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Omega Fund Management, LLC

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13F filer, CIK 1637359, Boston, MA

Omega Fund Management, LLC reported $222,365,157 across 12 holdings for the quarter ended 2025-09-30, in a 13F-HR filed 2025-11-14. Its ten largest share positions make up 99.5% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001193125-25-281790

Period
2025-09-30
Reported value
$222M
Holdings
12
Top 10 weight
99.5%
New
2
Sold out
3

Largest buys vs the previous quarter

SecurityShares changeApprox. value
BBOTnew+3,289,661$38.1M
IMAnew+455,361$3.71M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
UPBreduced-680,000-$12.8M
NUVBreduced-2,211,639-$8.18M
REPLreduced-1,726,531-$7.23M
LXEOexited-1,184,636-$4.76M
IKENA ONCOLOGY INCexited-2,249,123-$3.01M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q3 2025

Share positions as resolved from 13F-HR 0001193125-25-281790, largest first. % of portfolio is the value over $222,365,157, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
KMTSKESTRA MED TECHNOLOGIES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,795,893 shares; 2025Q2: 1,645,893 shares; 2025Q3: 1,645,893 shares 1,645,893$39.1M17.59%0Timeline
BBNXBETA BIONICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,988,287 shares; 2025Q2: 1,988,287 shares; 2025Q3: 1,920,125 shares 1,920,125$38.2M17.16%-68,162Timeline
BBOTBRIDGEBIO ONCOLOGY THERAPEUTQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 3,289,661 shares 3,289,661$38.1M17.13%newTimeline
BCAXBICARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,204,650 shares; 2024Q4: 2,204,650 shares; 2025Q1: 2,204,650 shares; 2025Q2: 2,204,650 shares; 2025Q3: 2,204,650 shares 2,204,650$34.8M15.66%0Timeline
NUVBNUVATION BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 13,072,340 shares; 2024Q4: 13,072,340 shares; 2025Q1: 13,072,340 shares; 2025Q2: 11,042,728 shares; 2025Q3: 8,831,089 shares 8,831,089$32.7M14.69%-2,211,639Timeline
UPBUPSTREAM BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,036,293 shares; 2025Q1: 2,036,293 shares; 2025Q2: 2,036,293 shares; 2025Q3: 1,356,293 shares 1,356,293$25.5M11.47%-680,000Timeline
IMAIMAGENEBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 455,361 shares 455,361$3.71M1.67%newTimeline
ENGNENGENE HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,076,357 shares; 2024Q4: 526,357 shares; 2025Q1: 526,357 shares; 2025Q2: 526,357 shares; 2025Q3: 526,357 shares 526,357$3.6M1.62%0Timeline
SANASANA BIOTECHNOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 843,750 shares; 2024Q4: 843,750 shares; 2025Q1: 843,750 shares; 2025Q2: 843,750 shares; 2025Q3: 843,750 shares 843,750$3M1.35%0Timeline
ALMSALUMIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 653,223 shares; 2024Q4: 653,223 shares; 2025Q1: 653,223 shares; 2025Q2: 653,223 shares; 2025Q3: 653,223 shares 653,223$2.61M1.17%0Timeline
REPLREPLIMUNE GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,461,319 shares; 2024Q4: 1,975,203 shares; 2025Q1: 1,975,203 shares; 2025Q2: 1,975,203 shares; 2025Q3: 248,672 shares 248,672$1.04M0.47%-1,726,531Timeline
ENGNWENGENE HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 321,502 shares; 2024Q4: 321,502 shares; 2025Q1: 321,502 shares; 2025Q2: 321,502 shares; 2025Q3: 89,702 shares 89,702$63.4K0.03%-231,800Timeline

Sold out in Q3 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
LXEOLEXEO THERAPEUTICS INC1,184,636$4.76Mshares
IKENA ONCOLOGY INCIKENA ONCOLOGY INC2,249,123$3.01Mshares
IMUXIMMUNIC INC1,788,160$1.25Mshares

How Q3 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001193125-25-281790 base2025-11-14acceptance time not in the bulk data set