Skip to content
Disclosery

PFM Health Sciences, LP

Follow

13F filer, CIK 1442756, SAN FRANCISCO, CA

PFM Health Sciences, LP reported $1,377,290,641 across 66 holdings for the quarter ended 2025-03-31, in a 13F-HR filed 2025-05-15. Its ten largest share positions make up 55.82% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001085146-25-003307

Period
2025-03-31
Reported value
$1.38B
Holdings
66
Top 10 weight
55.82%
New
13
Sold out
30

Largest buys vs the previous quarter

SecurityShares changeApprox. value
ELVnew+88,222$38.4M
ALNYnew+87,145$23.5M
BBIOadded+617,893$21.4M
CVSnew+312,305$21.2M
BDXnew+91,571$21M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
DXCMexited-328,763-$25.6M
NBIXexited-166,803-$22.8M
IJHexited-347,637-$21.7M
UNHreduced-39,684-$20.8M
LLYreduced-24,865-$20.5M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2025

Share positions as resolved from 13F-HR 0001085146-25-003307, largest first. % of portfolio is the value over $1,303,689,196, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
LLYELI LILLY & COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 298,643 shares; 2024Q4: 298,643 shares; 2025Q1: 273,778 shares 273,778$226M17.34%-24,865Timeline
ABBVABBVIE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 403,861 shares; 2024Q4: 331,741 shares; 2025Q1: 331,741 shares 331,741$69.5M5.33%0Timeline
THCTENET HEALTHCARE CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 589,409 shares; 2024Q4: 491,334 shares; 2025Q1: 491,334 shares 491,334$66.1M5.07%0Timeline
MCKMCKESSON CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 97,498 shares; 2024Q4: 97,498 shares; 2025Q1: 97,498 shares 97,498$65.6M5.03%0Timeline
AXSMAXSOME THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 467,427 shares; 2024Q4: 467,427 shares; 2025Q1: 556,545 shares 556,545$64.9M4.98%+89,118Timeline
VRTXVERTEX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 148,852 shares; 2024Q4: 126,989 shares; 2025Q1: 126,989 shares 126,989$61.6M4.72%0Timeline
ISRGINTUITIVE SURGICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 137,327 shares; 2024Q4: 93,073 shares; 2025Q1: 93,073 shares 93,073$46.1M3.54%0Timeline
PENPENUMBRA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 166,261 shares; 2024Q4: 166,261 shares; 2025Q1: 166,261 shares 166,261$44.5M3.41%0Timeline
SLNOSOLENO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 307,503 shares; 2025Q1: 595,206 shares 595,206$42.5M3.26%+287,703Timeline
ARGXARGENX SEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 86,832 shares; 2024Q4: 63,699 shares; 2025Q1: 68,999 shares 68,999$40.8M3.13%+5,300Timeline
ELVELEVANCE HEALTH INC FORMERLYQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 56,441 shares; 2024Q4: not reported; 2025Q1: 88,222 shares 88,222$38.4M2.94%newTimeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 290,242 shares; 2025Q1: 908,135 shares 908,135$31.4M2.41%+617,893Timeline
UHSUNIVERSAL HLTH SVCS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 213,983 shares; 2024Q4: 213,983 shares; 2025Q1: 155,520 shares 155,520$29.2M2.24%-58,463Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 90,766 shares; 2024Q4: 52,392 shares; 2025Q1: 186,916 shares 186,916$29.1M2.23%+134,524Timeline
EWEDWARDS LIFESCIENCES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 390,863 shares; 2024Q4: 594,172 shares; 2025Q1: 379,954 shares 379,954$27.5M2.11%-214,218Timeline
HCAHCA HEALTHCARE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 124,840 shares; 2024Q4: 69,441 shares; 2025Q1: 77,464 shares 77,464$26.8M2.05%+8,023Timeline
ALNYALNYLAM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 87,145 shares 87,145$23.5M1.8%newTimeline
MOHMOLINA HEALTHCARE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 70,088 shares; 2024Q4: 70,088 shares; 2025Q1: 70,088 shares 70,088$23.1M1.77%0Timeline
DHRDANAHER CORP DELQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 125,515 shares; 2024Q4: 125,515 shares; 2025Q1: 112,475 shares 112,475$23.1M1.77%-13,040Timeline
CVSCVS HEALTH CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 312,305 shares 312,305$21.2M1.62%newTimeline
BDXBECTON DICKINSON & COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 101,680 shares; 2024Q4: not reported; 2025Q1: 91,571 shares 91,571$21M1.61%newTimeline
IQVIQVIA HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 111,854 shares; 2024Q4: 111,854 shares; 2025Q1: 111,854 shares 111,854$19.7M1.51%0Timeline
WATWATERS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 51,063 shares; 2024Q4: 59,053 shares; 2025Q1: 51,858 shares 51,858$19.1M1.47%-7,195Timeline
UNHUNITEDHEALTH GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 75,588 shares; 2024Q4: 75,588 shares; 2025Q1: 35,904 shares 35,904$18.8M1.44%-39,684Timeline
OMOUTSET MED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,685,727 shares 1,685,727$18.6M1.43%newTimeline
HUMHUMANA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 101,954 shares; 2024Q4: 83,037 shares; 2025Q1: 63,238 shares 63,238$16.7M1.28%-19,799Timeline
SNDXSYNDAX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 423,910 shares; 2024Q4: 206,871 shares; 2025Q1: 926,424 shares 926,424$11.4M0.87%+719,553Timeline
OSCROSCAR HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 860,821 shares; 2024Q4: 860,821 shares; 2025Q1: 860,821 shares 860,821$11.3M0.87%0Timeline
INDIVIOR PLCINDIVIOR PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,159,833 shares 1,159,833$11.1M0.85%new
AZNASTRAZENECA PLC-SPONS ADRQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 150,200 shares 150,200$11M0.85%newTimeline
TMOTHERMO FISHER SCIENTIFIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 58,433 shares; 2024Q4: 21,040 shares; 2025Q1: 21,897 shares 21,897$10.9M0.84%+857Timeline
CNCCENTENE CORP DELQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 144,501 shares; 2025Q1: 135,398 shares 135,398$8.22M0.63%-9,103Timeline
CNTACENTESSA PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 269,158 shares; 2024Q4: 371,766 shares; 2025Q1: 570,546 shares 570,546$8.2M0.63%+198,780Timeline
ICLRICON PUB LTD COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 116,532 shares; 2024Q4: 128,637 shares; 2025Q1: 41,038 shares 41,038$7.18M0.55%-87,599Timeline
QUREUNIQURE NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 121,628 shares; 2024Q4: 283,158 shares; 2025Q1: 599,967 shares 599,967$6.36M0.49%+316,809Timeline
INBXINHIBRX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 135,546 shares; 2024Q4: 135,546 shares; 2025Q1: 439,283 shares 439,283$6.15M0.47%+303,737Timeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 183,092 shares; 2024Q4: 119,509 shares; 2025Q1: 160,866 shares 160,866$6.09M0.47%+41,357Timeline
NEONEOGENOMICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 585,381 shares 585,381$5.56M0.43%newTimeline
ERASERASCA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,876,911 shares; 2024Q4: 4,390,427 shares; 2025Q1: 3,489,559 shares 3,489,559$4.78M0.37%-900,868Timeline
BHVNBIOHAVEN LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 431,916 shares; 2025Q1: 197,307 shares 197,307$4.74M0.36%-234,609Timeline
BLUEPRINT MEDICINES CORPBLUEPRINT MEDICINES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 42,840 shares; 2025Q1: 46,453 shares 46,453$4.11M0.32%+3,613
PMVPPMV PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,011,040 shares; 2024Q4: 2,079,245 shares; 2025Q1: 3,301,942 shares 3,301,942$3.6M0.28%+1,222,697Timeline
SRPTSAREPTA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 88,216 shares; 2024Q4: 100,172 shares; 2025Q1: 50,809 shares 50,809$3.24M0.25%-49,363Timeline
XENEXENON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 179,878 shares; 2024Q4: 116,998 shares; 2025Q1: 92,236 shares 92,236$3.09M0.24%-24,762Timeline
AMLXAMYLYX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 834,135 shares 834,135$2.95M0.23%newTimeline
IOBTQIO BIOTECH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,341,107 shares; 2024Q4: 2,341,107 shares; 2025Q1: 2,341,107 shares 2,341,107$2.55M0.2%0Timeline
XRTSPDR SERIES TRUSTQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 36,471 shares 36,471$2.52M0.19%newTimeline
HOWLWEREWOLF THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,398,747 shares; 2024Q4: 2,905,465 shares; 2025Q1: 2,506,520 shares 2,506,520$2.44M0.19%-398,945Timeline
CRBUCARIBOU BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,306,671 shares; 2024Q4: 3,876,462 shares; 2025Q1: 2,506,435 shares 2,506,435$2.29M0.18%-1,370,027Timeline
SGMTSAGIMET BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 649,006 shares; 2024Q4: 649,006 shares; 2025Q1: 649,006 shares 649,006$2.12M0.16%0Timeline
CAPRCAPRICOR THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 152,779 shares; 2024Q4: 54,357 shares; 2025Q1: 140,681 shares 140,681$1.34M0.1%+86,324Timeline
CMPSCOMPASS PATHWAYS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 451,267 shares; 2024Q4: 451,267 shares; 2025Q1: 451,267 shares 451,267$1.29M0.1%0Timeline
MGXMETAGENOMI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,034,002 shares; 2024Q4: 885,803 shares; 2025Q1: 885,803 shares 885,803$1.2M0.09%0Timeline
SPRINGWORKS THERAPEUTICS INCSPRINGWORKS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 26,437 shares 26,437$1.17M0.09%new
KROSKEROS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 101,050 shares; 2024Q4: 104,323 shares; 2025Q1: 104,323 shares 104,323$1.06M0.08%0Timeline
ACLXARCELLX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 60,602 shares; 2024Q4: 56,603 shares; 2025Q1: 15,488 shares 15,488$1.02M0.08%-41,115Timeline
VERVE THERAPEUTICS INCVERVE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 125,999 shares; 2024Q4: 125,999 shares; 2025Q1: 155,495 shares 155,495$711K0.05%+29,496
GPCRSTRUCTURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 40,400 shares 40,400$699K0.05%newTimeline
CELCCELCUITY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 710,255 shares; 2024Q4: 158,746 shares; 2025Q1: 53,349 shares 53,349$539K0.04%-105,397Timeline
IOVAIOVANCE BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 132,152 shares; 2024Q4: 132,152 shares; 2025Q1: 132,152 shares 132,152$440K0.03%0Timeline
TURNSTONE BIOLOGICS CORPTURNSTONE BIOLOGICS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 932,348 shares; 2024Q4: 932,348 shares; 2025Q1: 932,348 shares 932,348$382K0.03%0
BOLDBOUNDLESS BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 240,513 shares; 2024Q4: 240,513 shares; 2025Q1: 240,513 shares 240,513$363K0.03%0Timeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
XLVSELECT SECTOR SPDR TR SHScall429,700$62.7M-35,000
XRTSPDR SERIES TRUST ETFcall157,200$10.9Mnew

Principal amounts

Notes and convertibles filed as a face amount (PRN). A face amount is never added to a share count (H6).

SecurityTypeAmountValueChange
ASCENDIS PHARMA A/SASCENDIS PHARMA A/S Convertible bondprincipal23,000,000$27.3M0
SAREPTA THERAPEUTICS INCSAREPTA THERAPEUTICS INC NOTE 1.250% 9/1principal10,000,000$9.31M+2,250,000

Sold out in Q1 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
IEFISHARES TR1,000,000$92.5Mput
EWEDWARDS LIFESCIENCES CORP525,400$38.9Mcall
UNHUNITEDHEALTH GROUP INC57,300$29Mcall
NVONOVO-NORDISK A S334,900$28.8Mcall
DXCMDEXCOM INC328,763$25.6Mshares
NBIXNEUROCRINE BIOSCIENCES INC166,803$22.8Mshares
IJHISHARES TR347,637$21.7Mshares
RSPINVESCO EXCHANGE TRADED FD T108,041$18.9Mshares
UTHRUNITED THERAPEUTICS CORP DEL52,500$18.5Mshares
CAHCARDINAL HEALTH INC148,173$17.5Mshares
XBISPDR SERIES TRUST179,100$16.1Mput
KWEBKRANESHARES TRUST434,700$12.7Mcall
IWMISHARES TR54,800$12.1Mcall
SYKSTRYKER CORPORATION32,349$11.6Mshares
VEEVVEEVA SYS INC55,383$11.6Mshares
XLVSELECT SECTOR SPDR TR83,806$11.5Mshares
TEVATEVA PHARMACEUTICAL INDS LTD397,024$8.75Mshares
SPYSTATE STR SPDR S&P 500 ETF T12,427$7.28Mshares
SPRINGWORKS THERAPEUTICS INCSPRINGWORKS THERAPEUTICS INC150,000$5.42Mcall
KWEBKRANESHARES TRUST180,974$5.29Mshares
BNTXBIONTECH SE33,109$3.77Mshares
INTRA-CELLULAR THERAPIES INCINTRA-CELLULAR THERAPIES INC40,610$3.39Mshares
INSMINSMED INC43,774$3.02Mshares
TGTXTG THERAPEUTICS INC98,674$2.97Mshares
ADAPYADAPTIMMUNE THERAPEUTICS PLC S4,871,969$2.62Mshares
ALKSALKERMES PLC80,719$2.32Mshares
JAZZJAZZ PHARMACEUTICALS PLC17,597$2.17Mshares
BBIOBRIDGEBIO PHARMA INC50,000$1.37Mcall
GENERATION BIO COGENERATION BIO CO787,914$835Kshares
BLUEBIRD BIO INC COM NEWBLUEBIRD BIO INC COM NEW75,758$632Kshares

How Q1 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001085146-25-003307 base2025-05-15acceptance time not in the bulk data set