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13F-HR filed by BAKER BROS. ADVISORS LP

BAKER BROS. ADVISORS LP filed this 13F-HR for the quarter ended 2013-06-30, filed 2013-08-14, with 75 holding rows worth $5,055,751,000.

Accession
0001144204-13-045967
Filed
2013-08-14
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q2 2013

A holdings report, 75 entries on the cover page, a total value of $5,055,751,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $5,055,751,000 with VALUE read as thousands by filing date, 13F file number 028-10519. The quarter's positions are built on this report. The resolved quarter.

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
PHARMACYCLICS INC716933106COM10,771,138$855,982,000thousands by filing date
SEATTLE GENETICS INC812578102COM19,322,947$607,900,000thousands by filing date
GENOMIC HEALTH, INC.37244C101COM13,650,835$432,868,000thousands by filing date
Incyte Genomics Notes 4.75% 10/1/201545337CAH5CONV BONDS157,758,000$401,692,000thousands by filing dateprincipal
SYNAGEVA BIOPHARMA CORP87159A103COM9,223,182$387,189,000thousands by filing date
ACADIA PHARMACEUTICALS INC004225108COM19,955,126$362,186,000thousands by filing date
SALIX PHARMACEUTICALS INC SR NT CONV DTD 6/3/2010 2.75% 5/15/2015795435AC0CONVERTIBLE219,440,000$334,029,000thousands by filing dateprincipal
INCYTE CORP COM45337C102Stock14,810,559$325,832,000thousands by filing date
VIROPHARMA INC928241108COMMON STOCK8,528,603$244,344,000thousands by filing date
AUXILIUM PHARMACEUTICALS INC05334DAA5NOTE 1.500% 7/191,590,000$88,098,000thousands by filing dateprincipal
XOMA CORP DEL98419J107COM20,274,581$73,597,000thousands by filing date
Gilead Sciences,Inc.375558103COM1,245,800$63,872,000thousands by filing date
BIOMARIN PHARMACEUTICAL INC09061GAD3CNV22,898,000$63,217,000thousands by filing dateprincipal
AEGERION PHARMACEUTICALS INC00767E102COM924,343$58,548,000thousands by filing date
HALOZYME THERAPEUTICS INC COM40637H109Stock6,553,150$52,098,000thousands by filing date
REPROS THERAPEUTICS INC76028H209COM2,778,654$51,266,000thousands by filing date
MEDIVATION INC58501NAA9NOTE39,500,000$50,054,000thousands by filing dateprincipal
GILEAD SCIENCES INC375558AP8CORPORATE OBLIG21,500,000$48,664,000thousands by filing dateprincipal
INTERMUNE INC45884XAF0NOTE 2.500%12/141,000,000$43,896,000thousands by filing dateprincipal
BIOMARIN PHARMACEUTICAL INC09061G101COM783,311$43,662,000thousands by filing date
CERUS CORP157085101COM8,455,306$37,372,000thousands by filing date
CLOVIS ONCOLOGY INC189464100COM525,113$35,172,000thousands by filing date
VANDA PHARMACEUTICALS INC921659108COM3,966,179$32,047,000thousands by filing date
ARIAD PHARMACEUTICALS INC04033A100COM1,450,000$25,361,000thousands by filing date
STEMLINE THERAPEUTICS INC85858C107COM900,000$21,456,000thousands by filing date
INTERCEPT PHARMACEUTICALS IN45845P108COM462,847$20,754,000thousands by filing date
MEDIVATION INC58501N101COM398,331$19,598,000thousands by filing date
PROGENICS PHARMACEUTICALS IN743187106COM4,200,000$18,732,000thousands by filing date
DERMA SCIENCES INC249827502COM PAR $.011,358,857$18,141,000thousands by filing date
Intermune Inc Notes 5% 3/1/1545884XAD5CONV BONDS16,860,000$17,756,000thousands by filing dateprincipal
AVANIR PHARMACEUTICALS INC05348P401CL A NEW3,578,591$16,462,000thousands by filing date
INFINITY PHARMACEUTICALS INC45665G303COM1,016,433$16,458,000thousands by filing date
QUESTCOR PHARMACEUTICALS INC74835Y101COM315,846$14,352,000thousands by filing date
SYNERGY PHARMACEUTICALS DEL871639308COM NEW2,608,271$11,268,000thousands by filing date
CHELSEA THERAPEUTICS INTL LT163428105COM4,775,787$10,984,000thousands by filing date
PORTOLA PHARMACEUTICALS INC COM737010108Stock399,914$9,826,000thousands by filing date
INSMED INC COM PAR $.01457669307Stock795,803$9,518,000thousands by filing date
IRONWOOD PHARMACEUTICALS INC46333X108COMMON STOCK922,160$9,157,000thousands by filing date
BIOCRYST PHARMACEUTICALS INC COM09058V103Stock5,563,615$8,623,000thousands by filing date
Threshold Pharma885807107COM1,595,048$8,390,000thousands by filing date
Synta Pharmaceuticals Corp.87162T206COM1,399,040$6,981,000thousands by filing date
ARRAY BIOPHARMA INC COM04269X105Stock1,500,000$6,810,000thousands by filing date
QLT INC746927102COMMON STOCK1,535,863$6,742,000thousands by filing date
ISIS PHARMACEUTICALS INC464330109COM247,036$6,638,000thousands by filing date
CHEMOCENTRYX INC16383L106COM375,000$5,303,000thousands by filing date
AMBIT BIOSCIENCES CORP02318X100COM747,962$5,236,000thousands by filing date
XENOPORT INC98411C100COM1,034,112$5,119,000thousands by filing date
Anacor Pharmaceuticals32420101 COM876,463$4,899,000thousands by filing dateThe CUSIP as filed is malformed.
PROTHENA CORP PLC SHSG72800108Stock369,650$4,772,000thousands by filing date
KYTHERA BIOPHARMACEUTICALS I501570105COM165,000$4,463,000thousands by filing date
ACHILLION PHARMACEUTICALS IN00448Q201COM455,000$3,722,000thousands by filing date
PUMA BIOTECHNOLOGY INC74587V107COMMON STOCK83,333$3,697,000thousands by filing date
MEI Pharma, Inc.55279B103COM515,612$3,677,000thousands by filing date
BIODELIVERY SCIENCES INTL IN09060J106COM900,505$3,656,000thousands by filing date
ZOGENIX INC98978L105COM2,001,000$3,422,000thousands by filing date
SALIX PHARMACEUTICALS INC795435106COM45,571$3,015,000thousands by filing date
IDERA PHARMACEUTICALS INC45168K306COM4,500,000$2,948,000thousands by filing date
VENTRUS BIOSCIENCES INC922822101COM1,215,840$2,918,000thousands by filing date
LIGAND PHARMACEUTICALS INC53220K207COM73,400$2,745,000thousands by filing date
DISCOVERY LABORATORIES INC N254668403COM NEW1,518,617$2,308,000thousands by filing date
ENANTA PHARMACEUTICALS INC29251M106COM125,000$2,214,000thousands by filing date
ARQULE INC04269E107COM879,805$2,041,000thousands by filing date
CYTRX CORP232828509COM PAR $.0011,000,000$2,000,000thousands by filing date
RECEPTOS, INC.756207106COMMON STOCK100,000$1,989,000thousands by filing date
GERON CORP374163103COM1,000,000$1,500,000thousands by filing date
AMICUS THERAPEUTICS INC03152W109COM515,072$1,200,000thousands by filing date
TESARO INC881569107COM31,218$1,022,000thousands by filing date
BIODEL INC09064M204COM229,885$961,000thousands by filing date
ORASURE TECHNOLOGIES INC68554V108COM243,467$945,000thousands by filing date
LPATH INC-CLASS A548910306CMN200,000$880,000thousands by filing date
EPIZYME INC29428V104COM20,000$563,000thousands by filing date
ZIOPHARM ONCOLOGY INC98973P101COM254,199$536,000thousands by filing date
CUBIST PHARMACEUTICALS INC229678107COM5,000$241,000thousands by filing date
BIO GREEN MED SOL 6pcnt PFDCONV23254L207COMMON STOCK20,979$151,000thousands by filing date
Aradigm Corp.038505301COM100,000$16,000thousands by filing date

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001144204-13-045967this filing2013-08-14acceptance time not in the bulk data set