Merck & Co., Inc. in group Merck & Co., Inc. More: the full row for Merck & Co., Inc. 14,044,943 $49.3M 30.01% 0 13F-HR Timeline Group LIGHTSPEED MANAGEMENT COMPANY, L.L.C. More: the full row for LIGHTSPEED MANAGEMENT COMPANY, L.L.C. 8,160,734 $28.6M 20.99% 0 13F-HR Timeline ARK Investment Management LLC in group ARK Investment Management LLC More: the full row for ARK Investment Management LLC 7,188,197 $25.2M 0.25% +412,762 13F-HR Timeline Group AIGH Capital Management LLC More: the full row for AIGH Capital Management LLC 3,968,948 $13.9M 7.23% +169,884 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,998,522 $10.5M <0.01% +43,352 13F-HR Timeline Group Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 1,704,784 $5.98M 0.01% +1,406,895 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,290,591 $4.53M <0.01% -444,295 13F-HR Timeline Group Blue Water Life Science Advisors, LP More: the full row for Blue Water Life Science Advisors, LP 1,175,400 $4.13M 4.09% +42,500 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 3 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 1,125,327 $3.95M +214,564 Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,033,954 $3.63M 0.01% +113,086 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 871,512 $3.06M <0.01% -445,784 13F-HR Timeline Group Wellington Shields Capital Management, … group of 2 filers holding More: the full row for Wellington Shields Capital Management, LLC 718,820 $2.52M -4,850 Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 696,286 $2.44M <0.01% +626,276 13F-HR Timeline Group Sumitomo Mitsui Trust Group, Inc. in group Sumitomo Mitsui Trust Group, … More: the full row for Sumitomo Mitsui Trust Group, Inc. 675,974 $2.37M <0.01% -57,339 13F-HR Timeline Group Amova Asset Management Americas, Inc. in group Amova Asset Management Americ… More: the full row for Amova Asset Management Americas, Inc. 675,974 $2.37M 0.03% -57,339 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 635,029 $2.23M <0.01% +224,946 13F-HR Timeline Group KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 604,290 $2.12M 0.05% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 559,957 $1.97M <0.01% +310,209 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 514,176 $1.81M <0.01% +16,083 13F-HR Timeline Group STATE OF MICHIGAN RETIREMENT SYSTEM More: the full row for STATE OF MICHIGAN RETIREMENT SYSTEM 493,798 $1.73M 0.01% 0 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 402,276 $1.41M <0.01% +3,755 13F-HR Timeline JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 366,962 $1.29M 0.01% -21,560 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 310,522 $1.09M <0.01% -105,384 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 284,426 $998K <0.01% +101,706 13F-HR/A Timeline Group HOWLAND CAPITAL MANAGEMENT LLC More: the full row for HOWLAND CAPITAL MANAGEMENT LLC 282,808 $993K 0.04% +20,200 13F-HR Timeline PERKINS CAPITAL MANAGEMENT INC More: the full row for PERKINS CAPITAL MANAGEMENT INC 257,307 $903K 0.95% 0 13F-HR Timeline Bruce & Co., Inc. More: the full row for Bruce & Co., Inc. 253,000 $888K 0.28% 0 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 247,012 $867K <0.01% -154,302 13F-HR/A Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 202,490 $711K <0.01% +110,806 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 201,002 $706K <0.01% -11,525 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 195,263 $685K <0.01% -3,100 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 177,094 $621K <0.01% new 13F-HR Timeline LPL Financial LLC More: the full row for LPL Financial LLC 147,915 $519K <0.01% +4,000 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 144,667 $508K 0.05% +58,333 13F-HR Timeline Williams Jones Wealth Management, LLC. More: the full row for Williams Jones Wealth Management, LLC. 134,072 $471K 0.01% 0 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 131,006 $460K -48,956 Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 122,959 $432K 0.01% +100,804 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 114,531 $402K <0.01% +100,171 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 97,039 $341K <0.01% +8,034 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 85,991 $302K <0.01% -23,377 13F-HR/A Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 85,000 $299K <0.01% -10,000 13F-HR Timeline EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 83,628 $294K 0.13% +36,115 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 82,666 $290K 0.01% +49,197 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 78,341 $275K <0.01% +2,395 13F-HR/A Timeline Group Dynamic Technology Lab Private Ltd More: the full row for Dynamic Technology Lab Private Ltd 76,729 $269K 0.04% +33,044 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 75,200 $264K <0.01% -6,200 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 67,377 $236K <0.01% +17,056 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 58,083 $204K 0.01% new 13F-HR Timeline IQ EQ FUND MANAGEMENT (IRELAND) Ltd More: the full row for IQ EQ FUND MANAGEMENT (IRELAND) Ltd 55,583 $195K 0.02% +30,415 13F-HR Timeline Centiva Capital, LP More: the full row for Centiva Capital, LP 50,527 $177K 0.01% +10,155 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 47,046 $165K <0.01% +46,905 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 46,311 $163K <0.01% +4,384 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 44,939 $158K <0.01% new 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 43,777 $154K <0.01% new 13F-HR Timeline STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 40,000 $140K <0.01% +15,000 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 39,600 $139K <0.01% 0 13F-HR Timeline Group HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 39,106 $137K <0.01% -1,812 13F-HR Timeline Group Green Alpha Advisors, LLC More: the full row for Green Alpha Advisors, LLC 37,283 $131K 0.14% -1,699 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 34,172 $120K <0.01% +11,118 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 30,600 $107K <0.01% -55,000 13F-HR Timeline Quantessence Capital LLC More: the full row for Quantessence Capital LLC 28,495 $100K 0.03% new 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 25,932 $91K <0.01% -8,475 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 24,920 $87.5K <0.01% +7,574 13F-HR Timeline LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 24,232 $85.1K <0.01% new 13F-HR Timeline Group Massar Capital Management, LP More: the full row for Massar Capital Management, LP 23,973 $84.1K 0.1% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 22,943 $80.5K <0.01% +2 13F-HR/A Timeline Group IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 22,000 $77.2K <0.01% 0 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 21,924 $77K <0.01% new 13F-HR Timeline Group SIH Partners, LLLP in group SIH Partners, LLLP More: the full row for SIH Partners, LLLP 19,966 $70.1K 0.01% new 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 18,490 $64.9K <0.01% new 13F-HR Timeline Group Diametric Capital, LP More: the full row for Diametric Capital, LP 18,444 $64.7K 0.08% new 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 18,350 $64.4K <0.01% 0 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 17,704 $62.1K 0.01% +2,724 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 16,522 $59.8K <0.01% 0 13F-HR Timeline WEXFORD CAPITAL LP More: the full row for WEXFORD CAPITAL LP 16,316 $57.3K 0.01% new 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 15,432 $54.2K <0.01% +875 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 13,869 $48.7K <0.01% -321 13F-HR Timeline Group Focus Partners Wealth in group Focus Partners Wealth More: the full row for Focus Partners Wealth 13,527 $47.5K <0.01% 0 13F-HR/A Timeline Group Prime Capital Investment Advisors, LLC More: the full row for Prime Capital Investment Advisors, LLC 11,468 $40.3K <0.01% -304 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 10,600 $37.2K <0.01% -500 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 6,093 $21.4K <0.01% +3,812 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 4,870 $17.1K <0.01% -984 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 3,709 $13K <0.01% 0 13F-HR/A Timeline Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 2,953 $10.7K <0.01% +599 13F-HR Timeline Group Berbice Capital Management LLC More: the full row for Berbice Capital Management LLC 200 $9.65K 0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 2,426 $8.51K <0.01% +475 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 2,030 $7.12K <0.01% +1,828 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 1,912 $6.71K <0.01% new 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,809 $6.35K <0.01% +326 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,287 $4.52K <0.01% -46,943 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,274 $4.47K <0.01% -70,582 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,000 $3.51K <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 590 $2.07K <0.01% -98 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 522 $1.83K <0.01% 0 13F-HR Timeline Group Asset Dedication, LLC More: the full row for Asset Dedication, LLC 400 $1.4K <0.01% +200 13F-HR Timeline PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 195 $1.13K <0.01% 0 13F-HR Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 400 $1K <0.01% new 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 209 $734 <0.01% +131 13F-HR Timeline Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 203 $713 <0.01% new 13F-HR Timeline ORG Partners LLC More: the full row for ORG Partners LLC 100 $345 <0.01% new 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.