13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2024-06-30, filed 2024-08-14, with 118 holding rows worth $733,237,722.
- Accession
- 0001496201-24-000010
- Filer
- CIK 1496201
- Filed
- 2024-08-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q2 2024
A holdings report, 119 entries on the cover page, a total value of $733,237,722 stated on the cover page (in dollars after the unit check, H1), rows summing to $733,237,722 with VALUE read as dollars as filed, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare Management LP028-15865
- included managerSphera Global Healthcare GP Ltd. 028-15864
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 3,268,900 | $53,119,625 | dollars as filed | call |
| VANECK ETF TRUST | 92189F676 | COM | 149,800 | $39,052,862 | dollars as filed | put |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 910,070 | $23,052,073 | dollars as filed | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 449,515 | $21,810,468 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 384,924 | $20,855,182 | dollars as filed | |
| Amazon.com, Inc | 023135106 | COM | 101,432 | $19,601,734 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 822,047 | $16,876,625 | dollars as filed | |
| META PLATFORMS INC CL A | 30303M102 | COM | 33,439 | $16,860,613 | dollars as filed | |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 190,060 | $14,822,779 | dollars as filed | |
| Microsoft Corp | 594918104 | COM | 32,927 | $14,716,723 | dollars as filed | |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 81,461 | $14,008,848 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 83,659 | $13,218,122 | dollars as filed | |
| Apple Inc | 037833100 | COM | 61,500 | $12,953,130 | dollars as filed | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 789,416 | $12,828,010 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 610,826 | $12,576,907 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 293,832 | $12,076,495 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 13,190 | $11,941,962 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 283,424 | $11,722,417 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 309,265 | $11,445,898 | dollars as filed | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 78,080 | $11,145,139 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 47,412 | $10,991,050 | dollars as filed | |
| INVESCO QQQ TR | 46090E103 | COM | 22,900 | $10,971,619 | dollars as filed | call |
| SKYE BIOSCIENCE INC | 83086J200 | COM NEW | 1,298,312 | $10,399,479 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871202 | COM NEW | 454,227 | $10,310,953 | dollars as filed | |
| Johnson & Johnson | 478160104 | COM | 69,831 | $10,206,499 | dollars as filed | |
| ASMLHLDGNVFSPONSOREDADR1ADRREPS1ORDSHS | N07059210 | STOK | 9,901 | $10,126,050 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 147,633 | $8,735,445 | dollars as filed | |
| Salesforce.com, Inc | 79466L302 | COM | 33,600 | $8,638,560 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 731,111 | $8,495,510 | dollars as filed | |
| PERSPECTIVE THERAPEUTICS INC | 46489V302 | COMMON STOCK | 786,909 | $7,845,483 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 403,265 | $7,581,382 | dollars as filed | |
| Merck & Co.,Inc. | 58933Y105 | COM | 59,600 | $7,378,480 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 1,707,999 | $7,344,396 | dollars as filed | |
| CYBIN INC | 23256X100 | COM | 25,581,395 | $6,932,558 | dollars as filed | |
| VIGIL NEUROSCIENCE INC | 92673K108 | COM | 1,692,166 | $6,768,664 | dollars as filed | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 140,238 | $6,683,743 | dollars as filed | |
| INOZYME PHARMA INC | 45790W108 | COM | 1,462,724 | $6,523,749 | dollars as filed | |
| AbbVie,Inc. | 00287Y109 | COM | 38,000 | $6,517,760 | dollars as filed | |
| PALO ALTO NETWORKS INC | 697435105 | COM | 18,000 | $6,102,180 | dollars as filed | |
| SENTINELONE INC | 81730H109 | CL A | 283,804 | $5,974,074 | dollars as filed | |
| TOWER SEMICONDUCTOR LTD SHS NEW | M87915274 | Stock | 149,600 | $5,880,776 | dollars as filed | |
| Applied Materials,Inc. | 038222105 | COM | 24,604 | $5,806,298 | dollars as filed | |
| ENPHASE ENERGY INC COM | 29355A107 | Stock | 56,792 | $5,662,730 | dollars as filed | |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 32,100 | $5,520,237 | dollars as filed | call |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 50,000 | $5,323,000 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 327,539 | $5,322,509 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 204,600 | $5,182,518 | dollars as filed | call |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 442,752 | $5,180,198 | dollars as filed | |
| 4D MOLECULAR THERAPEUTICS INC COM | 35104E100 | Stock | 242,526 | $5,090,621 | dollars as filed | |
| Micron Technology,Inc. | 595112103 | COM | 37,000 | $4,866,610 | dollars as filed | |
| Day One Biopharmaceuticals Inc | 23954D109 | Common Stock | 347,627 | $4,790,300 | dollars as filed | |
| CATALYST PHARMACEUTICALS INC | 14888U101 | COM | 288,000 | $4,461,120 | dollars as filed | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 206,933 | $4,455,267 | dollars as filed | |
| JFROG LTD ORD SHS | M6191J100 | Stock | 117,881 | $4,426,432 | dollars as filed | |
| 89BIO INC | 282559103 | COM | 526,547 | $4,217,641 | dollars as filed | |
| OUTLOOK THERAPEUTICS INC | 69012T305 | COM | 571,428 | $4,217,139 | dollars as filed | |
| WIX COM LTD SHS | M98068105 | Stock | 25,177 | $4,004,905 | dollars as filed | |
| LAM RESEARCH CORP | 512807108 | COM | 3,700 | $3,939,945 | dollars as filed | |
| SAVARA INC | 805111101 | COM | 962,687 | $3,879,629 | dollars as filed | |
| GSK PLC SPONSORED ADR | 37733W204 | ADR | 100,000 | $3,850,000 | dollars as filed | |
| Qualcomm Incorporated | 747525103 | COM | 18,825 | $3,749,564 | dollars as filed | |
| ELEDON PHARMACEUTICALS INC | 28617k101 | COM | 1,297,021 | $3,424,135 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 141,620 | $3,322,405 | dollars as filed | |
| SHL TELEMEDICINE LTD SPONSORED ADS | 78423T200 | ADR | 632,456 | $3,223,438 | dollars as filed | |
| Applied Therapeutics Inc | 03828A101 | Common Stock | 674,268 | $3,148,832 | dollars as filed | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 139,419 | $3,120,197 | dollars as filed | |
| Broadcom Inc. | 11135F101 | COM | 19,360 | $3,108,306 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 75,000 | $3,102,000 | dollars as filed | call |
| Analog Devices,Inc. | 032654105 | COM | 13,000 | $2,967,380 | dollars as filed | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 94,318 | $2,884,244 | dollars as filed | |
| VISTAGEN THERAPEUTICS INC | 92840H400 | COM | 808,550 | $2,813,754 | dollars as filed | |
| PLIANT THERAPEUTICS INC | 729139105 | COM | 258,554 | $2,779,456 | dollars as filed | |
| ALECTOR INC | 014442107 | COMMON STOCK | 610,000 | $2,769,400 | dollars as filed | |
| ENLIGHT RENEWABLE ENERGY LTD SHS | M4056D110 | Stock | 169,280 | $2,735,565 | dollars as filed | |
| PROMIS NEUROSCIENCES INC | 74346M406 | COM NEW | 1,814,213 | $2,721,320 | dollars as filed | |
| KLA CORP | 482480100 | COM | 3,300 | $2,720,883 | dollars as filed | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 70,269 | $2,647,033 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 58,044 | $2,616,043 | dollars as filed | |
| CARGO THERAPEUTICS INC COM | 14179K101 | Stock | 155,506 | $2,553,409 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 90,000 | $2,518,200 | dollars as filed | |
| NVIDIA Corp | 67066G104 | COM | 20,000 | $2,470,800 | dollars as filed | |
| GLOBAL-E ONLINE LTD NPV | M5216V106 | SHS | 66,884 | $2,425,883 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 15,000 | $2,370,000 | dollars as filed | call |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 1,012,749 | $2,339,450 | dollars as filed | |
| TABOOLA.COM LTD | M8744T106 | ORD SHS | 667,384 | $2,295,801 | dollars as filed | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 312,469 | $2,265,400 | dollars as filed | |
| L3HARRIS TECHNOLOGIES INC COM | 502431109 | Stock | 10,000 | $2,245,800 | dollars as filed | |
| ADC THERAPEUTICS SA | H0036K147 | COMMON STOCK | 685,547 | $2,166,329 | dollars as filed | |
| NUTRIEN LTD COM | 67077M108 | Stock | 40,730 | $2,073,564 | dollars as filed | |
| Perion Network Ltd | M78673114 | COM | 234,609 | $1,958,985 | dollars as filed | |
| KYVERNA THERAPEUTICS INC | 501976104 | COMMON STOCK | 236,029 | $1,770,218 | dollars as filed | |
| ALUMIS INC | 022307102 | COM | 125,000 | $1,662,500 | dollars as filed | |
| CLIMB BIO INC | 28658R106 | COMMON STOCK | 215,179 | $1,529,923 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 626,810 | $1,529,416 | dollars as filed | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 162,842 | $1,481,862 | dollars as filed | |
| VIR BIOTECHNOLOGY INC | 92764N102 | COM | 162,051 | $1,442,254 | dollars as filed | |
| MONTE ROSA THERAPEUTICS INC | 61225M102 | COM | 375,000 | $1,402,500 | dollars as filed | |
| MARVELL TECHNOLOGY INC | 573874104 | COM | 20,000 | $1,398,000 | dollars as filed | |
| UPWORK INC | 91688F104 | COM | 117,000 | $1,257,750 | dollars as filed | |
| ARROWHEAD PHARMACEUTICALS IN | 04280A100 | COM | 48,175 | $1,252,068 | dollars as filed | |
| COMPUGEN LTD | M25722105 | ORD | 739,239 | $1,241,922 | dollars as filed | |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 2,051,676 | $1,231,006 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 16,589 | $1,111,463 | dollars as filed | |
| APREA THERAPEUTICS INC | 03836J201 | COM NEW | 270,000 | $1,098,900 | dollars as filed | |
| TAIWAN SEMICONDUCTOR MFG | 874039100 | SPONSORED ADS | 5,650 | $982,027 | dollars as filed | |
| ELEVATION ONCOLOGY INC COM | 28623U101 | Stock | 330,000 | $891,000 | dollars as filed | |
| VARONIS SYS INC | 922280102 | COM | 16,000 | $767,520 | dollars as filed | |
| CARTESIAN THERAPEUTICS INC | 816212302 | COMMON STOCK | 25,070 | $677,141 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 1,556 | $669,142 | dollars as filed | |
| LAVA THERAPEUTICS NV | N51517105 | SHS | 367,582 | $661,648 | dollars as filed | |
| PRIME MEDICINE INC | 74168J101 | COM | 127,424 | $654,959 | dollars as filed | |
| ICL GROUP LTD SHS | M53213100 | Stock | 107,238 | $458,979 | dollars as filed | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 59,000 | $365,800 | dollars as filed | put |
| IMMATICS N.V | N44445117 | *W EXP 07/01/202 | 100,000 | $277,000 | dollars as filed | |
| CAMTEK LTD ORD | M20791105 | Stock | 1,940 | $242,966 | dollars as filed | |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 222,134 | $200,121 | dollars as filed | |
| ARBE ROBOTICS LTD ORDINARY SHARES | M1R95N100 | Stock | 43,165 | $82,445 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 36,050 | $68,495 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001496201-24-000010 | this filing | 2024-08-14 | acceptance time not in the bulk data set |