13F-HR/A filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR/A for the quarter ended 2023-12-31, filed 2024-02-15, with 99 holding rows worth $621,338,814.
- Accession
- 0001496201-24-000005
- Filer
- CIK 1496201
- Filed
- 2024-02-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2023
A holdings report, amendment of type restatement, 100 entries on the cover page, a total value of $621,338,814 stated on the cover page (in dollars after the unit check, H1), rows summing to $621,338,814 with VALUE read as dollars as filed, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare Management LP028-15865
- included managerSphera Global Healthcare GP Ltd.028-15864
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPDR SER TR | 78464A870 | S&P BIOTECH | 500,000 | $44,645,000 | dollars as filed | put |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 2,469,100 | $25,777,404 | dollars as filed | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 499,515 | $24,840,881 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 223,820 | $18,686,732 | dollars as filed | |
| NOVA LTD COM | M7516K103 | Stock | 132,000 | $18,135,480 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 772,964 | $16,703,752 | dollars as filed | |
| TOWER SEMICONDUCTOR LTD SHS NEW | M87915274 | Stock | 528,300 | $16,123,716 | dollars as filed | |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 67,718 | $13,510,418 | dollars as filed | |
| Merck & Co.,Inc. | 58933Y105 | COM | 123,600 | $13,474,872 | dollars as filed | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 1,284,000 | $13,404,959 | dollars as filed | call |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 315,644 | $12,518,441 | dollars as filed | |
| Johnson & Johnson | 478160104 | COM | 79,831 | $12,512,711 | dollars as filed | |
| META PLATFORMS INC CL A | 30303M102 | COM | 34,303 | $12,141,890 | dollars as filed | |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 180,060 | $12,127,041 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 46,346 | $11,992,954 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 282,146 | $11,390,234 | dollars as filed | |
| GLOBAL-E ONLINE LTD NPV | M5216V106 | SHS | 269,794 | $10,691,936 | dollars as filed | |
| FUSION PHARMACEUTICALS INC | 36118A100 | COM | 1,085,639 | $10,432,991 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 703,287 | $10,113,267 | dollars as filed | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 93,080 | $9,629,126 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 201,044 | $9,613,924 | dollars as filed | |
| Microsoft Corp | 594918104 | COM | 23,848 | $8,967,802 | dollars as filed | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 1,151,145 | $8,840,794 | dollars as filed | |
| INHIBRX INC | 45720L107 | COM | 226,551 | $8,608,938 | dollars as filed | |
| Amazon.com, Inc | 023135106 | COM | 55,676 | $8,459,411 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 14,190 | $8,271,635 | dollars as filed | |
| Day One Biopharmaceuticals Inc | 23954D109 | Common Stock | 513,000 | $7,489,800 | dollars as filed | |
| TABOOLA.COM LTD | M8744T106 | ORD SHS | 1,724,948 | $7,469,025 | dollars as filed | |
| Advanced Micro Devices,Inc. | 007903107 | COM | 50,387 | $7,427,548 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W108 | COM | 328,986 | $7,329,808 | dollars as filed | |
| AbbVie,Inc. | 00287Y109 | COM | 46,000 | $7,128,620 | dollars as filed | |
| WIX COM LTD SHS | M98068105 | Stock | 57,477 | $7,070,821 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 36,230 | $6,934,784 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 245,000 | $6,872,250 | dollars as filed | |
| INOZYME PHARMA INC | 45790W108 | COM | 1,562,907 | $6,657,984 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 621,111 | $6,540,299 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 27,767 | $6,424,728 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 743,591 | $6,394,883 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 230,333 | $6,334,158 | dollars as filed | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 170,270 | $6,214,855 | dollars as filed | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 60,000 | $6,058,070 | dollars as filed | |
| SENTINELONE INC | 81730H109 | CL A | 213,418 | $5,856,190 | dollars as filed | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 190,783 | $5,717,767 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871103 | COM | 713,063 | $5,626,063 | dollars as filed | |
| INCYTE CORP COM | 45337C102 | Stock | 89,556 | $5,623,221 | dollars as filed | |
| GRACELL BIOTECHNOLOGIES INC | 38406L103 | ADR | 502,936 | $5,049,477 | dollars as filed | |
| SHL TELEMEDICINE LTD SPONSORED ADS | 78423T200 | ADR | 632,456 | $5,043,837 | dollars as filed | |
| PALO ALTO NETWORKS INC | 697435105 | COM | 16,585 | $4,890,585 | dollars as filed | |
| ENPHASE ENERGY INC COM | 29355A107 | Stock | 34,800 | $4,598,472 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 115,700 | $4,588,662 | dollars as filed | call |
| 89BIO INC | 282559103 | COM | 408,674 | $4,564,889 | dollars as filed | |
| SOLAREDGE TECHNOLOGIES INC | 83417M104 | COM | 48,000 | $4,492,800 | dollars as filed | |
| ALPINE IMMUNE SCIENCES INC | 02083G100 | COM | 234,841 | $4,476,069 | dollars as filed | |
| ARROWHEAD PHARMACEUTICALS IN | 04280A100 | COM | 144,899 | $4,433,909 | dollars as filed | |
| ENPHASE ENERGY INC COM | 29355A107 | Stock | 32,100 | $4,241,694 | dollars as filed | call |
| VISTAGEN THERAPEUTICS INC | 92840H400 | COM | 808,550 | $4,155,947 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 20,000 | $3,828,200 | dollars as filed | call |
| JFROG LTD ORD SHS | M6191J100 | Stock | 109,905 | $3,803,812 | dollars as filed | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 136,525 | $3,762,629 | dollars as filed | |
| UPWORK INC | 91688F104 | COM | 252,784 | $3,758,898 | dollars as filed | |
| GSK PLC SPONSORED ADR | 37733W204 | ADR | 100,000 | $3,706,000 | dollars as filed | |
| PLIANT THERAPEUTICS INC | 729139105 | COM | 193,554 | $3,505,263 | dollars as filed | |
| ENLIGHT RENEWABLE ENERGY LTD SHS | M4056D110 | Stock | 169,280 | $3,240,019 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 35,800 | $2,988,942 | dollars as filed | call |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 183,650 | $2,703,328 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 90,000 | $2,591,100 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 26,400 | $2,545,752 | dollars as filed | call |
| SOLAREDGE TECHNOLOGIES INC | 83417M104 | COM | 26,800 | $2,508,480 | dollars as filed | call |
| PROTHENA CORP PLC SHS | G72800108 | Stock | 68,200 | $2,478,388 | dollars as filed | call |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 626,810 | $2,419,487 | dollars as filed | |
| PROMIS NEUROSCIENCES INC | 74346M406 | COM NEW | 1,834,042 | $2,109,148 | dollars as filed | |
| ICL GROUP LTD SHS | M53213100 | Stock | 420,000 | $2,104,200 | dollars as filed | |
| Broadcom Inc. | 11135F101 | COM | 1,800 | $2,009,250 | dollars as filed | |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 2,051,676 | $1,943,758 | dollars as filed | |
| VIGIL NEUROSCIENCE INC | 92673K108 | COM | 535,120 | $1,808,706 | dollars as filed | |
| RIGEL PHARMACEUTICALS INC | 766559603 | COMMON STOCK | 1,228,126 | $1,780,783 | dollars as filed | |
| CARGO THERAPEUTICS INC COM | 14179K101 | Stock | 75,000 | $1,736,250 | dollars as filed | |
| Gilead Sciences,Inc. | 375558103 | COM | 20,000 | $1,620,200 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 259,201 | $1,524,102 | dollars as filed | |
| COMPUGEN LTD | M25722105 | ORD | 769,239 | $1,523,093 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 100,000 | $1,472,000 | dollars as filed | call |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 1,338,090 | $1,221,007 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 12,500 | $1,205,375 | dollars as filed | |
| FIVE9 INC | 338307101 | COM | 15,000 | $1,180,350 | dollars as filed | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 126,800 | $1,166,560 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 996,710 | $989,235 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 30,000 | $838,200 | dollars as filed | |
| PRIME MEDICINE INC | 74168J101 | COM | 73,980 | $655,463 | dollars as filed | |
| SELECTA BIOSCIENCES INC | 816212104 | COM | 752,137 | $518,523 | dollars as filed | |
| MEDIWOUND LTD | M68830112 | COMMON STOCK | 48,980 | $498,124 | dollars as filed | |
| ELEVATION ONCOLOGY INC COM | 28623U101 | Stock | 900,000 | $483,300 | dollars as filed | |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 180,000 | $444,600 | dollars as filed | |
| MORPHIC HLDG INC | 61775R105 | COM | 14,952 | $431,814 | dollars as filed | |
| IMMATICS N.V | N44445117 | *W EXP 07/01/202 | 100,000 | $292,000 | dollars as filed | |
| MONTE ROSA THERAPEUTICS INC | 61225M102 | COM | 48,511 | $274,087 | dollars as filed | |
| REPLIMUNE GROUP INC | 76029N106 | COMMON STOCK | 16,096 | $135,689 | dollars as filed | |
| FREELINE THERAPEUTICS HLDGS | 35655L206 | ADR | 16,445 | $104,755 | dollars as filed | |
| ARBE ROBOTICS LTD ORDINARY SHARES | M1R95N100 | Stock | 43,165 | $94,100 | dollars as filed | |
| PERSPECTIVE THERAPEUTICS INC | 46489V104 | COM | 25,671 | $10,320 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001496201-24-000002 | superseded | 2024-02-14 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001496201-24-000005 | this filing | 2024-02-15 | acceptance time not in the bulk data set |