13F-HR filed by RTW INVESTMENTS, LP
RTW INVESTMENTS, LP filed this 13F-HR for the quarter ended 2022-12-31, filed 2023-02-14, with 77 holding rows worth $4,898,669,194.
- Accession
- 0001493152-23-004608
- Filer
- CIK 1493215
- Filed
- 2023-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2022
A holdings report, 77 entries on the cover page, a total value of $4,898,669,194 stated on the cover page (in dollars after the unit check, H1), rows summing to $4,898,669,194 with VALUE read as dollars as filed, 13F file number 028-16670. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerRTW MASTER FUND, LTD.028-16671
- included managerRTW Innovation Master Fund Ltd.028-19525
- included managerRTW Venture Fund Ltd028-19571
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 1,683,362 | $400,050,979 | dollars as filed | |
| PROMETHEUS BIOSCIENCES INC | 74349U108 | COM | 3,354,303 | $368,973,330 | dollars as filed | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 17,687,772 | $346,149,698 | dollars as filed | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 5,559,322 | $317,270,507 | dollars as filed | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 435,500 | $239,825,495 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 2,980,482 | $229,884,577 | dollars as filed | |
| MASIMO CORP COM | 574795100 | Stock | 1,501,493 | $222,145,889 | dollars as filed | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 5,615,387 | $214,339,322 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 3,966,915 | $183,787,172 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 482,195 | $182,669,932 | dollars as filed | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 3,643,114 | $165,069,495 | dollars as filed | |
| ESTABLISHMENT LABS HOLDINGS | G31249108 | COMMON STOCK | 2,374,138 | $155,862,160 | dollars as filed | |
| PENUMBRA INC COM | 70975L107 | Stock | 698,371 | $155,359,613 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 3,084,215 | $137,463,463 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 5,605,566 | $124,387,510 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 2,574,198 | $117,949,752 | dollars as filed | |
| ILLUMINA INC | 452327109 | COM | 564,375 | $114,116,625 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 2,609,283 | $104,814,898 | dollars as filed | |
| VERICEL CORP | 92346J108 | COM | 3,099,904 | $81,651,471 | dollars as filed | |
| CUTERA INC | 232109108 | COM | 1,798,675 | $79,537,409 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 3,670,938 | $58,441,333 | dollars as filed | |
| GLOBUS MED INC CL A | 379577208 | Stock | 747,685 | $55,530,565 | dollars as filed | |
| AXONICS INC | 05465P101 | COM | 884,974 | $55,337,424 | dollars as filed | |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 1,551,778 | $50,882,801 | dollars as filed | |
| REGENXBIO INC | 75901B107 | COM | 1,845,366 | $41,852,901 | dollars as filed | |
| AVADEL PHARMACEUTICALS, PLC | 05337M104 | COMMON STOCK-FO | 5,741,939 | $41,112,283 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 3,591,986 | $39,188,567 | dollars as filed | |
| ADICET BIO INC | 007002108 | COM | 4,241,472 | $37,918,760 | dollars as filed | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 4,356,920 | $37,905,204 | dollars as filed | |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 2,548,125 | $37,355,513 | dollars as filed | |
| BICYCLE THERAPEUTICS PLC-ADR | 088786108 | SPONSORED ADS | 1,258,587 | $37,254,175 | dollars as filed | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 4,993,279 | $36,351,071 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 3,870,981 | $35,729,155 | dollars as filed | |
| 10X GENOMICS INC CL A COM | 88025U109 | Stock | 872,592 | $31,797,252 | dollars as filed | |
| OYSTER POINT PHARMA INC | 69242L106 | COMMON STOCK | 2,304,977 | $25,746,593 | dollars as filed | |
| OLINK HLDG AB | 680710100 | ADR | 981,918 | $24,921,079 | dollars as filed | |
| OUTSET MEDICAL INC | 690145107 | COM | 909,652 | $23,487,215 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 2,168,957 | $21,082,262 | dollars as filed | |
| IVERIC BIO INC | 46583P102 | COM | 821,288 | $17,583,776 | dollars as filed | |
| Milestone Pharmaceuticals Inc | 59935V107 | COM | 4,315,102 | $17,087,804 | dollars as filed | |
| CINCOR PHARMA INC | 17240Y109 | COM | 1,389,705 | $17,079,474 | dollars as filed | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 2,819,472 | $16,634,885 | dollars as filed | |
| ALLAKOS INC | 01671P100 | COM | 1,643,500 | $13,838,270 | dollars as filed | |
| CASTLE BIOSCIENCES INC | 14843C105 | COMMON STOCK | 516,995 | $12,170,062 | dollars as filed | |
| GUARDANT HEALTH INC COM | 40131M109 | Stock | 430,887 | $11,720,126 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 1,000,000 | $10,180,000 | dollars as filed | |
| HEALTH SCIENCES ACQ CORP 2 | G4411D109 | ORD SHS | 1,000,000 | $9,980,000 | dollars as filed | |
| WHITEHAWK THERAPEUTICS INC | 00032Q104 | CMN | 764,701 | $9,811,114 | dollars as filed | |
| MONTE ROSA THERAPEUTICS INC | 61225M102 | COM | 1,214,572 | $9,242,893 | dollars as filed | |
| SIGHT SCIENCES INC | 82657M105 | COMMON STOCK | 665,323 | $8,123,594 | dollars as filed | |
| APYX MEDICAL CORPORATION | 03837C106 | COM | 3,398,279 | $7,951,973 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 857,464 | $7,605,706 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 845,000 | $7,359,950 | dollars as filed | |
| RELMADA THERAPEUTICS INC | 75955J402 | COMMON STOCK | 2,067,824 | $7,216,706 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 802,717 | $6,413,709 | dollars as filed | |
| JOUNCE THERAPEUTICS INC | 481116101 | COM | 5,106,341 | $5,668,039 | dollars as filed | |
| IMMUNIC INC | 4525EP101 | COM | 3,861,290 | $5,405,806 | dollars as filed | |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 500,000 | $5,250,000 | dollars as filed | |
| SUMMIT HEALTHCRE ACQUISTN CO | G8566R128 | UNIT 06/03/2026 | 500,000 | $5,060,000 | dollars as filed | |
| ARYA SCIENCES ACQU CORP IV | G31659108 | COM | 500,000 | $5,050,000 | dollars as filed | |
| ARYA SCIENCES ACQUISITN CORP | G31658100 | CLASS A ORD SHS | 500,000 | $5,045,000 | dollars as filed | |
| TENAYA THERAPEUTICS INC | 87990A106 | COM | 2,458,750 | $4,942,088 | dollars as filed | |
| DERMTECH INC | 24984K105 | COM | 2,718,356 | $4,811,490 | dollars as filed | |
| AKOYA BIOSCIENCES INC COM | 00974H104 | Stock | 483,815 | $4,630,110 | dollars as filed | |
| TELA BIO INC | 872381108 | COM | 390,364 | $4,489,186 | dollars as filed | |
| BRAINSWAY LTD | 10501L106 | CMN | 1,602,381 | $3,957,881 | dollars as filed | |
| EXAGEN INC | 30068X103 | COM | 1,364,336 | $3,274,406 | dollars as filed | |
| Johnson & Johnson | 478160104 | COM | 18,127 | $3,202,135 | dollars as filed | |
| MEDICUS SCIENCES ACQUISITION | G5960S108 | CL A SHS | 300,000 | $3,021,000 | dollars as filed | |
| THIRD HARMONIC BIO INC | 88427A107 | COM | 609,687 | $2,621,654 | dollars as filed | |
| 908 DEVICES INC COM | 65443P102 | Stock | 312,000 | $2,377,440 | dollars as filed | |
| PULMONX CORP | 745848101 | COM | 275,000 | $2,318,250 | dollars as filed | |
| NYXOAH S A | B6S7WD106 | SHS | 269,993 | $1,347,265 | dollars as filed | |
| NAUTILUS BIOTECHNOLOGY INC | 63909J108 | COM | 600,000 | $1,080,000 | dollars as filed | |
| SCIENCE 37 HOLDINGS INC | 808644108 | COM | 2,586,108 | $1,073,752 | dollars as filed | |
| MIROMATRIX MED INC | 60471P108 | COM | 280,000 | $837,200 | dollars as filed | |
| MEDICUS SCIENCES ACQUISITION | G5960S124 | *W EXP 02/12/202 | 33,331 | $3,000 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001493152-23-004608 | this filing | 2023-02-14 | acceptance time not in the bulk data set |