13F-HR filed by BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP filed this 13F-HR for the quarter ended 2015-12-31, filed 2016-02-16, with 133 holding rows worth $12,071,272,000.
- Accession
- 0001144204-16-082790
- Filer
- CIK 1263508
- Filed
- 2016-02-16
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2015
A holdings report, 133 entries on the cover page, a total value of $12,071,272,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $12,071,272,000 with VALUE read as thousands by filing date, 13F file number 028-10519. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| INCYTE CORP COM | 45337C102 | Stock | 19,475,316 | $2,112,098,000 | thousands by filing date | |
| SEATTLE GENETICS INC | 812578102 | COM | 37,293,728 | $1,673,743,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 6,542,599 | $1,248,001,000 | thousands by filing date | |
| AbbVie,Inc. | 00287Y109 | COM | 14,373,538 | $851,488,000 | thousands by filing date | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 20,481,442 | $730,163,000 | thousands by filing date | |
| Incyte Corporation | 45337CAL6 | NOTE 1.25% 11/15/2020 | 274,500,000 | $596,530,000 | thousands by filing date | principal |
| Incyte Corporation | 45337CAK8 | NOTE 0.375% 11/15/2018 | 259,000,000 | $556,688,000 | thousands by filing date | principal |
| GENOMIC HEALTH, INC. | 37244C101 | COM | 13,659,264 | $480,806,000 | thousands by filing date | |
| ANACOR PHARMACEUTICALS INC | 032420101 | COM | 4,198,520 | $474,307,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 4,115,083 | $431,096,000 | thousands by filing date | |
| DYAX CORP | 26746E103 | COM | 8,310,017 | $312,623,000 | thousands by filing date | |
| DBV TECHNOLOGIES S A | 23306J101 | ADR | 5,462,019 | $198,326,000 | thousands by filing date | |
| ACORDA THERAPEUTICS INC | 00484M106 | COM | 3,580,112 | $153,157,000 | thousands by filing date | |
| ANACOR PHARMACEUTICALS INC | 032420AC5 | Bond | 42,000,000 | $152,294,000 | thousands by filing date | principal |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 14,217,779 | $146,727,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061GAD3 | CNV | 22,379,000 | $115,158,000 | thousands by filing date | principal |
| CLOVIS ONCOLOGY INC | 189464AB6 | NOTE 2.500% 9/1 | 129,300,000 | $110,982,000 | thousands by filing date | principal |
| BELLICUM PHARMACEUTICALS INC | 079481107 | COM | 4,865,647 | $98,627,000 | thousands by filing date | |
| GILEAD SCIENCES INC | 375558AP8 | CORPORATE OBLIG | 20,944,000 | $93,469,000 | thousands by filing date | principal |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 2,955,074 | $93,380,000 | thousands by filing date | |
| CERUS CORP | 157085101 | COM | 13,553,275 | $85,657,000 | thousands by filing date | |
| AQUINOX PHARMACEUTICALS INC | 03842B101 | COM | 6,747,332 | $84,207,000 | thousands by filing date | |
| HERON THERAPEUTICS INC | 427746102 | COM | 2,907,784 | $77,638,000 | thousands by filing date | |
| IMMUNOGEN INC | 45253H101 | COMMON STOCK | 4,452,445 | $60,420,000 | thousands by filing date | |
| ACORDA THERAPEUTICS INC | 00484MAA4 | NOTE 1.750% 6/1 | 51,583,000 | $59,297,000 | thousands by filing date | principal |
| SPARK THERAPEUTICS INC | 84652J103 | COM | 1,262,382 | $57,199,000 | thousands by filing date | |
| INVITAE CORP | 46185L103 | COM | 6,554,967 | $53,816,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 850,739 | $48,126,000 | thousands by filing date | |
| VERSARTIS INC | 92529L102 | COM | 3,241,783 | $40,166,000 | thousands by filing date | |
| SANGAMO THERAPEUTICS INC | 800677106 | COM | 4,055,876 | $37,030,000 | thousands by filing date | |
| HALOZYME THERAPEUTICS INC COM | 40637H109 | Stock | 1,931,057 | $33,465,000 | thousands by filing date | |
| INTRA-CELLULAR THERAPIES INC | 46116X101 | COMMON STOCK | 609,166 | $32,767,000 | thousands by filing date | |
| MEDIVATION INC | 58501N101 | COM | 659,752 | $31,892,000 | thousands by filing date | |
| PROGENICS PHARMACEUTICALS IN | 743187106 | COM | 4,350,808 | $26,670,000 | thousands by filing date | |
| Gilead Sciences,Inc. | 375558103 | COM | 249,995 | $25,297,000 | thousands by filing date | |
| TG THERAPEUTICS INC COM | 88322Q108 | Stock | 2,003,991 | $23,908,000 | thousands by filing date | |
| EXELIXIS INC | 30161QAC8 | NOTE 4.250% 8/1 | 20,000,000 | $23,260,000 | thousands by filing date | principal |
| LAKEFRONT BIOTHERAPEUTICS NV | 36315X101 | SPON ADR | 369,276 | $23,220,000 | thousands by filing date | |
| ATYR PHARMA INC | 002120103 | COM | 2,335,125 | $22,954,000 | thousands by filing date | |
| ACHILLION PHARMACEUTICALS IN | 00448Q201 | COM | 2,000,000 | $21,580,000 | thousands by filing date | |
| IDERA PHARMACEUTICALS INC | 45168K306 | COM | 6,983,107 | $21,578,000 | thousands by filing date | |
| CATALYST PHARMACEUTICALS INC | 14888U101 | COM | 8,275,630 | $20,275,000 | thousands by filing date | |
| ALKERMES PLC | G01767105 | SHS | 250,251 | $19,865,000 | thousands by filing date | |
| XENOPORT INC | 98411C100 | COM | 3,475,672 | $19,081,000 | thousands by filing date | |
| NOVAVAX INC | 670002104 | COMMON STOCK | 2,195,687 | $18,422,000 | thousands by filing date | |
| ARRAY BIOPHARMA INC COM | 04269X105 | Stock | 4,310,666 | $18,191,000 | thousands by filing date | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 1,000,000 | $18,150,000 | thousands by filing date | |
| ADVANCED ACCELERATOR APPLIC SPONSORED ADS | 00790T100 | ADR | 567,454 | $17,744,000 | thousands by filing date | |
| AEGERION PHARMACEUTICALS INC | 00767EAB8 | NOTE 2.000 8/1 | 26,517,000 | $17,552,000 | thousands by filing date | principal |
| DERMA SCIENCES INC | 249827502 | COM PAR $.01 | 3,752,390 | $17,148,000 | thousands by filing date | |
| FOAMIX PHARMACEUTICALS LTD | M46135105 | SHS | 2,046,967 | $16,601,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061GAE1 | NOTE 0.750%10/1 | 12,228,000 | $15,698,000 | thousands by filing date | principal |
| ZOGENIX INC. | 98978L204 | Common Stock | 1,000,000 | $14,740,000 | thousands by filing date | |
| Alcobra Ltd | M2239P109 | SHS | 2,336,359 | $14,672,000 | thousands by filing date | |
| Lion Biotechnologies | 53619R102 | COM | 1,817,429 | $14,031,000 | thousands by filing date | |
| DIMENSION THERAPEUTICS INC | 25433V105 | COM | 1,234,481 | $13,925,000 | thousands by filing date | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 123,894 | $13,898,000 | thousands by filing date | |
| GLOBAL BLOOD THERAPEUTICS USD | 37890U108 | COM | 400,000 | $12,932,000 | thousands by filing date | |
| XENCOR INC | 98401F105 | COMMON STOCK | 872,072 | $12,750,000 | thousands by filing date | |
| MACROGENICS INC | 556099109 | COM | 363,676 | $11,263,000 | thousands by filing date | |
| DERMIRA INC | 24983L104 | COM | 275,000 | $9,518,000 | thousands by filing date | |
| CONCERT PHARMACEUTICALS INC | 206022105 | COM | 495,908 | $9,407,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 505,521 | $9,261,000 | thousands by filing date | |
| BLUEBIRD BIO INC | 09609G100 | COM | 141,105 | $9,062,000 | thousands by filing date | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 988,299 | $8,578,000 | thousands by filing date | |
| LIGAND PHARMACEUTICALS INC | 53220K504 | COM NEW | 73,386 | $7,957,000 | thousands by filing date | |
| IGNYTA INC | 451731103 | COM | 571,000 | $7,651,000 | thousands by filing date | |
| AERIE PHARMACEUTICALS INC | 00771V108 | COM | 299,356 | $7,289,000 | thousands by filing date | |
| ENDOCYTE INC | 29269A102 | COM | 1,695,865 | $6,800,000 | thousands by filing date | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 100,000 | $6,492,000 | thousands by filing date | |
| ARROWHEAD RESEARCH CORP | 042797209 | COM | 1,009,509 | $6,208,000 | thousands by filing date | |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 105,000 | $6,122,000 | thousands by filing date | |
| CURIS INC | 231269101 | COM | 1,999,303 | $5,818,000 | thousands by filing date | |
| AKARI THERAPEUTICS PLC | 00972G108 | ADR | 395,882 | $5,740,000 | thousands by filing date | |
| OMEROS CORP | 682143102 | COM | 336,226 | $5,289,000 | thousands by filing date | |
| NEURODERM LTD | M74231107 | ORD SHS | 305,000 | $5,200,000 | thousands by filing date | |
| OSIRIS THERAPEUTICS INC NEW | 68827R108 | COM | 499,193 | $5,182,000 | thousands by filing date | |
| TREVENA INC | 89532E109 | COM | 450,000 | $4,725,000 | thousands by filing date | |
| PROTEON THERAPEUTICS INC | 74371L109 | COM | 298,591 | $4,631,000 | thousands by filing date | |
| AIMMUNE THERAPEUTICS INC. | 00900T107 | Common Stock | 250,000 | $4,613,000 | thousands by filing date | |
| Medgenics Inc New | 58436Q203 | COM NEW | 765,000 | $4,605,000 | thousands by filing date | |
| AMRN 3.5 1/32 | 220480AB3 | Bond 30/360P2 U | 5,000,000 | $4,480,000 | thousands by filing date | principal |
| SERES THERAPEUTICS INC | 81750R102 | COM | 125,000 | $4,386,000 | thousands by filing date | |
| AMARIN CORP PLC | 023111206 | SPONS ADR NEW | 2,205,710 | $4,169,000 | thousands by filing date | |
| SUNESIS PHARMACEUTICALS INC | 867328601 | COM NEW | 4,450,000 | $3,994,000 | thousands by filing date | |
| LOXO ONCOLOGY INC | 548862101 | COM | 137,735 | $3,919,000 | thousands by filing date | |
| EPIZYME INC | 29428V104 | COM | 232,481 | $3,724,000 | thousands by filing date | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 57,140 | $3,539,000 | thousands by filing date | |
| JUNO THERAPEUTICS INC | 48205A109 | COM | 80,000 | $3,518,000 | thousands by filing date | |
| VITAE PHARMACEUTICALS INC | 92847N103 | COM | 187,597 | $3,396,000 | thousands by filing date | |
| NABRIVA THERAPEUTICS AG | 62957M104 | SPONSORED ADR | 350,000 | $3,367,000 | thousands by filing date | |
| Sierra Oncology, Inc. | 74346L101 | common | 200,000 | $3,008,000 | thousands by filing date | |
| IMMUNE DESIGN CORP. | 45252L103 | Common Stock | 148,937 | $2,991,000 | thousands by filing date | |
| KARYOPHARM THERAPEUTICS INC | 48576U106 | COM | 216,990 | $2,875,000 | thousands by filing date | |
| AFFIMED N V | N01045108 | COM | 400,000 | $2,848,000 | thousands by filing date | |
| FLEXION THERAPEUTICS INC | 33938J106 | COM | 146,642 | $2,826,000 | thousands by filing date | |
| ARRAY BIOPHARMA INC | 04269XAA3 | NOTE 3.000% 6/0 | 3,000,000 | $2,816,000 | thousands by filing date | principal |
| OPHTHOTECH CORP | 683745103 | COM | 35,649 | $2,800,000 | thousands by filing date | |
| NATERA INC COM | 632307104 | Stock | 250,000 | $2,700,000 | thousands by filing date | |
| TRILLIUM THERAPEUTICS INC COM NEW | 89620X506 | Stock | 211,792 | $2,671,000 | thousands by filing date | |
| ENANTA PHARMACEUTICALS INC | 29251M106 | COM | 75,357 | $2,488,000 | thousands by filing date | |
| PROTALIX BIOTHERAPEUTICS INC | 74365AAB7 | NOTE 4.500% 9/1 | 3,423,000 | $2,375,000 | thousands by filing date | principal |
| OHR PHARMACEUTICAL INC | 67778H200 | COMMON STOCK | 370,370 | $2,274,000 | thousands by filing date | |
| STEMLINE THERAPEUTICS INC | 85858C107 | COM | 333,497 | $2,104,000 | thousands by filing date | |
| MAST THERAPEUTICS INC | 576314108 | COM | 4,797,442 | $2,016,000 | thousands by filing date | |
| IRONWOOD PHARMACEUTICALS INC | 46333X108 | COMMON STOCK | 169,163 | $1,961,000 | thousands by filing date | |
| MEDIWOUND LTD | M68830104 | ORD SHS | 225,000 | $1,922,000 | thousands by filing date | |
| ASSEMBLY BIOSCIENCES INC | 045396108 | COM | 250,000 | $1,878,000 | thousands by filing date | |
| DYNAVAX TECHNOLOGIES CORP | 268158201 | COM NEW | 75,000 | $1,812,000 | thousands by filing date | |
| AURINIA PHARMACEUTICALS INC COM | 05156V102 | Stock | 711,499 | $1,789,000 | thousands by filing date | |
| CYTRX CORP | 232828509 | COM PAR $.001 | 659,995 | $1,749,000 | thousands by filing date | |
| CELLECTIS ADS | 15117K103 | COM | 50,000 | $1,552,000 | thousands by filing date | |
| MARINUS PHARMACEUTICALS INC | 56854Q101 | COM | 200,000 | $1,528,000 | thousands by filing date | |
| ACCELERON PHARMA INC | 00434H108 | COM | 28,765 | $1,403,000 | thousands by filing date | |
| TENAX THERAPEUTICS INC | 88032L100 | COM | 420,000 | $1,378,000 | thousands by filing date | |
| PALATIN TECHNOLOGIES INC | 696077403 | COM PAR $ .01 | 2,050,000 | $1,361,000 | thousands by filing date | |
| ADAPTIMMUNE THERAPEUTICS PLC | 00653A107 | SPONDS ADR | 100,000 | $1,206,000 | thousands by filing date | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 11,340 | $1,068,000 | thousands by filing date | |
| CHIMERIX INC COM | 16934W106 | Stock | 115,216 | $1,031,000 | thousands by filing date | |
| BIODELIVERY SCIENCES INTL IN | 09060J106 | COM | 210,021 | $1,006,000 | thousands by filing date | |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 142,000 | $963,000 | thousands by filing date | |
| Arbutus Biopharma Corp | 03879J100 | Common Shares, without par value | 180,582 | $804,000 | thousands by filing date | |
| FIVE PRIME THERAPEUTICS INC. | 33830X104 | Common Stock | 19,247 | $799,000 | thousands by filing date | |
| DISCOVERY LABORATORIES INC N | 254668403 | COM NEW | 3,569,643 | $764,000 | thousands by filing date | |
| RITTER PHARMACEUTICALS INC | 767836109 | COM | 400,000 | $680,000 | thousands by filing date | |
| ACHAOGEN INC | 004449104 | COM | 100,000 | $574,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 30,000 | $496,000 | thousands by filing date | |
| Foundation Medicine Inc | 350465100 | COM | 20,892 | $440,000 | thousands by filing date | |
| CHEMOCENTRYX INC | 16383L106 | COM | 49,064 | $397,000 | thousands by filing date | |
| LA JOLLA PHARMACEUTICAL CO | 503459604 | COM PAR $.0001 2 | 13,746 | $371,000 | thousands by filing date | |
| APTOSE BIOSCIENCES INC COM | 03835T200 | Stock | 33,397 | $84,000 | thousands by filing date | |
| BIO GREEN MED SOL 6pcnt PFDCONV | 23254L207 | COMMON STOCK | 13,253 | $52,000 | thousands by filing date | |
| BIOTIME INC | 09066L162 | W EXP 10/01/201 | 20,084 | $24,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001144204-16-082790 | this filing | 2016-02-16 | acceptance time not in the bulk data set |