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13F-HR filed by EcoR1 Capital, LLC

EcoR1 Capital, LLC filed this 13F-HR for the quarter ended 2021-12-31, filed 2022-02-14, with 76 holding rows worth $3,138,062,000.

Accession
0001567619-22-003866
Filed
2022-02-14
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q4 2021

A holdings report, 76 entries on the cover page, a total value of $3,138,062,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $3,138,062,000 with VALUE read as thousands by filing date, 13F file number 028-16764. The quarter's positions are built on this report. The resolved quarter.

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
PROTHENA CORP PLC SHSG72800108Stock11,284,280$557,443,000thousands by filing date
ANAPTYSBIO INC032724106COM7,521,024$261,356,000thousands by filing date
ARCUS BIOSCIENCES INC03969F109COM5,523,358$223,530,000thousands by filing date
XENCOR INC98401F105COMMON STOCK4,906,106$196,833,000thousands by filing date
APELLIS PHARMACEUTICALS INC03753U106COM4,033,882$190,722,000thousands by filing date
MORPHIC HLDG INC61775R105COM3,951,566$187,225,000thousands by filing date
LAKEFRONT BIOTHERAPEUTICS NV36315X101SPON ADR2,224,403$122,631,000thousands by filing date
NUVATION BIO INC COM CL A67080N101Stock13,896,543$118,121,000thousands by filing date
ALECTOR INC014442107COMMON STOCK4,994,970$103,146,000thousands by filing date
PROTAGONIST THERAPEUTICS74366E102COM2,639,706$90,278,000thousands by filing date
CRISPR THERAPEUTICS AG NAMEN AKTH17182108Stock1,077,483$81,652,000thousands by filing date
GRITSTONE BIO INC39868T105COM6,012,232$77,317,000thousands by filing date
ACADIA PHARMACEUTICALS INC004225108COM3,060,593$71,434,000thousands by filing date
AVIDITY BIOSCIENCES INC COM05370A108Stock2,759,505$65,593,000thousands by filing date
ITEOS THERAPEUTICS INC46565G104COM1,303,157$60,675,000thousands by filing date
RELAY THERAPEUTICS INC COM75943R102Stock1,779,084$54,636,000thousands by filing date
KURA ONCOLOGY INC COM50127T109Stock3,724,437$52,142,000thousands by filing date
ORIC PHARMACEUTICALS INC68622P109COM3,468,944$50,993,000thousands by filing date
2SEVENTY BIO INC COMMON STOCK901384107Stock1,917,063$49,134,000thousands by filing date
ATEA PHARMACEUTICALS INC04683R106COMMON STOCK5,376,134$48,063,000thousands by filing date
DESIGN THERAPEUTICS INC25056L103COM2,152,997$46,096,000thousands by filing date
SAGE THERAPEUTICS INC78667J108COM940,636$40,015,000thousands by filing date
JANUX THERAPEUTICS INC47103J105COM1,411,975$27,858,000thousands by filing date
PARDES BIOSCIENCES INC69945Q105COM1,597,139$26,145,000thousands by filing date
Ventyx Biosciences Inc92332V107Common Stock1,300,000$25,818,000thousands by filing date
EDGEWISE THERAPEUTICS INC28036F105COM1,279,175$19,546,000thousands by filing date
OVID THERAPEUTICS INC690469101COMMON STOCK6,082,200$19,524,000thousands by filing date
AKOUOS INC00973J101COM1,975,984$16,796,000thousands by filing date
CRINETICS PHARMACEUTICALS INC COM22663K107Stock590,169$16,767,000thousands by filing date
ALNYLAM PHARMACEUTICALS INC COM02043Q107Stock98,146$16,644,000thousands by filing date
SOLID BIOSCIENCES INC COM NEW83422E105Stock9,202,702$16,105,000thousands by filing date
HALOZYME THERAPEUTICS INC COM40637H109Stock392,000$15,762,000thousands by filing date
LEGEND BIOTECH CORP52490G102SPONSORED ADS307,594$14,337,000thousands by filing date
TANGO THERAPEUTICS INC87583X109COM1,300,000$14,222,000thousands by filing date
ERASCA INC COM29479A108Stock700,000$10,906,000thousands by filing date
ARVINAS INC04335A105COM130,300$10,703,000thousands by filing date
CENTESSA PHARMACEUTICALS PLC152309100SPONSORED ADS882,176$9,933,000thousands by filing date
IMMUNOVANT INC45258J102COM1,140,819$9,720,000thousands by filing date
VOYAGER THERAPEUTICS INC92915B106COMMON STOCK3,557,507$9,641,000thousands by filing date
NURIX THERAPEUTICS INC67080M103COMMON STOCK309,540$8,961,000thousands by filing date
GRAPHITE BIO INC38870X104COM688,900$8,563,000thousands by filing date
NUVATION BIO INC67080N119WARR963,333$8,188,000thousands by filing date
ARS PHARMACEUTICALS INC82835W108COM1,060,010$7,060,000thousands by filing date
C4 THERAPEUTICS INC12529R107COM STK200,000$6,440,000thousands by filing date
FRAZIER LIFESCIENCES ACQU COG3710A105CMN587,615$5,729,000thousands by filing date
APPLIED MOLECULAR TRANS INC03824M109COM400,000$5,592,000thousands by filing date
KRONOS BIO INC50107A104COM387,357$5,264,000thousands by filing date
JIYA ACQUISITION CORP47760M102CMN500,000$4,885,000thousands by filing date
NEOLEUKIN THERAPEUTICS INC64049K104COM860,619$4,148,000thousands by filing date
HEALTH SCIENCES ACQ CORP 2G4411D109ORD SHS400,000$4,032,000thousands by filing date
GRITSTONE BIO INC39868T105COM307,000$3,948,000thousands by filing datecall
AC IMMUNE SAH00263105SHS749,585$3,710,000thousands by filing date
VERVE THERAPEUTICS INC92539P101COM100,000$3,687,000thousands by filing date
KINNATE BIOPHARMA INC49705R105COM175,000$3,101,000thousands by filing date
DYNE THERAPEUTICS INC COM26818M108Stock215,000$2,556,000thousands by filing date
MOONLAKE IMMUNOTHERAPEUTICSG4444C102COM200,000$1,978,000thousands by filing date
5 01 ACQUISITION CORP33836P105CMN200,000$1,970,000thousands by filing date
BCLS ACQUISITION CORPG0904B105CMN200,000$1,960,000thousands by filing date
EUCRATES BIOMEDICAL ACQU CORG3141W106CMN200,000$1,952,000thousands by filing date
Adverum Biotechnologies, Inc.00773U108Common Stock1,046,700$1,842,000thousands by filing date
ARYA SCIENCES ACQU CORP IVG31659108COM150,000$1,487,000thousands by filing date
PMV PHARMACEUTICALS INC69353Y103COM50,000$1,155,000thousands by filing date
CARIBOU BIOSCIENCES INC COM142038108Stock75,000$1,132,000thousands by filing date
ALIGOS THERAPEUTICS INC COM NEW01626L105Stock91,044$1,081,000thousands by filing date
REPARE THERAPEUTICS INC760273102COM50,000$1,055,000thousands by filing date
TURMERIC ACQUISITION CORPG9127T108CMN100,000$982,000thousands by filing date
VTV THERAPEUTICS INC CL A918385105Stock834,333$830,000thousands by filing date
MONTE ROSA THERAPEUTICS INC61225M102COM37,593$768,000thousands by filing date
CAREMAX INC14171W111*W EXP 06/08/202100,000$768,000thousands by filing date
BOLT BIOTHERAPEUTICS INC097702104COM150,000$735,000thousands by filing date
EUCRATES BIOMEDICAL ACQU CORG3141W122*W EXP 10/23/20266,666$651,000thousands by filing date
FRAZIER LIFESCIENCES ACQU COG3710A113WTS66,665$650,000thousands by filing date
VAXCYTE INC COM92243G108Stock20,800$495,000thousands by filing date
OMEGA ALPHA SPACG6749V107CL A50,000$489,000thousands by filing date
SURROZEN INC86889P117*W EXP 08/01/20366,665$429,000thousands by filing date
TURMERIC ACQUISITION CORPG9127T124WTS33,333$327,000thousands by filing date

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001567619-22-003866this filing2022-02-14acceptance time not in the bulk data set