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Avidity Partners Management LP

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13F filer, CIK 1791827, DALLAS, TX

Avidity Partners Management LP reported $346,693,009 across 39 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-13. Its ten largest share positions make up 71.88% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001791827-26-000002

Period
2025-12-31
Reported value
$347M
Holdings
39
Top 10 weight
71.88%
New
11
Sold out
15

Largest buys vs the previous quarter

SecurityShares changeApprox. value
ALNYnew+21,000$8.35M
ICLRnew+33,100$6.03M
Anew+41,500$5.65M
CNCnew+119,400$4.91M
RGENadded+27,000$4.42M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
DNTHreduced-1,100,000-$45.3M
NTRAreduced-58,600-$13.4M
BMYexited-257,600-$11.6M
DHRreduced-37,700-$8.63M
MDTreduced-83,000-$7.97M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001791827-26-000002, largest first. % of portfolio is the value over $346,693,009, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
DNTHDIANTHUS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,917,231 shares; 2024Q4: 2,873,000 shares; 2025Q1: 1,720,902 shares; 2025Q2: 1,742,902 shares; 2025Q3: 3,204,184 shares; 2025Q4: 2,104,184 shares 2,104,184$86.7M25.01%-1,100,000Timeline
CGONCG ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,656,000 shares; 2024Q4: 1,097,800 shares; 2025Q1: 980,942 shares; 2025Q2: 1,499,942 shares; 2025Q3: 1,600,899 shares; 2025Q4: 1,472,699 shares 1,472,699$61.1M17.64%-128,200Timeline
JBIOJADE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,127,186 shares; 2025Q3: 1,127,186 shares; 2025Q4: 1,400,708 shares 1,400,708$21.6M6.23%+273,522Timeline
ORKAORUKA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 790,926 shares; 2024Q4: 352,124 shares; 2025Q1: 352,124 shares; 2025Q2: 352,124 shares; 2025Q3: 660,424 shares; 2025Q4: 660,424 shares 660,424$20M5.77%0Timeline
TEVATEVA PHARMACEUTICAL INDS LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 481,000 shares; 2025Q2: 689,500 shares; 2025Q3: 510,000 shares; 2025Q4: 417,300 shares 417,300$13M3.76%-92,700Timeline
BSXBOSTON SCIENTIFIC CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 962,000 shares; 2024Q4: 515,000 shares; 2025Q1: 336,000 shares; 2025Q2: 321,800 shares; 2025Q3: 164,300 shares; 2025Q4: 114,500 shares 114,500$10.9M3.15%-49,800Timeline
MDTMEDTRONIC PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 190,600 shares; 2025Q4: 107,600 shares 107,600$10.3M2.98%-83,000Timeline
CATXPERSPECTIVE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,444,002 shares; 2024Q4: 2,694,600 shares; 2025Q1: 2,197,270 shares; 2025Q2: 1,858,596 shares; 2025Q3: 2,994,033 shares; 2025Q4: 3,210,733 shares 3,210,733$8.83M2.55%+216,700Timeline
ALNYALNYLAM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 21,000 shares 21,000$8.35M2.41%newTimeline
RGENREPLIGEN CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 106,500 shares; 2025Q3: 23,300 shares; 2025Q4: 50,300 shares 50,300$8.24M2.38%+27,000Timeline
CNTXCONTEXT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 7,417,155 shares; 2024Q4: 7,477,200 shares; 2025Q1: 7,477,200 shares; 2025Q2: 7,477,255 shares; 2025Q3: 8,981,855 shares; 2025Q4: 5,504,855 shares 5,504,855$8.09M2.33%-3,477,000Timeline
MCKMCKESSON CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 13,500 shares; 2025Q3: 5,800 shares; 2025Q4: 9,520 shares 9,520$7.81M2.25%+3,720Timeline
ICLRICON PUB LTD COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 33,100 shares 33,100$6.03M1.74%newTimeline
AAGILENT TECHNOLOGIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 41,500 shares 41,500$5.65M1.63%newTimeline
PFEPFIZER INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 366,400 shares; 2025Q4: 203,600 shares 203,600$5.07M1.46%-162,800Timeline
CNCCENTENE CORP DELQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 119,400 shares 119,400$4.91M1.42%newTimeline
KVUEKENVUE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 265,200 shares; 2025Q4: 232,800 shares 232,800$4.02M1.16%-32,400Timeline
DHRDANAHER CORP DELQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 95,000 shares; 2024Q4: 67,000 shares; 2025Q1: 44,500 shares; 2025Q2: 89,700 shares; 2025Q3: 54,700 shares; 2025Q4: 17,000 shares 17,000$3.89M1.12%-37,700Timeline
TMOTHERMO FISHER SCIENTIFIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 68,600 shares; 2024Q4: 44,600 shares; 2025Q1: 15,500 shares; 2025Q2: 29,600 shares; 2025Q3: 18,900 shares; 2025Q4: 6,700 shares 6,700$3.88M1.12%-12,200Timeline
NVONOVO-NORDISK A SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 67,300 shares 67,300$3.42M0.99%newTimeline
PHATPHATHOM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,804,493 shares; 2024Q4: 1,390,100 shares; 2025Q1: 800,000 shares; 2025Q2: 1,064,500 shares; 2025Q3: 306,000 shares; 2025Q4: 206,076 shares 206,076$3.42M0.99%-99,924Timeline
EHCENCOMPASS HEALTH CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 74,000 shares; 2025Q3: 41,900 shares; 2025Q4: 31,600 shares 31,600$3.35M0.97%-10,300Timeline
CITHE CIGNA GROUPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 16,600 shares; 2025Q4: 11,600 shares 11,600$3.19M0.92%-5,000Timeline
CORCENCORA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 39,300 shares; 2025Q2: 32,800 shares; 2025Q3: 19,000 shares; 2025Q4: 9,400 shares 9,400$3.17M0.92%-9,600Timeline
INSMINSMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 592,000 shares; 2024Q4: 232,800 shares; 2025Q1: 107,000 shares; 2025Q2: 59,000 shares; 2025Q3: 11,600 shares; 2025Q4: 17,700 shares 17,700$3.08M0.89%+6,100Timeline
WATWATERS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 8,100 shares 8,100$3.08M0.89%newTimeline
ACADACADIA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 169,000 shares; 2025Q2: not reported; 2025Q3: 144,000 shares; 2025Q4: 106,900 shares 106,900$2.86M0.82%-37,100Timeline
GMABGENMAB A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 650,000 shares; 2025Q3: 248,100 shares; 2025Q4: 92,000 shares 92,000$2.83M0.82%-156,100Timeline
NTRANATERA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 556,400 shares; 2024Q4: 223,800 shares; 2025Q1: 119,200 shares; 2025Q2: 199,300 shares; 2025Q3: 70,400 shares; 2025Q4: 11,800 shares 11,800$2.7M0.78%-58,600Timeline
IMUXIMMUNIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 8,266,000 shares; 2024Q4: 7,966,400 shares; 2025Q1: 4,454,408 shares; 2025Q2: 5,615,811 shares; 2025Q3: 4,699,411 shares; 2025Q4: 4,699,411 shares 4,699,411$2.51M0.72%0Timeline
ACHCACADIA HEALTHCARE COMPANY INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 985,000 shares; 2024Q4: 658,000 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 169,000 shares 169,000$2.4M0.69%newTimeline
ITGRINTEGER HLDGS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 29,800 shares 29,800$2.34M0.67%newTimeline
ELVNENLIVEN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 11,300 shares; 2025Q2: 11,300 shares; 2025Q3: 140,300 shares; 2025Q4: 140,300 shares 140,300$2.16M0.62%0Timeline
PVLAPALVELLA THERAPEUTICS INC NEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 19,300 shares 19,300$2.02M0.58%newTimeline
HQYHEALTHEQUITY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 78,000 shares; 2025Q2: 92,000 shares; 2025Q3: 25,300 shares; 2025Q4: 16,900 shares 16,900$1.55M0.45%-8,400Timeline
SCYXSCYNEXIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,448,728 shares; 2024Q4: 1,228,910 shares; 2025Q1: 1,228,910 shares; 2025Q2: 1,228,910 shares; 2025Q3: 3,350,528 shares; 2025Q4: 2,081,660 shares 2,081,660$1.32M0.38%-1,268,868Timeline
IQVIQVIA HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 4,400 shares 4,400$992K0.29%newTimeline
KPTIKARYOPHARM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 134,566 shares; 2025Q2: 134,566 shares; 2025Q3: 134,566 shares; 2025Q4: 134,566 shares 134,566$990K0.29%0Timeline
CORTCORCEPT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 22,000 shares 22,000$766K0.22%newTimeline

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
BMYBRISTOL-MYERS SQUIBB CO257,600$11.6Mshares
MTSRMETSERA INC140,500$7.35Mshares
UNHUNITEDHEALTH GROUP INC17,800$6.15Mshares
ARVNARVINAS INC698,363$5.95Mshares
JNJJOHNSON & JOHNSON26,800$4.97Mshares
ABBVABBVIE INC19,800$4.58Mshares
CARLCARLSMED INC321,912$4.31Mshares
ARQTARCUTIS BIOTHERAPEUTICS INC214,400$4.04Mshares
EXASEXACT SCIENCES CORP73,600$4.03Mshares
ASNDASCENDIS PHARMA A/S14,500$2.88Mshares
BEAMBEAM THERAPEUTICS INC112,000$2.72Mshares
WVEWAVE LIFE SCIENCES LTD297,500$2.18Mshares
XENEXENON PHARMACEUTICALS INC53,400$2.14Mshares
AKROAKERO THERAPEUTICS INC40,500$1.92Mshares
IMRXIMMUNEERING CORP90,900$636Kshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001791827-26-000002 base2026-02-13acceptance time not in the bulk data set