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Disclosery

INVA INNOVIVA INC

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COM (common), issuer CIK 1080014

276 managers (286 13F filers) reported a position in INVA shares at 2026-03-31, 75,528,236 shares in all. 41 filers opened a position and 37 filers sold out during the quarter.

Managers
276
13F filers
286
New
41
Added
116
Reduced
87
Sold out
37
Shares held by filers
75,528,236

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2026

Filers in the available 13F reports with a share position at 2026-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
BlackRock, Inc.in group BlackRock, Inc.11,307,845$263M<0.01%+631,07013F-HRTimelineGroup
VANGUARD GROUP INCgroup of 7 filers holding7,984,060$186MnewTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP4,436,427$103M0.02%+76,02613F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC4,055,632$94.5M0.15%-154,54013F-HRTimeline
STATE STREET CORPin group STATE STREET CORP3,060,377$71.3M<0.01%+263,55713F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC2,279,451$53.1M0.04%+669,14613F-HRTimelineGroup
Sarissa Capital Management LP2,130,950$49.7M31.5%-685,07213F-HRTimeline
SYSTEMATIC FINANCIAL MANAGEMENT LP2,024,082$47.2M1.08%-90,44713F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,929,718$45M<0.01%+177,28013F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC1,910,021$44.5M0.02%-329,72113F-HRTimelineGroup
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPin group ARROWSTREET CAPITAL, LIMITED …1,887,570$44M0.02%-470,16513F-HRTimelineGroup
Boston Partnersin group Boston Trust Walden Corp1,718,867$40M0.04%+170,48913F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/1,619,994$37.7M<0.01%+100,79113F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC1,593,383$37.1M<0.01%+471,41213F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP1,504,411$35.1M0.04%+113,09813F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP1,484,264$34.6M0.03%+644,39913F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY1,310,750$30.5M<0.01%-107,98913F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co1,163,713$27.1M<0.01%+142,56713F-HRTimelineGroup
ROYCE & ASSOCIATES LP1,061,448$24.7M0.24%+141,13113F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\908,067$21.2M0.01%+58,19913F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.904,282$21.1M<0.01%+71,64713F-HRTimelineGroup
DZ BANK AG Deutsche Zentral Genossensch…in group DZ BANK AG Deutsche Zentral G…892,336$20.8M0.02%+195,42513F-HRTimelineGroup
Qube Research & Technologies Ltd786,107$18.3M0.03%-429,37813F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP774,303$18M<0.01%+76,22813F-HRTimelineGroup
Man Group plcin group Man Group plc744,791$17.4M0.04%-105,95313F-HRTimelineGroup
Nuveen, LLCin group TIAA620,482$14.5M<0.01%-27,03613F-HRTimelineGroup
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC574,825$13.4M0.04%new13F-HRTimeline
UBS Group AGgroup of 2 filers holding571,664$13.3M-60,469Timeline
VICTORY CAPITAL MANAGEMENT INC523,415$12.2M0.01%+155,41513F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE519,017$12.1M0.01%+182,11313F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC495,841$11.6M0.01%+124,73013F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp489,497$11.4M<0.01%+6,46413F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…469,519$10.9M0.01%+36,31613F-HRTimelineGroup
Assenagon Asset Management S.A.444,222$10.4M0.02%013F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC430,879$10M<0.01%-157,65013F-HRTimelineGroup
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC418,731$9.76M0.01%+79,62513F-HRTimelineGroup
Pacer Advisors, Inc.359,658$8.38M0.02%-21,71513F-HR/ATimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO350,571$8.03M<0.01%+200,76913F-HR/ATimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management322,009$7.5M0.01%+77,97913F-HRTimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP278,340$6.49M<0.01%+159,71813F-HRTimelineGroup
CX Institutional277,532$6.47M0.2%new13F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources257,607$6M<0.01%-1,134,73413F-HRTimelineGroup
Public Sector Pension Investment Board254,164$5.92M0.02%+8,37613F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.248,819$5.8M<0.01%-122,61313F-HRTimelineGroup
VOLORIDGE INVESTMENT MANAGEMENT, LLC234,359$5.46M0.02%-247,46213F-HRTimeline
Uniplan Investment Counsel, Inc.229,338$5.34M0.55%+9,82413F-HRTimeline
ASSETMARK, INCin group ASSETMARK, INC205,072$4.78M0.01%+19,75313F-HRTimelineGroup
TEACHER RETIREMENT SYSTEM OF TEXAS200,082$4.66M0.02%new13F-HRTimeline
RHUMBLINE ADVISERS199,898$4.66M<0.01%+53813F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC192,799$4.49M<0.01%+47,80113F-HR/ATimelineGroup
Legal & General Group Plcin group Legal & General Group Plc187,122$4.36M<0.01%-3,51613F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC176,077$4.1M<0.01%-2,23713F-HRTimelineGroup
Empowered Funds, LLC168,055$3.92M0.02%+93,42413F-HR/ATimeline
Integrated Wealth Concepts LLC165,214$3.85M0.03%-18,49513F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC163,301$3.8M0.04%-56,92113F-HRTimeline
EXCHANGE TRADED CONCEPTS, LLC161,248$3.76M0.03%-10,67113F-HRTimeline
HUSSMAN STRATEGIC ADVISORS, INC.147,000$3.43M0.74%+42,00013F-HRTimeline
NOMURA HOLDINGS INCin group NOMURA ASSET MANAGEMENT CO LTD144,087$3.36M0.03%-102,45813F-HRTimelineGroup
Swiss National Bank140,500$3.27M<0.01%+22,40013F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC136,417$3.18M<0.01%+72513F-HRTimelineGroup
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …134,239$3.13M<0.01%+31613F-HRTimelineGroup
Edgestream Partners, L.P.132,225$3.08M0.1%new13F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO131,205$3.06M<0.01%+44,14213F-HRTimelineGroup
MARTINGALE ASSET MANAGEMENT L P125,693$2.93M0.07%+18,54513F-HRTimeline
Dauntless Investment Group, LLC122,402$2.85M8.02%+116,86313F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
Gotham Asset Management, LLC121,799$2.84M0.01%-7,71913F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 3 filers holding115,209$2.68M-72,154Timeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …115,021$2.68M<0.01%-58,09813F-HRTimelineGroup
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC101,608$2.38M<0.01%-222,03813F-HRTimelineGroup
QRG CAPITAL MANAGEMENT, INC.101,311$2.36M0.02%+21,60713F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/93,940$2.19M<0.01%+16,76113F-HRTimeline
O'SHAUGHNESSY ASSET MANAGEMENT, LLC90,133$2.1M0.01%-1,20613F-HRTimeline
Janney Montgomery Scott LLC90,000$2.1M0.01%+15,00013F-HRTimeline
Orion Porfolio Solutions, LLC89,973$2.1M0.02%-15,19413F-HRTimeline
Oliver Luxxe Assets LLC84,960$1.98M0.3%+28913F-HRTimeline
Freestone Grove Partners LP81,846$1.91M0.01%-9,82713F-HRTimeline
Creative Planningin group Creative Planning79,770$1.86M<0.01%+9,65913F-HRTimelineGroup
KLP KAPITALFORVALTNING AS78,500$1.83M0.01%+3,00013F-HRTimeline
JAMES INVESTMENT RESEARCH, INC.77,227$1.8M0.2%+7013F-HRTimeline
NewEdge Wealth, LLC77,134$1.8M0.02%+26,73213F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS76,514$1.78M<0.01%-8,10413F-HRTimelineGroup
Synergy Asset Management, LLCin group Synergy Asset Management, LLC76,340$1.78M0.19%+1,98113F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…74,468$1.74M<0.01%+22,10313F-HRTimeline
CHASE INVESTMENT COUNSEL CORP70,000$1.63M0.43%013F-HRTimeline
JENNISON ASSOCIATES LLC69,767$1.63M<0.01%+23,36413F-HRTimeline
LSV ASSET MANAGEMENT69,323$1.61M<0.01%+11,32313F-HRTimeline
ALLIANCEBERNSTEIN L.P.80,651$1.61M<0.01%+14,01113F-HRTimeline
FMR LLCin group FMR LLC68,730$1.6M<0.01%+39,69813F-HRTimelineGroup
HEALTHCARE OF ONTARIO PENSION PLAN TRUS…68,000$1.58M<0.01%-262,75713F-HRTimeline
ALGERT GLOBAL LLC60,480$1.41M0.02%-57,48013F-HR/ATimeline
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co59,514$1.39M<0.01%-3,99513F-HRTimelineGroup
Aquatic Capital Management LLC56,913$1.33M0.04%new13F-HRTimeline
NEW YORK STATE TEACHERS RETIREMENT SYST…54,867$1.28M<0.01%-92213F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC53,533$1.25M<0.01%-199,57113F-HRTimeline
RITHOLTZ WEALTH MANAGEMENT53,180$1.24M0.02%-81713F-HRTimeline
HRT FINANCIAL LP53,136$1.24M<0.01%new13F-HRTimeline
State of Alaska, Department of Revenue50,639$1.18M0.01%-91013F-HRTimeline
Thrivent Financial for Lutheransin group Thrivent Financial for Luther…47,411$1.1M<0.01%-1,39713F-HRTimelineGroup
CANADA PENSION PLAN INVESTMENT BOARD46,600$1.09M<0.01%-9,50013F-HRTimeline
Cetera Investment Advisers45,340$1.06M<0.01%+11,52413F-HRTimeline
Horizon Investments, LLC44,461$1.04M0.01%+2,85813F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCgroup of 2 filers holding41,351$963K+29,926Timeline
SEGALL BRYANT & HAMILL, LLC40,233$937K0.01%-13313F-HR/ATimeline
MetLife Investment Management, LLCin group MetLife Investment Management…39,907$930K<0.01%+2,68313F-HRTimelineGroup
Quantbot Technologies LP39,407$918K0.04%+26,83313F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding39,046$910K+6,175Timeline
Illinois Municipal Retirement Fund36,990$862K0.01%+3,02613F-HRTimeline
MERCER GLOBAL ADVISORS INC /ADV36,317$846K<0.01%+10,26113F-HRTimeline
HighTower Advisors, LLC35,595$829K<0.01%+9,46713F-HRTimeline
Kendall Capital Management35,285$822K0.17%+4,19013F-HRTimeline
NewEdge Advisors, LLC32,647$761K<0.01%-3,33713F-HR/ATimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …31,971$745K<0.01%+2,21613F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC31,732$739K<0.01%-21,78013F-HRTimelineGroup
Louisiana State Employees Retirement Sy…31,500$734K0.01%-1,00013F-HRTimeline
IEQ CAPITAL, LLC31,487$734K<0.01%+1,63813F-HRTimeline
Engineers Gate Manager LP31,469$733K0.01%-43,81613F-HRTimeline
Quantinno Capital Management LP31,013$723K<0.01%+7,15213F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD30,405$708K<0.01%+1,29613F-HRTimeline
Vident Advisory, LLCin group Vident Advisory, LLC28,388$661K0.01%+12113F-HRTimelineGroup
MML INVESTORS SERVICES, LLC28,324$660K<0.01%-1,08613F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson27,858$649K<0.01%013F-HR/ATimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…27,729$646K<0.01%+9,09613F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN27,558$642K<0.01%-42,68013F-HR/ATimelineGroup
VIRTUS ADVISERS, LLCin group Virtus Investment Advisers, L…26,946$628K0.29%013F-HRTimelineGroup
Morningstar Investment Management LLCin group Morningstar Investment Manage…25,889$603K0.04%-16,96113F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…25,454$593K<0.01%-1,86213F-HRTimelineGroup
FOX RUN MANAGEMENT, L.L.C.25,798$591K0.1%-35,85513F-HRTimeline
Magnetar Financial LLCin group Magnetar Financial LLC24,774$577K0.01%+3,05513F-HRTimelineGroup
Cerity Partners LLCin group Cerity Partners LLC24,327$567K<0.01%+10,63913F-HRTimelineGroup
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…24,275$566K<0.01%new13F-HRTimelineGroup
QUADRANT CAPITAL GROUP LLC24,228$565K0.02%+71513F-HR/ATimeline
BRIDGEWAY CAPITAL MANAGEMENT, LLC24,188$564K0.01%-79,20013F-HRTimeline
Summit Global Investmentsin group Summit Global Investments23,626$550K0.03%new13F-HRTimelineGroup
denkapparat Operations GmbH23,428$546K0.23%013F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC22,480$524K<0.01%new13F-HRTimelineGroup
OPPENHEIMER & CO INCin group OPPENHEIMER ASSET MANAGEMENT …22,369$521K0.01%new13F-HRTimelineGroup
Amundiin group Amundi21,940$511K<0.01%-24,88413F-HRTimelineGroup
OAK ASSOCIATES LTD /OH/20,450$476K0.03%new13F-HRTimeline
Watershed Asset Management, L.L.C.20,366$475K0.49%-2,75713F-HRTimeline
BOKF, NAin group BOKF, NA20,328$474K0.01%-2,47813F-HRTimelineGroup
AMALGAMATED BANK20,194$471K<0.01%-19613F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND19,992$466K<0.01%-8,70013F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM19,510$455K<0.01%+2,82413F-HRTimeline
Police & Firemen's Retirement System of…19,499$454K<0.01%+2,04313F-HRTimeline
DARK FOREST CAPITAL MANAGEMENT LP19,436$453K0.04%+7,00713F-HRTimeline
YOUSIF CAPITAL MANAGEMENT, LLC19,283$449K0.01%-20913F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…18,636$434K<0.01%-2,45613F-HRTimelineGroup
Tidal Investments LLCin group Tidal Investments LLC18,253$425K<0.01%+99013F-HRTimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…17,702$412K<0.01%013F-HRTimeline
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCH…17,565$409K<0.01%-2013F-HRTimeline
NATIXIS ADVISORS, LLCin group Natixis Investment Managers17,152$400K<0.01%+5,39213F-HRTimelineGroup
FIFTH THIRD BANCORPin group FIFTH THIRD BANK, NATIONAL AS…17,038$397K<0.01%+16,41713F-HRTimelineGroup
OREGON PUBLIC EMPLOYEES RETIREMENT FUND16,207$378K<0.01%013F-HRTimeline
nVerses Capital, LLC15,888$370K0.34%new13F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/15,560$363K<0.01%+81813F-HRTimelineGroup
Vise Technologies, Inc.18,044$361K0.01%013F-HRTimeline
Mariner, LLCin group Mariner, LLC15,408$359K<0.01%+3,74613F-HRTimelineGroup
TEACHERS RETIREMENT SYSTEM OF THE STATE…15,182$354K<0.01%013F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…15,034$350K<0.01%013F-HRTimeline
ProShare Advisors LLC14,942$348K<0.01%-69613F-HRTimeline
GLENMEDE TRUST CO NAin group GLENMEDE TRUST CO NA14,560$339K<0.01%-2,35113F-HRTimelineGroup
WEALTH ENHANCEMENT ADVISORY SERVICES, L…14,437$332K<0.01%new13F-HRTimeline
Sterling Capital Management LLC14,243$332K0.01%-7,86713F-HRTimeline
CWM, LLCin group CWM, LLC14,060$328K<0.01%+5,02313F-HRTimelineGroup
PROFUND ADVISORS LLC13,791$321K0.01%-3,59213F-HRTimeline
AVIVA PLCin group AVIVA PLC13,298$310K<0.01%new13F-HRTimelineGroup
State of Wyoming13,193$307K0.04%+2,76313F-HRTimeline
China Universal Asset Management Co., L…13,145$306K0.02%+96113F-HRTimeline
New Vernon Capital Holdings II LLCin group New Vernon Capital Holdings I…13,122$306K0.23%013F-HRTimelineGroup
Ballentine Partners, LLC12,967$302K<0.01%-2,81513F-HRTimeline
Integrated Advisors Network LLC12,517$292K0.02%+2513F-HRTimeline
State of Tennessee, Department of Treas…12,516$292K<0.01%013F-HRTimeline
Crossmark Global Holdings, Inc.11,667$272K<0.01%-2013F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC11,636$271K<0.01%new13F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…11,162$260K<0.01%new13F-HRTimelineGroup
SG Americas Securities, LLC11,160$260K<0.01%-40,01613F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC11,059$258K<0.01%-21413F-HRTimelineGroup
Financiere des Professionnels - Fonds d…11,028$257K0.02%new13F-HRTimeline
EVERGREEN CAPITAL MANAGEMENT LLC11,026$257K0.01%+27713F-HRTimeline
BAILARD, INC.10,933$255K0.01%013F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…10,778$251K<0.01%new13F-HRTimelineGroup
Dynamic Technology Lab Private Ltd10,710$250K0.04%new13F-HRTimeline
Cornerstone Investment Partners, LLC10,434$243K0.01%new13F-HRTimeline
iSAM Funds (UK) Ltdin group iSAM Funds (UK) Ltd10,323$241K0.12%new13F-HRTimelineGroup
Maryland State Retirement & Pension Sys…10,260$239K<0.01%013F-HRTimeline
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC10,249$237K<0.01%-22,59613F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA10,061$235K<0.01%-62313F-HRTimelineGroup
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC9,876$230K<0.01%new13F-HRTimelineGroup
GRIMES & Co WEALTH MANAGEMENT, LLC9,869$230K0.01%-1,67413F-HRTimeline
Headlands Technologies LLC9,856$230K0.03%new13F-HRTimeline
JOURNEY STRATEGIC WEALTH LLC9,755$227K0.01%new13F-HRTimeline
Sequoia Financial Advisors, LLC9,652$225K<0.01%new13F-HRTimeline
HOHIMER WEALTH MANAGEMENT, LLC9,462$220K0.03%-2,36113F-HRTimeline
PRAXIS INVESTMENT MANAGEMENT INC9,029$210K0.01%-1,93113F-HRTimeline
Farther Finance Advisors, LLC8,713$204K<0.01%-62113F-HRTimeline
Ensign Peak Advisors, Inc8,350$195K<0.01%+2,60013F-HR/ATimeline
Lion Point Capital, LP8,200$191K1.14%013F-HRTimeline
GAMMA Investing LLC6,483$151K0.01%+66013F-HRTimeline
Vestcor Inc6,309$147K<0.01%013F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…6,137$143K<0.01%+87713F-HRTimelineGroup