JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 6,307,636 $27.9M 0.01% 0 13F-HR/A Timeline Group 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 5,869,091 $25.9M 7.19% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 4,933,432 $21.8M <0.01% +15,189 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 4,246,568 $18.7M 1.56% 0 13F-HR/A Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 2,632,437 $11.6M 0.02% +195,537 13F-HR Timeline Group ENAVATE SCIENCES GP, LLC More: the full row for ENAVATE SCIENCES GP, LLC 2,190,920 $9.66M 2.75% -844,905 13F-HR Timeline a16z Capital Management, L.L.C. in group a16z Capital Management, L.L.… More: the full row for a16z Capital Management, L.L.C. 2,125,339 $9.37M 0.73% 0 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 1,960,784 $8.65M 0.01% -220,895 13F-HR Timeline Group Trails Edge Capital Partners, LP More: the full row for Trails Edge Capital Partners, LP 1,939,563 $8.55M 2.01% -44,423 13F-HR Timeline VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 1,741,396 $7.68M new Timeline Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 1,389,622 $6.13M 5.39% +1,160,728 13F-HR Timeline HarbourVest Partners LLC More: the full row for HarbourVest Partners LLC 1,271,948 $5.61M 5.56% 0 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 653,594 $2.88M 0.34% new 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 456,371 $2.01M <0.01% +66,211 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 382,821 $1.69M <0.01% +46,528 13F-HR Timeline Group SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 339,521 $1.5M 0.05% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 336,047 $1.48M <0.01% new 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 146,900 $648K <0.01% +107,200 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 108,875 $480K <0.01% +14,344 13F-HR Timeline Group 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 108,000 $476K 0.04% -18,363 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 85,918 $379K <0.01% +75,816 13F-HR Timeline Group VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 82,450 $364K <0.01% -340 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 78,345 $346K <0.01% +59,522 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 70,666 $312K <0.01% -3,843 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 48,511 $214K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 34,693 $153K <0.01% -38,908 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 31,196 $138K <0.01% +31,174 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 30,747 $135K <0.01% new 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 25,000 $110K <0.01% 0 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 24,803 $109K <0.01% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 20,000 $88.2K <0.01% new 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 18,718 $82.5K <0.01% 0 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 17,326 $76.4K <0.01% new 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 16,000 $70.6K 0.01% +6,000 13F-HR Timeline Diametric Capital, LP More: the full row for Diametric Capital, LP 14,446 $63.7K 0.02% new 13F-HR Timeline Scientech Research LLC More: the full row for Scientech Research LLC 12,735 $56.2K 0.05% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 9,887 $43.6K <0.01% -11,516 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 9,505 $41.9K <0.01% -409 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 9,081 $40K <0.01% +3,936 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,405 $6.2K <0.01% +999 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 236 $1K <0.01% +218 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 74 $326 <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 36 $159 <0.01% +3 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 10 $44 <0.01% 0 13F-HR Timeline