EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 27,404,070 $14.8M 0.59% 0 13F-HR Timeline Long Focus Capital Management, LLC More: the full row for Long Focus Capital Management, LLC 20,494,393 $11M 0.85% +7,194,503 13F-HR Timeline NEA Management Company, LLC More: the full row for NEA Management Company, LLC 17,079,778 $9.2M 0.52% 0 13F-HR Timeline Two Seas Capital LP in group Two Seas Capital LP More: the full row for Two Seas Capital LP 14,835,146 $7.99M 0.94% new 13F-HR/A Timeline Group BAILLIE GIFFORD & CO in group BAILLIE GIFFORD & CO More: the full row for BAILLIE GIFFORD & CO 11,819,095 $6.37M <0.01% -4,956,765 13F-HR Timeline Group MPM ASSET MANAGEMENT LLC More: the full row for MPM ASSET MANAGEMENT LLC 5,555,461 $2.99M 2.41% 0 13F-HR Timeline MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 5,095,912 $2.75M 0.39% 0 13F-HR Timeline PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 4,871,969 $2.62M 0.2% -5,128,818 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 2,862,330 $1.54M <0.01% -1,790,995 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 2,526,524 $1.36M <0.01% +869,949 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 2,483,468 $1.34M 0.05% +58,000 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 1,764,506 $951K <0.01% +23,606 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,324,864 $714K <0.01% -374,161 13F-HR/A Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 916,941 $494K <0.01% -128,592 13F-HR Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 715,607 $385K 0.03% 0 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 529,123 $286K <0.01% +6,515 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 510,216 $269K <0.01% new 13F-HR Timeline Group Rathbones Group PLC More: the full row for Rathbones Group PLC 432,818 $233K <0.01% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 400,079 $216K <0.01% +3,287 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 326,937 $176K <0.01% +152,780 13F-HR Timeline Group Key Client Fiduciary Advisors, LLC More: the full row for Key Client Fiduciary Advisors, LLC 255,359 $138K 0.06% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 183,686 $99K <0.01% -99,940 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 183,479 $98.8K <0.01% +94,623 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 175,052 $94.3K <0.01% new 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 147,082 $79.2K +77,933 Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 141,744 $76.4K <0.01% +139,927 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 139,801 $75.3K <0.01% 0 13F-HR Timeline Group Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 122,696 $66K <0.01% +21,688 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 83,199 $44K <0.01% new 13F-HR Timeline CAPTRUST FINANCIAL ADVISORS More: the full row for CAPTRUST FINANCIAL ADVISORS 81,629 $44K <0.01% -1,412 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 63,967 $34.5K <0.01% -2,854 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 63,335 $34.1K <0.01% +28,526 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 51,333 $27.7K <0.01% 0 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 50,061 $27K <0.01% 0 13F-HR/A Timeline Group Palisades Investment Partners, LLC More: the full row for Palisades Investment Partners, LLC 47,114 $25.4K 0.01% +3,659 13F-HR Timeline Vontobel Holding Ltd. in group Vontobel Holding Ltd. More: the full row for Vontobel Holding Ltd. 43,000 $23.2K <0.01% 0 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 37,195 $20K <0.01% +24,603 13F-HR Timeline OPPENHEIMER & CO INC in group OPPENHEIMER ASSET MANAGEMENT … More: the full row for OPPENHEIMER & CO INC 32,043 $17.3K <0.01% -4,232 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 31,081 $16.7K <0.01% 13F-HR/A Timeline Group CSS LLC/IL More: the full row for CSS LLC/IL 30,702 $16.5K <0.01% 0 13F-HR Timeline SIMON QUICK ADVISORS, LLC More: the full row for SIMON QUICK ADVISORS, LLC 30,000 $16.2K <0.01% -452 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 29,559 $15.9K <0.01% -685,791 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 29,150 $15.7K <0.01% -160,322 13F-HR Timeline Group Newman Dignan & Sheerar, Inc. More: the full row for Newman Dignan & Sheerar, Inc. 27,957 $15.1K <0.01% 0 13F-HR Timeline LEGACY CAPITAL WEALTH MANAGEMENT, LLC More: the full row for LEGACY CAPITAL WEALTH MANAGEMENT, LLC 27,080 $14.6K 0.01% 13F-HR Timeline WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 26,816 $14.4K <0.01% +16,000 13F-HR/A Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 26,558 $14.3K <0.01% +11,300 13F-HR/A Timeline Group HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 26,064 $14.3K <0.01% 0 13F-HR Timeline Group STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 26,469 $14.3K <0.01% -1,150 13F-HR Timeline Group HUNTER ASSOCIATES INVESTMENT MANAGEMENT… More: the full row for HUNTER ASSOCIATES INVESTMENT MANAGEMENT LLC 22,000 $12K <0.01% -1,000 13F-HR Timeline Prosperity Wealth Management, Inc. in group Prosperity Financial Group, I… More: the full row for Prosperity Wealth Management, Inc. 21,870 $11.8K <0.01% -2,750 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 20,515 $11.1K <0.01% -27,855 13F-HR/A Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 19,748 $10.6K <0.01% +588 13F-HR/A Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 19,530 $10.5K <0.01% +14,865 13F-HR Timeline Group KINGSWOOD WEALTH ADVISORS, LLC More: the full row for KINGSWOOD WEALTH ADVISORS, LLC 18,690 $10.1K <0.01% new 13F-HR Timeline Clear Harbor Asset Management, LLC More: the full row for Clear Harbor Asset Management, LLC 18,525 $9.98K <0.01% new 13F-HR Timeline PKS Advisory Services, LLC More: the full row for PKS Advisory Services, LLC 17,000 $9.16K <0.01% 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 16,563 $8.92K <0.01% new 13F-HR Timeline Group COLUMBIA ADVISORY PARTNERS LLC More: the full row for COLUMBIA ADVISORY PARTNERS LLC 16,420 $8.85K 0.01% -15,000 13F-HR Timeline Baader Bank Aktiengesellschaft More: the full row for Baader Bank Aktiengesellschaft 18,095 $8.73K <0.01% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 16,160 $8.71K <0.01% -68,250 13F-HR Timeline Group X-Square Capital, LLC More: the full row for X-Square Capital, LLC 11,173 $6K <0.01% -7 13F-HR Timeline R Squared Ltd More: the full row for R Squared Ltd 8,770 $4.72K <0.01% 13F-HR Timeline Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 6,000 $3.23K <0.01% 0 13F-HR Timeline Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 4,610 $2.48K <0.01% -237 13F-HR Timeline CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 3,023 $1.87K <0.01% 0 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 3,023 $1.63K <0.01% 0 13F-HR Timeline Sandy Spring Bank More: the full row for Sandy Spring Bank 1,050 $566 <0.01% 0 13F-HR Timeline Raiffeisen Bank International AG in group Raiffeisen Bank International… More: the full row for Raiffeisen Bank International AG 907 $520 <0.01% 13F-HR Timeline Group Plante Moran Financial Advisors, LLC More: the full row for Plante Moran Financial Advisors, LLC 925 $498 <0.01% 0 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 755 $407 <0.01% 0 13F-HR Timeline Wilmington Savings Fund Society, FSB More: the full row for Wilmington Savings Fund Society, FSB 604 $325 <0.01% 0 13F-HR Timeline HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 287 $155 <0.01% 0 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 250 $135 <0.01% -6,933 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 213 $115 <0.01% 0 13F-HR Timeline Group Transce3nd, LLC More: the full row for Transce3nd, LLC 175 $94 <0.01% 13F-HR Timeline Investors Research Corp More: the full row for Investors Research Corp 100 $54 <0.01% 0 13F-HR Timeline TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 14 $8 <0.01% 0 13F-HR Timeline DANSKE BANK A/S More: the full row for DANSKE BANK A/S 1 $1 <0.01% 0 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.