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New Leaf Venture Partners, L.L.C.

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13F filer, CIK 1631614, New York, NY

New Leaf Venture Partners, L.L.C. reported $43,047,844 across 7 holdings for the quarter ended 2025-09-30, in a 13F-HR filed 2025-11-14.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001193125-25-280589

Period
2025-09-30
Reported value
$43M
Holdings
7
Top 10 weight
100%
New
0
Sold out
1

Largest buys vs the previous quarter

None.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
PASSAGE BIO INCreduced-2,410,496-$19.4M
ITRMFexited-345,020-$343K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q3 2025

Share positions as resolved from 13F-HR 0001193125-25-280589, largest first. % of portfolio is the value over $43,047,844, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 1,553,661 shares; 2024Q1: 1,553,661 shares; 2024Q2: 1,553,661 shares; 2024Q3: 1,553,661 shares; 2024Q4: 1,030,161 shares; 2025Q1: 1,030,161 shares; 2025Q2: 1,030,161 shares; 2025Q3: 1,030,161 shares 1,030,161$16.7M38.82%0Timeline
ARVNARVINAS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 1,289,521 shares; 2024Q1: 1,289,521 shares; 2024Q2: 1,289,521 shares; 2024Q3: 1,434,721 shares; 2024Q4: 1,585,721 shares; 2025Q1: 1,585,721 shares; 2025Q2: 1,585,721 shares; 2025Q3: 1,585,721 shares 1,585,721$13.5M31.38%0Timeline
CRNXCRINETICS PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 141,000 shares; 2024Q1: 141,000 shares; 2024Q2: 141,000 shares; 2024Q3: 141,000 shares; 2024Q4: 141,000 shares; 2025Q1: 141,000 shares; 2025Q2: 141,000 shares; 2025Q3: 141,000 shares 141,000$5.87M13.64%0Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 250,765 shares; 2024Q1: 250,765 shares; 2024Q2: 250,765 shares; 2024Q3: 250,765 shares; 2024Q4: 250,765 shares; 2025Q1: 250,765 shares; 2025Q2: 250,765 shares; 2025Q3: 250,765 shares 250,765$3.6M8.37%0Timeline
RALLYBIO CORPRALLYBIO CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 3,301,603 shares; 2024Q1: 3,301,603 shares; 2024Q2: 3,301,603 shares; 2024Q3: 3,301,603 shares; 2024Q4: 3,301,603 shares; 2025Q1: 3,301,603 shares; 2025Q2: 3,301,603 shares; 2025Q3: 3,301,603 shares 3,301,603$1.65M3.83%0
ALECALECTOR INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 339,569 shares; 2024Q1: 339,569 shares; 2024Q2: 339,569 shares; 2024Q3: 339,569 shares; 2024Q4: 339,569 shares; 2025Q1: 339,569 shares; 2025Q2: 339,569 shares; 2025Q3: 339,569 shares 339,569$1.01M2.33%0Timeline
PASSAGE BIO INCPASSAGE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: 2,497,922 shares; 2024Q1: 2,497,922 shares; 2024Q2: 2,497,922 shares; 2024Q3: 2,497,922 shares; 2024Q4: 2,497,922 shares; 2025Q1: 2,497,922 shares; 2025Q2: 2,497,922 shares; 2025Q3: 87,426 shares 87,426$702K1.63%-2,410,496

Sold out in Q3 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
ITRMFITERUM THERAPEUTICS PLC345,020$343Kshares

How Q3 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001193125-25-280589 base2025-11-14acceptance time not in the bulk data set