13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2023-03-31, filed 2023-05-15, with 81 holding rows worth $598,414,818.
- Accession
- 0001496201-23-000006
- Filer
- CIK 1496201
- Filed
- 2023-05-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2023
A holdings report, 81 entries on the cover page, a total value of $598,414,818 stated on the cover page (in dollars after the unit check, H1), rows summing to $598,414,818 with VALUE read as dollars as filed, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare Management LP028-15865
- included managerSphera Global Healthcare GP Ltd.028-15864
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| iShares Russell 2000 ETF | 464287655 | SHS | 420,900 | $75,088,557 | dollars as filed | put |
| SPY | 78462F103 | SHS | 75,000 | $30,704,251 | dollars as filed | put |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 529,515 | $28,816,206 | dollars as filed | |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 115,482 | $26,432,675 | dollars as filed | |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 285,060 | $19,786,015 | dollars as filed | |
| Johnson & Johnson | 478160104 | COM | 119,831 | $18,573,805 | dollars as filed | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 2,039,500 | $18,049,575 | dollars as filed | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 2,037,000 | $18,027,451 | dollars as filed | call |
| Microsoft Corp | 594918104 | COM | 54,623 | $15,747,811 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 683,061 | $14,426,248 | dollars as filed | |
| Merck & Co.,Inc. | 58933Y105 | COM | 120,600 | $12,830,634 | dollars as filed | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 71,540 | $11,384,876 | dollars as filed | |
| ENPHASE ENERGY INC | 29355AAK3 | NOTE 3/0 | 10,725,000 | $11,190,251 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 31,690 | $10,882,980 | dollars as filed | |
| NUTRIEN LTD COM | 67077M108 | Stock | 145,466 | $10,742,664 | dollars as filed | |
| INOZYME PHARMA INC | 45790W108 | COM | 1,781,858 | $10,210,046 | dollars as filed | |
| AbbVie,Inc. | 00287Y109 | COM | 63,000 | $10,040,310 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 33,516 | $9,318,453 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 561,983 | $9,317,678 | dollars as filed | |
| Amazon.com, Inc | 023135106 | COM | 85,680 | $8,849,887 | dollars as filed | |
| INVESCO QQQ TR | 46090E103 | COM | 26,353 | $8,457,468 | dollars as filed | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 317,625 | $8,175,668 | dollars as filed | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 159,100 | $7,706,804 | dollars as filed | |
| ENLIGHT RENEWABLE ENERGY LTD SHS | M4056D110 | Stock | 450,864 | $7,628,619 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 603,287 | $7,378,200 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 183,696 | $7,366,210 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871103 | COM | 4,044,008 | $7,319,654 | dollars as filed | |
| POINT BIOPHARMA GLOBAL INC | 730541109 | COM | 952,642 | $6,925,707 | dollars as filed | |
| CAMTEK LTD ORD | M20791105 | Stock | 239,494 | $6,789,655 | dollars as filed | |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 155,000 | $6,503,800 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 336,993 | $6,200,671 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 44,000 | $6,064,520 | dollars as filed | |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 1,888,228 | $5,910,154 | dollars as filed | |
| SELECT SECTOR SPDR TR | 81369Y704 | INDL | 57,700 | $5,838,086 | dollars as filed | put |
| BELLUS HEALTH INC NEW | 07987C204 | COM | 799,860 | $5,758,992 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 140,000 | $5,712,000 | dollars as filed | |
| IVERIC BIO INC | 46583P102 | COM | 231,591 | $5,634,609 | dollars as filed | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 421,018 | $5,599,539 | dollars as filed | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 60,000 | $5,520,000 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 780,852 | $5,387,879 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 339,000 | $5,308,740 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 167,488 | $5,160,305 | dollars as filed | |
| Perion Network Ltd | M78673114 | COM | 130,000 | $5,145,400 | dollars as filed | |
| KINIKSA PHARMACEUTICALS LTD | G5269C101 | COM CL A | 450,283 | $4,845,045 | dollars as filed | |
| FUSION PHARMACEUTICALS INC | 36118A100 | COM | 1,283,537 | $4,838,934 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 220,013 | $4,662,075 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 19,000 | $4,602,940 | dollars as filed | |
| GRACELL BIOTECHNOLOGIES INC | 38406L103 | ADR | 2,360,580 | $4,390,679 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 187,500 | $4,216,875 | dollars as filed | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 236,000 | $4,042,680 | dollars as filed | |
| PALO ALTO NETWORKS INC | 697435105 | COM | 20,000 | $3,994,800 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 175,400 | $3,532,556 | dollars as filed | call |
| VAXCYTE INC COM | 92243G108 | Stock | 90,000 | $3,373,200 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 200,000 | $3,316,000 | dollars as filed | call |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 300,000 | $3,237,000 | dollars as filed | |
| SELECTA BIOSCIENCES INC | 816212104 | COM | 2,325,000 | $3,231,750 | dollars as filed | |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 109,336 | $2,626,251 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 219,316 | $2,526,520 | dollars as filed | |
| RIGEL PHARMACEUTICALS INC | 766559603 | COMMON STOCK | 1,878,845 | $2,480,075 | dollars as filed | |
| Amgen Inc. | 031162100 | COM | 10,000 | $2,417,500 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 1,155,897 | $2,219,322 | dollars as filed | |
| CHINOOK THERAPEUTICS INC | 16961L106 | COM | 92,200 | $2,134,430 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 626,810 | $1,629,706 | dollars as filed | |
| ALPINE IMMUNE SCIENCES INC | 02083G100 | COM | 200,000 | $1,544,000 | dollars as filed | |
| MEDIWOUND LTD | M68830112 | COMMON STOCK | 111,127 | $1,480,212 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 82,747 | $1,328,917 | dollars as filed | |
| KEROS THERAPEUTICS INC COM | 492327101 | Stock | 30,119 | $1,286,081 | dollars as filed | |
| ALTIMMUNE INC | 02155H200 | COM NEW | 300,000 | $1,266,000 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 62,000 | $1,248,680 | dollars as filed | |
| ANNEXON INC | 03589W102 | COM | 250,000 | $962,500 | dollars as filed | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 187,800 | $895,806 | dollars as filed | |
| REATA PHARMACEUTICALS INC | 75615P103 | CL A | 7,689 | $699,084 | dollars as filed | |
| INFINITY PHARMACEUTICALS INC | 45665G303 | COM | 1,476,000 | $236,160 | dollars as filed | |
| FIVERR INTL LTD | 33835LAA3 | NOTE 11/0 | 250,000 | $208,223 | dollars as filed | |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 646,478 | $187,479 | dollars as filed | |
| OTONOMO TECHNOLOGIES LTD | M7571L103 | ORDINARY SHARES | 391,863 | $186,409 | dollars as filed | |
| ONCORUS INC | 68236R103 | COM | 540,258 | $185,903 | dollars as filed | |
| IMMATICS N.V | N44445117 | *W EXP 07/01/202 | 100,000 | $144,000 | dollars as filed | |
| CYCLACEL PHARMACE 6percent PFDCONV | 23254L603 | Stock | 250,000 | $142,625 | dollars as filed | |
| ARBE ROBOTICS LTD ORDINARY SHARES | M1R95N100 | Stock | 43,165 | $137,696 | dollars as filed | |
| Mersana Therapeutics Inc | 59045L106 | Common Stock | 10,621 | $43,652 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001496201-23-000006 | this filing | 2023-05-15 | acceptance time not in the bulk data set |