13F-HR filed by BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP filed this 13F-HR for the quarter ended 2019-03-31, filed 2019-05-15, with 96 holding rows worth $15,621,759,000.
- Accession
- 0001144204-19-026555
- Filer
- CIK 1263508
- Filed
- 2019-05-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2019
A holdings report, 96 entries on the cover page, a total value of $15,621,759,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $15,621,759,000 with VALUE read as thousands by filing date, 13F file number 028-10519. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SEATTLE GENETICS INC | 812578102 | COM | 51,049,760 | $3,738,884,000 | thousands by filing date | |
| INCYTE CORP COM | 45337C102 | Stock | 34,271,827 | $2,947,720,000 | thousands by filing date | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 11,959,824 | $1,578,697,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 8,558,068 | $1,156,880,000 | thousands by filing date | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 39,713,842 | $1,066,317,000 | thousands by filing date | |
| AMARIN CORP PLC | 023111206 | SPONS ADR NEW | 43,210,459 | $897,049,000 | thousands by filing date | |
| GENOMIC HEALTH, INC. | 37244C101 | COM | 10,198,943 | $714,436,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 7,589,294 | $674,157,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 3,390,270 | $399,035,000 | thousands by filing date | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 2,513,462 | $184,237,000 | thousands by filing date | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 1,169,278 | $146,464,000 | thousands by filing date | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 1,019,557 | $127,281,000 | thousands by filing date | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 15,118,081 | $123,061,000 | thousands by filing date | |
| HERON THERAPEUTICS INC | 427746102 | COM | 5,018,104 | $122,642,000 | thousands by filing date | |
| CLEMENTIA PHARMACEUTICALS IN | 185575107 | COM | 3,724,445 | $97,208,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 1,098,670 | $96,793,000 | thousands by filing date | |
| ARRAY BIOPHARMA INC COM | 04269X105 | Stock | 3,842,289 | $93,675,000 | thousands by filing date | |
| INVITAE CORP | 46185L103 | COM | 3,902,421 | $91,395,000 | thousands by filing date | |
| SPARK THERAPEUTICS INC | 84652J103 | COM | 751,927 | $85,629,000 | thousands by filing date | |
| CYMABAY THERAPEUTICS INC | 23257D103 | COM | 5,707,411 | $75,794,000 | thousands by filing date | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 2,708,200 | $74,232,000 | thousands by filing date | |
| GW PHARMACEUTICALS PLC | 36197T103 | ADS | 428,345 | $72,206,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125CAD1 | NOTE 2.250% 5/1 | 53,270,000 | $71,994,000 | thousands by filing date | principal |
| TRICIDA INC | 89610F101 | COM | 1,803,238 | $69,641,000 | thousands by filing date | |
| CERUS CORP | 157085101 | COM | 10,749,937 | $66,972,000 | thousands by filing date | |
| AUDENTES THERAPEUTICS INC. | 05070R104 | Common Stock | 1,715,183 | $66,926,000 | thousands by filing date | |
| PRINCIPIA BIOPHARMA INC | 74257L108 | COM | 1,787,807 | $60,785,000 | thousands by filing date | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 2,077,601 | $60,396,000 | thousands by filing date | |
| KODIAK SCIENCES INC | 50015M109 | COM | 9,145,115 | $59,718,000 | thousands by filing date | |
| KINIKSA PHARMACEUTICALS LTD | G5269C101 | COM CL A | 3,000,000 | $54,180,000 | thousands by filing date | |
| MYOKARDIA INC | 62857M105 | COM | 1,016,306 | $52,838,000 | thousands by filing date | |
| DBV TECHNOLOGIES S A | 23306J101 | ADR | 5,509,560 | $42,479,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 605,000 | $36,088,000 | thousands by filing date | |
| AQUINOX PHARMACEUTICALS INC | 03842B101 | COM | 10,934,154 | $29,468,000 | thousands by filing date | |
| ZYMEWORKS INC | 98985W102 | COM | 1,708,472 | $27,643,000 | thousands by filing date | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 784,674 | $25,816,000 | thousands by filing date | |
| RA PHARMACEUTICALS INC | 74933V108 | COM | 823,113 | $18,438,000 | thousands by filing date | |
| MERUS N V | N5749R100 | COM | 1,160,014 | $17,133,000 | thousands by filing date | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 1,200,000 | $17,076,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061GAH4 | NOTE 0.599% 8/0 | 15,000,000 | $15,385,000 | thousands by filing date | principal |
| AIMMUNE THERAPEUTICS INC. | 00900T107 | Common Stock | 673,908 | $15,062,000 | thousands by filing date | |
| CATALYST PHARMACEUTICALS INC | 14888U101 | COM | 2,900,000 | $14,790,000 | thousands by filing date | |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 1,713,604 | $13,795,000 | thousands by filing date | |
| XENCOR INC | 98401F105 | COMMON STOCK | 428,120 | $13,297,000 | thousands by filing date | |
| IDERA PHARMACEUTICALS INC | 45168K405 | COM PAR | 4,839,895 | $12,342,000 | thousands by filing date | |
| DERMIRA INC | 24983L104 | COM | 906,943 | $12,289,000 | thousands by filing date | |
| MARKER THERAPEUTICS INC | 57055L107 | COM | 1,500,000 | $9,900,000 | thousands by filing date | |
| SANGAMO THERAPEUTICS INC | 800677106 | COM | 999,823 | $9,538,000 | thousands by filing date | |
| ABEONA THERAPEUTICS INC | 00289Y107 | COM | 1,288,235 | $9,481,000 | thousands by filing date | |
| BELLICUM PHARMACEUTICALS INC | 079481107 | COM | 2,677,818 | $9,024,000 | thousands by filing date | |
| ANAPTYSBIO INC | 032724106 | COM | 113,086 | $8,261,000 | thousands by filing date | |
| ALBIREO PHARMA INC | 01345P106 | COMMON STOCK | 250,000 | $8,053,000 | thousands by filing date | |
| Inflarx Nv | N44821101 | COM | 178,987 | $6,764,000 | thousands by filing date | |
| SPRING BK PHARMACEUTICALS IN | 849431101 | COM | 613,144 | $6,432,000 | thousands by filing date | |
| BLUEBIRD BIO INC | 09609G100 | COM | 40,000 | $6,293,000 | thousands by filing date | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 313,725 | $6,118,000 | thousands by filing date | |
| MENLO THERAPEUTICS INC | 586858102 | COM | 700,000 | $5,495,000 | thousands by filing date | |
| MACROGENICS INC | 556099109 | COM | 302,600 | $5,441,000 | thousands by filing date | |
| SYROS PHARMACEUTICALS INC | 87184Q107 | COM | 574,835 | $5,254,000 | thousands by filing date | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 403,893 | $5,077,000 | thousands by filing date | |
| AUTOLUS THERAPEUTICS PLC SPON | 05280R100 | COM | 156,773 | $4,934,000 | thousands by filing date | |
| HALOZYME THERAPEUTICS INC COM | 40637H109 | Stock | 299,969 | $4,830,000 | thousands by filing date | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 425,000 | $4,225,000 | thousands by filing date | |
| FORTY SEVEN INC | 34983P104 | COM | 250,000 | $4,040,000 | thousands by filing date | |
| ACCELERON PHARMA INC | 00434H108 | COM | 83,900 | $3,907,000 | thousands by filing date | |
| ACORDA THERAPEUTICS INC | 00484M106 | COM | 292,134 | $3,882,000 | thousands by filing date | |
| SIERRA ONCOLOGY INC | 82640U107 | COM | 2,000,000 | $3,420,000 | thousands by filing date | |
| LA JOLLA PHARMACEUTICAL CO | 503459604 | COM PAR $.0001 2 | 505,240 | $3,249,000 | thousands by filing date | |
| ACHILLION PHARMACEUTICALS IN | 00448Q201 | COM | 1,095,359 | $3,242,000 | thousands by filing date | |
| Aravive Inc | 03890D108 | Common / Ordinary Stock | 430,885 | $3,033,000 | thousands by filing date | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 131,250 | $2,987,000 | thousands by filing date | |
| LAKEFRONT BIOTHERAPEUTICS NV | 36315X101 | SPON ADR | 25,072 | $2,953,000 | thousands by filing date | |
| ASSEMBLY BIOSCIENCES INC | 045396108 | COM | 148,587 | $2,926,000 | thousands by filing date | |
| CHEMOCENTRYX INC | 16383L106 | COM | 207,029 | $2,876,000 | thousands by filing date | |
| Y-mAbs Therapeutics Inc | 984241109 | Common Stock | 102,800 | $2,694,000 | thousands by filing date | |
| ALKERMES PLC | G01767105 | SHS | 67,000 | $2,445,000 | thousands by filing date | |
| ORCHARD THERAPEUTICS PLC | 68570P101 | ADR | 125,000 | $2,235,000 | thousands by filing date | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 128,538 | $2,195,000 | thousands by filing date | |
| G1 THERAPEUTICS INC | 3621LQ109 | COM | 127,236 | $2,112,000 | thousands by filing date | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 194,377 | $2,090,000 | thousands by filing date | |
| HARPOON THERAPEUTICS INC | 41358P106 | COM | 214,285 | $2,029,000 | thousands by filing date | |
| FOAMIX PHARMACEUTICALS LTD | M46135105 | SHS | 498,189 | $1,868,000 | thousands by filing date | |
| CONSTELLATION PHARMACEUTICALS INC. | 210373106 | Common Stock | 133,333 | $1,807,000 | thousands by filing date | |
| GALMED PHARMACEUTICALS LTD | M47238106 | SHS | 215,594 | $1,761,000 | thousands by filing date | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 121,534 | $1,518,000 | thousands by filing date | |
| MOLECULAR TEMPLATES INC | 608550109 | COM | 254,230 | $1,477,000 | thousands by filing date | |
| ADAMAS PHARMACEUTICALS INC | 00548A106 | COM | 172,630 | $1,227,000 | thousands by filing date | |
| CONTRAFECT CORP | 212326102 | COM | 2,914,536 | $1,159,000 | thousands by filing date | |
| INFINITY PHARMACEUTICALS INC | 45665G303 | COM | 580,400 | $1,091,000 | thousands by filing date | |
| AFFIMED N V | N01045108 | COM | 200,000 | $840,000 | thousands by filing date | |
| FULGENT GENETICS INC | 359664109 | COM | 125,000 | $744,000 | thousands by filing date | |
| AQUESTIVE THERAPEUTICS INC COM | 03843E104 | Stock | 99,600 | $688,000 | thousands by filing date | |
| SUNESIS PHARMACEUTICALS INC | 867328700 | COM | 556,665 | $676,000 | thousands by filing date | |
| DYNAVAX TECHNOLOGIES CORP | 268158201 | COM NEW | 75,000 | $548,000 | thousands by filing date | |
| TRILLIUM THERAPEUTICS INC COM NEW | 89620X506 | Stock | 505,262 | $333,000 | thousands by filing date | |
| RITTER PHARMACEUTICALS INC COM NEW | 767836307 | Stock | 279,999 | $244,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001144204-19-026555 | this filing | 2019-05-15 | acceptance time not in the bulk data set |