EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 5,945,488 $59.6M 0.99% +950,760 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 4,354,501 $43.6M 1.77% +1,819,936 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 4,227,634 $42.4M <0.01% +768,181 13F-HR Timeline Group Sands Capital Alternatives, LLC More: the full row for Sands Capital Alternatives, LLC 3,708,043 $37.2M 8.82% +137,930 13F-HR Timeline FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 3,607,920 $36.2M 0.21% -706,000 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,038,595 $30.4M <0.01% +124,675 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 2,525,040 $25.3M 0.04% +1,537,689 13F-HR Timeline Group VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 2,244,663 $22.5M new Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 2,211,518 $22.2M 0.62% +1,611,518 13F-HR Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 2,000,000 $20M 0.2% -500,000 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 1,414,838 $14.2M 0.93% +736,576 13F-HR Timeline DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 1,324,000 $13.3M 0.16% +385,692 13F-HR Timeline Group Omega Fund Management, LLC More: the full row for Omega Fund Management, LLC 1,316,183 $13.2M 8.08% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 946,087 $9.48M <0.01% +82,954 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 932,678 $9.35M <0.01% +11,214 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 860,866 $8.63M 0.01% -84,595 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 842,944 $8.45M 0.17% +240,000 13F-HR/A Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 623,341 $6.25M +371,798 Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 617,915 $6.19M 0.01% +532,942 13F-HR Timeline Group Bruce & Co., Inc. More: the full row for Bruce & Co., Inc. 550,700 $5.52M 1.58% new 13F-HR Timeline HEALTHCARE OF ONTARIO PENSION PLAN TRUS… More: the full row for HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 546,132 $5.47M 0.01% -780,968 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 485,854 $4.87M 0.09% +474,651 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 322,467 $3.23M <0.01% -9,156 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 307,229 $3.03M <0.01% -41,442 13F-HR/A Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 295,818 $2.96M <0.01% +11,365 13F-HR Timeline Group PURA VIDA INVESTMENTS, LLC More: the full row for PURA VIDA INVESTMENTS, LLC 281,250 $2.82M 18.94% 0 13F-HR Timeline Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 248,449 $2.49M 0.12% +127,203 13F-HR Timeline First Eagle Investment Management, LLC in group First Eagle Investment Manage… More: the full row for First Eagle Investment Management, LLC 242,000 $2.42M <0.01% -11,702 13F-HR/A Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 241,601 $2.42M 0.02% +125,840 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 218,094 $2.19M 0.01% -41,538 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 188,883 $1.86M <0.01% -9,056 13F-HR Timeline Group BRIDGER MANAGEMENT, LLC More: the full row for BRIDGER MANAGEMENT, LLC 163,124 $1.63M 1.28% new 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 136,343 $1.37M 0.02% +128,096 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 136,215 $1.36M <0.01% -296,125 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 121,334 $1.22M <0.01% -284,074 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 114,719 $1.15M <0.01% +77,345 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 35,400 $1.08M <0.01% 0 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 98,804 $990K <0.01% -979 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 85,928 $861K <0.01% +549 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 85,800 $860K 0.01% -704 13F-HR Timeline Group Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 72,152 $723K 0.02% -133 13F-HR Timeline Group LAZARD ASSET MANAGEMENT LLC in group LAZARD ASSET MANAGEMENT LLC More: the full row for LAZARD ASSET MANAGEMENT LLC 71,905 $720K <0.01% new 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 71,211 $714K <0.01% +16,670 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 69,470 $696K <0.01% -158,486 13F-HR Timeline Group Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 67,879 $680K <0.01% +35,996 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 65,495 $656K <0.01% -345,108 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 60,287 $604K <0.01% +9,882 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 59,624 $597K <0.01% new 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 58,156 $583K <0.01% +40,778 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 56,616 $567K 0.01% new 13F-HR Timeline Corient Private Wealth LP in group Corient Private Wealth LP More: the full row for Corient Private Wealth LP 56,082 $562K <0.01% new 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 52,142 $522K <0.01% -268,738 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 48,063 $482K 0.01% +4,073 13F-HR Timeline Group Values First Advisors, Inc. More: the full row for Values First Advisors, Inc. 47,551 $476K 0.25% +12,360 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 46,430 $465K <0.01% +3,572 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 43,701 $438K <0.01% +4,401 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 42,046 $421K 0.05% new 13F-HR Timeline Quantbot Technologies LP More: the full row for Quantbot Technologies LP 41,295 $414K 0.02% -48,110 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 39,267 $393K <0.01% +27,946 13F-HR Timeline Group Centiva Capital, LP More: the full row for Centiva Capital, LP 39,157 $392K 0.02% new 13F-HR Timeline DRW Securities, LLC More: the full row for DRW Securities, LLC 36,735 $368K 0.02% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 35,472 $356K <0.01% -497,277 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 31,988 $321K <0.01% +25,290 13F-HR Timeline Group Evanson Asset Management, LLC More: the full row for Evanson Asset Management, LLC 31,272 $313K 0.02% 0 13F-HR Timeline Bridgefront Capital, LLC More: the full row for Bridgefront Capital, LLC 25,909 $260K 0.06% new 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 25,427 $255K <0.01% -57,435 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 24,437 $245K 0.01% new 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 23,904 $240K <0.01% +11,880 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 23,681 $237K <0.01% -182,156 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 22,720 $228K <0.01% 0 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 21,522 $216K <0.01% -28,790 13F-HR/A Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 20,818 $209K <0.01% +10,120 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 19,464 $195K <0.01% -97,896 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 19,274 $193K <0.01% -46,602 13F-HR Timeline Caprock Group, LLC More: the full row for Caprock Group, LLC 18,847 $189K <0.01% +6,730 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 17,972 $180K <0.01% -30,128 13F-HR Timeline Group Gladstone Institutional Advisory LLC More: the full row for Gladstone Institutional Advisory LLC 14,200 $142K 0.01% 0 13F-HR Timeline BANK OF MONTREAL /CAN/ in group BANK OF MONTREAL /CAN/ More: the full row for BANK OF MONTREAL /CAN/ 13,522 $135K <0.01% +661 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 13,428 $135K <0.01% -1,405 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 12,200 $122K <0.01% 0 13F-HR Timeline BROWN ADVISORY INC in group BROWN ADVISORY INC More: the full row for BROWN ADVISORY INC 11,946 $120K <0.01% 0 13F-HR Timeline Group 49 WEALTH MANAGEMENT, LLC More: the full row for 49 WEALTH MANAGEMENT, LLC 11,906 $119K 0.01% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 10,610 $106K <0.01% -35,829 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 10,346 $104K <0.01% 0 13F-HR Timeline Bayesian Capital Management, LP More: the full row for Bayesian Capital Management, LP 10,017 $100K 0.12% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 8,495 $85.1K <0.01% -193,397 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 7,344 $73.6K <0.01% -53,320 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 6,036 $60.5K <0.01% -498 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 5,514 $55.2K <0.01% +2,084 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 3,548 $35K <0.01% -4,861 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,202 $32.1K <0.01% 0 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 3,199 $32.1K <0.01% -13,912 13F-HR Timeline Group Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 3,003 $30.1K <0.01% +979 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,991 $30K <0.01% -4,483 13F-HR Timeline Group Essential Partners LLC More: the full row for Essential Partners LLC 2,389 $23.9K 0.01% +2,243 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,107 $21.1K <0.01% -290 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 2,013 $20.2K <0.01% +69 13F-HR Timeline Group CoreCap Advisors, LLC More: the full row for CoreCap Advisors, LLC 1,489 $14.9K <0.01% +1,108 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 1,300 $13K <0.01% +675 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 1,151 $11.5K <0.01% -1,352 13F-HR/A Timeline Group JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 1,054 $11.3K <0.01% +217 13F-HR Timeline Group Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 673 $6.74K <0.01% +630 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 594 $5.95K <0.01% -185 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 557 $5.58K <0.01% +280 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 389 $3.9K <0.01% -1,598 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 378 $3.79K <0.01% -122 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 371 $3.71K <0.01% +79 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 299 $3K <0.01% -844 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 238 $2.38K <0.01% +219 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 221 $2.21K <0.01% +192 13F-HR Timeline Group FIFTH THIRD BANCORP in group FIFTH THIRD BANK, NATIONAL AS… More: the full row for FIFTH THIRD BANCORP 119 $1.19K <0.01% new 13F-HR Timeline Group HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 106 $1.06K <0.01% new 13F-HR Timeline Torren Management, LLC More: the full row for Torren Management, LLC 82 $822 <0.01% -54 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 64 $641 <0.01% -36 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 62 $621 <0.01% -359 13F-HR Timeline WPG Advisers, LLC More: the full row for WPG Advisers, LLC 55 $551 <0.01% -131 13F-HR Timeline Blue Trust, Inc. More: the full row for Blue Trust, Inc. 47 $471 <0.01% 0 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 42 $421 <0.01% -64 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 39 $391 <0.01% new 13F-HR/A Timeline Basecamp Wealth Advisors LLC More: the full row for Basecamp Wealth Advisors LLC 27 $271 <0.01% new 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 20 $200 <0.01% 0 13F-HR Timeline Root Financial Partners, LLC More: the full row for Root Financial Partners, LLC 16 $160 <0.01% new 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 14 $140 <0.01% -15 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 9 $90 <0.01% -8 13F-HR Timeline SJS Investment Consulting Inc. More: the full row for SJS Investment Consulting Inc. 6 $61 <0.01% new 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 7 $0 0% new 13F-HR Timeline Value filed as zero, left out of ratios.