13F-HR filed by BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP filed this 13F-HR for the quarter ended 2023-12-31, filed 2024-02-14, with 84 holding rows worth $8,788,600,529.
- Accession
- 0001104659-24-024053
- Filer
- CIK 1263508
- Filed
- 2024-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2023
A holdings report, 84 entries on the cover page, a total value of $8,788,600,529 stated on the cover page (in dollars after the unit check, H1), rows summing to $8,788,600,529 with VALUE read as dollars as filed, 13F file number 028-10519. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| INCYTE CORP COM | 45337C102 | Stock | 36,179,122 | $2,271,687,070 | dollars as filed | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 10,568,897 | $1,906,206,263 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 42,864,612 | $1,342,091,002 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 1,969,798 | $455,771,861 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 6,398,365 | $294,132,839 | dollars as filed | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 4,121,440 | $242,134,600 | dollars as filed | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 2,520,731 | $172,216,342 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 5,995,928 | $152,656,327 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 5,148,657 | $147,663,483 | dollars as filed | |
| Invitae Corporation | 46185LAD5 | Notes 1.5% 4/1/2028 | 300,000,000 | $131,152,500 | dollars as filed | principal |
| ABCELLERA BIOLOGICS INC COM | 00288U106 | Stock | 22,909,753 | $130,814,690 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 7,593,024 | $85,269,660 | dollars as filed | |
| REPLIMUNE GROUP INC | 76029N106 | COMMON STOCK | 9,545,336 | $80,467,182 | dollars as filed | |
| ENTRADA THERAPEUTICS INC COM | 29384C108 | Stock | 4,865,819 | $73,425,209 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 1,466,547 | $70,130,278 | dollars as filed | |
| CEREVEL THERAPEUTICS HLDNG I | 15678U128 | COM | 1,600,000 | $67,840,000 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 5,838,853 | $61,483,122 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 10,126,176 | $60,655,794 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 151,215 | $57,526,722 | dollars as filed | |
| DENALI THERAPEUTICS INC COM | 24823R105 | Stock | 2,607,196 | $55,950,426 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 2,368,378 | $55,301,626 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 17,310,490 | $52,623,890 | dollars as filed | |
| KINIKSA PHARMACEUTICALS LTD | G5269C101 | COM CL A | 2,809,577 | $49,279,981 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 993,679 | $45,768,855 | dollars as filed | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 10,123,824 | $43,228,728 | dollars as filed | |
| CERUS CORP | 157085101 | COM | 19,477,339 | $42,071,052 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 3,882,125 | $40,063,530 | dollars as filed | |
| AEROVATE THERAPEUTICS INC | 008064107 | COM | 1,680,517 | $38,030,100 | dollars as filed | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 1,062,123 | $37,790,336 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 3,112,786 | $34,053,879 | dollars as filed | |
| SERA PROGNOSTICS INC | 81749D107 | CMN | 5,434,399 | $32,497,706 | dollars as filed | |
| BICYCLE THERAPEUTICS PLC-ADR | 088786108 | SPONSORED ADS | 1,790,390 | $32,370,251 | dollars as filed | |
| IGM BIOSCIENCES INC | 449585108 | COM | 3,691,011 | $30,672,301 | dollars as filed | |
| BIOMEA FUSION INC | 09077A106 | CMN | 2,108,949 | $30,621,939 | dollars as filed | |
| MONTE ROSA THERAPEUTICS INC | 61225M102 | COM | 4,916,095 | $27,775,937 | dollars as filed | |
| VERVE THERAPEUTICS INC | 92539P101 | COM | 1,691,530 | $23,579,928 | dollars as filed | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 169,934 | $21,082,012 | dollars as filed | |
| GRACELL BIOTECHNOLOGIES INC | 38406L103 | ADR | 2,080,000 | $20,883,200 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 425,009 | $17,905,629 | dollars as filed | |
| Tscan Therapeutics Inc | 89854M101 | COM | 2,784,792 | $16,235,337 | dollars as filed | |
| Day One Biopharmaceuticals Inc | 23954D109 | Common Stock | 1,000,000 | $14,600,000 | dollars as filed | |
| DBV TECHNOLOGIES S A | 23306J101 | ADR | 14,614,264 | $13,924,471 | dollars as filed | |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 1,160,117 | $12,772,888 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 2,006,451 | $10,995,351 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 2,030,134 | $10,678,505 | dollars as filed | |
| 2SEVENTY BIO INC COMMON STOCK | 901384107 | Stock | 2,497,526 | $10,664,436 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 343,000 | $10,629,570 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 247,644 | $9,821,561 | dollars as filed | |
| PRIME MEDICINE INC | 74168J101 | COM | 1,028,466 | $9,112,209 | dollars as filed | |
| NEUROGENE INC | 64135M105 | COMMON STOCK | 453,516 | $8,789,140 | dollars as filed | |
| ADAPTIMMUNE THERAPEUTICS PLC | 00653A107 | SPONDS ADR | 10,969,282 | $8,698,641 | dollars as filed | |
| SANA BIOTECHNOLOGY INC | 799566104 | COM | 2,000,000 | $8,160,000 | dollars as filed | |
| SAGIMET BIOSCIENCES INC A | 786700104 | COMMON STOCK | 1,456,518 | $7,894,328 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 535,478 | $7,801,914 | dollars as filed | |
| ATHIRA PHARMA INC | 04746L104 | COM | 3,153,807 | $7,663,751 | dollars as filed | |
| OPTHEA LTD | 68386J208 | SPONSORED ADS | 2,588,645 | $7,636,503 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 750,000 | $7,425,000 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 4,004,756 | $7,088,418 | dollars as filed | |
| HOOKIPA PHARMA INC | 43906K100 | COM | 8,128,151 | $6,583,802 | dollars as filed | |
| Invitae Corporation | 46185LAH6 | Series A Notes 4.5% 3/15/2028 | 9,274,000 | $6,272,702 | dollars as filed | principal |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 190,476 | $5,622,852 | dollars as filed | |
| XENCOR INC | 98401F105 | COMMON STOCK | 245,431 | $5,210,500 | dollars as filed | |
| CYPHERPUNK TECHNOLOGIES INC | 52187K200 | COM NEW | 1,172,175 | $4,858,665 | dollars as filed | |
| DESIGN THERAPEUTICS INC | 25056L103 | COM | 1,500,000 | $3,975,000 | dollars as filed | |
| TALIS BIOMEDICAL CORP | 87424L207 | COM NEW | 508,323 | $3,787,006 | dollars as filed | |
| PERSPECTIVE THERAPEUTICS INC | 46489V104 | COM | 7,639,703 | $3,071,161 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 48,885 | $3,069,978 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W108 | COM | 131,533 | $2,930,555 | dollars as filed | |
| CENTURY THERAPEUTICS INC | 15673T100 | COM | 797,460 | $2,647,567 | dollars as filed | |
| Mersana Therapeutics Inc | 59045L106 | Common Stock | 1,086,115 | $2,519,787 | dollars as filed | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 1,557,630 | $2,429,903 | dollars as filed | |
| ACHILLES THERAPEUTICS PL-ADR | 00449L102 | COM | 2,102,792 | $1,869,382 | dollars as filed | |
| KALA BIO INC | 483119202 | COM NEW | 266,613 | $1,866,291 | dollars as filed | |
| ALIGOS THERAPEUTICS INC COM NEW | 01626L105 | Stock | 2,076,400 | $1,378,730 | dollars as filed | |
| INVITAE CORP | 46185L103 | COM | 1,764,546 | $1,106,017 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 35,000 | $1,007,650 | dollars as filed | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 322,024 | $998,274 | dollars as filed | |
| WHITEHAWK THERAPEUTICS INC | 00032Q104 | CMN | 251,727 | $508,489 | dollars as filed | |
| PROTARA THERAPEUTICS INC | 74365U107 | COM STK | 199,671 | $374,403 | dollars as filed | |
| CABALETTA BIO INC | 12674W109 | COMMON STOCK | 13,331 | $302,614 | dollars as filed | |
| FOGHORN THERAPEUTICS INC | 344174107 | COMMON STOCK | 45,027 | $290,424 | dollars as filed | |
| ATRECA INC | 04965G109 | COM | 2,177,499 | $287,430 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 10,607 | $146,907 | dollars as filed | |
| SURROZEN INC | 86889P117 | *W EXP 08/01/203 | 833,333 | $16,167 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-24-024053 | this filing | 2024-02-14 | acceptance time not in the bulk data set |