Q4: 1,035,742 shares 1,035,742$435K0.29%+31,018Timeline
BIIBBIOGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 2,412 shares; 2024Q2: 2,412 shares; 2024Q3: 2,412 shares; 2024Q4: 2,412 shares; 2025Q1: 2,412 shares; 2025Q2: 2,412 shares; 2025Q3: 2,412 shares; 2025Q4: 2,412 shares 2,412$424K0.28%0Timeline
TEMTEMPUS AI INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 6,507 shares 6,507$384K0.25%newTimeline
TSLATESLA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 500 shares; 2025Q4: 500 shares 500$225K0.15%0Timeline
HTZHERTZ GLOBAL HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 15,000 shares 15,000$77.1K0.05%newTimeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
TELADOC HEALTH INCTELADOC HEALTH INC OPTIONcall650,000$4.55M+179,500
NOVAVAX INCNOVAVAX INC NOTE 5.000%12/1call600,000$4.03Mnew
ARDELYX INCARDELYX INC COMcall600,000$3.5M-32,800
BIOHAVEN LTDBIOHAVEN LTD COMcall232,900$2.63M-42,100
PFIZER INCPFIZER INC CALLcall25,000$622Knew

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
NOVAVAX INCNOVAVAX INC635,000$5.51Mcall
PLTRPALANTIR TECHNOLOGIES INC29,500$5.38Mshares
CNCCENTENE CORP DEL110,300$3.94Mshares
NVAXNOVAVAX INC243,000$2.11Mshares
KOIDKRANESHARES TRUST22,400$719Kshares
BDSXBIODESIX INC15,000$113Kshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001012622-26-000001 base2026-02-18acceptance time not in the bulk data set