13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2021-09-30, filed 2021-11-15, with 116 holding rows worth $1,190,277,000.
- Accession
- 0001496201-21-000007
- Filer
- CIK 1496201
- Filed
- 2021-11-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q3 2021
A holdings report, 116 entries on the cover page, a total value of $1,190,277,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $1,190,277,000 with VALUE read as thousands by filing date, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare Management LP
- included managerSphera Global Healthcare GP Ltd.
- included managerSphera Healthcare US Inc.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| Eli Lilly and Company | 532457108 | COM | 348,495 | $80,520,000 | thousands by filing date | |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 1,291,667 | $77,578,000 | thousands by filing date | |
| AbbVie,Inc. | 00287Y109 | COM | 596,294 | $64,322,000 | thousands by filing date | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 400,000 | $50,284,000 | thousands by filing date | put |
| Pfizer Inc. | 717081103 | COM | 1,106,528 | $47,592,000 | thousands by filing date | |
| iShares Russell 2000 ETF | 464287655 | SHS | 210,000 | $45,938,000 | thousands by filing date | put |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 843,400 | $40,660,000 | thousands by filing date | |
| Johnson & Johnson | 478160104 | COM | 238,948 | $38,590,000 | thousands by filing date | |
| Bristol-Myers Squibb Company | 110122108 | COM | 500,000 | $29,585,000 | thousands by filing date | call |
| GENERAC HLDGS INC | 368736104 | COM | 71,013 | $29,021,000 | thousands by filing date | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 359,260 | $21,103,000 | thousands by filing date | |
| Microsoft Corp | 594918104 | COM | 67,536 | $19,040,000 | thousands by filing date | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 381,774 | $17,058,000 | thousands by filing date | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 247,917 | $15,728,000 | thousands by filing date | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 145,982 | $15,385,000 | thousands by filing date | |
| PALO ALTO NETWORKS INC | 697435105 | COM | 31,000 | $14,849,000 | thousands by filing date | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 788,735 | $14,773,000 | thousands by filing date | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 750,603 | $14,344,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 50,000 | $14,149,000 | thousands by filing date | call |
| SOLAREDGE TECHNOLOGIES INC | 83417M104 | COM | 50,000 | $13,261,000 | thousands by filing date | |
| FATE THERAPEUTICS INC | 31189P102 | COM | 219,299 | $12,998,000 | thousands by filing date | |
| ALTIMMUNE INC | 02155H200 | COM NEW | 1,088,854 | $12,315,000 | thousands by filing date | |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 494,809 | $12,202,000 | thousands by filing date | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 688,475 | $11,814,000 | thousands by filing date | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 350,000 | $11,739,000 | thousands by filing date | call |
| META PLATFORMS INC CL A | 30303M102 | COM | 34,400 | $11,675,000 | thousands by filing date | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 548,643 | $11,549,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 149,017 | $11,518,000 | thousands by filing date | |
| TWILIO INC CL A | 90138F102 | Stock | 35,500 | $11,326,000 | thousands by filing date | |
| ALTIMMUNE INC | 02155H200 | COM NEW | 1,000,000 | $11,310,000 | thousands by filing date | call |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 37,786 | $10,733,000 | thousands by filing date | |
| WIX COM LTD | 92940WAD1 | NOTE 8/1 | 11,100,000 | $10,722,000 | thousands by filing date | |
| VINCERX PHARMA INC | 92731L106 | COM NEW | 654,572 | $10,584,000 | thousands by filing date | |
| VISTAGEN THERAPEUTICS INC | 92840H202 | COM | 3,824,938 | $10,480,000 | thousands by filing date | |
| KORNIT DIGITAL LTD | M6372Q113 | SHS | 72,076 | $10,432,000 | thousands by filing date | |
| IMMATICS N.V | N44445109 | SHS | 800,043 | $10,401,000 | thousands by filing date | |
| INHIBRX INC | 45720L107 | COM | 310,077 | $10,329,000 | thousands by filing date | |
| AUDIOCODES LTD | M15342104 | ORD | 316,428 | $10,297,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 1,050,000 | $10,227,000 | thousands by filing date | call |
| ARYA SCIENCES ACQU CORP IV | G31659108 | COM | 1,000,000 | $10,060,000 | thousands by filing date | |
| OMEGA THERAPEUTICS INC | 68217N105 | COMMON STOCK | 527,948 | $9,952,000 | thousands by filing date | |
| ALX ONCOLOGY HOLDINGS INC | 00166B105 | COMMON STOCK | 128,706 | $9,506,000 | thousands by filing date | |
| NIKE,Inc. Class B | 654106103 | COM | 65,000 | $9,440,000 | thousands by filing date | |
| GRAPHITE BIO INC | 38870X104 | COM | 531,269 | $8,707,000 | thousands by filing date | |
| SUNRUN INC | 86771W105 | COM | 189,000 | $8,316,000 | thousands by filing date | |
| ONCORUS INC | 68236R103 | COM | 880,702 | $8,226,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 832,878 | $8,112,000 | thousands by filing date | |
| CAESARSTONE LTD | M20598104 | ORD SHS | 644,146 | $8,000,000 | thousands by filing date | |
| IVERIC BIO INC | 46583P102 | COM | 485,001 | $7,876,000 | thousands by filing date | |
| AUTODESK INC COM | 052769106 | Stock | 27,500 | $7,842,000 | thousands by filing date | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 294,619 | $7,510,000 | thousands by filing date | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 130,330 | $7,037,000 | thousands by filing date | |
| AFFIMED N V | N01045108 | COM | 1,117,619 | $6,907,000 | thousands by filing date | |
| BCLS ACQUISITION CORP | G0904B105 | CMN | 687,900 | $6,879,000 | thousands by filing date | |
| MERUS N V | N5749R100 | COM | 309,427 | $6,807,000 | thousands by filing date | |
| VERINT SYS INC | 92343X100 | COM | 150,000 | $6,719,000 | thousands by filing date | |
| TEADS HLDG CO | 69002R103 | COM | 431,194 | $6,382,000 | thousands by filing date | |
| BIOATLA INC | 09077B104 | COM | 214,300 | $6,309,000 | thousands by filing date | |
| ZENDESK INC | 98936J101 | COM | 53,910 | $6,275,000 | thousands by filing date | |
| RESEARCH ALLIANCE CORP II | 760873109 | CMN | 600,000 | $5,910,000 | thousands by filing date | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 373,510 | $5,707,000 | thousands by filing date | |
| POINT BIOPHARMA GLOBAL INC | 730541109 | COM | 739,190 | $5,684,000 | thousands by filing date | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 190,525 | $5,678,000 | thousands by filing date | |
| SUTRO BIOPHARMA INC | 869367102 | COM | 294,825 | $5,569,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 172,000 | $5,506,000 | thousands by filing date | |
| CALIX INC | 13100M509 | COM | 105,290 | $5,204,000 | thousands by filing date | |
| ALLOT LTD | M0854Q105 | SHS | 341,067 | $5,068,000 | thousands by filing date | |
| NAUTILUS BIOTECHNOLOGY INC | 63909J108 | COM | 800,000 | $4,912,000 | thousands by filing date | |
| CARIBOU BIOSCIENCES INC COM | 142038108 | Stock | 200,000 | $4,774,000 | thousands by filing date | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 491,159 | $4,691,000 | thousands by filing date | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 260,379 | $4,614,000 | thousands by filing date | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 250,000 | $4,430,000 | thousands by filing date | call |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 801,256 | $4,391,000 | thousands by filing date | |
| IRONSOURCE LTD NPV | M5R75Y101 | CL A ORD SHS | 367,070 | $3,990,000 | thousands by filing date | |
| ALIGOS THERAPEUTICS INC COM NEW | 01626L105 | Stock | 249,197 | $3,865,000 | thousands by filing date | |
| DYNAVAX TECHNOLOGIES CORP | 268158201 | COM NEW | 198,880 | $3,820,000 | thousands by filing date | |
| ESSA PHARMA INC | 29668H708 | COM NEW | 469,402 | $3,755,000 | thousands by filing date | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 225,083 | $3,655,000 | thousands by filing date | |
| IMMUNIC INC | 4525EP101 | COM | 389,812 | $3,450,000 | thousands by filing date | |
| EUCRATES BIOMEDICAL ACQU COR | G3141W106 | CMN | 329,025 | $3,218,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 100,000 | $3,201,000 | thousands by filing date | call |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 23,647 | $3,172,000 | thousands by filing date | |
| Leslie's Inc | 527064109 | Common Stock | 150,000 | $3,081,000 | thousands by filing date | |
| OTONOMO TECHNOLOGIES LTD | M7571L103 | ORDINARY SHARES | 600,000 | $2,868,000 | thousands by filing date | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 9,249 | $2,793,000 | thousands by filing date | |
| DICE THERAPEUTICS INC | 23345J104 | COM | 85,000 | $2,784,000 | thousands by filing date | |
| CYCLACEL PHARMACE 6percent PFDCONV | 23254L603 | Stock | 508,322 | $2,679,000 | thousands by filing date | |
| MONTE ROSA THERAPEUTICS INC | 61225M102 | COM | 119,647 | $2,666,000 | thousands by filing date | |
| Hippo Holdings, Inc. (HIPO) | 433539103 | Common Stocks | 564,967 | $2,644,000 | thousands by filing date | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 100,391 | $2,634,000 | thousands by filing date | |
| CVRX INC | 126638105 | COMMON STOCK | 150,000 | $2,481,000 | thousands by filing date | |
| CYTEIR THERAPEUTICS INC | 23284P103 | COMMON | 135,145 | $2,372,000 | thousands by filing date | |
| ANNEXON INC | 03589W102 | COM | 123,637 | $2,301,000 | thousands by filing date | |
| TURMERIC ACQUISITION CORP | G9127T108 | CMN | 219,440 | $2,148,000 | thousands by filing date | |
| ARYA SCIENCES ACQUISITN CORP | G31658100 | CLASS A ORD SHS | 200,000 | $1,976,000 | thousands by filing date | |
| JIYA ACQUISITION CORP | 47760M102 | CMN | 199,028 | $1,946,000 | thousands by filing date | |
| ACHILLES THERAPEUTICS PL-ADR | 00449L102 | COM | 242,500 | $1,889,000 | thousands by filing date | |
| Applied Materials,Inc. | 038222105 | COM | 14,500 | $1,867,000 | thousands by filing date | |
| MOLECULAR PARTNERS AG | 60853G106 | ADS | 80,555 | $1,580,000 | thousands by filing date | |
| ERASCA INC COM | 29479A108 | Stock | 70,000 | $1,485,000 | thousands by filing date | |
| LAVA THERAPEUTICS NV | N51517105 | SHS | 215,359 | $1,275,000 | thousands by filing date | |
| FRAZIER LIFESCIENCES ACQU CO | G3710A105 | CMN | 126,687 | $1,244,000 | thousands by filing date | |
| MAGIC SOFTWARE ENTERPRISES LTD ORD | 559166103 | Stock | 57,704 | $1,154,000 | thousands by filing date | |
| OMEGA ALPHA SPAC | G6749V107 | CL A | 100,000 | $974,000 | thousands by filing date | |
| NICE SYS INC | 65366HAB9 | BOND | 250,000 | $846,000 | thousands by filing date | |
| AC IMMUNE SA | H00263105 | SHS | 121,019 | $812,000 | thousands by filing date | |
| YUMANITY THERAPEUTICS INC | 98872L102 | COM | 75,836 | $783,000 | thousands by filing date | |
| CM LIFE SCIENCES III INC | 125841205 | UNIT 04/30/2028 | 75,000 | $769,000 | thousands by filing date | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 22,000 | $738,000 | thousands by filing date | |
| Amazon.com, Inc | 023135106 | COM | 161 | $529,000 | thousands by filing date | |
| UPWORK INC | 91688F104 | COM | 10,000 | $450,000 | thousands by filing date | |
| IMMATICS N.V | N44445117 | *W EXP 07/01/202 | 100,000 | $423,000 | thousands by filing date | |
| SARISSA CAPITAL ACQUISITN CO | G7823W102 | CMN | 23,900 | $236,000 | thousands by filing date | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 4,235 | $157,000 | thousands by filing date | |
| LOGICBIO THERAPEUTICS INC | 54142F102 | COM | 24,042 | $110,000 | thousands by filing date | |
| OUTLOOK THERAPEUTICS INC | 69012T115 | *W EXP 02/18/202 | 129,500 | $26,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001496201-21-000007 | this filing | 2021-11-15 | acceptance time not in the bulk data set |