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ARCH Venture Management, LLC

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13F filer, CIK 1274403, CHICAGO, IL

ARCH Venture Management, LLC reported $677,093,705 across 10 holdings for the quarter ended 2026-03-31, in a 13F-HR filed 2026-05-15.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001012975-26-000461

Period
2026-03-31
Reported value
$677M
Holdings
10
Top 10 weight
100%
New
1
Sold out
0

Largest buys vs the previous quarter

SecurityShares changeApprox. value
GENBnew+1,944,426$24.3M
LYELadded+488,090$9.79M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
ERASreduced-3,963,997-$64.1M
TXGreduced-519,705-$11M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2026

Share positions as resolved from 13F-HR 0001012975-26-000461, largest first. % of portfolio is the value over $677,093,705, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
MAZEMAZE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 4,120,053 shares; 2025Q2: 4,120,053 shares; 2025Q3: 4,120,053 shares; 2025Q4: 4,120,053 shares; 2026Q1: 4,120,053 shares 4,120,053$123M18.16%0Timeline
RAPPRAPPORT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 3,728,738 shares; 2024Q4: 3,728,738 shares; 2025Q1: 3,728,738 shares; 2025Q2: 3,728,738 shares; 2025Q3: 3,728,738 shares; 2025Q4: 3,728,738 shares; 2026Q1: 3,728,738 shares 3,728,738$117M17.23%0Timeline
VIRVIR BIOTECHNOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 12,916,663 shares; 2025Q3: 12,916,663 shares; 2025Q4: 12,916,663 shares; 2026Q1: 12,916,663 shares 12,916,663$116M17.09%0Timeline
ERASERASCA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 11,055,554 shares; 2024Q4: 11,055,554 shares; 2025Q1: 11,055,554 shares; 2025Q2: 11,055,554 shares; 2025Q3: 11,055,554 shares; 2025Q4: 11,055,554 shares; 2026Q1: 7,091,557 shares 7,091,557$115M16.95%-3,963,997Timeline
BEAMBEAM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 4,834,653 shares; 2024Q4: 4,540,132 shares; 2025Q1: 4,540,132 shares; 2025Q2: 4,540,132 shares; 2025Q3: 4,540,132 shares; 2025Q4: 4,540,132 shares; 2026Q1: 4,540,132 shares 4,540,132$108M15.98%0Timeline
LYELLYELL IMMUNOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,820,634 shares; 2025Q3: 2,759,072 shares; 2025Q4: 2,759,072 shares; 2026Q1: 3,247,162 shares 3,247,162$65.1M9.62%+488,090Timeline
GENBGENERATE BIOMEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,944,426 shares 1,944,426$24.3M3.59%newTimeline
TXG10X GENOMICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 737,539 shares; 2026Q1: 217,834 shares 217,834$4.62M0.68%-519,705Timeline
GOSSGOSSAMER BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 8,055,916 shares; 2024Q4: 8,055,916 shares; 2025Q1: 8,055,916 shares; 2025Q2: 8,055,916 shares; 2025Q3: 8,055,916 shares; 2025Q4: 8,055,916 shares; 2026Q1: 8,055,916 shares 8,055,916$2.65M0.39%0Timeline
QTTBQ32 BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 320,482 shares; 2024Q4: 320,482 shares; 2025Q1: 320,482 shares; 2025Q2: 320,482 shares; 2025Q3: 320,482 shares; 2025Q4: 320,482 shares; 2026Q1: 320,482 shares 320,482$2.06M0.3%0Timeline

How Q1 2026 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001012975-26-000461 base2026-05-15acceptance time not in the bulk data set