13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2021-06-30, filed 2021-08-17, with 134 holding rows worth $1,478,461,000 by the sum of the rows.
- Accession
- 0001496201-21-000004
- Filer
- CIK 1496201
- Filed
- 2021-08-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q2 2021
A holdings report, 134 entries on the cover page, a total value of $1,432,197,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $1,478,461,000 with VALUE read as thousands by filing date, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
The cover page states a total of $1,432,197,000, 3% less than the sum of the rows, $1,478,461,000. This page uses the sum of the rows.
Other managers
- included managerSphera Global Healthcare GP Ltd 028-15864
- included managerSphera Global Healthcare Management LP 028-15865
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPDR SER TR | 78464A870 | S&P BIOTECH | 625,000 | $84,625,000 | thousands by filing date | put |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 1,147,673 | $68,745,000 | thousands by filing date | |
| Johnson & Johnson | 478160104 | COM | 405,608 | $66,820,000 | thousands by filing date | |
| Merck & Co.,Inc. | 58933Y105 | COM | 772,601 | $60,085,000 | thousands by filing date | |
| Merck & Co.,Inc. | 58933Y105 | COM | 772,600 | $60,085,000 | thousands by filing date | put |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 276,130 | $51,412,000 | thousands by filing date | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 843,400 | $44,413,000 | thousands by filing date | |
| GENERAC HLDGS INC | 368736104 | COM | 104,363 | $43,327,000 | thousands by filing date | |
| ENPHASE ENERGY INC COM | 29355A107 | Stock | 230,000 | $42,235,000 | thousands by filing date | call |
| Eli Lilly and Company | 532457108 | COM | 181,895 | $41,748,000 | thousands by filing date | |
| AbbVie,Inc. | 00287Y109 | COM | 366,194 | $41,248,000 | thousands by filing date | |
| iShares Expanded Tech-Software Sector ETF | 464287515 | SHS | 105,000 | $40,954,000 | thousands by filing date | put |
| Technology Select Sector SPDR Fund | 81369Y803 | SHS | 210,000 | $31,009,000 | thousands by filing date | put |
| iShares Russell 2000 ETF | 464287655 | SHS | 105,000 | $24,084,000 | thousands by filing date | put |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 518,611 | $19,624,000 | thousands by filing date | |
| FIVERR INTL LTD ORD SHS | M4R82T106 | Stock | 79,000 | $19,157,000 | thousands by filing date | call |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 76,786 | $19,001,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 1,910,000 | $18,909,000 | thousands by filing date | call |
| INVESCO EXCH TRADED FD TR II | 46138G706 | SOLAR ETF | 210,000 | $18,759,000 | thousands by filing date | call |
| ESSA PHARMA INC | 29668H708 | COM NEW | 648,303 | $18,522,000 | thousands by filing date | |
| KORNIT DIGITAL LTD | M6372Q113 | SHS | 147,793 | $18,375,000 | thousands by filing date | |
| Microsoft Corp | 594918104 | COM | 67,536 | $18,295,000 | thousands by filing date | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 868,886 | $18,116,000 | thousands by filing date | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 97,946 | $17,335,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 50,000 | $17,313,000 | thousands by filing date | call |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 195,117 | $16,080,000 | thousands by filing date | |
| FATE THERAPEUTICS INC | 31189P102 | COM | 165,299 | $14,346,000 | thousands by filing date | |
| LIVEPERSON, INC. | 538146101 | COM | 225,000 | $14,229,000 | thousands by filing date | |
| Amazon.com, Inc | 023135106 | COM | 4,061 | $13,970,000 | thousands by filing date | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 302,965 | $13,597,000 | thousands by filing date | |
| VISTAGEN THERAPEUTICS INC | 92840H202 | COM | 4,080,673 | $12,854,000 | thousands by filing date | |
| AUDIOCODES LTD | M15342104 | ORD | 385,194 | $12,746,000 | thousands by filing date | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 259,895 | $12,605,000 | thousands by filing date | |
| VARONIS SYS INC | 922280102 | COM | 218,013 | $12,562,000 | thousands by filing date | |
| ONCORUS INC | 68236R103 | COM | 893,548 | $12,331,000 | thousands by filing date | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 706,294 | $12,049,000 | thousands by filing date | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 634,088 | $11,953,000 | thousands by filing date | |
| AFFIMED N V | N01045108 | COM | 1,276,702 | $10,852,000 | thousands by filing date | |
| ALX ONCOLOGY HOLDINGS INC | 00166B105 | COMMON STOCK | 192,728 | $10,538,000 | thousands by filing date | |
| TWILIO INC CL A | 90138F102 | Stock | 26,500 | $10,445,000 | thousands by filing date | |
| THERAPEUTICS ACQUISITION COR | 88339T103 | COM CL A | 1,009,497 | $10,378,000 | thousands by filing date | |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 378,642 | $9,852,000 | thousands by filing date | |
| CAESARSTONE LTD | M20598104 | ORD SHS | 644,146 | $9,508,000 | thousands by filing date | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 547,187 | $9,395,000 | thousands by filing date | |
| META PLATFORMS INC CL A | 30303M102 | COM | 27,000 | $9,388,000 | thousands by filing date | |
| SOLAREDGE TECHNOLOGIES INC | 83417M104 | COM | 32,200 | $8,899,000 | thousands by filing date | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 52,550 | $8,508,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 23,995 | $8,309,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 832,878 | $8,245,000 | thousands by filing date | |
| NAUTILUS BIOTECHNOLOGY INC | 63909J108 | COM | 800,000 | $8,080,000 | thousands by filing date | |
| NKARTA INC | 65487U108 | COMMON STOCK | 252,478 | $8,001,000 | thousands by filing date | |
| SHATTUCK LABS INC | 82024L103 | COMMON STOCK | 274,214 | $7,949,000 | thousands by filing date | |
| ONTO INNOVATION INC COM | 683344105 | Stock | 107,548 | $7,855,000 | thousands by filing date | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 233,135 | $7,847,000 | thousands by filing date | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 369,714 | $7,779,000 | thousands by filing date | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 47,309 | $7,642,000 | thousands by filing date | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 186,600 | $7,443,000 | thousands by filing date | call |
| BCLS ACQUISITION CORP | G0904B105 | CMN | 687,900 | $7,244,000 | thousands by filing date | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 20,900 | $7,173,000 | thousands by filing date | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 334,794 | $7,027,000 | thousands by filing date | |
| VERINT SYS INC | 92343X100 | COM | 150,000 | $6,761,000 | thousands by filing date | |
| ALTIMMUNE INC | 02155H200 | COM NEW | 683,395 | $6,731,000 | thousands by filing date | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 244,157 | $6,477,000 | thousands by filing date | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 116,000 | $6,393,000 | thousands by filing date | call |
| MERUS N V | N5749R100 | COM | 286,506 | $6,037,000 | thousands by filing date | |
| RESEARCH ALLIANCE CORP II | 760873109 | CMN | 600,000 | $6,000,000 | thousands by filing date | |
| ORCHARD THERAPEUTICS PLC | 68570P101 | ADR | 1,366,564 | $5,999,000 | thousands by filing date | |
| ATERIAN INC | 02156U101 | COM | 399,999 | $5,852,000 | thousands by filing date | |
| SUTRO BIOPHARMA INC | 869367102 | COM | 294,825 | $5,481,000 | thousands by filing date | |
| ALLOT LTD | M0854Q105 | SHS | 276,187 | $5,477,000 | thousands by filing date | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 173,891 | $5,371,000 | thousands by filing date | |
| ARYA SCIENCES ACQU CORP IV | G31659108 | COM | 500,000 | $5,360,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 172,000 | $5,298,000 | thousands by filing date | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 801,256 | $5,240,000 | thousands by filing date | |
| FIVERR INTL LTD ORD SHS | M4R82T106 | Stock | 21,500 | $5,214,000 | thousands by filing date | |
| INHIBRX INC | 45720L107 | COM | 189,083 | $5,204,000 | thousands by filing date | |
| ATERIAN INC | 02156U101 | COM | 355,600 | $5,202,000 | thousands by filing date | call |
| CURIS INC | 231269200 | COM | 588,264 | $4,747,000 | thousands by filing date | |
| CVRX INC | 126638105 | COMMON STOCK | 150,000 | $4,200,000 | thousands by filing date | |
| SUNRUN INC | 86771W105 | COM | 72,000 | $4,016,000 | thousands by filing date | |
| NOVABRIDGE BIOSCIENCES | 44975P103 | CMN | 46,350 | $3,891,000 | thousands by filing date | |
| SIGILON THERAPEUTICS INC | 82657L107 | COM | 360,239 | $3,865,000 | thousands by filing date | |
| BEAM THERAPEUTICS INC | 07373V105 | COM | 28,425 | $3,659,000 | thousands by filing date | |
| PLAYTIKA HOLDING CORP | 72815L107 | COMMON STOCK | 150,000 | $3,576,000 | thousands by filing date | |
| ARKO CORP | 041242108 | COMMON STOCK | 369,875 | $3,399,000 | thousands by filing date | |
| ANNEXON INC | 03589W102 | COM | 148,318 | $3,339,000 | thousands by filing date | |
| EUCRATES BIOMEDICAL ACQU COR | G3141W106 | CMN | 329,025 | $3,239,000 | thousands by filing date | |
| IVERIC BIO INC | 46583P102 | COM | 500,000 | $3,155,000 | thousands by filing date | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 100,391 | $3,130,000 | thousands by filing date | |
| GRACELL BIOTECHNOLOGIES INC | 38406L103 | ADR | 233,850 | $3,040,000 | thousands by filing date | |
| CYCLACEL PHARMACE 6percent PFDCONV | 23254L603 | Stock | 508,322 | $3,009,000 | thousands by filing date | |
| Nexxen International LTD | 89484T104 | SPON ADR | 150,000 | $2,985,000 | thousands by filing date | |
| VINCERX PHARMA INC | 92731L106 | COM NEW | 227,450 | $2,955,000 | thousands by filing date | |
| SENTINELONE INC | 81730H109 | CL A | 68,400 | $2,907,000 | thousands by filing date | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 84,074 | $2,872,000 | thousands by filing date | |
| ACHILLES THERAPEUTICS PL-ADR | 00449L102 | COM | 292,194 | $2,861,000 | thousands by filing date | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 9,249 | $2,785,000 | thousands by filing date | |
| FREQUENCY THERAPEUTICS INC | 35803L108 | COM | 275,160 | $2,741,000 | thousands by filing date | |
| CYTEIR THERAPEUTICS INC | 23284P103 | COMMON | 125,000 | $2,675,000 | thousands by filing date | |
| PERRIGO CO PLC SHS | G97822103 | Stock | 52,500 | $2,407,000 | thousands by filing date | |
| TWIST BIOSCIENCE CORP | 90184D100 | COM | 18,000 | $2,399,000 | thousands by filing date | |
| CEREVEL THERAPEUTICS HLDNG I | 15678U102 | *W EXP 06/09/202 | 165,295 | $2,379,000 | thousands by filing date | |
| CENTURY THERAPEUTICS INC | 15673T100 | COM | 80,000 | $2,347,000 | thousands by filing date | |
| LAVA THERAPEUTICS NV | N51517105 | SHS | 215,359 | $2,343,000 | thousands by filing date | |
| MONTE ROSA THERAPEUTICS INC | 61225M102 | COM | 100,000 | $2,270,000 | thousands by filing date | |
| TURMERIC ACQUISITION CORP | G9127T108 | CMN | 219,440 | $2,170,000 | thousands by filing date | |
| JIYA ACQUISITION CORP | 47760M102 | CMN | 199,028 | $1,978,000 | thousands by filing date | |
| HEALTHCOR CATALIO ACQU CORP | G44125105 | CL A SHS | 200,000 | $1,970,000 | thousands by filing date | |
| HEALTHCARE CAPITAL CORP | 42228c200 | COM | 196,610 | $1,962,000 | thousands by filing date | |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 150,000 | $1,700,000 | thousands by filing date | |
| WIX COM LTD SHS | M98068105 | Stock | 5,700 | $1,655,000 | thousands by filing date | |
| PLIANT THERAPEUTICS INC | 729139105 | COM | 51,000 | $1,485,000 | thousands by filing date | |
| SINGULAR GENOMICS SYSTEMS IN | 82933R100 | COM | 53,867 | $1,480,000 | thousands by filing date | |
| CLARIM ACQUISITION CORP | 18049C207 | UNIT 99/99/9999 | 148,886 | $1,478,000 | thousands by filing date | |
| PRAXIS PRECISION MEDICINES I | 74006W108 | COM | 75,600 | $1,382,000 | thousands by filing date | |
| YUMANITY THERAPEUTICS INC | 98872L102 | COM | 115,298 | $1,343,000 | thousands by filing date | |
| DFP HEALTHCARE ACQUISITNS CO | 23343Q100 | COM CL A | 126,491 | $1,257,000 | thousands by filing date | |
| FRAZIER LIFESCIENCES ACQU CO | G3710A105 | CMN | 126,687 | $1,237,000 | thousands by filing date | |
| LEFTERIS ACQUISITION CORP | 52470X109 | COM CL A | 114,428 | $1,116,000 | thousands by filing date | |
| CELCUITY INC | 15102K100 | COM | 45,000 | $1,080,000 | thousands by filing date | |
| OMEGA ALPHA SPAC | G6749V107 | CL A | 100,000 | $995,000 | thousands by filing date | |
| MSP RECOVERY INC COM CL A | 53625R104 | Stock | 99,859 | $986,000 | thousands by filing date | |
| E MERGE TECHNOLOGY ACQUISITI | 26873Y104 | CMN | 100,000 | $976,000 | thousands by filing date | |
| CM LIFE SCIENCES III INC | 125841205 | UNIT 04/30/2028 | 75,000 | $821,000 | thousands by filing date | |
| GRAPHITE BIO INC | 38870X104 | COM | 24,957 | $767,000 | thousands by filing date | |
| NICE SYS INC | 65366HAB9 | BOND | 250,000 | $731,000 | thousands by filing date | |
| APOLLO STRATEGIC GROWTH CAPITAL | G0411R106 | COMMON STOCK-FO | 73,055 | $714,000 | thousands by filing date | |
| TAILWIND INTERNATNAL ACQ COR | G8662F127 | UNIT 99/99/9999 | 48,342 | $483,000 | thousands by filing date | |
| ELEVATION ONCOLOGY INC COM | 28623U101 | Stock | 30,000 | $407,000 | thousands by filing date | |
| IMMATICS N.V | N44445117 | *W EXP 07/01/202 | 100,000 | $344,000 | thousands by filing date | |
| MAGIC SOFTWARE ENTERPRISES LTD ORD | 559166103 | Stock | 15,976 | $259,000 | thousands by filing date | |
| SARISSA CAPITAL ACQUISITN CO | G7823W102 | CMN | 23,900 | $237,000 | thousands by filing date | |
| CEREVEL THERAPEUTICS HLDNG I | 15678U128 | COM | 9,212 | $236,000 | thousands by filing date | |
| OUTLOOK THERAPEUTICS INC | 69012T115 | *W EXP 02/18/202 | 129,500 | $49,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001496201-21-000004 | this filing | 2021-08-17 | acceptance time not in the bulk data set |