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CHI Advisors LLC

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13F filer, CIK 1791468, NEW YORK, NY

CHI Advisors LLC reported $375,461,657 across 23 holdings for the quarter ended 2022-12-31, in a 13F-HR filed 2023-02-13. Its ten largest share positions make up 91.87% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001085146-23-001058

Period
2022-12-31
Reported value
$375M
Holdings
23
Top 10 weight
91.87%
New
1
Sold out
3

Largest buys vs the previous quarter

SecurityShares changeApprox. value
VECTIVBIO HLDG AGadded+1,373,321$11.9M
RALLYBIO CORPadded+531,812$3.49M
IKENA ONCOLOGY INCadded+423,068$1.13M
KEZAR LIFE SCIENCES INCadded+126,658$892K
CGEMadded+74,359$784K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
PROMETHEUS BIOSCIENCES INCreduced-677,985-$74.6M
AKOUOS INCexited-1,288,358-$8.71M
PLRXreduced-239,866-$4.64M
REPARE THERAPEUTICS INCreduced-269,721-$3.97M
EIGER BIOPHARMACEUTICALS INCexited-455,100-$3.43M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2022

Share positions as resolved from 13F-HR 0001085146-23-001058, largest first. % of portfolio is the value over $375,432,407, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
PROMETHEUS BIOSCIENCES INCPROMETHEUS BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 1,752,243 shares; 2022Q1: 1,585,096 shares; 2022Q2: 1,671,976 shares; 2022Q3: 1,601,785 shares; 2022Q4: 923,800 shares 923,800$102M27.07%-677,985
PLRXPLIANT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 2,569,479 shares; 2022Q1: 2,657,457 shares; 2022Q2: 3,106,807 shares; 2022Q3: 3,409,758 shares; 2022Q4: 3,169,892 shares 3,169,892$61.3M16.32%-239,866Timeline
VECTIVBIO HLDG AGVECTIVBIO HLDG AGQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 2,675,408 shares; 2022Q1: 3,084,310 shares; 2022Q2: 3,782,199 shares; 2022Q3: 4,119,572 shares; 2022Q4: 5,492,893 shares 5,492,893$47.6M12.68%+1,373,321
REPARE THERAPEUTICS INCREPARE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 2,212,256 shares; 2022Q1: 2,581,097 shares; 2022Q2: 2,646,781 shares; 2022Q3: 3,069,847 shares; 2022Q4: 2,800,126 shares 2,800,126$41.2M10.97%-269,721
CGEMCULLINAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 2,476,720 shares; 2022Q1: 2,753,047 shares; 2022Q2: 3,047,609 shares; 2022Q3: 3,243,185 shares; 2022Q4: 3,317,544 shares 3,317,544$35M9.32%+74,359Timeline
LRMRLARIMAR THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 1,515,148 shares; 2022Q1: 1,515,148 shares; 2022Q2: 1,515,148 shares; 2022Q3: 3,415,148 shares; 2022Q4: 3,473,366 shares 3,473,366$14.3M3.82%+58,218Timeline
CMPXCOMPASS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 3,023,692 shares; 2022Q1: 2,829,712 shares; 2022Q2: 2,829,712 shares; 2022Q3: 2,829,712 shares; 2022Q4: 2,829,712 shares 2,829,712$14.2M3.79%0Timeline
KEZAR LIFE SCIENCES INCKEZAR LIFE SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 272,250 shares; 2022Q1: 314,612 shares; 2022Q2: 1,840,793 shares; 2022Q3: 1,762,793 shares; 2022Q4: 1,889,451 shares 1,889,451$13.3M3.54%+126,658
KROSKEROS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 17,518 shares; 2022Q1: 62,229 shares; 2022Q2: 103,429 shares; 2022Q3: 200,229 shares; 2022Q4: 215,059 shares 215,059$10.3M2.75%+14,830Timeline
OMEGA THERAPEUTICS INCOMEGA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 1,055,882 shares; 2022Q1: 1,055,882 shares; 2022Q2: 1,055,882 shares; 2022Q3: 1,055,882 shares; 2022Q4: 1,055,882 shares 1,055,882$6.03M1.61%0
RALLYBIO CORPRALLYBIO CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: not reported; 2022Q1: not reported; 2022Q2: not reported; 2022Q3: 194,297 shares; 2022Q4: 726,109 shares 726,109$4.77M1.27%+531,812
IKENA ONCOLOGY INCIKENA ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 814,756 shares; 2022Q1: 814,755 shares; 2022Q2: 1,090,937 shares; 2022Q3: 1,214,304 shares; 2022Q4: 1,637,372 shares 1,637,372$4.36M1.16%+423,068
PRECISION BIOSCIENCES INCPRECISION BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 606,629 shares; 2022Q1: 606,629 shares; 2022Q2: 3,003,751 shares; 2022Q3: 3,674,820 shares; 2022Q4: 3,549,820 shares 3,549,820$4.22M1.13%-125,000
2SEVENTY BIO INC COMMON STO…2SEVENTY BIO INC COMMON STOCKQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: not reported; 2022Q1: 819,672 shares; 2022Q2: 819,672 shares; 2022Q3: 530,223 shares; 2022Q4: 333,252 shares 333,252$3.12M0.83%-196,971
ORCHARD THERAPEUTICS PLCORCHARD THERAPEUTICS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 6,449,856 shares; 2022Q1: 5,307,751 shares; 2022Q2: 5,307,751 shares; 2022Q3: 7,987,396 shares; 2022Q4: 7,987,396 shares 7,987,396$2.96M0.79%0
INOZYME PHARMA INCINOZYME PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 892,057 shares; 2022Q1: 892,057 shares; 2022Q2: 2,033,802 shares; 2022Q3: 1,996,277 shares; 2022Q4: 2,204,876 shares 2,204,876$2.32M0.62%+208,599
FREELINE THERAPEUTICS HLDGSFREELINE THERAPEUTICS HLDGSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 1,876,389 shares; 2022Q1: 4,862,319 shares; 2022Q2: 4,862,319 shares; 2022Q3: 4,814,419 shares; 2022Q4: 4,814,419 shares 4,814,419$2.29M0.61%0
CRVSCORVUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 400,000 shares; 2022Q1: 1,703,137 shares; 2022Q2: 2,214,184 shares; 2022Q3: 2,384,402 shares; 2022Q4: 2,384,402 shares 2,384,402$2.03M0.54%0Timeline
G1 THERAPEUTICS INCG1 THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 230,000 shares; 2022Q1: 488,635 shares; 2022Q2: 767,235 shares; 2022Q3: 323,945 shares; 2022Q4: 333,945 shares 333,945$1.81M0.48%+10,000
OVIDOVID THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 400,000 shares; 2022Q1: 852,888 shares; 2022Q2: 864,822 shares; 2022Q3: 864,822 shares; 2022Q4: 864,822 shares 864,822$1.61M0.43%0Timeline
ONCORUS INCONCORUS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: 2,106,903 shares; 2022Q1: 2,417,436 shares; 2022Q2: 2,367,436 shares; 2022Q3: 2,367,436 shares; 2022Q4: 2,367,436 shares 2,367,436$600K0.16%0
DIREXION SHS ETF TRDIREXION SHS ETF TRQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2021Q1: restricted; 2021Q2: restricted; 2021Q3: restricted; 2021Q4: not reported; 2022Q1: not reported; 2022Q2: not reported; 2022Q3: 50,000 shares; 2022Q4: 25,000 shares 25,000$431K0.11%-25,000

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
PLRXPLIANT THERAPEUTICS INC COMcall30,000$29.2Knew

Sold out in Q4 2022

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
AKOUOS INCAKOUOS INC1,288,358$8.71Mshares
EIGER BIOPHARMACEUTICALS INCEIGER BIOPHARMACEUTICALS INC455,100$3.43Mshares
NKTXNKARTA INC117,599$1.55Mshares

How Q4 2022 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001085146-23-001058 base2023-02-13acceptance time not in the bulk data set