BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 4,865,819 $28.2M 0.2% 0 13F-HR Timeline Group MPM ASSET MANAGEMENT LLC More: the full row for MPM ASSET MANAGEMENT LLC 4,381,062 $25.4M 57.09% 0 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 4,256,379 $24.7M 9.04% -52,000 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,044,044 $11.9M <0.01% +21,894 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,604,225 $9.3M <0.01% -635 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 954,419 $5.54M <0.01% -106,297 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 836,609 $4.85M <0.01% +666,287 13F-HR Timeline Group StepStone Group LP More: the full row for StepStone Group LP 761,277 $4.42M 2.08% 0 13F-HR Timeline CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 67,334 $3.91M 0.08% new 13F-HR/A Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 645,119 $3.74M <0.01% +13,565 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 594,300 $3.45M <0.01% +214,800 13F-HR Timeline TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 584,955 $3.39M 0.17% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 498,615 $2.89M <0.01% +2,753 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 394,279 $2.29M <0.01% -29,706 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 360,526 $2.09M <0.01% -2,206,952 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 346,756 $2.01M <0.01% +183,659 13F-HR/A Timeline Group ROYCE & ASSOCIATES LP More: the full row for ROYCE & ASSOCIATES LP 345,507 $2M 0.02% +122,256 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 335,741 $1.95M <0.01% +235,384 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 315,810 $1.83M 0.01% +95,074 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 297,943 $1.72M <0.01% +252,137 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 287,873 $1.67M <0.01% +154,143 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 253,607 $1.47M <0.01% -46,714 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 247,516 $1.44M <0.01% +196,358 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 222,336 $1.29M <0.01% +138,186 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 185,259 $1.07M <0.01% -18,434 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 148,212 $860K <0.01% +145,167 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 144,694 $839K new Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 133,878 $776K <0.01% +117,844 13F-HR/A Timeline Group ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 129,812 $753K 0.01% new 13F-HR/A Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 126,448 $733K <0.01% +89,975 13F-HR/A Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 122,865 $713K 0.01% +112,288 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 122,676 $712K 0.01% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 105,806 $614K <0.01% +7,778 13F-HR Timeline Group MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 105,000 $609K 0.01% 0 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 96,681 $561K <0.01% +79,272 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 93,079 $540K 0.03% new 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 75,394 $437K <0.01% +300 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 71,548 $415K <0.01% new 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 69,926 $406K <0.01% +24,980 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 60,630 $352K <0.01% +2,548 13F-HR/A Timeline Group Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 58,229 $338K <0.01% +39,607 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 56,932 $330K <0.01% +1,108 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 56,416 $327K <0.01% 0 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 55,960 $325K 0.03% new 13F-HR Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 52,079 $302K <0.01% +7,447 13F-HR Timeline Nan Fung Group Holdings Ltd More: the full row for Nan Fung Group Holdings Ltd 49,082 $285K 0.48% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 42,139 $245K <0.01% +22,797 13F-HR Timeline Group GREAT LAKES ADVISORS, LLC More: the full row for GREAT LAKES ADVISORS, LLC 41,029 $238K <0.01% new 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 40,000 $232K <0.01% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 39,428 $229K <0.01% +333 13F-HR Timeline Corton Capital Inc. More: the full row for Corton Capital Inc. 38,849 $225K 0.55% +10,094 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 37,788 $219K <0.01% -10,000 13F-HR Timeline MARTINGALE ASSET MANAGEMENT L P More: the full row for MARTINGALE ASSET MANAGEMENT L P 37,053 $215K 0.01% -2,410 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 31,946 $185K <0.01% -464,183 13F-HR Timeline Group Atom Investors LP More: the full row for Atom Investors LP 30,812 $179K 0.01% new 13F-HR Timeline OCCUDO QUANTITATIVE STRATEGIES LP More: the full row for OCCUDO QUANTITATIVE STRATEGIES LP 29,486 $171K 0.02% +19,338 13F-HR Timeline OXFORD ASSET MANAGEMENT LLP More: the full row for OXFORD ASSET MANAGEMENT LLP 29,161 $169K 0.06% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 29,075 $169K <0.01% +6,682 13F-HR Timeline Group PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O… More: the full row for PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 28,202 $164K <0.01% +13,200 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 25,754 $149K 0.01% new 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 24,320 $141K <0.01% +1,620 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 21,616 $125K <0.01% +3,516 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 21,008 $122K <0.01% +5,473 13F-HR Timeline Group HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 20,639 $117K <0.01% new 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 19,021 $110K -5,738 Timeline SHERBROOKE PARK ADVISERS LLC More: the full row for SHERBROOKE PARK ADVISERS LLC 18,573 $108K 0.05% new 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 17,894 $103K <0.01% new 13F-HR Timeline Group Allspring Global Investments Holdings, … in group Allspring Global Investments … More: the full row for Allspring Global Investments Holdings, LLC 15,935 $92.4K <0.01% -157 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 14,579 $84.6K -2,275 Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 14,495 $84.1K 0.02% +2,516 13F-HR Timeline Group NewEdge Advisors, LLC More: the full row for NewEdge Advisors, LLC 14,167 $82.2K <0.01% new 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 13,991 $81.1K <0.01% -21,629 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 13,843 $80.3K <0.01% -3,859 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 11,954 $69.3K <0.01% new 13F-HR Timeline Inscription Capital, LLC More: the full row for Inscription Capital, LLC 11,835 $68.6K 0.01% new 13F-HR Timeline AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 11,570 $67.1K 0.03% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 11,508 $66.7K <0.01% -25,307 13F-HR Timeline Group IHT Wealth Management, LLC More: the full row for IHT Wealth Management, LLC 11,100 $64.4K <0.01% +400 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 9,471 $54.9K <0.01% +4,547 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 8,877 $51.5K <0.01% 0 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 8,808 $51.1K <0.01% +3,707 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 7,358 $42.7K <0.01% +3,463 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 7,160 $41.5K <0.01% -9,169 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 6,667 $38.7K <0.01% -956 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 6,475 $37.6K <0.01% -33,150 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 4,019 $23.3K <0.01% +2,555 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 3,800 $22K <0.01% -41,200 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 2,557 $14.8K <0.01% 0 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,417 $14K <0.01% 0 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 2,049 $11.9K <0.01% -11,357 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 2,018 $11.7K <0.01% -94,668 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 1,941 $11.3K <0.01% +1,244 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,790 $10.4K <0.01% +1 13F-HR Timeline Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 1,358 $7.88K <0.01% new 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 1,279 $7.42K <0.01% +814 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 1,193 $7K <0.01% +816 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 1,157 $6.71K <0.01% new 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 852 $5K <0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 807 $4.68K <0.01% -151 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 432 $2.51K <0.01% -314 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 389 $2.26K <0.01% +382 13F-HR Timeline Group Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 346 $2.01K <0.01% new 13F-HR Timeline Group Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 250 $1.45K <0.01% 0 13F-HR Timeline Private Wealth Management Group, LLC More: the full row for Private Wealth Management Group, LLC 212 $1.23K <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 197 $1.15K <0.01% -14 13F-HR Timeline Group Covestor Ltd More: the full row for Covestor Ltd 221 $1K <0.01% -156 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 150 $1K <0.01% 0 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 161 $934 <0.01% +28 13F-HR Timeline Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 115 $667 <0.01% +102 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 29 $168 <0.01% -255 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 11 $64 <0.01% +6 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 2 $12 <0.01% +2 13F-HR/A Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 1 $6 <0.01% -30 13F-HR Timeline