13F-HR filed by BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP filed this 13F-HR for the quarter ended 2022-12-31, filed 2023-02-14, with 113 holding rows worth $16,651,382,602.
- Accession
- 0001104659-23-021551
- Filer
- CIK 1263508
- Filed
- 2023-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2022
A holdings report, 113 entries on the cover page, a total value of $16,651,382,602 stated on the cover page (in dollars after the unit check, H1), rows summing to $16,651,382,602 with VALUE read as dollars as filed, 13F file number 028-10519. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SEAGEN INC | 81181C104 | COM | 46,912,266 | $6,028,695,304 | dollars as filed | |
| INCYTE CORP COM | 45337C102 | Stock | 36,154,971 | $2,903,967,271 | dollars as filed | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 11,668,897 | $2,566,457,206 | dollars as filed | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 7,620,494 | $788,644,924 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 41,923,486 | $667,421,897 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 4,954,855 | $605,136,441 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 1,545,113 | $448,469,048 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 6,354,608 | $185,046,185 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 12,710,818 | $145,920,191 | dollars as filed | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 2,520,731 | $143,858,118 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 2,368,378 | $129,787,114 | dollars as filed | |
| REPLIMUNE GROUP INC | 76029N106 | COMMON STOCK | 4,578,280 | $124,529,216 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 17,310,490 | $123,943,108 | dollars as filed | |
| HORIZON THERAPEUTICS PLC | G46188101 | SHS | 969,727 | $110,354,933 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 280,159 | $106,132,634 | dollars as filed | |
| ABCELLERA BIOLOGICS INC COM | 00288U106 | Stock | 10,450,180 | $105,860,323 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 2,879,825 | $71,880,432 | dollars as filed | |
| CHINOOK THERAPEUTICS INC | 16961L106 | COM | 2,534,102 | $66,393,472 | dollars as filed | |
| ENTRADA THERAPEUTICS INC COM | 29384C108 | Stock | 4,865,819 | $65,785,873 | dollars as filed | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 1,409,784 | $63,877,313 | dollars as filed | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 10,123,824 | $61,147,897 | dollars as filed | |
| CERUS CORP | 157085101 | COM | 16,067,558 | $58,646,587 | dollars as filed | |
| AEROVATE THERAPEUTICS INC | 008064107 | COM | 1,976,868 | $57,922,232 | dollars as filed | |
| IGM BIOSCIENCES INC | 449585108 | COM | 3,156,102 | $53,685,295 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 5,187,081 | $45,179,476 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 3,882,125 | $42,625,733 | dollars as filed | |
| KINIKSA PHARMACEUTICALS LTD | G5269C101 | COM CL A | 2,799,577 | $41,937,663 | dollars as filed | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 1,528,538 | $39,757,273 | dollars as filed | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 1,668,355 | $30,314,010 | dollars as filed | |
| DENALI THERAPEUTICS INC COM | 24823R105 | Stock | 1,088,738 | $30,277,804 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 751,639 | $29,637,126 | dollars as filed | |
| VERVE THERAPEUTICS INC | 92539P101 | COM | 1,416,530 | $27,409,856 | dollars as filed | |
| DICE THERAPEUTICS INC | 23345J104 | COM | 862,207 | $26,900,858 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 1,225,255 | $25,767,113 | dollars as filed | |
| BICYCLE THERAPEUTICS PLC-ADR | 088786108 | SPONSORED ADS | 843,814 | $24,976,894 | dollars as filed | |
| ANAPTYSBIO INC | 032724106 | COM | 775,924 | $24,045,885 | dollars as filed | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 302,716 | $23,981,162 | dollars as filed | |
| DBV TECHNOLOGIES S A | 23306J101 | ADR | 14,614,264 | $22,359,824 | dollars as filed | |
| FIBROGEN INC | 31572Q808 | COM | 1,375,211 | $22,030,880 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 470,974 | $21,820,225 | dollars as filed | |
| HERON THERAPEUTICS INC | 427746102 | COM | 8,131,678 | $20,329,195 | dollars as filed | |
| 2SEVENTY BIO INC COMMON STOCK | 901384107 | Stock | 2,062,744 | $19,327,911 | dollars as filed | |
| INSMED INC | 457669AB5 | NOTE 0.750% 6/0 | 23,500,000 | $19,229,604 | dollars as filed | principal |
| PRIME MEDICINE INC | 74168J101 | COM | 1,028,466 | $19,108,898 | dollars as filed | |
| BIOMEA FUSION INC | 09077A106 | CMN | 2,104,559 | $17,741,432 | dollars as filed | |
| BLUEBIRD BIO INC | 09609G100 | COM | 2,499,715 | $17,298,028 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 2,006,451 | $17,115,027 | dollars as filed | |
| INVITAE CORP | 46185L103 | COM | 8,402,035 | $15,627,785 | dollars as filed | |
| OPTHEA LTD | 68386J208 | SPONSORED ADS | 2,691,391 | $14,425,856 | dollars as filed | |
| ADAPTIMMUNE THERAPEUTICS PLC | 00653A107 | SPONDS ADR | 9,830,877 | $14,353,080 | dollars as filed | |
| CYMABAY THERAPEUTICS INC | 23257D103 | COM | 2,170,464 | $13,608,809 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 1,708,472 | $13,428,590 | dollars as filed | |
| WHITEHAWK THERAPEUTICS INC | 00032Q104 | CMN | 989,928 | $12,700,776 | dollars as filed | |
| CABALETTA BIO INC | 12674W109 | COMMON STOCK | 1,344,000 | $12,432,000 | dollars as filed | |
| VERASTEM INC | 92337C104 | COM | 26,988,898 | $10,863,032 | dollars as filed | |
| ALTIMMUNE INC | 02155H200 | COM NEW | 653,562 | $10,751,095 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 1,108,913 | $10,235,267 | dollars as filed | |
| CINCOR PHARMA INC | 17240Y109 | COM | 807,212 | $9,920,635 | dollars as filed | |
| VOR BIOPHARMA INC | 929033108 | COM | 1,465,925 | $9,748,401 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 434,782 | $9,647,813 | dollars as filed | |
| PACIFIC BIOSCIENCES CALIF INC COM | 69404D108 | Stock | 1,127,782 | $9,225,257 | dollars as filed | |
| POINT BIOPHARMA GLOBAL INC | 730541109 | COM | 1,169,103 | $8,522,761 | dollars as filed | |
| REATA PHARMACEUTICALS INC | 75615P103 | CL A | 223,976 | $8,508,848 | dollars as filed | |
| SUMMIT THERAPEUTICS INC | 86627T108 | COM | 2,000,000 | $8,500,000 | dollars as filed | |
| Veru Inc | 92536C103 | Common Stock | 1,609,579 | $8,498,577 | dollars as filed | |
| AFFIMED N V | N01045108 | COM | 6,596,830 | $8,180,069 | dollars as filed | |
| INVITAE CORP | 46185LAB9 | NOTE 2.000% 9/0 | 10,300,000 | $8,058,143 | dollars as filed | principal |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 1,557,630 | $7,834,879 | dollars as filed | |
| DESIGN THERAPEUTICS INC | 25056L103 | COM | 692,131 | $7,101,264 | dollars as filed | |
| BIOHAVEN LTD | G1110E107 | COM | 476,190 | $6,609,517 | dollars as filed | |
| VERA THERAPEUTICS INC | 92337R101 | COMMON STOCK | 333,333 | $6,449,994 | dollars as filed | |
| ALECTOR INC | 014442107 | COMMON STOCK | 681,991 | $6,294,777 | dollars as filed | |
| MACROGENICS INC | 556099109 | COM | 892,579 | $5,989,205 | dollars as filed | |
| ATHIRA PHARMA INC | 04746L104 | COM | 1,879,836 | $5,959,080 | dollars as filed | |
| CENTURY THERAPEUTICS INC | 15673T100 | COM | 1,149,340 | $5,896,114 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 716,653 | $5,726,057 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 750,000 | $5,437,500 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 222,222 | $5,293,328 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 500,000 | $4,470,000 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W108 | COM | 1,830,315 | $4,356,150 | dollars as filed | |
| Tscan Therapeutics Inc | 89854M101 | COM | 2,784,792 | $4,316,428 | dollars as filed | |
| Aravive Inc | 03890D108 | Common / Ordinary Stock | 3,261,224 | $4,304,816 | dollars as filed | |
| CYTEIR THERAPEUTICS INC | 23284P103 | COMMON | 2,492,118 | $4,111,995 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 100,000 | $4,017,000 | dollars as filed | |
| TALIS BIOMEDICAL CORP | 87424L108 | CMN | 7,624,835 | $3,398,389 | dollars as filed | |
| Instil Bio, Inc. | 45783C101 | Common Stock | 5,273,789 | $3,322,487 | dollars as filed | |
| XENCOR INC | 98401F105 | COMMON STOCK | 123,127 | $3,206,227 | dollars as filed | |
| ITEOS THERAPEUTICS INC | 46565G104 | COM | 150,346 | $2,936,257 | dollars as filed | |
| KALA BIO INC | 483119202 | COM NEW | 76,813 | $2,930,416 | dollars as filed | |
| ATRECA INC | 04965G109 | COM | 3,532,760 | $2,828,328 | dollars as filed | |
| HOOKIPA PHARMA INC | 43906K100 | COM | 3,475,535 | $2,815,183 | dollars as filed | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 322,024 | $2,801,609 | dollars as filed | |
| ATARA BIOTHERAPEUTICS INC COM NEW | 046513107 | Stock | 744,186 | $2,440,930 | dollars as filed | |
| NKARTA INC | 65487U108 | COMMON STOCK | 400,000 | $2,396,000 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 48,885 | $2,344,036 | dollars as filed | |
| ACHILLES THERAPEUTICS PL-ADR | 00449L102 | COM | 2,591,366 | $2,332,229 | dollars as filed | |
| FATE THERAPEUTICS INC | 31189P102 | COM | 215,695 | $2,176,363 | dollars as filed | |
| ALIGOS THERAPEUTICS INC COM NEW | 01626L105 | Stock | 2,076,400 | $1,978,602 | dollars as filed | |
| NEOLEUKIN THERAPEUTICS INC | 64049K104 | COM | 3,821,740 | $1,945,266 | dollars as filed | |
| KRONOS BIO INC | 50107A104 | COM | 1,198,151 | $1,941,005 | dollars as filed | |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 3,410,106 | $1,534,207 | dollars as filed | |
| TCR2 THERAPEUTICS INC | 87808K106 | COM | 753,064 | $752,160 | dollars as filed | |
| PROTARA THERAPEUTICS INC | 74365U107 | COM STK | 199,671 | $535,118 | dollars as filed | |
| GENETRON HLDGS LTD | 37186H100 | ADS | 455,306 | $509,943 | dollars as filed | |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 61,946 | $436,100 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 19,950 | $398,601 | dollars as filed | |
| FOGHORN THERAPEUTICS INC | 344174107 | COMMON STOCK | 45,027 | $287,272 | dollars as filed | |
| SERA PROGNOSTICS INC | 81749D107 | CMN | 201,562 | $253,968 | dollars as filed | |
| LEAP THERAPEUTICS INC | 52187K101 | COM | 559,705 | $251,867 | dollars as filed | |
| VINCERX PHARMA INC | 92731L106 | COM NEW | 241,379 | $246,207 | dollars as filed | |
| BELLICUM PHARMACEUTICALS INC COM NEW | 079481404 | Stock | 249,123 | $179,369 | dollars as filed | |
| SURROZEN INC | 86889P117 | *W EXP 08/01/203 | 833,333 | $45,917 | dollars as filed | |
| ATYR PHARMA INC | 002120202 | COM NEW | 8,565 | $18,757 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-23-021551 | this filing | 2023-02-14 | acceptance time not in the bulk data set |