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New Leaf Venture Partners, L.L.C.

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13F filer, CIK 1631614, New York, NY

New Leaf Venture Partners, L.L.C. reported $74,801,573 across 9 holdings for the quarter ended 2024-12-31, in a 13F-HR filed 2025-02-13.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0000950123-25-002058

Period
2024-12-31
Reported value
$74.8M
Holdings
9
Top 10 weight
100%
New
0
Sold out
1

Largest buys vs the previous quarter

SecurityShares changeApprox. value
ARVNadded+151,000$2.89M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
EWTXreduced-523,500-$14M
X4 PHARMACEUTICALS INCexited-335,000-$224K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2024

Share positions as resolved from 13F-HR 0000950123-25-002058, largest first. % of portfolio is the value over $74,801,573, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
ARVNARVINAS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q1: restricted; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: 1,289,521 shares; 2024Q1: 1,289,521 shares; 2024Q2: 1,289,521 shares; 2024Q3: 1,434,721 shares; 2024Q4: 1,585,721 shares 1,585,721$30.4M40.64%+151,000Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q1: restricted; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: 1,553,661 shares; 2024Q1: 1,553,661 shares; 2024Q2: 1,553,661 shares; 2024Q3: 1,553,661 shares; 2024Q4: 1,030,161 shares 1,030,161$27.5M36.77%-523,500Timeline
CRNXCRINETICS PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q1: restricted; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: 141,000 shares; 2024Q1: 141,000 shares; 2024Q2: 141,000 shares; 2024Q3: 141,000 shares; 2024Q4: 141,000 shares 141,000$7.21M9.64%0Timeline
RALLYBIO CORPRALLYBIO CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q1: restricted; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: 3,301,603 shares; 2024Q1: 3,301,603 shares; 2024Q2: 3,301,603 shares; 2024Q3: 3,301,603 shares; 2024Q4: 3,301,603 shares 3,301,603$3.17M4.24%0
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q1: restricted; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: 250,765 shares; 2024Q1: 250,765 shares; 2024Q2: 250,765 shares; 2024Q3: 250,765 shares; 2024Q4: 250,765 shares 250,765$1.96M2.61%0Timeline
RCKTROCKET PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q1: restricted; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: 118,242 shares; 2024Q1: 118,242 shares; 2024Q2: 150,706 shares; 2024Q3: 150,706 shares; 2024Q4: 150,706 shares 150,706$1.89M2.53%0Timeline
PASSAGE BIO INCPASSAGE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q1: restricted; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: 2,497,922 shares; 2024Q1: 2,497,922 shares; 2024Q2: 2,497,922 shares; 2024Q3: 2,497,922 shares; 2024Q4: 2,497,922 shares 2,497,922$1.42M1.89%0
ALECALECTOR INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q1: restricted; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: 339,569 shares; 2024Q1: 339,569 shares; 2024Q2: 339,569 shares; 2024Q3: 339,569 shares; 2024Q4: 339,569 shares 339,569$642K0.86%0Timeline
ITRMFITERUM THERAPEUTICS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q1: restricted; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: 97,084 shares; 2024Q1: 97,084 shares; 2024Q2: 97,086 shares; 2024Q3: 345,020 shares; 2024Q4: 345,020 shares 345,020$611K0.82%0Timeline

Sold out in Q4 2024

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
X4 PHARMACEUTICALS INCX4 PHARMACEUTICALS INC335,000$224Kshares

How Q4 2024 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0000950123-25-002058 base2025-02-13acceptance time not in the bulk data set