13F-HR filed by SABBY MANAGEMENT, LLC
SABBY MANAGEMENT, LLC filed this 13F-HR for the quarter ended 2015-09-30, filed 2015-11-16, with 379 holding rows worth $2,427,276,000.
- Accession
- 0001144204-15-065626
- Filer
- CIK 1535610
- Filed
- 2015-11-16
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q3 2015
A holdings report, 379 entries on the cover page, a total value of $2,427,276,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $2,427,276,000 with VALUE read as thousands by filing date, 13F file number 028-15245. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerMintz Hal 028-13502
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPDR S&P 500 ETF TR | 78462F953 | PUT | 16,250 | $306,773,000 | thousands by filing date | put |
| ISHARES TR | 464287955 | PUT | 25,500 | $273,123,000 | thousands by filing date | put |
| ELI LILLY & CO | 532457908 | CALL | 21,855 | $182,904,000 | thousands by filing date | call |
| GILEAD SCIENCES INC | 375558903 | COM | 9,896 | $97,169,000 | thousands by filing date | call |
| BIOGEN INC | 09062X903 | CALL | 3,090 | $90,169,000 | thousands by filing date | call |
| GILEAD SCIENCES INC | 375558953 | PUT | 4,973 | $48,830,000 | thousands by filing date | put |
| MEDICINES COMPANY | 584688905 | COM | 11,749 | $44,599,000 | thousands by filing date | call |
| ZOGENIX INC | 98978L904 | CALL | 31,115 | $42,005,000 | thousands by filing date | call |
| BIOGEN INC | 09062X953 | COM | 1,419 | $41,408,000 | thousands by filing date | put |
| ABBVIE INC | 00287Y909 | CALL | 7,456 | $40,568,000 | thousands by filing date | call |
| iShares Russell 2000 ETF | 464287655 | SHS | 327,168 | $35,727,000 | thousands by filing date | |
| EDWARDS LIFESCIENCES CORP | 28176E958 | COM | 1,682 | $34,896,000 | thousands by filing date | put |
| BIOMARIN PHARMACEUTICAL INC | 09061G951 | COM | 2,911 | $30,659,000 | thousands by filing date | put |
| TENET HEALTHCARE CORP | 88033G907 | CALL | 7,745 | $28,595,000 | thousands by filing date | call |
| BIOMARIN PHARMACEUTICAL INC | 09061G901 | COM | 2,375 | $25,014,000 | thousands by filing date | call |
| GW PHARMACEUTICALS PLC | 36197T953 | PUT | 2,712 | $24,780,000 | thousands by filing date | put |
| MOBILEYE N V AMSTELVEEN | N51488957 | PUT | 5,158 | $23,459,000 | thousands by filing date | put |
| MYLAN N V | N59465959 | PUT | 5,756 | $23,174,000 | thousands by filing date | put |
| BIOGEN INC COM | 09062X103 | Stock | 78,629 | $22,945,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607900 | COM | 6,671 | $21,421,000 | thousands by filing date | call |
| ELI LILLY & CO | 532457958 | PUT | 2,438 | $20,404,000 | thousands by filing date | put |
| SPDR SERIES TRUST | 78464A950 | PUT | 3,144 | $19,571,000 | thousands by filing date | put |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 174,073 | $18,333,000 | thousands by filing date | |
| BRISTOL-MYERS SQUIBB CO | 110122908 | CALL | 3,073 | $18,192,000 | thousands by filing date | call |
| ALEXION PHARMACEUTICALS INC | 015351959 | COM | 975 | $15,248,000 | thousands by filing date | put |
| MYLAN NV | N59465109 | SHS EURO | 376,827 | $15,171,000 | thousands by filing date | |
| PIONEER NATURAL RESOURCES CO | 723787107 | COM | 123,600 | $15,035,000 | thousands by filing date | |
| PIONEER NATURAL RESOURCES CO | 723787957 | COM | 1,236 | $15,035,000 | thousands by filing date | put |
| GLOBAL BLOOD THERAPEUTICS USD | 37890U108 | COM | 342,857 | $14,455,000 | thousands by filing date | |
| ALNYLAM PHARMACEUTICALS INC | 02043Q907 | CALL | 1,676 | $13,468,000 | thousands by filing date | call |
| NEWLINK GENETICS CORP | 651511907 | COM | 3,701 | $13,264,000 | thousands by filing date | call |
| ABBVIE INC | 00287Y959 | COM | 2,272 | $12,362,000 | thousands by filing date | put |
| APPLE INC | 037833900 | CALL | 1,110 | $12,243,000 | thousands by filing date | call |
| UNITED THERAPEUTICS CORP DEL | 91307C902 | OPTION | 918 | $12,048,000 | thousands by filing date | call |
| INTEROIL CORP COMMON STOCK | 460951956 | Cmn | 3,356 | $11,313,000 | thousands by filing date | put |
| INTEROIL CORP | 460951106 | COM | 328,705 | $11,081,000 | thousands by filing date | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 77,255 | $10,983,000 | thousands by filing date | |
| TENET HEALTHCARE CORP | 88033G957 | PUT | 2,907 | $10,733,000 | thousands by filing date | put |
| MOBILEYE NV XXXMANDATORY MERGER EFF: 06/03/18 | N51488117 | FOREIGN ORDINARIES | 235,819 | $10,725,000 | thousands by filing date | |
| HERON THERAPEUTICS INC | 427746902 | COM | 4,223 | $10,304,000 | thousands by filing date | call |
| CEMPRA INC | 15130J909 | COM | 3,649 | $10,159,000 | thousands by filing date | call |
| KITE PHARMA INC | 49803L959 | COM | 1,823 | $10,150,000 | thousands by filing date | put |
| MANNKIND CORP | 56400P901 | Option | 30,930 | $9,929,000 | thousands by filing date | call |
| GEVO INC COM PAR | 374396208 | Stock | 100,000 | $9,819,000 | thousands by filing date | |
| TENET HEALTHCARE CORP COM NEW | 88033G407 | Stock | 245,938 | $9,080,000 | thousands by filing date | |
| ACORDA THERAPEUTICS INC | 00484MAA4 | NOTE 1.750% 6/1 | 9,600,000 | $8,664,000 | thousands by filing date | |
| AGIOS PHARMACEUTICALS INC | 00847X954 | COM | 1,173 | $8,280,000 | thousands by filing date | put |
| REGULUS THERAPEUTICS INC | 75915K901 | CALL | 12,127 | $7,931,000 | thousands by filing date | call |
| TENAX THERAPEUTICS INC | 88032L100 | COM | 2,604,660 | $7,892,000 | thousands by filing date | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 109,521 | $7,731,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 49,397 | $7,725,000 | thousands by filing date | |
| EXACT SCIENCES CORP | 30063P955 | PUT | 4,293 | $7,723,000 | thousands by filing date | put |
| PERRIGO CO PLC | G97822903 | SHS | 491 | $7,722,000 | thousands by filing date | call |
| KITE PHARMA INC | 49803L109 | COM | 137,099 | $7,634,000 | thousands by filing date | |
| BLUEBIRD BIO INC | 09609G900 | COM | 889 | $7,605,000 | thousands by filing date | call |
| ACADIA PHARMACEUTICALS INC | 004225958 | COM | 2,259 | $7,471,000 | thousands by filing date | put |
| MDCO 1.375 6/17 | 584688AC9 | Bond 30/360P2 U | 5,000,000 | $7,278,000 | thousands by filing date | |
| MYLAN N V | N59465909 | CALL | 1,747 | $7,033,000 | thousands by filing date | call |
| TOKAI PHARMACEUTICALS INC COM | 88907J107 | Stock | 654,283 | $6,772,000 | thousands by filing date | |
| MANNKIND CORP COMMON STOCK | 56400P951 | Cmn | 20,875 | $6,701,000 | thousands by filing date | put |
| BLUEPRINT MEDICINES CORP | 09627Y109 | COM | 308,504 | $6,583,000 | thousands by filing date | |
| GW PHARMACEUTICALS PLC | 36197T103 | ADS | 71,757 | $6,556,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061GAE1 | NOTE 0.750%10/1 | 5,000,000 | $6,459,000 | thousands by filing date | |
| ALNYLAM PHARMACEUTICALS INC | 02043Q957 | COM | 789 | $6,340,000 | thousands by filing date | put |
| ANADARKO PETROLEUM CORP | 032511107 | COM | 102,300 | $6,178,000 | thousands by filing date | |
| ANADARKO PETROLEUM CORP | 032511957 | COM | 1,023 | $6,178,000 | thousands by filing date | put |
| NOVAVAX INC CMN STOCK | 670002954 | Cmn | 8,418 | $5,952,000 | thousands by filing date | put |
| SAREPTA THERAPEUTICS INC | 803607950 | COM | 1,836 | $5,895,000 | thousands by filing date | put |
| BARCLAYS BK PLC IPATH S&P MT E | 06740C519 | COM | 450,500 | $5,861,000 | thousands by filing date | |
| SPARK THERAPEUTICS INC | 84652J903 | CALL | 1,402 | $5,851,000 | thousands by filing date | call |
| SPARK THERAPEUTICS INC | 84652J953 | PUT | 1,379 | $5,755,000 | thousands by filing date | put |
| THERAPEUTICSMD INC | 88338N907 | COM | 9,800 | $5,743,000 | thousands by filing date | call |
| NEUROCRINE BIOSCIENCES INC | 64125C909 | COM | 1,403 | $5,583,000 | thousands by filing date | call |
| KONINKLIJKE PHILIPS N V | 500472903 | NY REGIS SHS NEW | 2,374 | $5,569,000 | thousands by filing date | call |
| INTRA CELLULAR THERAPIES INC | 46116X901 | CALL | 1,378 | $5,518,000 | thousands by filing date | call |
| OPKO HEALTH INC | 68375N953 | COM | 6,456 | $5,429,000 | thousands by filing date | put |
| HALOZYME THERAPEUTICS INC | 40637H909 | COM | 4,014 | $5,391,000 | thousands by filing date | call |
| EXACT SCIENCES CORP COM | 30063P105 | Stock | 289,112 | $5,201,000 | thousands by filing date | |
| OPKO HEALTH INC | 68375N103 | COM | 615,157 | $5,173,000 | thousands by filing date | |
| STANDARD BIOTOOLS INC | 34385P108 | COM | 628,260 | $5,095,000 | thousands by filing date | |
| DYNAVAX TECHNOLOGIES CORP | 268158901 | COM NEW | 2,073 | $5,087,000 | thousands by filing date | call |
| DEPOMED INC CMN STOCK | 249908904 | Cmn | 2,680 | $5,052,000 | thousands by filing date | call |
| GENOCEA BIOSCIENCES INC | 372427104 | COM | 729,141 | $4,995,000 | thousands by filing date | |
| NIVALIS THERAPEUTICS INC | 65481J109 | COM | 384,734 | $4,990,000 | thousands by filing date | |
| HCA HEALTHCARE INC | 40412C901 | CALL | 624 | $4,827,000 | thousands by filing date | call |
| ACHILLION PHARMACEUTICALS IN | 00448Q901 | Cmn | 6,916 | $4,779,000 | thousands by filing date | call |
| ACADIA PHARMACEUTICALS INC | 004225908 | COM | 1,438 | $4,755,000 | thousands by filing date | call |
| AVALANCHE BIOT | 05337G107 | Common Stock | 574,260 | $4,732,000 | thousands by filing date | |
| CELLDEX THERAPEUTICS INC | 15117B903 | Cmn | 4,448 | $4,688,000 | thousands by filing date | call |
| ISIS PHARMACEUTICALS INC | 464330909 | COM | 1,159 | $4,685,000 | thousands by filing date | call |
| DERMIRA INC | 24983L104 | COM | 190,000 | $4,435,000 | thousands by filing date | |
| Gilead Sciences,Inc. | 375558103 | COM | 45,140 | $4,432,000 | thousands by filing date | |
| Arbutus Biopharma Corp | 03879J100 | Common Shares, without par value | 725,007 | $4,415,000 | thousands by filing date | |
| RAPTOR PHARMACEUTICAL CORP | 75382F906 | Cmn | 7,289 | $4,410,000 | thousands by filing date | call |
| NEUROCRINE BIOSCIENCES INC | 64125C959 | COM | 1,267 | $4,397,000 | thousands by filing date | put |
| INOVIO PHARMACEUTICALS INC | 45773H201 | COM NEW | 737,551 | $4,263,000 | thousands by filing date | |
| ZS PHARMA INC | 98979G955 | PUT | 640 | $4,202,000 | thousands by filing date | put |
| ENDO INTL PLC | G30401906 | CALL | 601 | $4,164,000 | thousands by filing date | call |
| RADIUS HEALTH INC | 750469907 | COM | 578 | $4,006,000 | thousands by filing date | call |
| HERON THERAPEUTICS INC | 427746102 | COM | 160,323 | $3,912,000 | thousands by filing date | |
| CIDARA THERAPEUTICS INC COM NEW | 171757107 | Stock | 306,044 | $3,893,000 | thousands by filing date | |
| OPKO HEALTH INC | 68375N903 | COM | 4,500 | $3,785,000 | thousands by filing date | call |
| NORTHWEST BIOTHERAPEUTICS IN | 66737P950 | Cmn | 6,042 | $3,776,000 | thousands by filing date | put |
| NOVAVAX INC | 670002104 | COMMON STOCK | 527,040 | $3,726,000 | thousands by filing date | |
| TRANSENTERIX INC | 89366M201 | COM NEW | 1,591,117 | $3,596,000 | thousands by filing date | |
| NW Biotherapeutics | 66737P600 | USD | 572,518 | $3,578,000 | thousands by filing date | |
| VERTEX PHARMACEUTICALS INC | 92532F900 | CALL | 341 | $3,551,000 | thousands by filing date | call |
| ENDO INTL PLC | G30401106 | SHS | 50,658 | $3,510,000 | thousands by filing date | |
| BLUEBIRD BIO INC | 09609G950 | COM | 406 | $3,473,000 | thousands by filing date | put |
| NEVRO CORP | 64157F953 | PUT | 745 | $3,456,000 | thousands by filing date | put |
| CHAMPION HOMES INC | 830830105 | COM | 447,944 | $3,454,000 | thousands by filing date | |
| INTEC PHARMA LTD JERUSALEM | M53644106 | SHS | 613,910 | $3,438,000 | thousands by filing date | |
| DYNAVAX TECHNOLOGIES CORP | 268158201 | COM NEW | 134,954 | $3,312,000 | thousands by filing date | |
| HORIZON PHARMA PLC | G4617B955 | PUT | 1,658 | $3,286,000 | thousands by filing date | put |
| HORIZON PHARMA PLC | G4617B105 | SHS | 164,658 | $3,264,000 | thousands by filing date | |
| AMICUS THERAPEUTIC | 03152W959 | PUT | 2,322 | $3,248,000 | thousands by filing date | put |
| Lion Biotechnologies | 53619R102 | COM | 561,894 | $3,237,000 | thousands by filing date | |
| ZELTIQ AESTHETICS INC | 98933Q908 | COM | 1,000 | $3,203,000 | thousands by filing date | call |
| AOXING PHARMACEUTICAL CO INC | 03740A106 | COM | 2,134,054 | $3,158,000 | thousands by filing date | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 30,000 | $3,124,000 | thousands by filing date | |
| MOBILEYE N V AMSTELVEEN | N51488907 | CALL | 686 | $3,120,000 | thousands by filing date | call |
| BENITEC BIOPHARMA LTD | 082053307 | SPONS ADR NEW | 505,220 | $3,107,000 | thousands by filing date | |
| PTC THERAPEUTICS INC | 69366J900 | COM | 1,161 | $3,100,000 | thousands by filing date | call |
| ZAFGEN INC | 98885E903 | CALL | 960 | $3,067,000 | thousands by filing date | call |
| NEUROMETRIX EQUITY WARRANTS | 641255138 | *W | 12,212,278 | $3,052,000 | thousands by filing date | |
| CEMPRA INC | 15130J959 | COM | 1,082 | $3,012,000 | thousands by filing date | put |
| NOVAVAX INC CMN STOCK | 670002904 | Cmn | 4,018 | $2,841,000 | thousands by filing date | call |
| COMMUNITY HEALTH SYS INC NEW | 203668958 | COM | 662 | $2,831,000 | thousands by filing date | put |
| LEXICON PHARMACEUTICALS INC | 528872302 | COMMON STOCK | 261,595 | $2,810,000 | thousands by filing date | |
| PLURISTEM THERAPEUTICS INC | 72940R102 | COM | 1,474,369 | $2,683,000 | thousands by filing date | |
| MEDGENICS INC | 58436Q112 | *W EXP 03/31/201 | 1,453,640 | $2,544,000 | thousands by filing date | |
| OVASCIENCE INC | 69014Q101 | COM | 297,955 | $2,530,000 | thousands by filing date | |
| FEI CO CMN STOCK | 30241L909 | Cmn | 340 | $2,483,000 | thousands by filing date | call |
| REGENERON PHARMACEUTICALS | 75886F957 | COM | 53 | $2,465,000 | thousands by filing date | put |
| SANGAMO THERAPEUTICS INC | 800677106 | COM | 435,225 | $2,455,000 | thousands by filing date | |
| REVANCE THERAPEUTICS INC | 761330909 | COM | 815 | $2,425,000 | thousands by filing date | call |
| LIPOCINE INC NEW | 53630X104 | CMN | 201,409 | $2,383,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351909 | COM | 152 | $2,377,000 | thousands by filing date | call |
| LA JOLLA PHARMACEUTICAL CO | 503459604 | COM PAR $.0001 2 | 85,011 | $2,362,000 | thousands by filing date | |
| REGULUS THERAPEUTICS INC | 75915K101 | COM | 356,504 | $2,332,000 | thousands by filing date | |
| INOVIO PHARMACEUTICALS INC | 45773H901 | COM NEW | 3,965 | $2,292,000 | thousands by filing date | call |
| TRANSENTERIX INC | 89366M901 | CALL | 10,026 | $2,266,000 | thousands by filing date | call |
| INVIVO THERAPEUTICS HLDGS CO | 46186M909 | COM NEW | 2,608 | $2,248,000 | thousands by filing date | call |
| REDHILL BIOPHARMA LTD | 757468103 | ADR | 173,550 | $2,241,000 | thousands by filing date | |
| PARATEK PHARMACEUTICALS INC | 699374302 | Equity | 117,046 | $2,224,000 | thousands by filing date | |
| IGNYTA INC | 451731103 | COM | 252,974 | $2,221,000 | thousands by filing date | |
| BIOCRYST PHARMACEUTICALS INC | 09058V953 | COM | 1,929 | $2,199,000 | thousands by filing date | put |
| PUMA BIOTECHNOLOGY INC | 74587V957 | PUT | 288 | $2,170,000 | thousands by filing date | put |
| CYTOKINETICS INC | 23282W905 | COM NEW | 3,106 | $2,078,000 | thousands by filing date | call |
| REPROS THERAPEUTICS CMN STK | 76028H959 | Cmn | 2,793 | $2,075,000 | thousands by filing date | put |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 60,000 | $2,065,000 | thousands by filing date | |
| REPROS THERAPEUTICS CMN STK | 76028H909 | Cmn | 2,777 | $2,063,000 | thousands by filing date | call |
| BIODELIVERY SCIENCES INTL IN | 09060J106 | COM | 368,641 | $2,050,000 | thousands by filing date | |
| CEMPRA INC | 15130J109 | COM | 73,195 | $2,038,000 | thousands by filing date | |
| VAPOR CORP DEL | 922099502 | UNIT 99/99/9999 | 225,387 | $2,015,000 | thousands by filing date | |
| PUMA BIOTECHNOLOGY INC | 74587V107 | COMMON STOCK | 26,704 | $2,012,000 | thousands by filing date | |
| RICEBRAN TECHNOLOGIES | 762831204 | COM NEW | 901,973 | $1,975,000 | thousands by filing date | |
| VASCULAR SOLUTIONS INC | 92231M959 | COM | 607 | $1,967,000 | thousands by filing date | put |
| BRAINSTORM CELL THERAPEUTICS | 10501E201 | COM | 852,348 | $1,952,000 | thousands by filing date | |
| ZS PHARMA INC | 98979G905 | CALL | 297 | $1,950,000 | thousands by filing date | call |
| DYAX CORP | 26746E953 | Cmn | 1,017 | $1,941,000 | thousands by filing date | put |
| SERES THERAPEUTICS INC | 81750R102 | COM | 64,775 | $1,920,000 | thousands by filing date | |
| SORRENTO THERAPEUTICS INC | 83587F902 | CALL | 2,275 | $1,909,000 | thousands by filing date | call |
| GLOBUS MED INC | 379577958 | CL A | 913 | $1,886,000 | thousands by filing date | put |
| OVASCIENCE INC | 69014Q951 | PUT | 2,200 | $1,868,000 | thousands by filing date | put |
| COMMUNITY HEALTH SYSTEMS INC | 203668108 | COMMON STOCK | 43,397 | $1,856,000 | thousands by filing date | |
| CESCA THERAPEUTICS INC | 157131103 | COM | 3,500,037 | $1,855,000 | thousands by filing date | |
| CHINA BIOLOGIC PRODUCTS INC | 16938C106 | COMM STK | 20,000 | $1,796,000 | thousands by filing date | |
| QUEST RESOURCE HOLDING CORP | 74836W104 | COMM | 3,148,401 | $1,795,000 | thousands by filing date | |
| XTL BIOPHARMACEUTICALS-ADR | 98386D208 | COM | 1,149,886 | $1,794,000 | thousands by filing date | |
| FOAMIX PHARMACEUTICALS LTD | M46135105 | SHS | 243,361 | $1,784,000 | thousands by filing date | |
| ONCOSEC MED INC | 68234L207 | COM NEW | 340,169 | $1,752,000 | thousands by filing date | |
| IMMUNOCELLULAR THERAPEUTICS | 452536105 | COM | 4,169,243 | $1,751,000 | thousands by filing date | |
| ACURA PHARMACEUTICALS INC COM | 00509L802 | COM | 743,603 | $1,747,000 | thousands by filing date | |
| BELLICUM PHARMACEUTICALS INC | 079481107 | COM | 120,094 | $1,745,000 | thousands by filing date | |
| BARCLAYS BK PLC CALL | 06740C909 | CALL | 1,334 | $1,736,000 | thousands by filing date | call |
| UNIQURE NV | N90064901 | CALL | 844 | $1,726,000 | thousands by filing date | call |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 40,019 | $1,694,000 | thousands by filing date | |
| TOBIRA THERAPEUTICS INC COM | 88883P101 | COM | 174,943 | $1,690,000 | thousands by filing date | |
| NUVASIVE INC | 670704105 | COM | 35,000 | $1,688,000 | thousands by filing date | |
| INFINITY PHARMACEUTICALS INC | 45665G903 | Cmn | 1,971 | $1,665,000 | thousands by filing date | call |
| FORWARD PHARMA A/S | 34986J105 | SPONSORED ADR | 70,000 | $1,649,000 | thousands by filing date | |
| AGIOS PHARMACEUTICALS INC | 00847X904 | COM | 233 | $1,645,000 | thousands by filing date | call |
| MOMENTA PHARMACEUTICALS INC. COMMON STOCK | 60877T900 | Cmn | 1,000 | $1,641,000 | thousands by filing date | call |
| OMEROS CORP | 682143902 | CALL | 1,489 | $1,632,000 | thousands by filing date | call |
| APPLIED GENETIC TECHNOL CORP | 03820J100 | COM | 124,000 | $1,629,000 | thousands by filing date | |
| AMARIN CORP PLC | 023111206 | SPONS ADR NEW | 8,183 | $1,579,000 | thousands by filing date | call |
| ENDO INTL PLC | G30401956 | PUT | 224 | $1,552,000 | thousands by filing date | put |
| NUVASIVE INC COMMON STOCK | 670704905 | Cmn | 320 | $1,543,000 | thousands by filing date | call |
| NEWLINK GENETICS CORP | 651511957 | COM | 430 | $1,541,000 | thousands by filing date | put |
| CARDICA INC | 14141R101 | COM | 5,281,185 | $1,521,000 | thousands by filing date | |
| DYAX CORP | 26746E103 | COM | 79,613 | $1,520,000 | thousands by filing date | |
| ADVAXIS INC | 007624908 | CALL | 1,460 | $1,494,000 | thousands by filing date | call |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 105,190 | $1,479,000 | thousands by filing date | |
| TROVAGENE INC | 897238909 | CALL | 2,600 | $1,479,000 | thousands by filing date | call |
| SYNERGY PHARMACEUTICALS DEL | 871639908 | CALL | 2,785 | $1,476,000 | thousands by filing date | call |
| PUMA BIOTECHNOLOGY INC | 74587V907 | COM | 195 | $1,470,000 | thousands by filing date | call |
| DYNAVAX TECHNOLOGIES CORP | 268158951 | COM NEW | 594 | $1,458,000 | thousands by filing date | put |
| MEDICINOVA INC | 58468P206 | COM NEW | 500,000 | $1,420,000 | thousands by filing date | |
| INSMED INC | 457669957 | COM PAR $.01 | 764 | $1,419,000 | thousands by filing date | put |
| DISCOVERY LABORATORIES INC N | 254668403 | COM NEW | 4,703,551 | $1,411,000 | thousands by filing date | |
| SORRENTO THERAPEUTICS INC | 83587F202 | COMMON STOCK | 167,064 | $1,402,000 | thousands by filing date | |
| ABEONA THERAPEUTICS INC | 00289Y107 | COM | 340,702 | $1,380,000 | thousands by filing date | |
| TTOO | 89853L104 | Stock | 154,521 | $1,354,000 | thousands by filing date | |
| OCERA THERAPEUTICS INC COM | 67552A108 | COM | 426,544 | $1,348,000 | thousands by filing date | |
| RELYPSA INC | 759531106 | Common Stock | 69,980 | $1,295,000 | thousands by filing date | |
| ADAMAS PHARMACEUTICALS INC | 00548A106 | COM | 76,717 | $1,284,000 | thousands by filing date | |
| AbbVie,Inc. | 00287Y109 | COM | 23,516 | $1,280,000 | thousands by filing date | |
| PACIRA BIOSCIENCES INC COM | 695127100 | Stock | 31,100 | $1,278,000 | thousands by filing date | |
| ANTARES PHARMA INC | 036642106 | COM | 722,567 | $1,228,000 | thousands by filing date | |
| ENDOLOGIX INC | 29266S106 | COM | 100,000 | $1,226,000 | thousands by filing date | |
| ANTHERA PHARMACEUTICALS INC | 03674U901 | COM NEW | 2,000 | $1,218,000 | thousands by filing date | call |
| VASCULAR SOLUTIONS INC | 92231M109 | COMMON STOCK | 37,296 | $1,209,000 | thousands by filing date | |
| NEWLINK GENETICS CORP | 651511107 | COM | 33,658 | $1,206,000 | thousands by filing date | |
| CYCLACEL PHARMACEUTICALS INC | 23254L306 | COM | 2,356,091 | $1,202,000 | thousands by filing date | |
| ANACOR PHARMACEUTICALS INC | 032420901 | COM | 100 | $1,177,000 | thousands by filing date | call |
| ANACOR PHARMACEUTICALS INC | 032420951 | COM | 100 | $1,177,000 | thousands by filing date | put |
| POZEN INC | 73941U102 | COMMON STOCK | 200,000 | $1,167,000 | thousands by filing date | |
| PROVECTUS BIOPHARMACEUTICALS | 74373P108 | COMMON STOCK | 1,982,137 | $1,140,000 | thousands by filing date | |
| TROVAGENE INC | 897238309 | COM | 200,000 | $1,138,000 | thousands by filing date | |
| HALOZYME THERAPEUTICS INC | 40637H959 | COM | 840 | $1,128,000 | thousands by filing date | put |
| CHINA JO-JO DRUGSTORES INC | 16949A206 | COM NEW | 614,149 | $1,118,000 | thousands by filing date | |
| GALENA BIOPHARMA INC | 363256958 | Cmn | 6,832 | $1,081,000 | thousands by filing date | put |
| RARE ELEMENT RES LTD | 75381M102 | COM | 3,843,873 | $1,080,000 | thousands by filing date | |
| CELLECTAR BIOSCIENCES INC | 15117F112 | *W EXP 08/19/201 | 653,712 | $1,079,000 | thousands by filing date | |
| SAGE THERAPEUTICS INC | 78667J908 | COM | 251 | $1,062,000 | thousands by filing date | call |
| VTV THERAPEUTICS INC CL A | 918385105 | Stock | 160,556 | $1,047,000 | thousands by filing date | |
| Alliqua BioMedical Inc | 019621200 | COM NEW | 330,128 | $1,047,000 | thousands by filing date | |
| HEARTWARE INTL INC | 422368950 | Cmn | 199 | $1,041,000 | thousands by filing date | put |
| Rocket Pharmaceuticals Inc | 45780V102 | SHS | 110,000 | $1,034,000 | thousands by filing date | |
| INTREXON CORP | 46122T902 | CALL | 325 | $1,034,000 | thousands by filing date | call |
| AMICUS THERAPEUTIC | 03152W909 | CALL | 730 | $1,021,000 | thousands by filing date | call |
| CAPRICOR THERAPEUTICS INC | 14070B101 | COM | 250,450 | $1,014,000 | thousands by filing date | |
| EXELIXIS INC | 30161Q904 | COM | 1,783 | $1,000,000 | thousands by filing date | call |
| CYTORI THERAPEUTICS INC | 23283K105 | COM | 2,941,880 | $1,000,000 | thousands by filing date | |
| ARIAD PHARMACEUTICALS INC | 04033A100 | COM | 169,000 | $987,000 | thousands by filing date | |
| ARIAD PHARMACEUTICALS INC CMN STOCK | 04033A950 | Cmn | 1,690 | $987,000 | thousands by filing date | put |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 86,395 | $985,000 | thousands by filing date | |
| INSMED INC | 457669907 | CALL | 511 | $949,000 | thousands by filing date | call |
| ZAFGEN INC | 98885E953 | PUT | 296 | $946,000 | thousands by filing date | put |
| DEPOMED INC | 249908104 | COM | 50,000 | $943,000 | thousands by filing date | |
| ANACOR PHARMACEUTICALS INC | 032420101 | COM | 8,000 | $942,000 | thousands by filing date | |
| NEVRO CORP | 64157F903 | CALL | 203 | $942,000 | thousands by filing date | call |
| NATERA INC COM | 632307104 | Stock | 86,523 | $939,000 | thousands by filing date | |
| HEARTWARE INTL INC | 422368100 | COM | 17,500 | $915,000 | thousands by filing date | |
| GW PHARMACEUTICALS PLC | 36197T903 | CALL | 100 | $914,000 | thousands by filing date | call |
| CHAMPIONS ONCOLOGY INC | 15870P307 | COM NEW | 169,397 | $893,000 | thousands by filing date | |
| PORTOLA PHARMACEUTICALS INC | 737010958 | PUT | 206 | $878,000 | thousands by filing date | put |
| ADVAXIS INC | 007624208 | COM NEW | 85,700 | $877,000 | thousands by filing date | |
| ADVAXIS INC | 007624958 | PUT | 852 | $872,000 | thousands by filing date | put |
| TONIX PHARMACEUTICALS HLDG C | 890260901 | Cmn | 1,631 | $863,000 | thousands by filing date | call |
| IDERA PHARMACEUTICALS INC | 45168K906 | COM NEW | 2,558 | $857,000 | thousands by filing date | call |
| STEMCELLS INC | 85857R204 | COM NEW | 2,039,122 | $856,000 | thousands by filing date | |
| SYNERGY PHARMACEUTICALS DEL | 871639958 | PUT | 1,613 | $855,000 | thousands by filing date | put |
| CYNAPSUS THERAPEUTICS INC | 23257Y859 | COM PAR NO PAR | 52,169 | $845,000 | thousands by filing date | |
| AQUINOX PHARMACEUTICALS INC | 03842B101 | COM | 60,000 | $844,000 | thousands by filing date | |
| CTI BIOPHARMA CORP | 12648L906 | Cmn | 5,747 | $839,000 | thousands by filing date | call |
| TONIX PHARMACEUTICALS HOLDING | 890260201 | COM NEW | 158,140 | $837,000 | thousands by filing date | |
| MOMENTA PHARMACEUTICALS INC | 60877T100 | COM | 50,030 | $821,000 | thousands by filing date | |
| EDAP TMS S A | 268311957 | SPONSORED ADR | 1,466 | $819,000 | thousands by filing date | put |
| RADIUS HEALTH INC | 750469207 | COM NEW | 11,600 | $804,000 | thousands by filing date | |
| TESARO INC | 881569107 | COM | 20,000 | $802,000 | thousands by filing date | |
| TESARO INC | 881569957 | PUT | 200 | $802,000 | thousands by filing date | put |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 134,997 | $787,000 | thousands by filing date | |
| CYTOKINETICS INC | 23282W955 | PUT | 1,176 | $787,000 | thousands by filing date | put |
| ZS PHARMA INC | 98979G105 | Common Stock | 11,875 | $780,000 | thousands by filing date | |
| NEUROMETRIX INC | 641255302 | COM PAR $0.0001 | 873,454 | $771,000 | thousands by filing date | |
| BELLICUM PHARMACEUTICALS INC | 079481907 | CALL | 526 | $764,000 | thousands by filing date | call |
| CELLECTAR BIOSCIENCES INC | 15117F203 | COM NEW | 381,172 | $751,000 | thousands by filing date | |
| MELA SCIENCES INC | 55277R308 | COM NEW | 657,860 | $750,000 | thousands by filing date | |
| SUNEDISON INC | 86732Y909 | COM | 1,000 | $718,000 | thousands by filing date | call |
| EYEGATE PHARMACEUTICALS INC | 30233M107 | COM | 243,790 | $695,000 | thousands by filing date | |
| Transition Therapeutics, Inc. | 893716209 | COM | 382,600 | $685,000 | thousands by filing date | |
| VIGGLE INC | 92672V204 | COM NEW | 812,687 | $666,000 | thousands by filing date | |
| DBV TECHNOLOGIES S A | 23306J101 | ADR | 18,541 | $660,000 | thousands by filing date | |
| Adobe Systems Inc | 98979H103 | COM | 163,365 | $647,000 | thousands by filing date | |
| COLLABRX INC | 19422J108 | COM | 920,375 | $635,000 | thousands by filing date | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 23,387 | $624,000 | thousands by filing date | |
| TETRAPHASE PHARMACEUTICALS INC | 88165N105 | COMMON STOCK | 81,185 | $606,000 | thousands by filing date | |
| OVASCIENCE INC | 69014Q901 | CALL | 692 | $588,000 | thousands by filing date | call |
| CYMABAY THERAPEUTICS INC | 23257D103 | COM | 293,294 | $569,000 | thousands by filing date | |
| OPHTHOTECH CORP | 683745903 | CALL | 140 | $567,000 | thousands by filing date | call |
| ESPERION THERAPEUTICS INC NEW COM | 29664W105 | Stock | 23,990 | $566,000 | thousands by filing date | |
| RELYPSA INC | 759531906 | Cmn | 300 | $555,000 | thousands by filing date | call |
| LEXICON PHARMACEUTICALS INC | 528872902 | COM NEW | 510 | $548,000 | thousands by filing date | call |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 6,809 | $547,000 | thousands by filing date | |
| ENTEROMEDICS INC | 29365M208 | COM NEW | 2,063,336 | $536,000 | thousands by filing date | |
| REGENERON PHARMACEUTICALS COM | 75886F107 | Stock | 1,150 | $535,000 | thousands by filing date | |
| BIOTIE THERAPIES OYJ | 09074D103 | SPONSORED ADR | 40,000 | $524,000 | thousands by filing date | |
| FIBROGEN INC | 31572Q808 | COM | 23,597 | $517,000 | thousands by filing date | |
| SUPERCONDUCTOR TECHNOLOGIES | 867931404 | COM PAR $0.001 | 796,934 | $494,000 | thousands by filing date | |
| STANDARD BIOTOOLS INC | 34385P908 | CALL | 3,617 | $488,000 | thousands by filing date | call |
| SYNERGY PHARMACEUTICALS DEL | 871639118 | *W EXP 12/06/201 | 291,206 | $486,000 | thousands by filing date | |
| PROGENICS PHARMACEUTICAL INC CMN STOCK | 743187906 | Cmn | 840 | $480,000 | thousands by filing date | call |
| ARBUTUS BIOPHARMA CORP | 03879J900 | COM | 787 | $479,000 | thousands by filing date | call |
| PORTOLA PHARMACEUTICALS INC COM | 737010108 | Stock | 11,201 | $477,000 | thousands by filing date | |
| BELLICUM PHARMACEUTICALS INC | 079481957 | PUT | 325 | $472,000 | thousands by filing date | put |
| ANTARES PHARMA INC. COMMON STOCK | 036642906 | Cmn | 2,742 | $466,000 | thousands by filing date | call |
| OMEROS CORP | 682143102 | COM | 42,377 | $464,000 | thousands by filing date | |
| MEI PHARMA INC | 55279B202 | COM NEW | 295,491 | $464,000 | thousands by filing date | |
| IDERA PHARMACEUTICALS INC | 45168K306 | COM | 137,700 | $461,000 | thousands by filing date | |
| NOVO-NORDISK A S | 670100955 | ADR | 84 | $456,000 | thousands by filing date | put |
| CASTLIGHT HEALTH INC | 14862Q900 | CALL | 1,065 | $447,000 | thousands by filing date | call |
| BIODELIVERY SCIENCES INTL IN | 09060J956 | COM | 789 | $439,000 | thousands by filing date | put |
| AVALANCHE BIOTECHNOLOGIES INC | 05337G907 | COM | 530 | $437,000 | thousands by filing date | call |
| BIODEL INC | 09064M204 | COM | 983,670 | $433,000 | thousands by filing date | |
| MERRIMACK PHARMACEUTICALS IN | 590328900 | COM | 500 | $426,000 | thousands by filing date | call |
| INTREXON CORP | 46122T952 | PUT | 134 | $426,000 | thousands by filing date | put |
| UNIQURE NV | N90064951 | SHS | 208 | $425,000 | thousands by filing date | put |
| NEVRO CORP | 64157F103 | COM | 9,066 | $421,000 | thousands by filing date | |
| SESEN BIO, INC. | 286221106 | COM | 171,541 | $413,000 | thousands by filing date | |
| VITAL THERAPIES INC | 92847R954 | PUT | 1,000 | $404,000 | thousands by filing date | put |
| ROCKWELL MEDICAL INC | 774374952 | Cmn | 494 | $381,000 | thousands by filing date | put |
| AERIE PHARMACEUTICALS INC | 00771V908 | CALL | 215 | $381,000 | thousands by filing date | call |
| CYTRX CORP | 232828509 | COM PAR $.001 | 159,584 | $378,000 | thousands by filing date | |
| IDERA PHARMACEUTICALS INC | 45168K956 | COM NEW | 1,111 | $372,000 | thousands by filing date | put |
| ROCKWELL MED INC | 774374102 | COM | 46,469 | $358,000 | thousands by filing date | |
| PERSEON CORP | 715270112 | Wt | 1,743,292 | $355,000 | thousands by filing date | |
| AFFIMED N V | N01045108 | COM | 56,773 | $350,000 | thousands by filing date | |
| GLOBUS MED INC CL A | 379577208 | Stock | 16,700 | $345,000 | thousands by filing date | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 21,950 | $320,000 | thousands by filing date | |
| ZELTIQ AESTHETICS INC | 98933Q108 | COM | 10,000 | $320,000 | thousands by filing date | |
| PTC THERAPEUTICS INC | 69366J950 | PUT | 119 | $318,000 | thousands by filing date | put |
| OXIGENE INC | 691828404 | COM PAR$.001 | 328,431 | $305,000 | thousands by filing date | |
| ACELRX PHARMACEUTICALS INC | 00444T100 | COM | 98,602 | $301,000 | thousands by filing date | |
| NANOSPHERE INC COM NEW | 63009F204 | Stock | 181,946 | $297,000 | thousands by filing date | |
| VALEANT PHARMACEUTICALS INTE | 91911K952 | COM | 16 | $285,000 | thousands by filing date | put |
| LEXICON PHARMACEUTICALS INC | 528872952 | COM NEW | 260 | $279,000 | thousands by filing date | put |
| CONATUS PHARMACEUTICALS INC | 20600T108 | COM | 62,500 | $278,000 | thousands by filing date | |
| PIERIS PHARMACEUTICALS INC | 720795103 | COM | 150,708 | $276,000 | thousands by filing date | |
| AXOVANT SCIENCES LTD | G0750W104 | COM | 21,053 | $272,000 | thousands by filing date | |
| RAPTOR PHARMACEUTICAL CORP | 75382F956 | Cmn | 436 | $264,000 | thousands by filing date | put |
| ALKERMES PLC | G01767105 | SHS | 537 | $260,000 | thousands by filing date | call |
| NEURODERM LTD | M74231107 | ORD SHS | 12,416 | $257,000 | thousands by filing date | |
| BIOLASE INC | 090911108 | COMMON STOCK | 283,231 | $255,000 | thousands by filing date | |
| BIODELIVERY SCIENCES INTL IN | 09060J906 | COM | 458 | $255,000 | thousands by filing date | call |
| INFINITY PHARMACEUTICALS INC | 45665G303 | COM | 30,000 | $254,000 | thousands by filing date | |
| INFINITY PHARMACEUTICALS INC | 45665G953 | Cmn | 300 | $254,000 | thousands by filing date | put |
| CELLDEX THERAPEUTICS INC | 15117B953 | Cmn | 238 | $251,000 | thousands by filing date | put |
| AVALANCHE BIOTECHNOLOGIES IN | 05337G957 | COM | 300 | $247,000 | thousands by filing date | put |
| MACROGENICS INC | 556099909 | COM | 114 | $244,000 | thousands by filing date | call |
| IMMUNE DESIGN CORP. | 45252L103 | Common Stock | 20,000 | $244,000 | thousands by filing date | |
| CASI PHARMACEUTICALS INC | 14757U109 | COM | 202,536 | $217,000 | thousands by filing date | |
| AMARIN CORPORATION PLC -ADR | 023111906 | ADR | 1,118 | $216,000 | thousands by filing date | put |
| PEREGRINE PHARMACEUTICALS IN | 713661304 | COM NEW | 10,907 | $215,000 | thousands by filing date | |
| LPATH INC-CLASS A | 548910306 | CMN | 1,086,171 | $213,000 | thousands by filing date | |
| VALEANT PHARMACEUTICALS INTL | 91911K102 | COM | 1,171 | $209,000 | thousands by filing date | |
| EYEGATE PHARMACEUTICALS INC | 30233M115 | *W EXP 08/05/202 | 200,000 | $204,000 | thousands by filing date | |
| APPLIED DNA SCIENCES INC | 03815U110 | *W EXP 11/21/201 | 63,310 | $196,000 | thousands by filing date | |
| PERSEON CORP | 715270203 | Cmn | 569,985 | $177,000 | thousands by filing date | |
| MANNKIND CORP | 56400P201 | COM | 53,800 | $173,000 | thousands by filing date | |
| OCULAR THERAPEUTIX INC | 67576A900 | COM | 115 | $162,000 | thousands by filing date | call |
| EXELIXIS INC | 30161Q954 | COM | 280 | $157,000 | thousands by filing date | put |
| VITAL THERAPIES INC | 92847R104 | COM | 38,700 | $156,000 | thousands by filing date | |
| INSPIREMD INC | 45779A309 | COM | 927,876 | $153,000 | thousands by filing date | |
| HEAT BIOLOGICS INC | 42237K102 | COM | 32,201 | $149,000 | thousands by filing date | |
| BENITEC BIOPHARMA LTD | 082053117 | *W EXP 08/14/202 | 391,826 | $143,000 | thousands by filing date | |
| SKYSTAR BIO-PHARMA CO | 830884300 | COM PAR $.001 | 147,926 | $141,000 | thousands by filing date | |
| CELSION CORPORATION COM PAR | 15117N404 | Stock | 76,805 | $128,000 | thousands by filing date | |
| SANGAMO THERAPEUTICS INC | 800677906 | CALL | 215 | $121,000 | thousands by filing date | call |
| ENDOCYTE INC | 29269A102 | COM | 26,423 | $121,000 | thousands by filing date | |
| ACTINIUM PHARMACEUTICALS INC | 00507W107 | COM | 68,427 | $121,000 | thousands by filing date | |
| ADAPTIMMUNE THERAPEUTICS PLC | 00653A107 | SPONDS ADR | 10,004 | $120,000 | thousands by filing date | |
| Ocugen | 43358V109 | Common | 27,505 | $110,000 | thousands by filing date | |
| VITAL THERAPIES INC | 92847R904 | CALL | 250 | $101,000 | thousands by filing date | call |
| CELSION CORPORATION | 15117N954 | COM PAR | 546 | $91,000 | thousands by filing date | put |
| APRICUS BIOSCIENCES INC | 03832V959 | Cmn | 605 | $88,000 | thousands by filing date | put |
| ORAMED PHARMACEUTICALS INC | 68403P203 | COM NEW | 10,558 | $58,000 | thousands by filing date | |
| ACELRX PHARMACEUTICALS INC | 00444T950 | COM | 186 | $57,000 | thousands by filing date | put |
| KERYX BIOPHARMACEUTICALS INC CMN STK | 492515951 | Cmn | 158 | $56,000 | thousands by filing date | put |
| PLURISTEM THERAPEUTICS INC COMMON STOCK | 72940R952 | Cmn | 292 | $53,000 | thousands by filing date | put |
| ACELRX PHARMACEUTICALS INC | 00444T900 | COM | 172 | $52,000 | thousands by filing date | call |
| INTELLIPHARMACEUTICS INTL IN | 458173951 | PUT | 187 | $47,000 | thousands by filing date | put |
| OPEXA THERAPEUTICS INC | 68372T129 | *W EXP 04/13/201 | 382,765 | $46,000 | thousands by filing date | |
| XOMA CORP | 98419J907 | Cmn | 500 | $38,000 | thousands by filing date | call |
| CHINA MOBILE LTD-SPON ADR | 16941M909 | COM | 481 | $19,000 | thousands by filing date | call |
| APRICUS BIOSCIENCES INC | 03832V109 | COM | 12,176 | $18,000 | thousands by filing date | |
| BIO PATH HOLDINGS INC | 09057N102 | COM | 14,873 | $17,000 | thousands by filing date | |
| BIODEL INC | 09064M954 | Cmn | 182 | $8,000 | thousands by filing date | put |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001144204-15-065626 | this filing | 2015-11-16 | acceptance time not in the bulk data set |