FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 5,113,224 $30.8M 0.05% -258,551 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 4,322,747 $26M 2.17% 0 13F-HR/A Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 4,294,259 $25.9M 0.01% +4,285,259 13F-HR/A Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 4,258,600 $25.7M 0.05% new 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 3,215,000 $19.4M 1% -96,000 13F-HR Timeline FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 2,365,000 $14.2M 0.08% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 2,133,731 $12.9M new Timeline Foresite Capital Management VI LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management VI LLC 1,986,600 $12M 2.6% new 13F-HR Timeline Group Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 1,655,500 $9.97M 9.91% 0 13F-HR Timeline Spruce Street Capital LP More: the full row for Spruce Street Capital LP 1,655,500 $9.97M 2.4% 0 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 1,419,000 $8.55M 0.01% -1,419,000 13F-HR Timeline Group Trails Edge Capital Partners, LP More: the full row for Trails Edge Capital Partners, LP 1,419,000 $8.55M 2.01% new 13F-HR Timeline DV Trading LLC More: the full row for DV Trading LLC 889,254 $5.36M 0.49% new 13F-HR Timeline ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 709,500 $4.27M 3.04% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 708,291 $4.27M <0.01% +570,380 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 624,857 $3.76M <0.01% +552,188 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 338,735 $2.04M <0.01% +268,816 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 248,476 $1.5M 0.47% new 13F-HR/A Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 218,759 $1.32M <0.01% new 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 119,131 $718K <0.01% new 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 93,308 $562K <0.01% new 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 89,700 $540K <0.01% -59,500 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 67,570 $407K <0.01% +65,763 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 56,349 $340K <0.01% +32,330 13F-HR Timeline Group Apella Capital, LLC More: the full row for Apella Capital, LLC 42,250 $284K <0.01% -130 13F-HR Timeline Brendel Financial Advisors LLC More: the full row for Brendel Financial Advisors LLC 41,799 $252K 0.12% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 39,970 $241K <0.01% +39,919 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 32,012 $193K <0.01% new 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 31,000 $187K <0.01% new 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 28,629 $172K <0.01% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 24,332 $147K <0.01% +13,277 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 21,394 $129K <0.01% -900 13F-HR Timeline Group Cannon Global Investment Management, LLC More: the full row for Cannon Global Investment Management, LLC 17,758 $107K 0.26% new 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 10,300 $62.1K <0.01% new 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 4,767 $28K <0.01% -5,812 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 420 $2.53K <0.01% 0 13F-HR Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 400 $2.41K <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 251 $1.51K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 92 $1K <0.01% -2,148 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 146 $880 <0.01% new 13F-HR Timeline Group NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 100 $602 <0.01% 0 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 62 $374 <0.01% 0 13F-HR Timeline Group