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TWO SIGMA INVESTMENTS, LP: ESPR position timeline

Available 13F reports, 13D and 13G stakes and each Form 3, 4 and 5 line of TWO SIGMA INVESTMENTS, LP on ESPR, newest first. How the timeline and the estimate are built.

TWO SIGMA INVESTMENTS, LP held 7,126,739 ESPR shares at 2026-06-30 per its 13F-HR filed 2026-08-14.

the latest 13F is the newest step

  1. period ended2026-06-30
    13F 7,126,739 shares
    Change vs previous 13F -2,332,040 shares

    0.02% of the 13F portfolio, value $22,520,495.

    13F-HR 0000899140-26-000855 filed by TWO SIGMA INVESTMENTS, LP
    Filed (acceptance time not in the bulk data set), ingested

    Acceptance time not in the bulk data set (spec §4.2).

  2. period ended2026-03-31
    13F 9,458,779 shares
    Share basis changed not comparable

    Membership change: TWO SIGMA ADVISERS, LP left the group. 0.02% of the 13F portfolio, value $25,917,054.

    13F-HR 0000899140-26-000547 filed by TWO SIGMA INVESTMENTS, LP
    Filed (acceptance time not in the bulk data set), ingested

    Acceptance time not in the bulk data set (spec §4.2).

  3. period ended2025-12-31
    13F 8,247,282 shares
    Change vs previous 13F +4,100,664 shares

    0.03% of the 13F portfolio, value $30,514,943.

    13F-HR 0000899140-26-000232 filed by TWO SIGMA INVESTMENTS, LP
    Filed (acceptance time not in the bulk data set), ingested

    • TWO SIGMA INVESTMENTS, LP: 4,742,082 shares
    • TWO SIGMA ADVISERS, LP: 3,505,200 shares

    Acceptance time not in the bulk data set (spec §4.2).

  4. period ended2025-09-30
    13F 4,146,618 shares
    Change vs previous 13F +224,924 shares

    0.01% of the 13F portfolio, value $10,988,538.

    13F-HR 0000899140-25-001286 filed by TWO SIGMA INVESTMENTS, LP
    Filed (acceptance time not in the bulk data set), ingested

    • TWO SIGMA INVESTMENTS, LP: 2,238,618 shares
    • TWO SIGMA ADVISERS, LP: 1,908,000 shares

    Acceptance time not in the bulk data set (spec §4.2).

  5. period ended2025-06-30
    13F 3,921,694 shares
    Change vs previous 13F -1,336,593 shares

    <0.01% of the 13F portfolio, value $3,860,515.

    13F-HR 0000899140-25-000953 filed by TWO SIGMA ADVISERS, LP
    Filed (acceptance time not in the bulk data set), ingested

    • TWO SIGMA INVESTMENTS, LP: 1,827,994 shares
    • TWO SIGMA ADVISERS, LP: 2,093,700 shares

    Acceptance time not in the bulk data set (spec §4.2).

  6. period ended2025-03-31
    13F 5,258,287 shares
    Change vs previous 13F -1,898,274 shares

    0.01% of the 13F portfolio, value $7,571,933.

    13F-HR 0000899140-25-000680 filed by TWO SIGMA INVESTMENTS, LP
    Filed (acceptance time not in the bulk data set), ingested

    • TWO SIGMA INVESTMENTS, LP: 2,731,287 shares
    • TWO SIGMA ADVISERS, LP: 2,527,000 shares

    Acceptance time not in the bulk data set (spec §4.2).

  7. period ended2024-12-31
    13F 7,156,561 shares
    Change vs previous 13F -68,598 shares

    0.02% of the 13F portfolio, value $15,744,434.

    13F-HR 0000899140-25-000264 filed by TWO SIGMA ADVISERS, LP
    Filed (acceptance time not in the bulk data set), ingested

    • TWO SIGMA INVESTMENTS, LP: 3,540,361 shares
    • TWO SIGMA ADVISERS, LP: 3,616,200 shares

    Acceptance time not in the bulk data set (spec §4.2).

  8. period ended2024-09-30
    13F 7,225,159 shares
    Change vs previous 13F not available

    0.01% of the 13F portfolio, value $11,921,512.

    13F-HR 0000919574-24-006611 filed by TWO SIGMA INVESTMENTS, LP
    Filed (acceptance time not in the bulk data set), ingested

    • TWO SIGMA INVESTMENTS, LP: 3,625,059 shares
    • TWO SIGMA ADVISERS, LP: 3,600,100 shares

    Acceptance time not in the bulk data set (spec §4.2).