13F-HR filed by BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP filed this 13F-HR for the quarter ended 2014-12-31, filed 2015-02-17, with 121 holding rows worth $9,797,208,000.
- Accession
- 0001144204-15-010112
- Filer
- CIK 1263508
- Filed
- 2015-02-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2014
A holdings report, 121 entries on the cover page, a total value of $9,797,208,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $9,797,208,000 with VALUE read as thousands by filing date, 13F file number 028-10519. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| PHARMACYCLICS INC | 716933106 | COM | 9,129,231 | $1,116,140,000 | thousands by filing date | |
| INCYTE CORP COM | 45337C102 | Stock | 14,845,559 | $1,085,359,000 | thousands by filing date | |
| SYNAGEVA BIOPHARMA CORP | 87159A103 | COM | 10,660,432 | $989,182,000 | thousands by filing date | |
| SEATTLE GENETICS INC | 812578102 | COM | 27,861,720 | $895,197,000 | thousands by filing date | |
| AVANIR PHARMACEUTICALS INC | 05348P401 | CL A NEW | 38,513,713 | $652,807,000 | thousands by filing date | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 20,481,442 | $650,286,000 | thousands by filing date | |
| SALIX PHARMACEUTICALS INC SR NT CONV DTD 6/3/2010 2.75% 5/15/2015 | 795435AC0 | CONVERTIBLE | 219,440,000 | $542,741,000 | thousands by filing date | principal |
| GENOMIC HEALTH, INC. | 37244C101 | COM | 13,656,318 | $436,592,000 | thousands by filing date | |
| Incyte Corporation | 45337CAL6 | NOTE 1.25% 11/15/2020 | 274,500,000 | $421,613,000 | thousands by filing date | principal |
| Incyte Corporation | 45337CAK8 | NOTE 0.375% 11/15/2018 | 259,000,000 | $388,039,000 | thousands by filing date | principal |
| INCYTE CORP | 45337CAJ1 | NOTE 4.750%10/0 | 40,446,000 | $336,182,000 | thousands by filing date | principal |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 3,713,950 | $335,741,000 | thousands by filing date | |
| ANACOR PHARMACEUTICALS INC | 032420101 | COM | 4,204,702 | $135,602,000 | thousands by filing date | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 10,713,686 | $130,278,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061GAD3 | CNV | 22,898,000 | $102,104,000 | thousands by filing date | principal |
| BELLICUM PHARMACEUTICALS INC | 079481107 | COM | 4,283,732 | $98,697,000 | thousands by filing date | |
| GILEAD SCIENCES INC | 375558AP8 | CORPORATE OBLIG | 21,500,000 | $88,977,000 | thousands by filing date | principal |
| DYAX CORP | 26746E103 | COM | 6,157,789 | $86,579,000 | thousands by filing date | |
| CERUS CORP | 157085101 | COM | 11,702,727 | $73,025,000 | thousands by filing date | |
| SALIX PHARMACEUTICALS INC | 795435106 | COM | 635,321 | $73,024,000 | thousands by filing date | |
| ACORDA THERAPEUTICS INC | 00484MAA4 | NOTE 1.750% 6/1 | 60,900,000 | $69,839,000 | thousands by filing date | principal |
| MEDIVATION INC | 58501NAA9 | NOTE | 34,720,000 | $67,334,000 | thousands by filing date | principal |
| VANDA PHARMACEUTICALS INC | 921659108 | COM | 4,472,153 | $64,041,000 | thousands by filing date | |
| XOMA CORP DEL | 98419J107 | COM | 16,924,013 | $60,757,000 | thousands by filing date | |
| XENOPORT INC | 98411C100 | COM | 6,903,628 | $60,545,000 | thousands by filing date | |
| VERSARTIS INC | 92529L102 | COM | 2,281,744 | $51,225,000 | thousands by filing date | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 2,380,074 | $44,079,000 | thousands by filing date | |
| DBV TECHNOLOGIES S A | 23306J101 | ADR | 1,519,229 | $41,201,000 | thousands by filing date | |
| PROGENICS PHARMACEUTICALS IN | 743187106 | COM | 4,449,797 | $33,640,000 | thousands by filing date | |
| DERMA SCIENCES INC | 249827502 | COM PAR $.01 | 3,537,137 | $32,931,000 | thousands by filing date | |
| TG THERAPEUTICS INC COM | 88322Q108 | Stock | 2,050,313 | $32,477,000 | thousands by filing date | |
| ACORDA THERAPEUTICS INC | 00484M106 | COM | 755,534 | $30,879,000 | thousands by filing date | |
| SALIX PHARMACEUTICAL 1.500 | 795435AE6 | NOTE 1.500% 3/ | 15,000,000 | $27,339,000 | thousands by filing date | principal |
| HALOZYME THERAPEUTICS INC COM | 40637H109 | Stock | 2,776,143 | $26,790,000 | thousands by filing date | |
| HERON THERAPEUTICS INC | 427746102 | COM | 2,607,784 | $26,234,000 | thousands by filing date | |
| Gilead Sciences,Inc. | 375558103 | COM | 256,108 | $24,141,000 | thousands by filing date | |
| CATALYST PHARMACEUTICALS INC | 14888U101 | COM | 6,715,462 | $19,945,000 | thousands by filing date | |
| REPROS THERAPEUTICS INC | 76028H209 | COM | 2,000,000 | $19,940,000 | thousands by filing date | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 163,393 | $18,307,000 | thousands by filing date | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 1,107,850 | $17,138,000 | thousands by filing date | |
| OMEROS CORP | 682143102 | COM | 648,101 | $16,060,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061GAE1 | NOTE 0.750%10/1 | 12,500,000 | $14,715,000 | thousands by filing date | principal |
| SANGAMO THERAPEUTICS INC | 800677106 | COM | 955,332 | $14,531,000 | thousands by filing date | |
| BLUEBIRD BIO INC | 09609G100 | COM | 150,000 | $13,758,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 554,590 | $12,390,000 | thousands by filing date | |
| CLOVIS ONCOLOGY INC | 189464100 | COM | 202,630 | $11,347,000 | thousands by filing date | |
| MACROGENICS INC | 556099109 | COM | 311,891 | $10,938,000 | thousands by filing date | |
| KYTHERA BIOPHARMACEUTICALS I | 501570105 | COM | 286,255 | $9,927,000 | thousands by filing date | |
| XENCOR INC | 98401F105 | COMMON STOCK | 591,371 | $9,486,000 | thousands by filing date | |
| ARROWHEAD RESEARCH CORP | 042797209 | COM | 1,230,802 | $9,083,000 | thousands by filing date | |
| AQUINOX PHARMACEUTICALS INC | 03842B101 | COM | 1,210,350 | $9,078,000 | thousands by filing date | |
| AERIE PHARMACEUTICALS INC | 00771V108 | COM | 299,356 | $8,738,000 | thousands by filing date | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 400,000 | $8,668,000 | thousands by filing date | |
| OSIRIS THERAPEUTICS INC NEW | 68827R108 | COM | 510,606 | $8,165,000 | thousands by filing date | |
| SUNESIS PHARMACEUTICALS INC | 867328601 | COM NEW | 3,200,000 | $8,160,000 | thousands by filing date | |
| LA JOLLA PHARMACEUTICAL CO | 503459604 | COM PAR $.0001 2 | 421,631 | $7,779,000 | thousands by filing date | |
| TEKMIRA PHARMACEUTICALS COR | 87911B209 | COM NEW | 484,156 | $7,335,000 | thousands by filing date | |
| CELLADON CORP | 15117E107 | Cmn | 375,000 | $7,324,000 | thousands by filing date | |
| NOVAVAX INC | 670002104 | COMMON STOCK | 1,223,362 | $7,255,000 | thousands by filing date | |
| IDERA PHARMACEUTICALS INC | 45168K306 | COM | 1,628,172 | $7,181,000 | thousands by filing date | |
| FOAMIX PHARMACEUTICALS LTD | M46135105 | SHS | 1,021,600 | $7,161,000 | thousands by filing date | |
| CHIMERIX INC COM | 16934W106 | Stock | 172,414 | $6,941,000 | thousands by filing date | |
| THRESHOLD PHARMACEUTICAL INC | 885807206 | COM NEW | 2,155,516 | $6,855,000 | thousands by filing date | |
| ARRAY BIOPHARMA INC COM | 04269X105 | Stock | 1,433,797 | $6,782,000 | thousands by filing date | |
| CONCERT PHARMACEUTICALS INC | 206022105 | COM | 505,418 | $6,732,000 | thousands by filing date | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 150,000 | $6,582,000 | thousands by filing date | |
| QLT INC | 746927102 | COMMON STOCK | 1,535,863 | $6,159,000 | thousands by filing date | |
| ISIS PHARMACEUTICALS INC | 464330109 | COM | 96,303 | $5,946,000 | thousands by filing date | |
| STEMLINE THERAPEUTICS INC | 85858C107 | COM | 338,671 | $5,778,000 | thousands by filing date | |
| ACHILLION PHARMACEUTICALS IN | 00448Q201 | COM | 438,337 | $5,370,000 | thousands by filing date | |
| IRONWOOD PHARMACEUTICALS INC | 46333X108 | COMMON STOCK | 346,160 | $5,303,000 | thousands by filing date | |
| INFINITY PHARMACEUTICALS INC | 45665G303 | COM | 312,025 | $5,270,000 | thousands by filing date | |
| JUNO THERAPEUTICS INC | 48205A109 | COM | 100,000 | $5,222,000 | thousands by filing date | |
| Mallinckrodt Plc | G5785G107 | SHS | 46,666 | $4,621,000 | thousands by filing date | |
| ALDER BIOPHARMACEUTICALS INC | 014339105 | COM | 153,350 | $4,461,000 | thousands by filing date | |
| DISCOVERY LABORATORIES INC N | 254668403 | COM NEW | 3,652,117 | $4,236,000 | thousands by filing date | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 481,697 | $4,008,000 | thousands by filing date | |
| IGNYTA INC | 451731103 | COM | 571,000 | $3,911,000 | thousands by filing date | |
| LIGAND PHARMACEUTICALS INC | 53220K504 | COM NEW | 73,400 | $3,906,000 | thousands by filing date | |
| ENANTA PHARMACEUTICALS INC | 29251M106 | COM | 75,357 | $3,832,000 | thousands by filing date | |
| EPIZYME INC | 29428V104 | COM | 201,963 | $3,811,000 | thousands by filing date | |
| CYTRX CORP | 232828509 | COM PAR $.001 | 1,350,000 | $3,699,000 | thousands by filing date | |
| KARYOPHARM THERAPEUTICS INC | 48576U106 | COM | 94,095 | $3,522,000 | thousands by filing date | |
| NEURODERM LTD | M74231107 | ORD SHS | 250,000 | $3,510,000 | thousands by filing date | |
| CELSUS THERAPEUTICS PLC | 15119A202 | COM | 673,887 | $3,235,000 | thousands by filing date | |
| ZOGENIX INC | 98978L105 | COM | 2,350,400 | $3,220,000 | thousands by filing date | |
| SYNERGY PHARMACEUTICALS DEL | 871639308 | COM NEW | 973,245 | $2,968,000 | thousands by filing date | |
| RECEPTOS, INC. | 756207106 | COMMON STOCK | 23,900 | $2,928,000 | thousands by filing date | |
| APTOSE BIOSCIENCES INC COM | 03835T200 | Stock | 479,164 | $2,833,000 | thousands by filing date | |
| Foundation Medicine Inc | 350465100 | COM | 126,147 | $2,803,000 | thousands by filing date | |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 75,000 | $2,745,000 | thousands by filing date | |
| MAST THERAPEUTICS INC | 576314108 | COM | 4,774,434 | $2,674,000 | thousands by filing date | |
| PROTALIX BIOTHERAPEUTICS INC | 74365AAB7 | NOTE 4.500% 9/1 | 3,500,000 | $2,645,000 | thousands by filing date | principal |
| LIPOCINE INC NEW | 53630X104 | CMN | 500,000 | $2,630,000 | thousands by filing date | |
| AURINIA PHARMACEUTICALS INC COM | 05156V102 | Stock | 727,669 | $2,599,000 | thousands by filing date | |
| BIODELIVERY SCIENCES INTL IN | 09060J106 | COM | 210,021 | $2,524,000 | thousands by filing date | |
| AFFIMED N V | N01045108 | COM | 400,000 | $2,480,000 | thousands by filing date | |
| BIOTA PHARMACEUTIALS INC | 090694100 | COM | 1,106,910 | $2,479,000 | thousands by filing date | |
| ORASURE TECHNOLOGIES INC | 68554V108 | COM | 234,664 | $2,379,000 | thousands by filing date | |
| MARINUS PHARMACEUTICALS INC | 56854Q101 | COM | 204,476 | $2,161,000 | thousands by filing date | |
| DERMIRA INC | 24983L104 | COM | 100,000 | $1,811,000 | thousands by filing date | |
| PROTEON THERAPEUTICS INC | 74371L109 | COM | 172,917 | $1,798,000 | thousands by filing date | |
| OPHTHOTECH CORP | 683745103 | COM | 36,776 | $1,650,000 | thousands by filing date | |
| MEDIWOUND LTD | M68830104 | ORD SHS | 225,000 | $1,499,000 | thousands by filing date | |
| PALATIN TECHNOLOGIES INC | 696077403 | COM PAR $ .01 | 2,050,000 | $1,497,000 | thousands by filing date | |
| Synta Pharmaceuticals Corp. | 87162T206 | COM | 500,000 | $1,325,000 | thousands by filing date | |
| GERON CORP | 374163103 | COM | 402,629 | $1,309,000 | thousands by filing date | |
| ACHAOGEN INC | 004449104 | COM | 100,000 | $1,305,000 | thousands by filing date | |
| LOXO ONCOLOGY INC | 548862101 | COM | 100,000 | $1,175,000 | thousands by filing date | |
| TESARO INC | 881569107 | COM | 31,218 | $1,161,000 | thousands by filing date | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 11,600 | $1,125,000 | thousands by filing date | |
| ACCELERON PHARMA INC | 00434H108 | COM | 28,765 | $1,121,000 | thousands by filing date | |
| RIGEL PHARMACEUTICALS INC | 766559603 | COMMON STOCK | 481,972 | $1,094,000 | thousands by filing date | |
| Alcobra Ltd | M2239P109 | SHS | 289,871 | $1,081,000 | thousands by filing date | |
| ZIOPHARM ONCOLOGY INC | 98973P101 | COM | 193,640 | $982,000 | thousands by filing date | |
| FIVE PRIME THERAPEUTICS INC. | 33830X104 | Common Stock | 19,823 | $535,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 30,672 | $454,000 | thousands by filing date | |
| CHEMOCENTRYX INC | 16383L106 | COM | 50,000 | $342,000 | thousands by filing date | |
| BIO GREEN MED SOL 6pcnt PFDCONV | 23254L207 | COMMON STOCK | 13,253 | $82,000 | thousands by filing date | |
| ASTERIAS BIOTHERAPEUTICS INC | 04624N107 | COM SER A | 16,775 | $54,000 | thousands by filing date | |
| BIOTIME INC | 09066L162 | W EXP 10/01/201 | 20,525 | $22,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001144204-15-010112 | this filing | 2015-02-17 | acceptance time not in the bulk data set |