Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 2,849,402 $8.99M 0.13% 0 13F-HR Timeline QVT Financial LP More: the full row for QVT Financial LP 2,313,702 $7.3M 0.65% new 13F-HR Timeline BML Capital Management, LLC More: the full row for BML Capital Management, LLC 2,100,000 $6.63M 4.12% +100,000 13F-HR Timeline ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 1,849,402 $5.83M 5.87% 0 13F-HR Timeline ACORN CAPITAL ADVISORS, LLC More: the full row for ACORN CAPITAL ADVISORS, LLC 1,147,052 $3.62M 1.95% 13F-HR/A Timeline Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 817,939 $2.58M 2.21% new 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 765,992 $2.42M <0.01% 0 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 456,022 $1.44M <0.01% -5,800 13F-HR Timeline Peapod Lane Capital LLC More: the full row for Peapod Lane Capital LLC 442,942 $1.4M 1.39% 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 345,253 $1.09M 0.04% -1,500,000 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 333,227 $1.05M 0.08% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 243,890 $769K <0.01% +1,002 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 217,294 $686K <0.01% +8,546 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 173,998 $549K <0.01% -2,785 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 130,241 $411K +81,724 Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 115,400 $364K 0.01% +22,100 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 91,151 $288K <0.01% +22,677 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 68,737 $217K <0.01% 0 13F-HR Timeline Group Marquette Asset Management, LLC More: the full row for Marquette Asset Management, LLC 63,564 $201K 0.03% 0 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 62,035 $196K <0.01% +54,591 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 59,174 $187K <0.01% +8,467 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 57,511 $181K <0.01% -14,434 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 41,600 $131K <0.01% -100 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 40,000 $126K <0.01% new 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 35,595 $112K <0.01% 0 13F-HR Timeline Group ABG Innovation Capital Partners III GP … More: the full row for ABG Innovation Capital Partners III GP Ltd 26,666 $84.1K 7.77% 0 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 26,400 $83.3K <0.01% 0 13F-HR Timeline Group Man Group plc in group Man Group plc More: the full row for Man Group plc 14,484 $45.7K <0.01% -11 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 13,245 $41.8K <0.01% -2,346 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 12,897 $40.7K <0.01% -4,900 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 12,761 $40.3K <0.01% +10,350 13F-HR/A Timeline Group Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 11,609 $36.6K 0.01% -512 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 6,589 $20.8K <0.01% +5,580 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 4,724 $14.9K <0.01% -99 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 3,333 $10.5K <0.01% 0 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 2,988 $9.44K <0.01% +1,539 13F-HR/A Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 1,512 $4.77K <0.01% 0 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,478 $4.66K <0.01% -2,759 13F-HR Timeline Group BARTLETT & CO. WEALTH MANAGEMENT LLC More: the full row for BARTLETT & CO. WEALTH MANAGEMENT LLC 1,333 $4.21K <0.01% 0 13F-HR Timeline Alerce Investment Management, L.P. More: the full row for Alerce Investment Management, L.P. 659 $2.08K <0.01% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 600 $1.89K <0.01% -2,222 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 500 $1.58K <0.01% new 13F-HR/A Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 428 $1.35K <0.01% 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 414 $1.31K <0.01% -1,379 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 558 $1K <0.01% -1,781 13F-HR Timeline TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 232 $731 <0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 197 $622 <0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 172 $543 <0.01% -41 13F-HR Timeline Group Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 77 $243 <0.01% 0 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 75 $237 <0.01% -6 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 8 $25 <0.01% 0 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 25 $0 0% 0 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.