13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2024-03-31, filed 2024-05-15, with 104 holding rows worth $711,744,424.
- Accession
- 0001496201-24-000006
- Filer
- CIK 1496201
- Filed
- 2024-05-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2024
A holdings report, 105 entries on the cover page, a total value of $711,744,424 stated on the cover page (in dollars after the unit check, H1), rows summing to $711,744,424 with VALUE read as dollars as filed, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare Management LP028-15865
- included managerSphera Global Healthcare GP Ltd.028-15864
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 3,132,700 | $44,202,396 | dollars as filed | call |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 380,000 | $36,058,200 | dollars as filed | put |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 1,889,700 | $26,663,667 | dollars as filed | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 499,515 | $24,276,429 | dollars as filed | |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 85,881 | $22,382,306 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 281,671 | $19,747,954 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 812,964 | $19,348,543 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 585,956 | $18,117,760 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 70,646 | $15,233,397 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871202 | COM NEW | 505,242 | $14,833,905 | dollars as filed | |
| PERSPECTIVE THERAPEUTICS INC | 46489V104 | COM | 12,443,621 | $14,807,909 | dollars as filed | |
| Merck & Co.,Inc. | 58933Y105 | COM | 103,600 | $13,670,020 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 610,826 | $13,028,919 | dollars as filed | |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 190,060 | $12,876,565 | dollars as filed | |
| SENTINELONE INC | 81730H109 | CL A | 550,818 | $12,839,568 | dollars as filed | |
| Johnson & Johnson | 478160104 | COM | 79,831 | $12,628,466 | dollars as filed | |
| META PLATFORMS INC CL A | 30303M102 | COM | 25,439 | $12,352,670 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 276,996 | $11,625,522 | dollars as filed | |
| Microsoft Corp | 594918104 | COM | 27,548 | $11,589,995 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 238,544 | $11,137,619 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 14,190 | $11,039,252 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 177,139 | $10,809,022 | dollars as filed | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 83,080 | $10,667,472 | dollars as filed | |
| CYBIN INC | 23256X100 | COM | 25,581,395 | $10,577,907 | dollars as filed | |
| INOZYME PHARMA INC | 45790W108 | COM | 1,372,907 | $10,516,468 | dollars as filed | |
| JFROG LTD ORD SHS | M6191J100 | Stock | 224,381 | $9,922,128 | dollars as filed | |
| Amazon.com, Inc | 023135106 | COM | 54,432 | $9,818,444 | dollars as filed | |
| FUSION PHARMACEUTICALS INC | 36118A100 | COM | 449,041 | $9,573,554 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 392,877 | $9,079,387 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 658,803 | $8,505,147 | dollars as filed | |
| Day One Biopharmaceuticals Inc | 23954D109 | Common Stock | 492,627 | $8,138,198 | dollars as filed | |
| GLOBAL-E ONLINE LTD NPV | M5216V106 | SHS | 208,784 | $7,589,298 | dollars as filed | |
| WIX COM LTD SHS | M98068105 | Stock | 52,877 | $7,269,530 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 55,614 | $7,199,788 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 666,111 | $7,000,827 | dollars as filed | |
| AbbVie,Inc. | 00287Y109 | COM | 38,000 | $6,919,800 | dollars as filed | |
| OUTLOOK THERAPEUTICS INC | 69012T305 | COM | 571,429 | $6,822,857 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 149,333 | $6,724,465 | dollars as filed | |
| Applied Materials,Inc. | 038222105 | COM | 32,000 | $6,599,360 | dollars as filed | |
| CAMTEK LTD ORD | M20791105 | Stock | 74,909 | $6,275,127 | dollars as filed | |
| NOVA LTD COM | M7516K103 | Stock | 35,106 | $6,227,102 | dollars as filed | |
| TOWER SEMICONDUCTOR LTD SHS NEW | M87915274 | Stock | 179,600 | $6,007,620 | dollars as filed | |
| 89BIO INC | 282559103 | COM | 515,882 | $6,004,866 | dollars as filed | |
| VIGIL NEUROSCIENCE INC | 92673K108 | COM | 1,730,414 | $5,900,712 | dollars as filed | |
| ENPHASE ENERGY INC COM | 29355A107 | Stock | 47,183 | $5,708,199 | dollars as filed | |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 992,749 | $5,460,120 | dollars as filed | |
| TABOOLA.COM LTD | M8744T106 | ORD SHS | 1,191,070 | $5,288,351 | dollars as filed | |
| 4D MOLECULAR THERAPEUTICS INC COM | 35104E100 | Stock | 162,161 | $5,166,449 | dollars as filed | |
| INCYTE CORP COM | 45337C102 | Stock | 89,556 | $5,102,005 | dollars as filed | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 183,722 | $4,949,471 | dollars as filed | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 50,000 | $4,836,500 | dollars as filed | |
| CATALYST PHARMACEUTICALS INC | 14888U101 | COM | 288,000 | $4,590,720 | dollars as filed | |
| GSK PLC SPONSORED ADR | 37733W204 | ADR | 100,000 | $4,287,000 | dollars as filed | |
| VISTAGEN THERAPEUTICS INC | 92840H400 | COM | 808,550 | $4,269,144 | dollars as filed | |
| Applied Therapeutics Inc | 03828A101 | Common Stock | 619,029 | $4,209,397 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 626,810 | $4,061,729 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 160,445 | $4,052,841 | dollars as filed | |
| SHL TELEMEDICINE LTD SPONSORED ADS | 78423T200 | ADR | 632,456 | $3,857,982 | dollars as filed | |
| PLIANT THERAPEUTICS INC | 729139105 | COM | 258,554 | $3,852,455 | dollars as filed | |
| PROMIS NEUROSCIENCES INC | 74346M406 | COM NEW | 1,834,047 | $3,503,030 | dollars as filed | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 70,269 | $3,458,640 | dollars as filed | |
| ALECTOR INC | 014442107 | COMMON STOCK | 560,000 | $3,371,200 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 48,886 | $3,043,642 | dollars as filed | |
| Apple Inc | 037833100 | COM | 17,500 | $3,000,900 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 20,000 | $2,989,000 | dollars as filed | call |
| ENLIGHT RENEWABLE ENERGY LTD SHS | M4056D110 | Stock | 169,280 | $2,864,218 | dollars as filed | |
| SOLAREDGE TECHNOLOGIES INC | 83417M104 | COM | 40,175 | $2,851,622 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 55,000 | $2,567,950 | dollars as filed | call |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 996,710 | $2,541,611 | dollars as filed | |
| Qualcomm Incorporated | 747525103 | COM | 15,000 | $2,539,500 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 90,000 | $2,497,500 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 125,000 | $2,311,250 | dollars as filed | |
| ELEVATION ONCOLOGY INC COM | 28623U101 | Stock | 430,000 | $2,205,900 | dollars as filed | |
| ELASTIC N V ORD SHS | N14506104 | Stock | 20,000 | $2,004,800 | dollars as filed | |
| Advanced Micro Devices,Inc. | 007903107 | COM | 11,000 | $1,985,390 | dollars as filed | |
| COMPUGEN LTD | M25722105 | ORD | 769,239 | $1,984,637 | dollars as filed | |
| NUTRIEN LTD COM | 67077M108 | Stock | 35,730 | $1,940,496 | dollars as filed | |
| SOLAREDGE TECHNOLOGIES INC | 83417M104 | COM | 26,800 | $1,902,264 | dollars as filed | call |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 2,051,676 | $1,849,791 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 100,000 | $1,849,000 | dollars as filed | call |
| APREA THERAPEUTICS INC | 03836J201 | COM NEW | 270,000 | $1,806,300 | dollars as filed | |
| ALPINE IMMUNE SCIENCES INC | 02083G100 | COM | 44,841 | $1,777,497 | dollars as filed | |
| FIVE9 INC | 338307101 | COM | 27,500 | $1,708,025 | dollars as filed | |
| CARGO THERAPEUTICS INC COM | 14179K101 | Stock | 75,000 | $1,674,000 | dollars as filed | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 112,842 | $1,588,251 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 25,000 | $1,556,500 | dollars as filed | call |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 50,000 | $1,546,000 | dollars as filed | call |
| PRIME MEDICINE INC | 74168J101 | COM | 205,242 | $1,436,694 | dollars as filed | |
| UPWORK INC | 91688F104 | COM | 117,000 | $1,434,420 | dollars as filed | |
| CORBUS PHARMACEUTICALS | 21833P301 | COM NEW | 35,000 | $1,373,400 | dollars as filed | |
| Broadcom Inc. | 11135F101 | COM | 1,001 | $1,326,735 | dollars as filed | |
| GERON CORP | 374163103 | COM | 384,356 | $1,268,375 | dollars as filed | |
| LAVA THERAPEUTICS NV | N51517105 | SHS | 367,582 | $1,224,048 | dollars as filed | |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 1,027,134 | $1,212,018 | dollars as filed | |
| VARONIS SYS INC | 922280102 | COM | 20,000 | $943,400 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 28,100 | $762,353 | dollars as filed | call |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 267,250 | $758,990 | dollars as filed | |
| ICL GROUP LTD SHS | M53213100 | Stock | 130,475 | $701,956 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 240,000 | $681,600 | dollars as filed | call |
| SELECTA BIOSCIENCES INC | 816212104 | COM | 25,071 | $488,889 | dollars as filed | |
| ALTO NEUROSCIENCE INC COM SHS | 02157Q109 | Stock | 30,500 | $468,175 | dollars as filed | |
| IMMATICS N.V | N44445117 | *W EXP 07/01/202 | 100,000 | $270,000 | dollars as filed | |
| ARBE ROBOTICS LTD ORDINARY SHARES | M1R95N100 | Stock | 43,165 | $90,215 | dollars as filed | |
| ANNEXON INC | 03589W102 | COM | 11,400 | $81,738 | dollars as filed | put |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001496201-24-000006 | this filing | 2024-05-15 | acceptance time not in the bulk data set |