13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2022-12-31, filed 2023-02-14, with 64 holding rows worth $465,932,418.
- Accession
- 0001496201-23-000003
- Filer
- CIK 1496201
- Filed
- 2023-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2022
A holdings report, 64 entries on the cover page, a total value of $465,932,418 stated on the cover page (in dollars after the unit check, H1), rows summing to $465,932,418 with VALUE read as dollars as filed, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare Management LP028-15865
- included managerSphera Global Healthcare GP Ltd.028-15864
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| INVESCO QQQ TR | 46090E903 | CALL | 231,000 | $61,510,680 | dollars as filed | call |
| INVESCO QQQ TR | 46090E953 | PUT | 210,000 | $55,918,800 | dollars as filed | put |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 400,060 | $27,124,068 | dollars as filed | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 559,515 | $27,097,311 | dollars as filed | |
| TEVA PHARMACEUTICAL INDS LTD | 881624909 | CALL | 2,222,300 | $20,267,376 | dollars as filed | call |
| Johnson & Johnson | 478160104 | COM | 109,831 | $19,401,646 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 710,561 | $18,083,777 | dollars as filed | |
| Merck & Co.,Inc. | 58933Y105 | COM | 120,600 | $13,380,570 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 671,644 | $12,291,085 | dollars as filed | |
| ALBIREO PHARMA INC | 01345P106 | COMMON STOCK | 463,828 | $10,023,323 | dollars as filed | |
| AbbVie,Inc. | 00287Y109 | COM | 60,000 | $9,696,600 | dollars as filed | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 71,540 | $9,682,224 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 25,690 | $9,398,430 | dollars as filed | |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 1,305,183 | $9,188,446 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 183,696 | $8,510,636 | dollars as filed | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 316,625 | $8,235,416 | dollars as filed | |
| KEROS THERAPEUTICS INC COM | 492327101 | Stock | 158,757 | $7,623,511 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 237,488 | $7,357,378 | dollars as filed | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 469,340 | $6,988,473 | dollars as filed | |
| TOWER SEMICONDUCTOR LTD | M87915954 | PUT | 161,600 | $6,981,120 | dollars as filed | put |
| POINT BIOPHARMA GLOBAL INC | 730541109 | COM | 952,642 | $6,944,760 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 558,287 | $6,928,342 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 780,852 | $6,801,221 | dollars as filed | |
| CINCOR PHARMA INC | 17240Y109 | COM | 529,640 | $6,509,276 | dollars as filed | |
| FIVE9 INC | 338307101 | COM | 95,000 | $6,446,600 | dollars as filed | |
| ALTIMMUNE INC | 02155H200 | COM NEW | 380,298 | $6,255,902 | dollars as filed | |
| CONCERT PHARMACEUTICALS INC | 206022105 | COM | 1,002,783 | $5,856,253 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 70,000 | $5,810,000 | dollars as filed | |
| GENERAC HLDGS INC | 368736104 | COM | 50,000 | $5,032,995 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 316,993 | $4,903,882 | dollars as filed | |
| KINIKSA PHARMACEUTICALS LTD | G5269C101 | COM CL A | 307,283 | $4,603,099 | dollars as filed | |
| LEONARDO DRS INC COM | 52661A108 | Stock | 335,557 | $4,288,418 | dollars as filed | |
| IVERIC BIO INC | 46583P102 | COM | 195,591 | $4,187,603 | dollars as filed | |
| BELLUS HEALTH INC NEW | 07987C204 | COM | 489,860 | $4,026,649 | dollars as filed | |
| FIVERR INTL LTD | 33835LAA3 | NOTE 11/0 | 4,951,000 | $4,013,955 | dollars as filed | |
| RIGEL PHARMACEUTICALS INC | 766559603 | COMMON STOCK | 2,278,845 | $3,418,268 | dollars as filed | |
| CHINOOK THERAPEUTICS INC | 16961L106 | COM | 127,200 | $3,332,640 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U956 | Equity Put | 60,000 | $3,102,600 | dollars as filed | put |
| CAMTEK LTD ORD | M20791105 | Stock | 110,000 | $2,415,600 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 1,155,897 | $2,392,707 | dollars as filed | |
| 89BIO INC | 282559103 | COM | 180,600 | $2,299,038 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 7,516 | $2,081,331 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 188,640 | $1,741,147 | dollars as filed | |
| INOZYME PHARMA INC | 45790W108 | COM | 1,625,058 | $1,706,311 | dollars as filed | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 187,800 | $1,633,860 | dollars as filed | |
| BIOATLA INC | 09077B104 | COM | 186,600 | $1,539,450 | dollars as filed | |
| ALPINE IMMUNE SCIENCES INC | 02083G100 | COM | 200,000 | $1,470,000 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 626,810 | $1,284,961 | dollars as filed | |
| MEDIWOUND LTD | M68830112 | COMMON STOCK | 75,413 | $1,017,321 | dollars as filed | |
| AUTOLUS THERAPEUTICS PLC SPON | 05280R100 | COM | 500,000 | $950,000 | dollars as filed | |
| Applied Materials,Inc. | 038222105 | COM | 8,499 | $827,558 | dollars as filed | |
| INFINITY PHARMACEUTICALS INC | 45665G303 | COM | 1,476,000 | $819,180 | dollars as filed | |
| NICE SYS INC | 65366HAB9 | BOND | 250,000 | $576,550 | dollars as filed | |
| TABOOLA.COM LTD | M8744T106 | ORD SHS | 120,000 | $369,600 | dollars as filed | |
| MAGIC SOFTWARE ENTERPRISES LTD ORD | 559166103 | Stock | 21,981 | $352,199 | dollars as filed | |
| IMMATICS N.V | N44445117 | *W EXP 07/01/202 | 100,000 | $251,000 | dollars as filed | |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 440,837 | $198,333 | dollars as filed | |
| CYCLACEL PHARMACE 6percent PFDCONV | 23254L603 | Stock | 250,000 | $166,750 | dollars as filed | |
| OTONOMO TECHNOLOGIES LTD | M7571L103 | ORDINARY SHARES | 391,863 | $159,488 | dollars as filed | |
| ARBE ROBOTICS LTD ORDINARY SHARES | M1R95N100 | Stock | 43,165 | $147,193 | dollars as filed | |
| ONCORUS INC | 68236R103 | COM | 540,258 | $136,847 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 7,149 | $82,857 | dollars as filed | |
| 89BIO INC | 282559903 | Equity Call | 3,600 | $45,828 | dollars as filed | call |
| TEADS HLDG CO | 69002R103 | COM | 12,148 | $43,976 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001496201-23-000003 | this filing | 2023-02-14 | acceptance time not in the bulk data set |