Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 560,000 $7.88M 0.59% new 13F-HR Timeline FLPUTNAM INVESTMENT MANAGEMENT CO More: the full row for FLPUTNAM INVESTMENT MANAGEMENT CO 414,958 $5.84M 0.07% +272,489 13F-HR Timeline Bleichroeder LP More: the full row for Bleichroeder LP 400,000 $5.63M 1.01% 0 13F-HR Timeline Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 396,201 $5.58M 0.91% new 13F-HR Timeline Dauntless Investment Group, LLC More: the full row for Dauntless Investment Group, LLC 354,208 $4.99M 8.65% +274,376 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 345,179 $4.86M 3.7% 0 13F-HR/A Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 200,300 $2.3M <0.01% +300 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 110,778 $1.56M <0.01% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 101,376 $1.43M <0.01% new 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 81,090 $1.14M <0.01% +67,156 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 68,491 $964K 0.03% new 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 61,550 $867K 0.04% new 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 57,140 $805K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 56,999 $803K <0.01% +33,000 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 50,616 $713K <0.01% new 13F-HR Timeline Group COOPERMAN LEON G More: the full row for COOPERMAN LEON G 50,000 $704K 0.02% new 13F-HR Timeline Westside Investment Management, Inc. More: the full row for Westside Investment Management, Inc. 47,585 $670K 0.09% -2,840 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 46,606 $656K <0.01% +45,606 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 44,231 $623K <0.01% new 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 31,186 $439K 0.01% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 30,090 $424K <0.01% +29,009 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 28,509 $401K <0.01% new 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 22,599 $318K <0.01% +6,850 13F-HR Timeline Group Sequoia Financial Advisors, LLC More: the full row for Sequoia Financial Advisors, LLC 20,003 $282K <0.01% -39,997 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 14,975 $211K <0.01% new 13F-HR Timeline Laird Norton Wetherby Trust Company, LLC in group Laird Norton Wetherby Trust C… More: the full row for Laird Norton Wetherby Trust Company, LLC 12,900 $182K <0.01% +500 13F-HR Timeline Group UNITED BANK More: the full row for UNITED BANK 12,851 $181K 0.02% new 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 12,700 $179K <0.01% 0 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 2,863 $41.4K <0.01% new 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 1,926 $27.1K <0.01% +358 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 1,296 $18.2K <0.01% -106 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 87 $1.23K <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 24 $338 <0.01% new 13F-HR Timeline Integrated Wealth Concepts LLC More: the full row for Integrated Wealth Concepts LLC 20 $282 <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 10 $140 <0.01% -8,734 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 1 $15 <0.01% 0 13F-HR Timeline