Darwin Global Management, Ltd. in group Darwin Global Management, Ltd. More: the full row for Darwin Global Management, Ltd. 3,057,412 $456M 12.1% +29,708 13F-HR Timeline Group Paradigm Biocapital Advisors LP in group Paradigm Biocapital Advisors … More: the full row for Paradigm Biocapital Advisors LP 1,114,784 $178M 3.63% new 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 768,359 $123M 0.02% +639,607 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 715,332 $114M 1.13% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 570,088 $90.9M 0.07% +11,206 13F-HR Timeline Group Holocene Advisors, LP More: the full row for Holocene Advisors, LP 494,495 $78.8M 0.19% +410,428 13F-HR Timeline EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 357,650 $57M 0.94% -25,441 13F-HR Timeline DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 304,013 $48.5M 0.57% +70,200 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 281,805 $44.9M 0.01% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 201,409 $32.1M <0.01% +173,396 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 151,979 $24.2M 0.48% -262,260 13F-HR/A Timeline Group Patient Square Capital LP More: the full row for Patient Square Capital LP 116,684 $18.6M 3.3% new 13F-HR Timeline Duquesne Family Office LLC More: the full row for Duquesne Family Office LLC 106,100 $16.9M 0.58% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 105,509 $16.8M <0.01% +60,910 13F-HR Timeline Group MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 88,045 $14M 1.08% +285 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 65,000 $10.4M 0.61% +45,000 13F-HR Timeline FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 62,574 $9.98M 0.04% -16,820 13F-HR Timeline Group PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 59,432 $9.48M 1% +39,609 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 52,000 $8.29M 0.01% new 13F-HR Timeline Longaeva Partners L.P. More: the full row for Longaeva Partners L.P. 33,492 $5.34M 0.26% new 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 33,410 $5.33M <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 32,525 $5.19M <0.01% +30,077 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 26,880 $4.29M 0.26% -12,959 13F-HR Timeline Group Artia Global Partners LP More: the full row for Artia Global Partners LP 24,989 $3.98M 0.9% +7,000 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 23,708 $3.78M 0.04% -1,124 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 20,294 $3.24M 0.09% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 19,600 $3.13M <0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 16,981 $2.71M 0.01% new 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 16,048 $2.56M <0.01% +308 13F-HR Timeline Group BANK OF MONTREAL /CAN/ in group BANK OF MONTREAL /CAN/ More: the full row for BANK OF MONTREAL /CAN/ 15,981 $2.55M <0.01% +443 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 15,072 $2.4M 0.02% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 15,058 $2.4M 0.04% new 13F-HR Timeline Group BALANCE CAPITAL PARTNERS L.P. More: the full row for BALANCE CAPITAL PARTNERS L.P. 14,500 $2.31M 2.63% new 13F-HR Timeline Verdad Advisers, LP More: the full row for Verdad Advisers, LP 13,813 $2.2M 2.48% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 12,222 $1.95M <0.01% -20,096 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 10,922 $1.74M <0.01% +2,758 13F-HR Timeline Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 10,692 $1.7M 0.01% new 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 10,427 $1.66M <0.01% -18 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 8,033 $1.28M 0.35% new 13F-HR Timeline Voleon Capital Management LP More: the full row for Voleon Capital Management LP 7,883 $1.26M 0.03% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 6,822 $1.09M <0.01% +2,646 13F-HR Timeline Group Arrowpoint Investment Partners (Singapo… in group Arrowpoint Investment Partner… More: the full row for Arrowpoint Investment Partners (Singapore) Pte. Ltd. 6,004 $957K 1.39% +2,955 13F-HR Timeline Group Amundi in group Amundi More: the full row for Amundi 4,210 $671K <0.01% new 13F-HR Timeline Group SmartHarvest Portfolios, LLC More: the full row for SmartHarvest Portfolios, LLC 4,187 $668K 0.28% +3 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 3,778 $602K <0.01% +1,926 13F-HR Timeline Group High Net Worth Advisory Group LLC More: the full row for High Net Worth Advisory Group LLC 3,500 $558K 0.13% 0 13F-HR Timeline Convergence Financial, LLC More: the full row for Convergence Financial, LLC 2,968 $473K 0.05% new 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 2,767 $441K <0.01% -10,454 13F-HR/A Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 2,489 $397K <0.01% new 13F-HR Timeline AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 2,372 $378K 0.05% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 2,257 $360K <0.01% +165 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 2,144 $342K <0.01% -611 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 2,008 $320K <0.01% -3,047 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 1,929 $308K 0.08% +47 13F-HR Timeline Group DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. in group DYMON ASIA CAPITAL (SINGAPORE… More: the full row for DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. 1,900 $303K 0.07% new 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 1,707 $272K 0.01% -72 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 1,645 $262K 0.02% +182 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 1,608 $256K 0.01% +10 13F-HR/A Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 1,596 $254K <0.01% new 13F-HR Timeline Merit Financial Group, LLC More: the full row for Merit Financial Group, LLC 1,415 $226K <0.01% new 13F-HR Timeline Independent Advisor Alliance More: the full row for Independent Advisor Alliance 1,319 $210K <0.01% 0 13F-HR Timeline FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 1,300 $207K <0.01% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 657 $105K <0.01% +12 13F-HR/A Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 349 $55.6K 0.01% -200 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 124 $19.8K <0.01% +24 13F-HR/A Timeline Group E Fund Management (Hong Kong) Co., Ltd. More: the full row for E Fund Management (Hong Kong) Co., Ltd. 83 $13.2K 0.01% new 13F-HR Timeline TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 70 $11.7K <0.01% 0 13F-HR Timeline Rossby Financial, LCC More: the full row for Rossby Financial, LCC 55 $9.2K <0.01% +42 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 22 $3.51K <0.01% -28 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 15 $2.51K <0.01% -86 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 13 $2.07K <0.01% new 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 6 $912 <0.01% 0 13F-HR Timeline Group Bell Investment Advisors, Inc More: the full row for Bell Investment Advisors, Inc 4 $638 <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 3 $448 <0.01% 0 13F-HR/A Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1 $159 <0.01% -2,136 13F-HR Timeline Group