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Checkpoint Capital L.P.

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13F filer, CIK 1977548, SAN FRANCISCO, CA

Checkpoint Capital L.P. reported $320,095,902 across 7 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-17.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001977548-26-000002

Period
2025-12-31
Reported value
$320M
Holdings
7
Top 10 weight
100%
New
1
Sold out
4

Largest buys vs the previous quarter

SecurityShares changeApprox. value
RYTMadded+228,493$24.5M
CYTKadded+129,236$8.21M
IRONadded+22,992$1.83M
CORTadded+9,064$315K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
CRNXexited-260,000-$10.8M
RVMDreduced-122,300-$9.74M
ARGXreduced-8,000-$6.73M
SEPNexited-283,158-$5.33M
STOKexited-212,049-$4.98M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001977548-26-000002, largest first. % of portfolio is the value over $315,631,062, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
ARGXARGENX SEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 92,500 shares; 2024Q4: 92,500 shares; 2025Q1: 115,000 shares; 2025Q2: 149,977 shares; 2025Q3: 150,000 shares; 2025Q4: 142,000 shares 142,000$119M37.83%-8,000Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 663,381 shares; 2024Q4: 727,982 shares; 2025Q1: 907,240 shares; 2025Q2: 1,060,000 shares; 2025Q3: 763,707 shares; 2025Q4: 992,200 shares 992,200$106M33.65%+228,493Timeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 25,543 shares; 2024Q4: 185,000 shares; 2025Q1: 243,311 shares; 2025Q2: 265,000 shares; 2025Q3: 430,000 shares; 2025Q4: 452,992 shares 452,992$36M11.4%+22,992Timeline
RVMDREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 210,000 shares; 2025Q1: 392,011 shares; 2025Q2: 280,000 shares; 2025Q3: 492,300 shares; 2025Q4: 370,000 shares 370,000$29.5M9.34%-122,300Timeline
CORTCORCEPT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 5,000 shares; 2025Q2: 343,917 shares; 2025Q3: 392,331 shares; 2025Q4: 401,395 shares 401,395$14M4.43%+9,064Timeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 466,813 shares; 2024Q4: 20,000 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 37,587 shares; 2025Q4: 166,823 shares 166,823$10.6M3.36%+129,236Timeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
CORTCORCEPT THERAPEUTICS INC COMcall128,300$4.46Mnew

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
CRNXCRINETICS PHARMACEUTICALS IN260,000$10.8Mshares
SEPNSEPTERNA INC283,158$5.33Mshares
STOKSTOKE THERAPEUTICS INC212,049$4.98Mshares
KYMRKYMERA THERAPEUTICS INC61,750$3.5Mshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001977548-26-000002 base2026-02-17acceptance time not in the bulk data set