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13F-HR filed by Ikarian Capital, LLC

Ikarian Capital, LLC filed this 13F-HR for the quarter ended 2022-03-31, filed 2022-05-13, with 196 holding rows worth $760,463,000.

Accession
0001420506-22-000935
Filed
2022-05-13
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q1 2022

A holdings report, 196 entries on the cover page, a total value of $760,463,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $760,463,000 with VALUE read as thousands by filing date, 13F file number 028-19721. The quarter's positions are built on this report. The resolved quarter.

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
SPDR SER TR78464A870S&P BIOTECH935,600$84,092,000thousands by filing datecall
NEUROCRINE BIOSCIENCES INC64125C109COM429,600$40,277,000thousands by filing datecall
BIOMARIN PHARMACEUTICAL INC09061G101COM313,800$24,192,000thousands by filing datecall
Amgen Inc.031162100COM100,000$24,182,000thousands by filing datecall
BIOGEN INC COM09062X103Stock112,200$23,629,000thousands by filing datecall
ALNYLAM PHARMACEUTICALS INC COM02043Q107Stock135,200$22,077,000thousands by filing datecall
REATA PHARMACEUTICALS INC75615P103CL A649,600$21,281,000thousands by filing dateput
BICYCLE THERAPEUTICS PLC-ADR088786108SPONSORED ADS478,784$21,009,000thousands by filing date
CELLDEX THERAPEUTICS INC NEW15117B202COM NEW595,500$20,282,000thousands by filing dateput
ALNYLAM PHARMACEUTICALS INC COM02043Q107Stock117,800$19,235,000thousands by filing dateput
CELLDEX THERAPEUTICS INC NEW15117B202COM NEW537,958$18,323,000thousands by filing date
KEZAR LIFE SCIENCES INC49372L100COM1,083,116$18,001,000thousands by filing date
UNITED THERAPEUTICS CORP DEL COM91307C102Stock100,000$17,942,000thousands by filing datecall
HORIZON THERAPEUTICS PLCG46188101SHS158,100$16,633,000thousands by filing datecall
Milestone Pharmaceuticals Inc59935V107COM1,928,752$12,383,000thousands by filing date
CELLDEX THERAPEUTICS INC NEW15117B202COM NEW344,100$11,718,000thousands by filing datecall
BICYCLE THERAPEUTICS PLC-ADR088786108SPONSORED ADS264,700$11,617,000thousands by filing datecall
HORIZON THERAPEUTICS PLCG46188101SHS110,116$11,585,000thousands by filing date
Gilead Sciences,Inc.375558103COM181,300$10,779,000thousands by filing dateput
Gilead Sciences,Inc.375558103COM181,300$10,779,000thousands by filing datecall
ATHIRA PHARMA INC04746L104COM784,200$10,587,000thousands by filing datecall
ADICET BIO INC007002108COM507,348$10,132,000thousands by filing date
ZENTALIS PHARMACEUTICALS INC98943L107COMMON STOCK202,203$9,329,000thousands by filing date
APELLIS PHARMACEUTICALS INC03753U106COM175,100$8,896,000thousands by filing datecall
SAGE THERAPEUTICS INC78667J108COM250,000$8,275,000thousands by filing datecall
SAGE THERAPEUTICS INC78667J108COM249,907$8,272,000thousands by filing date
VAXCYTE INC COM92243G108Stock315,991$7,630,000thousands by filing date
TRACON PHARMACEUTICALS INC89237H209COM NEW2,843,232$7,477,000thousands by filing date
XENON PHARMACEUTICALS INC COM98420N105Stock239,441$7,320,000thousands by filing date
BIOHAVEN PHARMACEUTICAL HOLDING11196105COM60,000$7,114,000thousands by filing date
SIERRA ONCOLOGY INC82640U404CMN217,915$6,983,000thousands by filing date
GOSSAMER BIO INC COM38341P102Stock775,315$6,730,000thousands by filing date
Vertex Pharmaceuticals Incorporated92532F100COM25,000$6,524,000thousands by filing date
RIGEL PHARMACEUTICALS INC766559603COMMON STOCK2,137,128$6,390,000thousands by filing date
KARUNA THERAPEUTICS INC48576A100COM50,000$6,340,000thousands by filing date
BELLUS HEALTH INC NEW07987C204COM913,327$6,283,000thousands by filing date
IMMATICS N.VN44445109SHS781,388$6,243,000thousands by filing date
SERES THERAPEUTICS INC81750R102COM840,624$5,986,000thousands by filing date
SCPHARMACEUTICALS INC810648105COM970,098$5,510,000thousands by filing date
LAKEFRONT BIOTHERAPEUTICS NV36315X101SPON ADR86,865$5,413,000thousands by filing date
AMYLYX PHARMACEUTICALS INC03237H101COM396,654$5,097,000thousands by filing date
Amgen Inc.031162100COM20,000$4,837,000thousands by filing date
ARCUS BIOSCIENCES INC03969F109COM150,000$4,734,000thousands by filing datecall
BICYCLE THERAPEUTICS PLC-ADR088786108SPONSORED ADS106,600$4,677,000thousands by filing dateput
KEZAR LIFE SCIENCES INC49372L100COM280,800$4,666,000thousands by filing datecall
Pfizer Inc.717081103COM80,000$4,142,000thousands by filing date
BLUEPRINT MEDICINES CORP09627Y109COM64,000$4,088,000thousands by filing datecall
BIOMARIN PHARMACEUTICAL INC09061G101COM50,000$3,856,000thousands by filing date
CHIMERIX INC COM16934W106Stock841,203$3,852,000thousands by filing date
PROTAGONIST THERAPEUTICS74366E102COM160,700$3,806,000thousands by filing datecall
WHITEHAWK THERAPEUTICS INC00032Q104CMN208,368$3,536,000thousands by filing date
INHIBRX INC45720L107COM157,842$3,516,000thousands by filing date
INTELLIA THERAPEUTICS INC45826J105COM47,408$3,445,000thousands by filing date
AMYLYX PHARMACEUTICALS INC03237H101COM250,000$3,213,000thousands by filing datecall
REATA PHARMACEUTICALS INC75615P103CL A86,905$2,846,000thousands by filing date
AYALA PHARMACEUTICALS INC05465V108COM708,383$2,819,000thousands by filing date
ATHIRA PHARMA INC04746L104COM200,000$2,700,000thousands by filing dateput
SATSUMA PHARMACEUTICALS INC80405P107COM653,448$2,482,000thousands by filing date
X4 Pharmaceuticals, Inc.98420X103COM1,372,022$2,402,000thousands by filing date
PARDES BIOSCIENCES INC69945Q105COM323,934$2,338,000thousands by filing date
ZAI LAB LTD ADR98887Q104ADR53,100$2,336,000thousands by filing datecall
OVID THERAPEUTICS INC690469101COMMON STOCK738,372$2,319,000thousands by filing date
SAVARA INC805111101COM1,622,552$2,126,000thousands by filing date
KYMERA THERAPEUTICS INC501575104COM50,000$2,117,000thousands by filing date
WAVE LIFE SCIENCES LTD SHSY95308105Stock1,048,039$2,095,000thousands by filing date
PMV PHARMACEUTICALS INC69353Y103COM100,000$2,082,000thousands by filing dateput
PMV PHARMACEUTICALS INC69353Y103COM100,000$2,082,000thousands by filing datecall
CABALETTA BIO INC12674W109COMMON STOCK1,020,070$2,070,000thousands by filing date
CONNECT BIOPHARMA HLDGS LTD207523101SHS677,859$2,047,000thousands by filing date
CLENE INC185634102COM514,283$2,026,000thousands by filing date
INHIBRX INC45720L107COM85,800$1,911,000thousands by filing datecall
GOSSAMER BIO INC COM38341P102Stock211,600$1,836,000thousands by filing datecall
LIQUIDIA CORPORATION COM NEW53635D202Stock243,904$1,751,000thousands by filing date
GLOBAL BLOOD THERAPEUTICS USD37890U108COM49,997$1,732,000thousands by filing date
LYRA THERAPEUTICS INC55234L105COM422,338$1,698,000thousands by filing date
ALDEYRA THERAPEUTICS INC01438T106COM375,000$1,667,000thousands by filing date
FINCH THERAPEUTICS GROUP INC31773D101COM330,523$1,662,000thousands by filing date
VIKING THERAPEUTICS INC92686J106COM532,429$1,596,000thousands by filing date
CLOVIS ONCOLOGY INC189464100COM772,339$1,561,000thousands by filing date
AUTOLUS THERAPEUTICS PLC SPON05280R100COM372,217$1,552,000thousands by filing date
PROTARA THERAPEUTICS INC74365U107COM STK296,426$1,515,000thousands by filing date
AILERON THERAPEUTICS INC COM NEW00887A105Stock2,902,086$1,487,000thousands by filing date
RENOVACOR INC75989E106COM343,283$1,456,000thousands by filing date
MACROGENICS INC556099109COM164,119$1,446,000thousands by filing date
ELEDON PHARMACEUTICALS INC28617k101COM362,537$1,429,000thousands by filing date
MERUS N VN5749R100COM53,703$1,420,000thousands by filing date
VASCULAR BIOGENICS LTDM96883109COM830,747$1,404,000thousands by filing date
CHEMOMAB THERAPEUTICS LTD16385C104SPONSORED ADS268,104$1,292,000thousands by filing date
SYNLOGIC INC87166L100COM519,775$1,248,000thousands by filing date
ADICET BIO INC007002108COM62,100$1,241,000thousands by filing datecall
ANEBULO PHARMACEUTICALS INC034569103COM181,199$1,225,000thousands by filing date
SYNAPTOGENIX INC87167T201COM NEW153,226$1,186,000thousands by filing date
BELLICUM PHARMACEUTICALS INC COM NEW079481404Stock523,348$1,131,000thousands by filing date
NUVATION BIO INC COM CL A67080N101Stock213,310$1,122,000thousands by filing date
AURINIA PHARMACEUTICALS INC COM05156V102Stock87,071$1,077,000thousands by filing date
PHATHOM PHARMACEUTICALS INC71722W107COMMON STOCK78,550$1,069,000thousands by filing date
CASI PHARMACEUTICALS INC14757U109COM1,320,155$1,067,000thousands by filing date
DBV TECHNOLOGIES S A23306J101ADR316,939$1,047,000thousands by filing date
ASCENDIS PHARMA A/S DKK 1.0 AD04351P101SPONSORED ADR8,763$1,028,000thousands by filing date
BRAINSTORM CELL THERAPEUTICS10501E201COM304,161$1,022,000thousands by filing date
MAXCYTE INC57777K106COM137,958$964,000thousands by filing date
VERASTEM INC92337C104COM678,023$956,000thousands by filing date
CABALETTA BIO INC12674W109COMMON STOCK449,000$912,000thousands by filing datecall
AKEBIA THERAPEUTICS INC00972D105COMMON STOCK1,200,000$860,000thousands by filing dateput
CORVUS PHARMACEUTICALS INC221015100COM510,126$837,000thousands by filing date
IVERIC BIO INC46583P102COM49,099$825,000thousands by filing date
TRICIDA INC89610F101COM92,900$764,000thousands by filing dateput
BCLS ACQUISITION CORPG0904B105CMN77,274$762,000thousands by filing date
HEPION PHARMACEUTICALS INC426897104COM582,137$751,000thousands by filing date
PANBELA THERAPEUTICS INC69833Q100COM355,959$750,000thousands by filing date
QUANTUM SI INC74765K105COM CL A157,363$736,000thousands by filing date
NEKTAR THERAPEUTICS640268108COM133,900$722,000thousands by filing datecall
IMMUNIC INC4525EP101COM61,500$696,000thousands by filing dateput
NEXTCURE INC65343E108COM141,058$686,000thousands by filing date
Inflarx NvN44821101COM349,468$639,000thousands by filing date
PLIANT THERAPEUTICS INC729139105COM90,805$636,000thousands by filing date
VISTAGEN THERAPEUTICS INC92840H202COM511,186$633,000thousands by filing date
SOLID BIOSCIENCES INC COM NEW83422E105Stock521,155$625,000thousands by filing date
ASTRIA THERAPEUTICS INC COM04635X102Stock92,223$619,000thousands by filing date
GEMINI THERAPEUTICS INC36870G105CMN443,096$615,000thousands by filing date
MYMD PHARMACEUTICALS INC62856X102COMMON131,389$612,000thousands by filing date
TENAX THERAPEUTICS INC88032L209COM735,097$596,000thousands by filing date
RELMADA THERAPEUTICS INC75955J402COMMON STOCK21,801$588,000thousands by filing date
KALVISTA PHARMACEUTICALS INC483497103COM39,730$586,000thousands by filing date
CYCLERION THERAPEUTICS INC23255M105COM527,462$585,000thousands by filing date
HARPOON THERAPEUTICS INC41358P106COM117,009$582,000thousands by filing date
AKEBIA THERAPEUTICS INC00972D105COMMON STOCK800,000$575,000thousands by filing datecall
INTERCEPT PHARMACEUTICALS IN45845P108COM35,149$572,000thousands by filing date
KODIAK SCIENCES INC50015M109COM73,100$565,000thousands by filing dateput
AVALO THERAPEUTICS INC05338F108CMN764,271$554,000thousands by filing date
DIAMEDICA THERAPEUTICS INC25253X207COMMON STOCK221,252$553,000thousands by filing date
MUSTANG BIO INC62818Q104COM546,824$551,000thousands by filing date
RENEO PHARMACEUTICALS INC75974E103COM185,597$546,000thousands by filing date
VTV THERAPEUTICS INC CL A918385105Stock742,980$536,000thousands by filing date
CORBUS PHARMACEUTICALS HLDGS21833P103COM997,627$530,000thousands by filing date
KODIAK SCIENCES INC50015M109COM68,100$526,000thousands by filing date
OTONOMY INC68906L105COM218,538$525,000thousands by filing date
REATA PHARMACEUTICALS INC75615P103CL A15,300$502,000thousands by filing datecall
ASSEMBLY BIOSCIENCES INC045396108COM227,076$468,000thousands by filing date
BLACK DIAMOND THERAPEUTICS I09203E105COM159,390$441,000thousands by filing date
APPLIED GENETIC TECHNOL CORP03820J100COM412,293$440,000thousands by filing date
OPUS GENETICS INC67577R102COMMON STOCK124,021$401,000thousands by filing date
IMMUNOPRECISE ANTIBODIES LTDCOM NEW45257F200cs77,650$399,000thousands by filing date
NEUROSENSE THERAPEUTICS LTDM74240108FOREIGN100,000$397,000thousands by filing date
REGULUS THERAPEUTICS INC75915K200COM NEW1,289,130$384,000thousands by filing date
VALLON PHARMACEUTICALS INC92023M101COM201,758$380,000thousands by filing date
ZAI LAB LTD ADR98887Q104ADR81,843$376,000thousands by filing date
FATE THERAPEUTICS INC31189P102COM9,640$374,000thousands by filing date
YUMANITY THERAPEUTICS INC98872L102COM236,284$355,000thousands by filing date
ALTAMIRA THERAPEUTICS LTDG0360L100SHS320,010$351,000thousands by filing date
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS85789A105Stock501,836$350,000thousands by filing date
CODIAK BIOSCIENCES INC192010106COM52,177$328,000thousands by filing date
CYCLACEL PHARMACE 6percent PFDCONV23254L603Stock104,741$319,000thousands by filing date
MEREO BIOPHARMA GROUP PLC589492107CMN915,856$318,000thousands by filing date
CATALYST BIOSCIENCES INC14888D208COM476,625$314,000thousands by filing date
ONCTERNAL THERAPEUTICS INC68236P107COM210,182$292,000thousands by filing date
EYEPOINT INC COM NEW30233G209Stock22,552$274,000thousands by filing date
AGENUS INC00847G705COM NEW108,933$267,000thousands by filing date
GENOCEA BIOSCIENCES INC372427401COMMON STOCK206,336$259,000thousands by filing date
BIOGEN INC COM09062X103Stock1,122$237,000thousands by filing date
PASSAGE BIO INC702712100COM71,856$223,000thousands by filing date
SEELOS THERAPEUTICS INC81577F109COM257,883$215,000thousands by filing date
Tempest Therapeutics, Inc.87978U108Common Stock61,827$210,000thousands by filing date
LARIMAR THERAPEUTICS INC517125100COM51,606$209,000thousands by filing date
ACLARIS THERAPEUTICS INC COM00461U105Stock12,124$208,000thousands by filing date
ALNYLAM PHARMACEUTICALS INC COM02043Q107Stock1,237$201,000thousands by filing date
KODIAK SCIENCES INC50015M109COM25,700$199,000thousands by filing datecall
ATYR PHARMA INC002120202COM NEW37,017$197,000thousands by filing date
ASLAN PHARMACEUTICALS LTD04522R101ADR970,747$192,000thousands by filing date
INVENTIVA SA46124U107ADS15,579$178,000thousands by filing date
BRIGHT MINDS BIOSCIENCES INC10919W108COM105,958$161,000thousands by filing date
OCULAR THERAPEUTIX INC67576A100COM29,644$147,000thousands by filing date
APTOSE BIOSCIENCES INC COM03835T200Stock106,952$147,000thousands by filing date
PUMA BIOTECHNOLOGY INC74587V107COMMON STOCK49,843$144,000thousands by filing date
ENVERIC BIOSCIENCES INC29405E109COM NEW423,834$141,000thousands by filing date
GAMIDA CELL LTDM47364100SHS32,689$135,000thousands by filing date
GOSSAMER BIO INC COM38341P102Stock14,900$129,000thousands by filing dateput
MIND MEDICINE (MINDMED) INC60255C109COMMON STOCK-FO105,958$118,000thousands by filing date
BIOXCEL THERAPEUTICS INC09075P105COM5,428$113,000thousands by filing date
ORCHARD THERAPEUTICS PLC68570P101ADR155,606$110,000thousands by filing date
NOVAVAX INC670002401COM NEW1,362$100,000thousands by filing date
COMPASS THERAPEUTICS INC20454B104COM74,171$100,000thousands by filing date
AMRYT PHARMA LTD - SPNR ADR03217L106COMMON EQUITY37,248$70,000thousands by filing date
ATHENEX INC04685N103COM80,039$68,000thousands by filing date
ACADIA PHARMACEUTICALS INC004225108COM1,882$46,000thousands by filing date
IGM BIOSCIENCES INC449585108COM1,587$43,000thousands by filing date
TANGO THERAPEUTICS INC87583X109COM5,456$42,000thousands by filing date
TRAWS PHARMA INC COM NEW68232V801Stock18,975$35,000thousands by filing date
SOLENO THERAPEUTIVS, INC.834203200COMM128,454$29,000thousands by filing date
PDS BIOTECHNOLOGY CORP70465T107COM3,672$22,000thousands by filing date
KINNATE BIOPHARMA INC49705R105COM1,990$22,000thousands by filing date
TG THERAPEUTICS INC COM88322Q108Stock2,292$21,000thousands by filing date
KARYOPHARM THERAPEUTICS INC48576U106COM830$6,000thousands by filing date
BAUDAX BIO INC07160F206COM NEW2,966$4,000thousands by filing date
BLUEBIRD BIO INC09609G100COM306$1,000thousands by filing date
2SEVENTY BIO INC COMMON STOCK901384107Stock99$1,000thousands by filing date

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001420506-22-000935this filing2022-05-13acceptance time not in the bulk data set