ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 5,389,264 $71.9M 11.68% +3,902,803 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,732,623 $36.5M <0.01% -52,614 13F-HR Timeline Group Madison Avenue Partners, LP More: the full row for Madison Avenue Partners, LP 2,691,465 $35.9M 2.4% new 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,631,648 $35.1M <0.01% +65,327 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 2,000,000 $26.7M 3.57% 0 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,620,692 $21.6M 1.53% +113,902 13F-HR Timeline Group Western Standard LLC More: the full row for Western Standard LLC 1,534,893 $20.5M 11.4% +1,399,979 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 1,418,984 $18.9M 0.96% +318,984 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,384,254 $18.5M <0.01% +81,715 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 1,297,383 $17.3M 0.02% +34,253 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 1,018,734 $13.6M 0.34% 0 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 883,560 $11.8M <0.01% +142,954 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 878,746 $11.7M <0.01% -818,811 13F-HR Timeline Group ALKEON CAPITAL MANAGEMENT LLC More: the full row for ALKEON CAPITAL MANAGEMENT LLC 850,511 $11.4M 0.06% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 829,297 $11.1M <0.01% +23,112 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 654,030 $8.73M 0.02% -570,109 13F-HR Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 552,506 $7.38M 0.79% 0 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 524,340 $7M 0.03% new 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 472,392 $6.31M <0.01% new 13F-HR Timeline Group PDT Partners, LLC More: the full row for PDT Partners, LLC 332,815 $4.44M 0.25% +56,755 13F-HR Timeline CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 318,400 $4.25M <0.01% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 295,477 $3.94M <0.01% +139,865 13F-HR Timeline Group Rangeley Capital, LLC More: the full row for Rangeley Capital, LLC 285,400 $3.81M 4.78% -122,834 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 283,403 $3.78M <0.01% +41,480 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 273,123 $3.65M <0.01% -16,888 13F-HR Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 265,707 $3.55M 0.01% +137,604 13F-HR Timeline Newtyn Management, LLC More: the full row for Newtyn Management, LLC 246,857 $3.3M 0.5% new 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 211,637 $2.83M <0.01% +188,675 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 171,763 $2.29M 0.01% +130,462 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 164,271 $2.19M <0.01% -277,269 13F-HR Timeline Group RBF Capital, LLC More: the full row for RBF Capital, LLC 150,000 $2M 0.1% -20,014 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 146,600 $1.96M <0.01% new 13F-HR Timeline Franklin Resources group of 2 filers holding More: the full row for Franklin Resources 132,301 $1.77M -62,718 Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 130,316 $1.74M 0.48% 0 13F-HR Timeline Tetragon Partners GP Ltd in group Tetragon Partners GP Ltd More: the full row for Tetragon Partners GP Ltd 128,000 $1.71M 0.31% -55,000 13F-HR Timeline Group Man Group plc in group Man Group plc More: the full row for Man Group plc 121,545 $1.62M <0.01% +87,532 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 121,130 $1.62M <0.01% +61,270 13F-HR/A Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 113,665 $1.52M <0.01% -8,184 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 109,349 $1.46M <0.01% +11,594 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 104,878 $1.4M 0.03% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 102,773 $1.37M <0.01% +10,344 13F-HR Timeline Group Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 101,297 $1.35M <0.01% +36,360 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 98,641 $1.32M <0.01% new 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 90,735 $1.21M 0.03% +20,223 13F-HR Timeline Nebula Research & Development LLC More: the full row for Nebula Research & Development LLC 90,406 $1.21M 0.1% -25,014 13F-HR Timeline MONIMUS CAPITAL MANAGEMENT, LP More: the full row for MONIMUS CAPITAL MANAGEMENT, LP 90,396 $1.21M 0.97% +6,341 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 75,855 $1.01M <0.01% -3,871,600 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 71,924 $960K <0.01% new 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 70,650 $943K <0.01% +48,514 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 70,149 $936K 0.01% +4,305 13F-HR Timeline Group ARROWSTREET CAPITAL, LIMITED PARTNERSHIP in group ARROWSTREET CAPITAL, LIMITED … More: the full row for ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 64,581 $862K <0.01% new 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 61,743 $824K <0.01% +53,489 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 61,455 $820K 0.06% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 57,281 $765K <0.01% +10,336 13F-HR Timeline Group ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 55,570 $742K 0.02% +28,090 13F-HR/A Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 54,294 $725K <0.01% -1,038 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 54,145 $723K 0.03% +6,024 13F-HR Timeline Group MACKENZIE FINANCIAL CORP More: the full row for MACKENZIE FINANCIAL CORP 53,877 $719K <0.01% new 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 52,618 $702K 0.26% +511 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 51,815 $692K <0.01% +7,146 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 48,415 $647K <0.01% +5,188 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 47,654 $636K <0.01% -2,552,803 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 47,000 $627K 0.01% +18,129 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 46,599 $622K <0.01% -35,337 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 43,395 $579K <0.01% +10,129 13F-HR Timeline Group LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 41,709 $557K <0.01% new 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 40,000 $534K 0.02% +9,116 13F-HR Timeline DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 7,550 $530K <0.01% 0 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 38,677 $516K <0.01% -234,665 13F-HR Timeline OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 37,891 $506K 0.01% -77,627 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 36,636 $489K <0.01% 0 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 36,078 $482K 0.04% -70,903 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 34,379 $459K <0.01% -37,378 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 30,622 $409K -151,250 Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 27,810 $371K <0.01% -700 13F-HR Timeline Polymer Capital Management (US) LLC More: the full row for Polymer Capital Management (US) LLC 27,181 $363K 0.06% +15,640 13F-HR Timeline PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O… More: the full row for PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 26,103 $348K <0.01% new 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 25,958 $347K 0.03% +12,724 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 24,226 $323K <0.01% +6,948 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 23,031 $307K 0.01% -26,663 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 22,898 $306K <0.01% -168,711 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 21,949 $293K <0.01% -7,787 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 21,945 $293K <0.01% +5,167 13F-HR Timeline Group LAZARD ASSET MANAGEMENT LLC in group LAZARD ASSET MANAGEMENT LLC More: the full row for LAZARD ASSET MANAGEMENT LLC 21,849 $291K <0.01% new 13F-HR Timeline Group Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 20,700 $279K <0.01% 0 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 19,749 $264K <0.01% +1,651 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 19,099 $255K <0.01% -2,023 13F-HR Timeline MARTINGALE ASSET MANAGEMENT L P More: the full row for MARTINGALE ASSET MANAGEMENT L P 13,858 $185K <0.01% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 13,705 $183K <0.01% -219,498 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 12,451 $166K <0.01% +988 13F-HR Timeline Group FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 12,354 $165K 0.03% -6,635 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 12,037 $161K <0.01% -94,896 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 11,421 $152K 0.01% -148 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 10,616 $142K <0.01% +7,700 13F-HR/A Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 10,108 $135K <0.01% +8,302 13F-HR/A Timeline Group AMERICAN FINANCIAL GROUP INC in group AMERICAN FINANCIAL GROUP INC More: the full row for AMERICAN FINANCIAL GROUP INC 10,105 $135K 0.05% 0 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 9,864 $132K <0.01% +9,848 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 9,400 $125K <0.01% new 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 9,349 $125K 0.07% -7,712 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 8,257 $110K <0.01% +1,892 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 8,157 $109K 0.01% +21 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 6,894 $92K 0.03% -2,013 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 5,000 $67K <0.01% +2,333 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3,153 $42.1K <0.01% +1,888 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 3,117 $41.6K <0.01% -2,837 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,887 $38.5K <0.01% 0 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 2,676 $35.7K <0.01% -686 13F-HR Timeline FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 2,500 $33K 0.01% 0 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 1,569 $20.9K -21,957 Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 1,297 $17.3K <0.01% +300 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,058 $14K <0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,036 $13.8K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 912 $12.2K <0.01% +882 13F-HR/A Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 820 $10.9K <0.01% +713 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 631 $8.42K <0.01% +261 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 622 $8.3K <0.01% +600 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 480 $6.41K <0.01% +107 13F-HR Timeline Quantbot Technologies LP More: the full row for Quantbot Technologies LP 386 $5.15K <0.01% 0 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 374 $4.99K <0.01% +137 13F-HR Timeline Sachetta, LLC More: the full row for Sachetta, LLC 244 $3.26K <0.01% 0 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 175 $2.34K <0.01% -5 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 133 $2K <0.01% 0 13F-HR Timeline Group Red Tortoise LLC More: the full row for Red Tortoise LLC 146 $1.95K <0.01% new 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 131 $1.75K <0.01% 13F-HR Timeline Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 119 $1.59K <0.01% new 13F-HR Timeline Private Wealth Management Group, LLC More: the full row for Private Wealth Management Group, LLC 102 $1.36K <0.01% 0 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 100 $1.33K <0.01% new 13F-HR Timeline Group Brooklyn Investment Group More: the full row for Brooklyn Investment Group 91 $1.22K <0.01% new 13F-HR/A Timeline Geneos Wealth Management Inc. More: the full row for Geneos Wealth Management Inc. 83 $1.11K <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 74 $988 <0.01% new 13F-HR/A Timeline Group PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 59 $788 <0.01% new 13F-HR Timeline Group Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 55 $735 <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 50 $668 <0.01% +40 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 1 $521 <0.01% new 13F-HR Timeline WPG Advisers, LLC More: the full row for WPG Advisers, LLC 24 $320 <0.01% 0 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 6 $81 <0.01% +3 13F-HR Timeline Avion Wealth More: the full row for Avion Wealth 36 $0 0% new 13F-HR/A Timeline Value filed as zero, left out of ratios. Capital Advisors, Ltd. LLC More: the full row for Capital Advisors, Ltd. LLC 30 $0 0% +14 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios. TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.