FMR LLC in group FMR LLC More: the full row for FMR LLC 3,355,339 $21M <0.01% +477 13F-HR Timeline Group Flagship Pioneering, LLC in group Flagship Pioneering, LLC More: the full row for Flagship Pioneering, LLC 2,607,303 $16.3M 0.38% 0 13F-HR Timeline Group BlackRock Inc. More: the full row for BlackRock Inc. 1,034,195 $6.49M <0.01% -14,616 13F-HR Timeline Alaska Permanent Fund Corp More: the full row for Alaska Permanent Fund Corp 980,194 $6.15M 0.1% 0 13F-HR Timeline Boxer Capital, LLC More: the full row for Boxer Capital, LLC 850,065 $5.33M 0.27% 0 13F-HR Timeline UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT… More: the full row for UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO 847,108 $5.31M 2.73% 0 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 668,488 $4.19M 0.01% +159,051 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 615,568 $3.86M <0.01% -67,370 13F-HR Timeline Group ORACLE INVESTMENT MANAGEMENT INC More: the full row for ORACLE INVESTMENT MANAGEMENT INC 504,602 $3.16M 0.64% -154,589 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 330,000 $2.07M <0.01% 0 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 318,291 $2M <0.01% +24,009 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 297,089 $1.86M <0.01% +42,555 13F-HR Timeline Group Artal Group S.A. in group Artal Group S.A. More: the full row for Artal Group S.A. 200,000 $1.25M 0.05% 0 13F-HR Timeline Group VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 196,434 $985K <0.01% -14,226 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 138,069 $866K <0.01% -6,120 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 101,279 $635K 0.09% new 13F-HR Timeline Trellus Management Company, LLC More: the full row for Trellus Management Company, LLC 84,033 $527K 0.65% 0 13F-HR Timeline Parametrica Management Ltd in group Parametrica Management Ltd More: the full row for Parametrica Management Ltd 69,584 $436K 0.32% 0 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 63,900 $401K <0.01% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 54,514 $343K <0.01% +17,042 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 52,177 $328K 0.1% +2,497 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 49,643 $311K <0.01% +41,009 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 40,827 $256K <0.01% 0 13F-HR Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 37,184 $234K <0.01% 0 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 36,268 $227K <0.01% new 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 35,566 $223K <0.01% new 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 32,045 $201K <0.01% new 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 30,068 $189K 0.01% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 24,459 $153K <0.01% +1,932 13F-HR/A Timeline Group HighTower Advisors, LLC More: the full row for HighTower Advisors, LLC 20,328 $127K <0.01% -1,000 13F-HR Timeline Forefront Analytics, LLC More: the full row for Forefront Analytics, LLC 19,310 $122K 0.05% new 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 18,500 $116K <0.01% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 13,218 $83K <0.01% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 12,208 $77K <0.01% -2,084 13F-HR Timeline Group MIRABELLA FINANCIAL SERVICES LLP More: the full row for MIRABELLA FINANCIAL SERVICES LLP 11,500 $72K 0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 10,932 $69K <0.01% 0 13F-HR/A Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 10,076 $63K <0.01% +2,254 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 9,550 $60K <0.01% -1,018 13F-HR Timeline Group AMERICAN INTERNATIONAL GROUP, INC. More: the full row for AMERICAN INTERNATIONAL GROUP, INC. 7,898 $50K <0.01% -555 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 6,792 $43K <0.01% -1,958 13F-HR Timeline ETF MANAGERS GROUP, LLC More: the full row for ETF MANAGERS GROUP, LLC 6,784 $43K <0.01% +23 13F-HR Timeline DENALI ADVISORS LLC More: the full row for DENALI ADVISORS LLC 6,500 $41K 0.02% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 5,855 $37K <0.01% -5,383 13F-HR Timeline Group Allspring Global Investments Holdings, … in group Allspring Global Investments … More: the full row for Allspring Global Investments Holdings, LLC 4,008 $25K <0.01% -250 13F-HR/A Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 2,585 $17K <0.01% new 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 2,589 $16K <0.01% new 13F-HR/A Timeline Amalgamated Financial Corp. More: the full row for Amalgamated Financial Corp. 2,589 $16K <0.01% 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 1,661 $10K <0.01% 0 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,625 $10K <0.01% -933 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,231 $8K <0.01% 0 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,190 $7K <0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,170 $7K <0.01% -3,596 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 978 $6K <0.01% -2,605 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 300 $2K <0.01% 0 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 254 $1K <0.01% -97 13F-HR Timeline CAPTRUST FINANCIAL ADVISORS More: the full row for CAPTRUST FINANCIAL ADVISORS 142 $1K <0.01% 0 13F-HR Timeline Laurel Wealth Advisors LLC More: the full row for Laurel Wealth Advisors LLC 100 $1K <0.01% 0 13F-HR Timeline Prospera Financial Services Inc More: the full row for Prospera Financial Services Inc 89 $1K <0.01% new 13F-HR Timeline SALEM INVESTMENT COUNSELORS INC More: the full row for SALEM INVESTMENT COUNSELORS INC 50 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 38 $0 0% +19 13F-HR Timeline Group Value filed as zero, left out of ratios. GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 22 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Investors Research Corp More: the full row for Investors Research Corp 22 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.