13F-HR filed by BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP filed this 13F-HR for the quarter ended 2021-03-31, filed 2021-05-17, with 126 holding rows worth $23,065,323,000.
- Accession
- 0001104659-21-068025
- Filer
- CIK 1263508
- Filed
- 2021-05-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2021
A holdings report, 126 entries on the cover page, a total value of $23,065,323,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $23,065,323,000 with VALUE read as thousands by filing date, 13F file number 028-10519. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SEAGEN INC | 81181C104 | COM | 47,270,759 | $6,564,018,000 | thousands by filing date | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 11,668,897 | $4,061,710,000 | thousands by filing date | |
| INCYTE CORP COM | 45337C102 | Stock | 32,001,387 | $2,600,753,000 | thousands by filing date | |
| KODIAK SCIENCES INC | 50015M109 | COM | 13,879,952 | $1,573,848,000 | thousands by filing date | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 41,910,704 | $1,081,296,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 3,993,312 | $610,617,000 | thousands by filing date | |
| INVITAE CORP | 46185L103 | COM | 15,749,182 | $601,776,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 7,589,294 | $573,068,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 3,540,270 | $456,270,000 | thousands by filing date | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 10,123,824 | $438,665,000 | thousands by filing date | |
| ABCELLERA BIOLOGICS INC COM | 00288U106 | Stock | 10,450,180 | $354,888,000 | thousands by filing date | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 1,119,557 | $308,315,000 | thousands by filing date | |
| IGM BIOSCIENCES INC | 449585108 | COM | 3,156,102 | $242,041,000 | thousands by filing date | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 1,409,784 | $241,496,000 | thousands by filing date | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 1,499,213 | $175,363,000 | thousands by filing date | |
| AMARIN CORP PLC | 023111206 | SPONS ADR NEW | 26,453,422 | $164,276,000 | thousands by filing date | |
| GLOBAL BLOOD THERAPEUTICS USD | 37890U108 | COM | 3,217,441 | $131,111,000 | thousands by filing date | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 12,710,818 | $129,269,000 | thousands by filing date | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 2,520,730 | $107,307,000 | thousands by filing date | |
| PACIFIC BIOSCIENCES CALIF INC COM | 69404D108 | Stock | 3,201,972 | $106,658,000 | thousands by filing date | |
| Instil Bio, Inc. | 45783C101 | Common Stock | 3,893,700 | $97,654,000 | thousands by filing date | |
| TALIS BIOMEDICAL CORP | 87424L108 | CMN | 7,574,835 | $97,337,000 | thousands by filing date | |
| HERON THERAPEUTICS INC | 427746102 | COM | 5,994,704 | $97,174,000 | thousands by filing date | |
| CERUS CORP | 157085101 | COM | 13,713,195 | $82,416,000 | thousands by filing date | |
| ALLAKOS INC | 01671P100 | COM | 703,050 | $80,696,000 | thousands by filing date | |
| DBV TECHNOLOGIES S A | 23306J101 | ADR | 14,614,264 | $77,894,000 | thousands by filing date | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 2,454,082 | $76,297,000 | thousands by filing date | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 1,959,211 | $76,135,000 | thousands by filing date | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 3,479,873 | $74,017,000 | thousands by filing date | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 2,156,001 | $73,433,000 | thousands by filing date | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 1,674,004 | $71,832,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 676,975 | $65,836,000 | thousands by filing date | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 760,412 | $58,582,000 | thousands by filing date | |
| FORMA THERAPEUTICS HLDGS INC | 34633R104 | SHS | 2,024,876 | $56,737,000 | thousands by filing date | |
| HORIZON THERAPEUTICS PLC | G46188101 | SHS | 599,110 | $55,142,000 | thousands by filing date | |
| ATRECA INC | 04965G109 | COM | 3,532,760 | $54,157,000 | thousands by filing date | |
| ZYMEWORKS INC | 98985W102 | COM | 1,708,472 | $53,954,000 | thousands by filing date | |
| ADAPTIMMUNE THERAPEUTICS PLC | 00653A107 | SPONDS ADR | 9,830,877 | $52,202,000 | thousands by filing date | |
| KINIKSA PHARMACEUTICALS LTD | G5269C101 | COM CL A | 2,799,577 | $51,820,000 | thousands by filing date | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 444,444 | $50,604,000 | thousands by filing date | |
| NEOLEUKIN THERAPEUTICS INC | 64049K104 | COM | 3,821,740 | $47,046,000 | thousands by filing date | |
| IMMATICS N.V | N44445109 | SHS | 3,992,756 | $44,759,000 | thousands by filing date | |
| DESIGN THERAPEUTICS INC | 25056L103 | COM | 1,436,636 | $42,955,000 | thousands by filing date | |
| ACHILLES THERAPEUTICS PL-ADR | 00449L102 | COM | 2,591,366 | $42,887,000 | thousands by filing date | |
| MERUS N V | N5749R100 | COM | 2,037,469 | $42,563,000 | thousands by filing date | |
| VERASTEM INC | 92337C104 | COM | 17,019,294 | $42,038,000 | thousands by filing date | |
| BIOATLA INC | 09077B104 | COM | 825,000 | $41,943,000 | thousands by filing date | |
| ALTIMMUNE INC | 02155H200 | COM NEW | 2,758,518 | $38,978,000 | thousands by filing date | |
| FULGENT GENETICS INC | 359664109 | COM | 401,016 | $38,746,000 | thousands by filing date | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 1,436,192 | $37,197,000 | thousands by filing date | |
| ALIGOS THERAPEUTICS INC COM NEW | 01626L105 | Stock | 1,610,000 | $36,611,000 | thousands by filing date | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 628,414 | $35,581,000 | thousands by filing date | |
| ADC THERAPEUTICS SA | H0036K147 | COMMON STOCK | 1,418,107 | $34,616,000 | thousands by filing date | |
| CHEMOCENTRYX INC | 16383L106 | COM | 656,710 | $33,650,000 | thousands by filing date | |
| OPTHEA LTD | 68386J208 | SPONSORED ADS | 3,308,705 | $31,664,000 | thousands by filing date | |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 3,410,106 | $27,008,000 | thousands by filing date | |
| NOVAVAX INC | 670002401 | COM NEW | 143,756 | $26,064,000 | thousands by filing date | |
| ALKERMES PLC | G01767105 | SHS | 1,228,170 | $22,942,000 | thousands by filing date | |
| MEREO BIOPHARMA GROUP PLC | 589492107 | CMN | 6,719,948 | $22,646,000 | thousands by filing date | |
| REATA PHARMACEUTICALS INC | 75615P103 | CL A | 223,976 | $22,330,000 | thousands by filing date | |
| OTONOMY INC | 68906L105 | COM | 7,220,074 | $18,411,000 | thousands by filing date | |
| AURINIA PHARMACEUTICALS INC COM | 05156V102 | Stock | 1,410,064 | $18,310,000 | thousands by filing date | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 500,000 | $16,250,000 | thousands by filing date | |
| XENCOR INC | 98401F105 | COMMON STOCK | 369,370 | $15,905,000 | thousands by filing date | |
| INVITAE CORP | 46185LAB9 | NOTE 2.000% 9/0 | 10,300,000 | $15,557,000 | thousands by filing date | principal |
| BIOMARIN PHARMACEUTICAL INC | 09061GAH4 | NOTE 0.599% 8/0 | 15,000,000 | $15,299,000 | thousands by filing date | principal |
| ATHIRA PHARMA INC | 04746L104 | COM | 806,367 | $14,837,000 | thousands by filing date | |
| ALBIREO PHARMA INC | 01345P106 | COMMON STOCK | 412,466 | $14,539,000 | thousands by filing date | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 751,639 | $13,454,000 | thousands by filing date | |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 647,313 | $12,830,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607AB6 | DBCV 1.500%11/1 | 9,174,000 | $11,970,000 | thousands by filing date | principal |
| CHINOOK THERAPEUTICS INC | 16961L106 | COM | 748,693 | $11,635,000 | thousands by filing date | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 238,095 | $10,388,000 | thousands by filing date | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 222,222 | $10,196,000 | thousands by filing date | |
| CYMABAY THERAPEUTICS INC | 23257D103 | COM | 2,170,464 | $9,854,000 | thousands by filing date | |
| GENETRON HLDGS LTD | 37186H100 | ADS | 455,306 | $9,771,000 | thousands by filing date | |
| HOOKIPA PHARMA INC | 43906K100 | COM | 700,481 | $9,421,000 | thousands by filing date | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 616,520 | $9,420,000 | thousands by filing date | |
| ANAPTYSBIO INC | 032724106 | COM | 427,179 | $9,206,000 | thousands by filing date | |
| IVERIC BIO INC | 46583P102 | COM | 1,406,037 | $8,689,000 | thousands by filing date | |
| NGM BIOPHARMACEUTICALS INC | 62921N105 | COM | 291,801 | $8,483,000 | thousands by filing date | |
| KARUNA THERAPEUTICS INC | 48576A100 | COM | 69,966 | $8,412,000 | thousands by filing date | |
| GAMIDA CELL LTD | M47364100 | SHS | 1,037,226 | $8,391,000 | thousands by filing date | |
| ASSEMBLY BIOSCIENCES INC | 045396108 | COM | 1,541,418 | $7,091,000 | thousands by filing date | |
| CABALETTA BIO INC | 12674W109 | COMMON STOCK | 636,363 | $7,064,000 | thousands by filing date | |
| BLUEBIRD BIO INC | 09609G100 | COM | 226,988 | $6,844,000 | thousands by filing date | |
| MACROGENICS INC | 556099109 | COM | 200,679 | $6,392,000 | thousands by filing date | |
| BURNING ROCK BIOTECH LTD | 12233L107 | SPONSORED ADS | 209,131 | $5,630,000 | thousands by filing date | |
| NEXIMMUNE INC | 65344D109 | COM | 294,117 | $5,612,000 | thousands by filing date | |
| SANGAMO THERAPEUTICS INC | 800677106 | COM | 429,063 | $5,376,000 | thousands by filing date | |
| ORCHARD THERAPEUTICS PLC | 68570P101 | ADR | 734,431 | $5,332,000 | thousands by filing date | |
| SYROS PHARMACEUTICALS INC | 87184Q107 | COM | 690,167 | $5,162,000 | thousands by filing date | |
| ITEOS THERAPEUTICS INC | 46565G104 | COM | 150,346 | $5,139,000 | thousands by filing date | |
| DENALI THERAPEUTICS INC COM | 24823R105 | Stock | 88,738 | $5,067,000 | thousands by filing date | |
| ALECTOR INC | 014442107 | COMMON STOCK | 239,228 | $4,818,000 | thousands by filing date | |
| EVOFEM BIOSCIENCES INC | 30048L104 | COM | 2,697,110 | $4,720,000 | thousands by filing date | |
| REPLIMUNE GROUP INC | 76029N106 | COMMON STOCK | 153,512 | $4,684,000 | thousands by filing date | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 186,915 | $4,667,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 58,700 | $4,375,000 | thousands by filing date | |
| PASSAGE BIO INC | 702712100 | COM | 235,362 | $4,114,000 | thousands by filing date | |
| HARMONY BIOSCIENCES HLDGS IN | 413197104 | COM | 123,600 | $4,084,000 | thousands by filing date | |
| TCR2 THERAPEUTICS INC | 87808K106 | COM | 176,461 | $3,896,000 | thousands by filing date | |
| TRICIDA INC | 89610F101 | COM | 729,300 | $3,858,000 | thousands by filing date | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 118,378 | $3,434,000 | thousands by filing date | |
| LEGEND BIOTECH CORP | 52490G102 | SPONSORED ADS | 115,626 | $3,355,000 | thousands by filing date | |
| LOGICBIO THERAPEUTICS INC | 54142F102 | COM | 451,478 | $3,287,000 | thousands by filing date | |
| PROTARA THERAPEUTICS INC | 74365U107 | COM STK | 199,671 | $3,143,000 | thousands by filing date | |
| ACCELERON PHARMA INC | 00434H108 | COM | 22,430 | $3,042,000 | thousands by filing date | |
| CONSTELLATION PHARMACEUTICALS INC. | 210373106 | Common Stock | 114,735 | $2,684,000 | thousands by filing date | |
| IDERA PHARMACEUTICALS INC | 45168K405 | COM PAR | 2,047,180 | $2,661,000 | thousands by filing date | |
| AUTOLUS THERAPEUTICS PLC SPON | 05280R100 | COM | 461,726 | $2,646,000 | thousands by filing date | |
| CHIASMA INC | 16706W102 | COM | 742,133 | $2,323,000 | thousands by filing date | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 363,980 | $2,302,000 | thousands by filing date | |
| INOZYME PHARMA INC | 45790W108 | COM | 106,999 | $2,119,000 | thousands by filing date | |
| MOLECULAR TEMPLATES INC | 608550109 | COM | 133,833 | $1,689,000 | thousands by filing date | |
| AFFIMED N V | N01045108 | COM | 164,605 | $1,302,000 | thousands by filing date | |
| OYSTER POINT PHARMA INC | 69242L106 | COMMON STOCK | 61,424 | $1,123,000 | thousands by filing date | |
| LEAP THERAPEUTICS INC | 52187K101 | COM | 559,705 | $1,063,000 | thousands by filing date | |
| BELLICUM PHARMACEUTICALS INC COM NEW | 079481404 | Stock | 249,123 | $937,000 | thousands by filing date | |
| LAKEFRONT BIOTHERAPEUTICS NV | 36315X101 | SPON ADR | 11,180 | $862,000 | thousands by filing date | |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 139,676 | $832,000 | thousands by filing date | |
| ADAMAS PHARMACEUTICALS INC | 00548A106 | COM | 147,996 | $710,000 | thousands by filing date | |
| GALMED PHARMACEUTICALS LTD | M47238106 | SHS | 184,927 | $634,000 | thousands by filing date | |
| Inflarx Nv | N44821101 | COM | 138,040 | $538,000 | thousands by filing date | |
| FREQUENCY THERAPEUTICS INC | 35803L108 | COM | 55,555 | $528,000 | thousands by filing date | |
| GENFIT S A | 372279109 | ADS | 14,720 | $68,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-21-068025 | this filing | 2021-05-17 | acceptance time not in the bulk data set |